LOCUS       NM_133721               7001 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus integrin alpha 9 (Itga9), transcript variant 1, mRNA.
ACCESSION   NM_133721 XM_985968
VERSION     NM_133721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7001)
  AUTHORS   Niibori-Nambu,A., Wang,C.Q., Chin,D.W.L., Chooi,J.Y., Hosoi,H.,
            Sonoki,T., Tham,C.Y., Nah,G.S.S., Cirovic,B., Tan,D.Q.,
            Takizawa,H., Sashida,G., Goh,Y., Tng,J., Fam,W.N., Fullwood,M.J.,
            Suda,T., Yang,H., Tergaonkar,V., Taniuchi,I., Li,S., Chng,W.J. and
            Osato,M.
  TITLE     Integrin-alpha9 overexpression underlies the niche-independent
            maintenance of leukemia stem cells in acute myeloid leukemia
  JOURNAL   Gene 928, 148761 (2024)
   PUBMED   39002785
  REMARK    GeneRIF: Integrin-alpha9 overexpression underlies the
            niche-independent maintenance of leukemia stem cells in acute
            myeloid leukemia.
REFERENCE   2  (bases 1 to 7001)
  AUTHORS   Jin,S., Song,Y., Zhou,L., Jiang,W., Qin,L., Wang,Y., Yu,R., Liu,Y.,
            Diao,Y., Zhang,F., Liu,K., Li,P., Hu,H., Jiang,B., Tang,W., Yi,F.,
            Gong,Y., Liu,G. and Sun,G.
  TITLE     Depletion of CUL4B in macrophages ameliorates diabetic kidney
            disease via miR-194-5p/ITGA9 axis
  JOURNAL   Cell Rep 42 (6), 112550 (2023)
   PUBMED   37224018
  REMARK    GeneRIF: Depletion of CUL4B in macrophages ameliorates diabetic
            kidney disease via miR-194-5p/ITGA9 axis.
REFERENCE   3  (bases 1 to 7001)
  AUTHORS   Jung,I.H., Elenbaas,J.S., Burks,K.H., Amrute,J.M., Xiangyu,Z.,
            Alisio,A. and Stitziel,N.O.
  TITLE     Vascular smooth muscle- and myeloid cell-derived integrin
            alpha9beta1 does not directly mediate the development of
            atherosclerosis in mice
  JOURNAL   Atherosclerosis 360, 15-20 (2022)
   PUBMED   36215801
REFERENCE   4  (bases 1 to 7001)
  AUTHORS   Lyons,O., Walker,J., Seet,C., Ikram,M., Kuchta,A., Arnold,A.,
            Hernandez-Vasquez,M., Frye,M., Vizcay-Barrena,G., Fleck,R.A.,
            Patel,A.S., Padayachee,S., Mortimer,P., Jeffery,S., Berland,S.,
            Mansour,S., Ostergaard,P., Makinen,T., Modarai,B., Saha,P. and
            Smith,A.
  TITLE     Mutations in EPHB4 cause human venous valve aplasia
  JOURNAL   JCI Insight 6 (18), e140952 (2021)
   PUBMED   34403370
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7001)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7001)
  AUTHORS   Stepp,M.A.
  TITLE     Alpha9 and beta8 integrin expression correlates with the merger of
            the developing mouse eyelids
  JOURNAL   Dev Dyn 214 (3), 216-228 (1999)
   PUBMED   10090148
REFERENCE   7  (bases 1 to 7001)
  AUTHORS   Stepp,M.A. and Zhu,L.
  TITLE     Upregulation of alpha 9 integrin and tenascin during epithelial
            regeneration after debridement in the cornea
  JOURNAL   J Histochem Cytochem 45 (2), 189-201 (1997)
   PUBMED   9016309
REFERENCE   8  (bases 1 to 7001)
  AUTHORS   Wang,A., Patrone,L., McDonald,J.A. and Sheppard,D.
  TITLE     Expression of the integrin subunit alpha 9 in the murine embryo
  JOURNAL   Dev Dyn 204 (4), 421-431 (1995)
   PUBMED   8601035
REFERENCE   9  (bases 1 to 7001)
  AUTHORS   Stepp,M.A., Zhu,L., Sheppard,D. and Cranfill,R.L.
  TITLE     Localized distribution of alpha 9 integrin in the cornea and
            changes in expression during corneal epithelial cell
            differentiation
  JOURNAL   J Histochem Cytochem 43 (4), 353-362 (1995)
   PUBMED   7534781
REFERENCE   10 (bases 1 to 7001)
  AUTHORS   Palmer,E.L., Ruegg,C., Ferrando,R., Pytela,R. and Sheppard,D.
  TITLE     Sequence and tissue distribution of the integrin alpha 9 subunit, a
            novel partner of beta 1 that is widely distributed in epithelia and
            muscle
  JOURNAL   J Cell Biol 123 (5), 1289-1297 (1993)
   PUBMED   8245132
  REMARK    Erratum:[J Cell Biol 1994 Feb;124(3):395]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB638856.1, AK153585.1, CN698186.1 and AC156800.2.
            
            On Jan 16, 2008 this sequence version replaced NM_133721.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ344342.1, BC150824.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               BB638856.1         20-590
            572-1170            AK153585.1         34-632
            1171-1716           CN698186.1         13-558
            1717-3366           AK153585.1         1179-2828
            3367-7001           AC156800.2         115588-119222       c
FEATURES             Location/Qualifiers
     source          1..7001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 70.32 cM"
     gene            1..7001
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /note="integrin alpha 9"
                     /db_xref="GeneID:104099"
                     /db_xref="MGI:MGI:104756"
     exon            1..407
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..3330
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="integrin alpha-9 isoform a precursor"
                     /protein_id="NP_598482.2"
                     /db_xref="CCDS:CCDS23604.1"
                     /db_xref="GeneID:104099"
                     /db_xref="MGI:MGI:104756"
                     /translation="MGGPAAARTGAGGLRALLLALVAAGVPAGAYNLDAQRPVRFQGP
                     SGSFFGYAVLEHFHDNTRWVLVGAPKADSKYSTSVKSPGAVFKCRVHTNPDRRCTELD
                     MARGRTRGAPCGKTCRGDRDDEWMGVSLARQPRADGRVLACAHRWKNIYYEADHILPH
                     GFCYLIPSNLQAKGKVLIPCYEEYKKKYGEEHGSCQAGIAGFFTEELVVMGAPGSFYW
                     AGTLKVLNLTDNTYFKLNDEAIMNRRYTYLGYAVTAGHFSHPSITDVVGGAPQDEGIG
                     KVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNMDGLSDLLVGAPMFSEIRD
                     EGQVTVYLNQGHGALEEQLTLTGDAAYNAHFGESIANLGDIDDDGFPDVAVGAPKEED
                     FAGAVYIYHGDANGIVPKYSMKLSGRRLNPTLRMFGQSISGGIDMDGNGYPDVTIGAF
                     LSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTVCFRFHGKNVPG
                     EIGLNYNLTADVAQKEKGQLPRVYFVLFGETAGQVSERLQLSHMDEVCHHYVAHVKRR
                     VQDVISPIVFEAAYSLDEHVMGEEDRELPDLTPVLRWKKGQRISQKNQTVFERNCQSE
                     DCAADLQLRGKLLLSSVDEKTPHLALGAVKNISLNISISNLGDDAYDANVSFNVSREL
                     FFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEILSF
                     IVTAQSGNLERSEALHDNTLTLTVPLVHEVDTSITGIVSPTSFVYGESVDASNFIQLD
                     DQECHFQPVNITLQVYNMGPSTLPGSSVSISFPSRLSPGGAEMFQVQDMVVSQEKGNC
                     SLQRNPTPCIIPQEQENIFHTIFAFFSKSGRKVLDCEKPGSFCLTLHCNLSALPKEES
                     RTINLYMLLNTEILKKDSSSVIQFMARAKVKVEPALRVVEIANGNPEETLVVFEALHN
                     LEPRGYVVGWIIAISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDGWD
                     WVQKNQ"
     exon            408..535
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            536..642
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            643..766
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            767..834
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            835..964
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1050
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1119
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1257
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1363
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1458
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1549
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1595
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1750
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1911
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2061
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2138
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2289
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2376
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2456
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2546
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2655
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2656..2763
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2889
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3009
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3111
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3231
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..7001
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6980..6985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /note="hexamer: AACAAA"
     polyA_site      7001
                     /gene="Itga9"
                     /gene_synonym="(alpha)9; 2610002H11Rik; 6720458D17Rik;
                     D130073C02; D9Ertd428e"
                     /note="major polyA site"
ORIGIN      
        1 cgggcccggg acccgctcct tccgagagcg cagacctctc ggcgggcatc gagaggacgc
       61 ggggcgctgg cggccgtccc tggccttgct ccggctctcg ctgtagccca tcgccgcgtc
      121 ccgggcttag actcggagcg tacggctccc gccccgggca gcggcgtgtc ccgggagccc
      181 cgatcgcggg gcagggcgca gggcggcggc cggctgggga tgggcggccc ggctgcggcg
      241 cggaccggcg ccggagggct ccgcgcgctg ctgctggcgc tggtggccgc gggggtcccg
      301 gccggcgcct acaacctgga cgcgcagcgc ccggtacgct tccagggccc ctcaggctcc
      361 ttcttcggct acgcggtgct ggagcacttc cacgacaaca cgcgctgggt cctcgtgggt
      421 gcaccgaagg cagattctaa atatagcact tcagtaaagt ctcctggagc tgtgtttaag
      481 tgtcgtgtcc ataccaaccc tgaccggaga tgcaccgagc tggacatggc tcgagggagg
      541 actcgtggtg cgccctgtgg gaagacctgc aggggagacc gggatgacga gtggatgggg
      601 gtgagcctgg cccggcagcc cagagcagat ggccgtgttt tggcctgtgc ccatcgttgg
      661 aagaacatct actacgaagc agaccacatc ctgccccatg gattctgcta cctcatccct
      721 tccaacctcc aggccaaagg caaggtgctg attccctgct acgaagagta taagaagaag
      781 tatggggaag aacatggctc ctgccaggcc ggaatagcag gcttcttcac agaggaactg
      841 gtggtcatgg gtgccccagg ctcgttttat tgggctggga cactcaaggt gctgaacctc
      901 acggacaaca catattttaa gttgaacgat gaagcgatta tgaacagacg gtatacttat
      961 ctgggctatg cagtgacggc tggccacttc tctcatccat ccatcactga tgtggtaggg
     1021 ggtgccccac aggatgaagg cattggaaag gtttatatat ttagagctga ccgaagatca
     1081 gggaccttaa taaagatctt tcaggcatca ggaaaaaaga tgggctctta cttcggctcc
     1141 tccttgtgtg cagtcgacct gaacatggac ggcctctctg acttgctcgt gggggctccc
     1201 atgttttctg agatcagaga tgaggggcag gtcaccgtct acctcaacca aggacatgga
     1261 gccctcgagg aacagctgac cctgactgga gatgccgcct acaacgcgca ctttggggag
     1321 agcatcgcca acctgggcga cattgatgat gacgggttcc cagatgtggc tgtcggggca
     1381 cctaaggagg aggactttgc tggcgcagtc tacatctatc atggtgatgc caatgggatt
     1441 gtccccaagt actcaatgaa gctgtctggg aggaggctaa acccgaccct gcggatgttt
     1501 gggcagtcca tatcaggggg cattgatatg gatggaaatg gctatcctga tgtcaccatc
     1561 ggagccttcc tgtccgacag cgtggttctc ctcagggcca gaccggtcat cacggtggat
     1621 gtctccatct tcctgccagg ctccatcaac atcacagcac ctcagtgtca cgatggacaa
     1681 cagcctgtga actgcctgaa tgtcaccgtg tgcttccggt tccatggcaa gaatgtacca
     1741 ggagaaatcg gtctgaacta caatctgacg gctgatgtgg cacagaagga gaagggccag
     1801 ctgcccagag tctattttgt gttgtttgga gagacggcag ggcaggtctc agaaaggctg
     1861 cagctgtccc acatggacga agtgtgtcat cactacgtgg cccacgtcaa gcggagagtc
     1921 caggatgtca tcagccccat tgtgtttgaa gccgcctaca gcctggatga gcatgtgatg
     1981 ggtgaggaag accgggagct gccagacctg acaccagtgc ttcgctggaa gaagggacaa
     2041 aggatctccc agaagaatca gacagttttt gaaaggaatt gccaatctga ggactgtgct
     2101 gccgacctgc agcttcgggg gaaactcctg ctttccagtg ttgacgagaa aaccccacac
     2161 ctggctttgg gggctgtgaa aaatatctct ctaaacatct ccatctccaa ccttggagac
     2221 gacgcctatg atgccaacgt gtcctttaat gtctccaggg aacttttctt catcaacatg
     2281 tggcagaagg aggagatggg catttcctgt gagctgctgg aatcagactt cctcaagtgc
     2341 agtgtgggat ttcctttcat gaggtcaaag tctaagtatg aattcagtgt catctttgat
     2401 acaagccacc tgtctgggga agaggaaatt ctcagcttca tcgtgactgc tcagagtggc
     2461 aacttggagc gctctgaagc cctgcatgac aacactctca cactgacagt gcccctggtg
     2521 catgaagtgg acacgtccat cactggaatt gtgtccccaa cctccttcgt gtatggcgag
     2581 tctgtggacg catccaactt cattcagctg gatgaccagg agtgtcattt ccaaccagtc
     2641 aacattactc tccaggtcta caacatgggt cccagcaccc ttcctgggtc atctgtcagc
     2701 atctccttcc ccagccggct gtcacctggt ggcgcagaga tgtttcaggt ccaggacatg
     2761 gtggtgagcc aagagaaggg taactgctct ctacaaagaa acccgacccc ctgcatcatc
     2821 cctcaagaac aagagaacat cttccacacc atatttgctt tcttctccaa gtctggaaga
     2881 aaagtgttgg actgtgaaaa gccagggagc ttctgcctaa cgttgcactg caaccttagt
     2941 gctcttccga aagaggagag ccgcaccatc aacctataca tgctactgaa cacagagata
     3001 ctgaagaagg acagctcctc tgtcatccag ttcatggctc gagccaaggt gaaggtggag
     3061 cctgccctga gagtggtgga gatagctaac gggaacccag aagagactct ggtggtcttc
     3121 gaggccttgc acaatctgga accccgtggc tacgttgtgg ggtggatcat cgccatcagt
     3181 ttgctggtgg ggatcctcat ttttctgctg ctggctgtgc tcctgtggaa gatgggcttc
     3241 ttccgcagaa ggtacaaaga gatcattgaa gctgagaaaa accggaaaga gaatgaagat
     3301 ggttgggact gggtccagaa aaaccagtga cccaccgtgc cagtcatgtg atgccctcat
     3361 gtccccatca ccagcctgtg gtccttgatc tttgtatctt tcatatttgg aagaaagaaa
     3421 tcttctccag atttttcgga ggccccactg atgctgttct cttcctcatc ccgtcaagcc
     3481 cggtgccgac ctgagatggc cacccctcca gccaggtcac atgactgggg ccaccaccac
     3541 tccccttcgc aagatgaact tagaactttg gaaaggcaag ctacagagca aagcaatatt
     3601 tatggatgca acattgcgtg gtcaaccctc aggggaaaac tgttacctaa aagtattttt
     3661 tataaatgta agccttttat attgatcatg tctttatatt tgtatcaatg ttttattatt
     3721 tctattaaat agttctataa ttcactcaag cactgaaatc ttggaaatac atgtccctgc
     3781 atacaaattt taaaagagaa ggaacttatt ctactttgga acttgttgtt agggaagaaa
     3841 aaaaaaactt gcagataaaa caaactgaag aaacctcatg aaatgaatcc accaagctgg
     3901 aggcactggg aaagcacaaa ggacatggca aggccgccta agacatttat tccccattgt
     3961 taccacccgg agttaagttc agagagcttg aagtatcggt gttttctctt atggacctct
     4021 cactgggaga ttctcagcag gaactgggat ggaaagcttg gtttcctctc agcagttgct
     4081 ctgtaccaca ctgatacatg cagcaggcac taaaccctct tctggagtca gcaagtgctg
     4141 gatggacaac tggtcaacct cagaatagca tctcatccta aacaacatgt gtcagagttc
     4201 agagcccagg accgaagctg tgctctctca gcaaaggcct gttttctctg tgtgtaagct
     4261 gttaccttgt ggtataatgt taacacaaga ctctccattt cctctgtcac tcttgctgtc
     4321 cccaactggt ggtgctgcag atacctcccc agagaggatc accccacatg gtttgtgttt
     4381 atgtcttagg tggaattctc aagagtcgaa ccctgaaata ggacttgggt gtaaataatt
     4441 tattgaggaa gtcttcccag aaggtaacag tgaggaagtt gagaatacaa gacaggagag
     4501 tacagggagc caggcaacag tgtcctttca ggggacaacc cacgaggtgg cttcaaacca
     4561 gttggatcta atgagcaagt cagactcagg aacctggact tttgtgatgc cacgcctgca
     4621 ggggatataa actttctgcc cttaggtctt gctgacaaga tgactctgtc ctctagagga
     4681 gaactttggg gggcaccctc aagtaaggag atccacaaat catgcaaaga actctgagcc
     4741 aagagcttta gtgctcccct cccccacaca agtgaatgct accttcagct ttgtgtagcc
     4801 aaaaaagcca tgagtctaag ctggtcctag gagtcaaaca ttacatctga cccatgacca
     4861 agtcaaactc actacaagga aggggcagcc cccccaaaaa aaaaaacagt gcacacccag
     4921 ctcttttaag ttttatcaaa agaaagaaga aagaagtctt ggctttacca gccatgtaca
     4981 tcctgatctg tagtcaggca ctatcctggt ggatcccctg agaacacagt cccctcgtgc
     5041 ctcagggtgg taagcctccc acaataggtg cagagtgtgg attcttcatg aaccccattt
     5101 gcagctgtcc tgtgatgatc gtgaattgtg tcatggtttc ctttaataaa tcatttgaga
     5161 gtctcaggtg gtgagaccac tacagaacca tctgcagtta tactcaaaat gcatttgtcc
     5221 ccactggctt acttcctgca gagggtatga ctgcatcaat ggagaaggat gcataactca
     5281 gctagccagc agagctgcac ctgagaaagt gtggaaggca ggaagggcag actcagctag
     5341 aatctggcca ctcagctgga tctcaaatgg tgaaccgcca tgactagtca catgctcaga
     5401 tgtcgataca acttcaggag gcagatttta aggaaactat atggttgctc aggaagcaaa
     5461 tcctaaaagg caccataggg gagaggaggc ctctttgcct atctgataat gttgagagct
     5521 aggggtgtgg ctgcctggca cagaggcagg gaaaggggtg gagcattgtc ttggaattct
     5581 ctcagctgag ttgttcaatg tctccatccc agtctccctc cagggatcag gaaaagtggg
     5641 caggtggatt gatgtgcctg tgttagctct ttctagaaca ttctttttaa aagcccactg
     5701 tgtcgcctgt tgtagccttc ctctgcctct gagttcattc tgcagacgtt ctccagggcg
     5761 ctatcaatag cctgcttgtt tttcagttgt gtcttctgtg ggtttaacca gctcaagaaa
     5821 gactagagca tccccaaagt gaaccctgcc acagaaaggc tatgacgtag acaaacaaga
     5881 acaccagcaa gaggggctgg tcgattgact agcgcacacc ctgtgtcctg ccactgtggt
     5941 ctcaggcaat gatttgggaa agcacctcag ggcccagcgg tttgacaggc tgcatgaagt
     6001 tgtctgtccg agtcccccat ccatctatcc ttgtgctcta ccactcaacc ccctacccaa
     6061 cccaccccca cgcaccaaat atcacatgac ctactaaagc caaaggcaag ggaaagtctc
     6121 aataaacagc atgctgttgg gacaccccgg ggaccagtga cccttgtggt gtggtcaagc
     6181 cccagtgtgg agggtgtgga aatgttattc acatttattt aaggatgaca catacgtgat
     6241 catatatacc tgattaccct ggaaacataa acctagagaa ggggtgccca gtgtcaactt
     6301 cctgagattt agcggcactg caaagcactg gcgtttgatg agtggcgtag gatgcagctc
     6361 agtcacagtg cttgcccgac acaggggagg catcatttgg gggacctgtc ccattgataa
     6421 acaaaaggca gaaactgaat attctcagaa tgacttcccc gagaacacag aattttagtc
     6481 gatgtgggtt tgggtagagg ggtatgtgtt ctatgataat gactgaaggg aggcggcaga
     6541 gcccctgggg ccaagggagc cttctagaac aacttctggg ttttcagcat gagggaagtg
     6601 atgagaaaat ctcccccccc cccgggtgtg gcgtggtgct ctctatagcc gatctgcttt
     6661 tcagtctatt aaagtgtttg gtttgctgtg tttgatcctg atgtacacag tgtgattggt
     6721 ggtgtgagtt taagctttct gggtggtttg ttgcatggca ggcacctctg ctctctgcat
     6781 gtctgcagct ttactgaggt gcacacacac acacacacac acacacacac acacacacac
     6841 actgcccgag aggatttgga gtgggagggc tgcccttcct cactgtgtct tgtgaattca
     6901 tgtctatttc tgcagtcact tctgaatcac ttgcactgtt tgggaaatgc caggtttaca
     6961 aaaaataagt ttagaataaa acaaaatctg gcttcaaatg a
//
