LOCUS       NM_001408100            5878 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus integrin alpha 8 (Itga8), transcript variant 2, mRNA.
ACCESSION   NM_001408100 XM_006497475
VERSION     NM_001408100.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5878)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5878)
  AUTHORS   Liu,L., Arevalo-Martinez,M., Rippe,C., Johansson,M.E., Holmberg,J.,
            Albinsson,S. and Sward,K.
  TITLE     Itga8-Cre-mediated deletion of YAP and TAZ impairs bladder
            contractility with minimal inflammation and chondrogenic
            differentiation
  JOURNAL   Am J Physiol Cell Physiol 325 (6), C1485-C1501 (2023)
   PUBMED   37927241
REFERENCE   3  (bases 1 to 5878)
  AUTHORS   Arevalo Martinez,M., Ritsvall,O., Bastrup,J.A., Celik,S.,
            Jakobsson,G., Daoud,F., Winqvist,C., Aspberg,A., Rippe,C.,
            Maegdefessel,L., Schiopu,A., Jepps,T.A., Holmberg,J., Sward,K. and
            Albinsson,S.
  TITLE     Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm
            development in mouse aorta
  JOURNAL   JCI Insight 8 (17), e170845 (2023)
   PUBMED   37561588
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5878)
  AUTHORS   Gao,G., Li,X., Jiang,Z., Osorio,L., Tang,Y.L., Yu,X., Jin,G. and
            Zhou,Z.
  TITLE     Isthmin-1 (Ism1) modulates renal branching morphogenesis and
            mesenchyme condensation during early kidney development
  JOURNAL   Nat Commun 14 (1), 2378 (2023)
   PUBMED   37185772
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5878)
  AUTHORS   Wilson,C.L., Hung,C.F., Burkel,B.M., Ponik,S.M., Gharib,S.A. and
            Schnapp,L.M.
  TITLE     Nephronectin is required to maintain right lung lobar separation
            during embryonic development
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 324 (3), L335-L344 (2023)
   PUBMED   36719987
REFERENCE   6  (bases 1 to 5878)
  AUTHORS   Kitchen,C.M., Cowan,S.L., Long,X. and Miano,J.M.
  TITLE     Expression and promoter analysis of a highly restricted integrin
            alpha gene in vascular smooth muscle
  JOURNAL   Gene 513 (1), 82-89 (2013)
   PUBMED   23142384
REFERENCE   7  (bases 1 to 5878)
  AUTHORS   Littlewood Evans,A. and Muller,U.
  TITLE     Stereocilia defects in the sensory hair cells of the inner ear in
            mice deficient in integrin alpha8beta1
  JOURNAL   Nat Genet 24 (4), 424-428 (2000)
   PUBMED   10742111
REFERENCE   8  (bases 1 to 5878)
  AUTHORS   Denda,S., Reichardt,L.F. and Muller,U.
  TITLE     Identification of osteopontin as a novel ligand for the integrin
            alpha8 beta1 and potential roles for this integrin-ligand
            interaction in kidney morphogenesis
  JOURNAL   Mol Biol Cell 9 (6), 1425-1435 (1998)
   PUBMED   9614184
REFERENCE   9  (bases 1 to 5878)
  AUTHORS   Denda,S., Muller,U., Crossin,K.L., Erickson,H.P. and Reichardt,L.F.
  TITLE     Utilization of a soluble integrin-alkaline phosphatase chimera to
            characterize integrin alpha 8 beta 1 receptor interactions with
            tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C
            fragments, but not to native tenascin-C
  JOURNAL   Biochemistry 37 (16), 5464-5474 (1998)
   PUBMED   9548928
REFERENCE   10 (bases 1 to 5878)
  AUTHORS   Muller,U., Wang,D., Denda,S., Meneses,J.J., Pedersen,R.A. and
            Reichardt,L.F.
  TITLE     Integrin alpha8beta1 is critically important for
            epithelial-mesenchymal interactions during kidney morphogenesis
  JOURNAL   Cell 88 (5), 603-613 (1997)
   PUBMED   9054500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL845313.9.
            
            On Jun 9, 2022 this sequence version replaced XM_006497475.4.
            
            Summary: This gene encodes a member of the integrin family of cell
            surface proteins that mediate cellular interactions with the
            extracellular matrix and other cells. The encoded protein undergoes
            proteolytic processing to generate the disulfide-linked
            heterodimeric alpha subunit which, in turn associates with a beta
            subunit to form the functional integrin receptor. Mice lacking the
            encoded protein mostly die after birth due to kidney defects, but
            some of animals that survive exhibit defects in the sensory hair
            cells of the inner ear. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.1499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-366               AL845313.9         204711-205076       c
            367-500             AL845313.9         203972-204105       c
            501-601             AL845313.9         168367-168467       c
            602-725             AL845313.9         165192-165315       c
            726-787             AL845313.9         160303-160364       c
            788-833             AL845313.9         159097-159142       c
            834-959             AL845313.9         156587-156712       c
            960-1004            AL845313.9         153215-153259       c
            1005-1048           AL845313.9         150644-150687       c
            1049-1105           AL845313.9         148280-148336       c
            1106-1158           AL845313.9         145545-145597       c
            1159-1364           AL845313.9         135838-136043       c
            1365-1556           AL845313.9         133184-133375       c
            1557-1602           AL845313.9         107865-107910       c
            1603-1710           AL845313.9         103209-103316       c
            1711-1766           AL845313.9         97513-97568         c
            1767-1921           AL845313.9         96546-96700         c
            1922-2059           AL845313.9         94840-94977         c
            2060-2127           AL845313.9         94305-94372         c
            2128-2275           AL845313.9         92607-92754         c
            2276-2368           AL845313.9         85793-85885         c
            2369-2448           AL845313.9         81778-81857         c
            2449-2529           AL845313.9         77287-77367         c
            2530-2635           AL845313.9         63456-63561         c
            2636-2794           AL845313.9         58506-58664         c
            2795-2923           AL845313.9         43512-43640         c
            2924-3037           AL845313.9         35573-35686         c
            3038-3088           AL845313.9         35007-35057         c
            3089-3190           AL845313.9         23081-23182         c
            3191-3313           AL845313.9         14109-14231         c
            3314-5878           AL845313.9         9771-12335          c
FEATURES             Location/Qualifiers
     source          1..5878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 9.12 cM"
     gene            1..5878
                     /gene="Itga8"
                     /note="integrin alpha 8"
                     /db_xref="GeneID:241226"
                     /db_xref="MGI:MGI:109442"
     exon            1..366
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..3400
                     /gene="Itga8"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="integrin alpha-8 isoform 2 preproprotein"
                     /protein_id="NP_001395029.1"
                     /db_xref="GeneID:241226"
                     /db_xref="MGI:MGI:109442"
                     /translation="MSAGTHCGPPGNRAPPFARLCCVSAALGMLWSPACLAFNLDVDK
                     LTVYSGPEGSYFGYSLDFYIPDARTASVLVGAPKANTSQPDIVEGGAVYYCPWPSERS
                     AQCKQIPFDTTNNRKIRVNGTKEPIEFKSNQWFGATVRAHKGKVVACAPLYHWRTLKP
                     NPAKDPVGTCYVAIQNFSAYAEHSPCRNSNADPEGQGYCQAGFSLDFYKNGDLIVGGP
                     GSFYWQGQVITVSIADIIANYSFKDILRKLAAEKQTDVAPASYDDSYLGYSVAAGEFT
                     GDSQQELVAGIPRGAQNFGYVSIINSTDMTFIQNFTGEQMASYFGYTVVVSDVNNDGM
                     DDILVGAPLFMEREFESNPREVGQVYLYLQASALLFQDPQVLTGTETFGRFGSSVAHL
                     GDLNQDGYNDIAIGVPFAGKDQRGKVLIYNGNPRGLHSKPSQVLQGIWGSQTIPSGFG
                     FSLRGDADIDKNDYPDLLVGAFGKGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQI
                     PEFPTPVACFSVRVCASIAGQSISNTIALLAEVQLDFLKQKGAIKRTLFLHNHQSHFT
                     FPFVMKQQKSLHCQDFMVYLRDETEFRDKLSPINISLNYSLDDSTFKDSLEVKPILNH
                     YRDNVVTEQAHILVDCGEDNLCVPDLKLSARPDKHQIIIGDENHLMLIINARNEGEGA
                     YEAELFVIIPEEADYVGIERNNKGLRPLSCEYKMENVTRMVVCDLGNPMVTGTNFSLG
                     LRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFERVQINITAIAQVEIRGVSHPPQIV
                     LPIHNWEPEKKPHKEEEVGPLVEHIYELHNIGPSTISDSILDVGWPFSARDEFLLYIF
                     HLQTLGPLQCQTNPEINPQDIKPAASPEDTPELSAFLRNATIPHLVRKRDVPVVQLHR
                     QSPARILNCTNIDCLQISCAVGRLGGGESAVLKVRSRLWAHTFLKEISVEETSQEQLV
                     KTLKRKNDHYALASLVSFEVKKMPYKEQPAKLPAGSTAVKTSVIWATPNVSFSIPLWV
                     IILAILLGLLVLAILTLALWKCGFFDRARPPQDEMTDREQLTSDKTPEA"
     exon            367..500
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            501..601
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            602..725
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            726..787
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            788..833
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            834..959
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1004
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1048
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1105
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1158
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1364
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1556
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1602
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1710
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1766
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1921
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2059
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2127
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2275
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2368
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2448
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2529
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2635
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2794
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2923
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..3037
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3088
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3190
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3313
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     exon            3314..5878
                     /gene="Itga8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga8"
                     /note="hexamer: AATAAA"
     polyA_site      5878
                     /gene="Itga8"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcgg ggtcggcggg ccgcacaggg cgagaggact gtcactgtgg acgctcctag
       61 ctcaccgacc cgggacaccg gcctctgggg agcgtcaggc cttctcctct gggctccacg
      121 gctcccgatc ccgggtgaac agcgttcggg aaggagggcg atgtctgcgg gaacccactg
      181 tggtcccccg gggaaccggg cacctccgtt cgcgcgtctc tgttgcgtct cggccgcgct
      241 ggggatgctg tggtcccctg cgtgtctggc gttcaacttg gatgtggaca agctcactgt
      301 gtacagtggc cccgagggca gctacttcgg ctactcactg gacttctaca tacctgatgc
      361 gcgcacagcc agtgtcttag tgggggcacc caaagccaac actagccagc cggatatcgt
      421 agaaggggga gctgtctact actgtccctg gccctcagag aggtctgcac agtgcaagca
      481 gataccgttt gacaccacca acaacaggaa aatcagagtt aatggaacca aagaacctat
      541 agaatttaaa tcaaaccagt ggtttggagc cacagtgaga gctcacaaag gaaaagttgt
      601 ggcttgtgcc cctttgtatc actggagaac tctgaaacct aatccagcga aggacccagt
      661 tggcacatgc tatgtagcaa ttcagaattt cagtgcctat gctgagcact caccttgtcg
      721 aaacagcaat gctgatcccg aaggccaagg ttactgccag gcagggttta gcctagactt
      781 ctataagaat ggagacctta tagtgggagg acctggaagt ttttactggc aaggtcaggt
      841 gatcactgtc agtatagcag acatcattgc aaattactca ttcaaggata ttctacgaaa
      901 attggccgca gaaaagcaga cagacgtggc tccagcttcc tatgatgaca gctaccttgg
      961 atattcggtc gctgctggag aattcactgg ggactctcag caagaattgg tggctgggat
     1021 tccaagagga gcacagaact ttggatatgt ctccatcatt aactccacag acatgacctt
     1081 cattcagaat tttactggtg agcagatggc atcttatttc ggatatactg ttgtggtatc
     1141 agatgttaac aatgatggca tggatgacat attggtcggg gcacctctct ttatggagcg
     1201 agaatttgaa agtaacccta gagaagtggg acaggtctac ttgtaccttc aagcaagcgc
     1261 cctcctcttc caagacccac aggtcctcac cggcacggag acatttggga gatttggtag
     1321 ctctgtggcc cacttggggg acctgaacca agatggatac aatgacatcg ccatcggtgt
     1381 gccctttgca ggcaaggatc aacgaggtaa agtcctcatt tacaatggaa acccaagagg
     1441 tttacacagc aagccttccc aagttctgca aggaatatgg gggtcacaga ccatcccttc
     1501 tggatttggc ttttctctaa gaggagatgc agacatagac aagaatgatt acccagattt
     1561 gcttgtaggg gcatttggaa aagggaaagt agctgtttac agagcaaggc cagttgtaac
     1621 cgtggatgcc cagcttctgc tgcacccgat gattatcaac cttgaaaata aaacttgcca
     1681 gattccagaa ttccctactc ctgtggcctg cttttctgta agagtctgtg catctatagc
     1741 aggccagagc atttcaaata caatagccct gctggccgag gtgcagttag atttcctgaa
     1801 gcaaaaagga gccatcaaac ggacgctctt tctccacaac caccagtccc atttcacctt
     1861 cccctttgtg atgaagcagc agaaatccct ccactgccag gattttatgg tttaccttcg
     1921 ggatgaaact gaattccgag ataaattgtc tccaatcaac atcagcctga actacagttt
     1981 ggatgattct acctttaaag acagcctgga agtgaagcca attttgaacc actacaggga
     2041 caatgtagtt actgagcagg ctcacatcct ggtggactgt ggagaagaca atctatgcgt
     2101 tcctgacttg aagctgtcag ctagaccaga taagcatcag ataattattg gcgatgaaaa
     2161 tcacctaatg ctcataataa atgcaagaaa tgagggagaa ggggcctacg aagccgaact
     2221 ctttgttatc atccccgaag aagcagatta tgttgggatt gagcgcaaca acaagggact
     2281 gaggcccctg agttgtgagt acaagatgga aaacgtgacc aggatggtgg tgtgtgacct
     2341 tgggaacccg atggtgactg gaacaaattt ttctctgggc ctccgatttg ctgttcctcg
     2401 ccttgagaaa acaaatatga gcattaactt cgatctccaa atcagaagct ccaataagga
     2461 caatcctgac agcaacttcg agcgtgtaca gatcaacatc actgccattg ctcaggtcga
     2521 aatcagagga gtgtcccacc ctccgcagat tgttctgccc atccacaact gggaaccaga
     2581 aaagaagcca cacaaagagg aggaagtcgg tcctttggtt gagcatattt atgagctgca
     2641 caatattgga cccagcacca tcagtgacag cattcttgac gtgggctggc cgttctctgc
     2701 acgggatgag tttctcctct atatttttca tcttcaaact ctgggacctc tacaatgtca
     2761 aacaaatcct gagatcaacc cacaggatat aaagcctgct gcctccccag aggatacccc
     2821 tgagctcagt gccttcttaa gaaatgctac aattccccat cttgtcagaa agagggatgt
     2881 gccagtggtc cagctccaca gacagagccc tgcaagaata ctgaactgta ccaacattga
     2941 ctgcttgcaa atctcttgtg cagtgggtcg cctgggagga ggcgaaagtg cagtcctaaa
     3001 ggtcagatcg agattgtggg cccacacgtt cctcaaggaa atttctgtag aagagacgag
     3061 ccaagagcag ttggtgaaga cactcaagag aaagaatgat cattatgctc ttgcatccct
     3121 ggtgtccttt gaagtcaaga agatgccgta taaagaacag ccagcaaagc tgccagcggg
     3181 gagcacagcg gttaagacgt cggttatttg ggccactccg aatgtctcct tctcaattcc
     3241 attgtgggtc ataatactag cgatccttct tggtttgctg gttctggcta tcttaacttt
     3301 agctttatgg aagtgtggat tctttgatag agcaagacct cctcaggatg aaatgacaga
     3361 cagggaacaa ctgaccagtg acaagacccc agaggcgtga cttggaaaca tgaagaccta
     3421 aaattcaagc actggtccta ttcaaagaaa gaaagggagg aaggacacaa gggctcaatg
     3481 atcatagcct tccatacctg ccaatgaccc agggaatgaa gagtccctaa tgatcacctc
     3541 atctaagtca tgcattggtg tggagtgcag agaaccccac gtgaaaagaa atgcagccac
     3601 taacactaca gaaacaatcc acagccatga agatttcctt tgttcttacc gtttcacatc
     3661 tggctgacat tctggaacag ctgtaggagc ttaggcagct gtctaggtca gcccaatatg
     3721 acttacaaaa acaattccta cagagatgag atgaactgag attgaacact actgtaatcc
     3781 gatggaatct cagacacctc cctatggaat agaacccttt ctaaggatgc gaaggctcag
     3841 ggagaaaagt gatatgatgt tgggactatg aaagtgctta tggaactaca gagatgattt
     3901 catcatggga agaccaaaaa tatatttatt tatgtttcct ttctctaggt agagaattgg
     3961 gccatttaga ggatgtggaa attaagattt ggttagctag atttcatcac tactcagttt
     4021 acttcctctt aagataacta ctctgtgcag atagcatatt taattgggct tcttcaggtg
     4081 ttagatggtg ttacacatgg tttggcatta gggctctgtt gtgcttaatt ttctgctgcc
     4141 tcgagtgact tttcttcatg ttctctggaa actcatgtct gcataattca actttacaaa
     4201 atcttatatt tatagtttct tttatatgtg taaaaaacta tttccagtga cttctgtaaa
     4261 gcattcattt caaggtactc actatgctga tgatgttgaa aagtacttgc acaattttgt
     4321 agagtccata taaaaagcaa tttaactata tgggtgaata ttatcttaat agctatagta
     4381 agcaccaata tttaccttga aatttacaca ctcattttca ttgtaatacc tcacatttat
     4441 ataaaagaga aaactgtgtt gaacataaat aagatgaaga tatataaagt tatacaagtg
     4501 tgagccaaac agaaactcac tcttaaggac atagcagtgc ttattacagc tttattgtcc
     4561 actctttatg gttaactttt cctagcaagt aatcttggag aatattttat atttaagcta
     4621 ttttaccatc atctttacct aaacattgct tagagctctt gtaaataatc cataataatt
     4681 tgtaatgttg tcattttgaa gtaatattga ccagccaaat taataagatt gtctgcacaa
     4741 ttttatatcc tttttataat aatgaaaaat tgctatggag aaatgctgaa caaaatgtta
     4801 tgtgcaatat tttatagacc tatgtatctg aggcatgttt acactggcat tagtttcttt
     4861 tttttaatta atatcctgat cactaagtct gatataacaa gctgaccaaa atcctaacgt
     4921 ttacaaaaca gaaaactctg tctcagtttc aacaatgaca ctttatttga aagatgaccc
     4981 aaactcacag acagtaaatt ttatgtggtg ccttaacctg gaaaggagcc atttggcttc
     5041 agttgctaca gttccttgga aagcaaatga aatgcacaga gtcaaacagc attgctgttc
     5101 atcttgccct gcttattagt taaatctgtc ctggtagctg gcttatgtct ataagggcta
     5161 gtgtctagga gtacgacact tgcctcaaag agtcacacac cagcctctgg ggttgtcttt
     5221 actgttagtc tttttggtgg gacaactcac tctacatttt aatttttatg attcctgatg
     5281 tggatccatt acaaacttct cagaagtttg gagtgcatct ctgatcttga aagaactcag
     5341 agaactctta gggtgaaatg ggaactgtgg gagacaaccc atatggggaa aactaaagat
     5401 gtcagggggg cgacaagacc aacacagaag aaggtatggg aatatcagag gcaaaacatg
     5461 gtttcccatg gtctcaactg tagaagtgca ggagggctat catacacatg cacacagaag
     5521 ctgaggtcag gtgacccctc tggggacatg ttcataggca tcccatcctc acagagaact
     5581 gagtattcaa caatgctcat ggcattgctg atgcttctgt catacattgg tattctcgag
     5641 gagtctatct gtatttctct ttaatgagtt ctttcctagt tctcacagct gtttttataa
     5701 gacagaggga aatgagcaga ttttctaatc ttggagattt ttatacagta aagcattcta
     5761 gttgtcactg aaatctaaat cttagaattc ttgtcttatt taaatacatg tatagagaca
     5821 gtgtagattt tcatgtacct atttacattg tcaccaataa aattaaaaat taaagaca
//
