LOCUS       NM_001330160            4034 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus integrin alpha 7 (Itga7), transcript variant 2, mRNA.
ACCESSION   NM_001330160 XM_006513267
VERSION     NM_001330160.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4034)
  AUTHORS   Jimenez-Pompa,A., Arribas,R.L., McIntosh,J.M. and Albillos,A.
  TITLE     Differential tyrosine and serine/threonine
            phosphorylation/dephosphorylation pathways regulate the expression
            of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse
            hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 684, 149115 (2023)
   PUBMED   37879250
  REMARK    GeneRIF: Differential tyrosine and serine/threonine
            phosphorylation/dephosphorylation pathways regulate the expression
            of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse
            hippocampal neurons.
REFERENCE   2  (bases 1 to 4034)
  AUTHORS   Chen,Z., Kelly,J.R., Morales,J.E., Sun,R.C., De,A., Burkin,D.J. and
            McCarty,J.H.
  TITLE     The alpha7 integrin subunit in astrocytes promotes endothelial
            blood-brain barrier integrity
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36960827
REFERENCE   3  (bases 1 to 4034)
  AUTHORS   Bugiardini,E., Nunes,A.M., Oliveira-Santos,A., Dagda,M.,
            Fontelonga,T.M., Barraza-Flores,P., Pittman,A.M., Morrow,J.M.,
            Parton,M., Houlden,H., Elliott,P.M., Syrris,P., Maas,R.P.,
            Akhtar,M.M., Kusters,B., Raaphorst,J., Schouten,M., Kamsteeg,E.J.,
            van Engelen,B., Hanna,M.G., Phadke,R., Lopes,L.R., Matthews,E. and
            Burkin,D.J.
  TITLE     Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac
            Dysfunction in Humans and Mice
  JOURNAL   J Am Heart Assoc 11 (23), e026494 (2022)
   PUBMED   36444867
  REMARK    GeneRIF: Integrin alpha7 Mutations Are Associated With Adult-Onset
            Cardiac Dysfunction in Humans and Mice.
REFERENCE   4  (bases 1 to 4034)
  AUTHORS   Han,S., Lim,S. and Yeo,S.
  TITLE     Association between Decreased ITGA7 Levels and Increased Muscle
            alpha-Synuclein in an MPTP-Induced Mouse Model of Parkinson's
            Disease
  JOURNAL   Int J Mol Sci 23 (10), 5646 (2022)
   PUBMED   35628462
  REMARK    GeneRIF: Association between Decreased ITGA7 Levels and Increased
            Muscle alpha-Synuclein in an MPTP-Induced Mouse Model of
            Parkinson's Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4034)
  AUTHORS   Ziober,B.L. and Kramer,R.H.
  TITLE     Identification and characterization of the cell type-specific and
            developmentally regulated alpha7 integrin gene promoter
  JOURNAL   J Biol Chem 271 (37), 22915-22922 (1996)
   PUBMED   8798472
REFERENCE   6  (bases 1 to 4034)
  AUTHORS   Zolkiewska,A. and Moss,J.
  TITLE     Processing of ADP-ribosylated integrin alpha 7 in skeletal muscle
            myotubes
  JOURNAL   J Biol Chem 270 (16), 9227-9233 (1995)
   PUBMED   7721841
REFERENCE   7  (bases 1 to 4034)
  AUTHORS   Song,W.K., Wang,W., Foster,R.F., Bielser,D.A. and Kaufman,S.J.
  TITLE     H36-alpha 7 is a novel integrin alpha chain that is developmentally
            regulated during skeletal myogenesis
  JOURNAL   J Cell Biol 117 (3), 643-657 (1992)
   PUBMED   1315319
  REMARK    Erratum:[J Cell Biol 1992 Jul;118(1):213]
REFERENCE   8  (bases 1 to 4034)
  AUTHORS   von der Mark,H., Durr,J., Sonnenberg,A., von der Mark,K.,
            Deutzmann,R. and Goodman,S.L.
  TITLE     Skeletal myoblasts utilize a novel beta 1-series integrin and not
            alpha 6 beta 1 for binding to the E8 and T8 fragments of laminin
  JOURNAL   J Biol Chem 266 (35), 23593-23601 (1991)
   PUBMED   1748636
REFERENCE   9  (bases 1 to 4034)
  AUTHORS   Kramer,R.H., Vu,M.P., Cheng,Y.F., Ramos,D.M., Timpl,R. and Waleh,N.
  TITLE     Laminin-binding integrin alpha 7 beta 1: functional
            characterization and expression in normal and malignant melanocytes
  JOURNAL   Cell Regul 2 (10), 805-817 (1991)
   PUBMED   1839357
REFERENCE   10 (bases 1 to 4034)
  AUTHORS   Kaufman,S.J., Foster,R.F., Haye,K.R. and Faiman,L.E.
  TITLE     Expression of a developmentally regulated antigen on the surface of
            skeletal and cardiac muscle cells
  JOURNAL   J Cell Biol 100 (6), 1977-1987 (1985)
   PUBMED   3889014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122380.4.
            
            On May 11, 2022 this sequence version replaced NM_001330160.1.
            
            Summary: This gene encodes a member of the integrin family of cell
            surface proteins that mediate cellular interactions with the
            extracellular matrix and other cells. The encoded transmembrane
            protein is the alpha subunit that forms a noncovalent heterodimer
            with the beta subunit to form the functional integrin receptor that
            binds to laminin. Mice lacking the encoded protein exhibit symptoms
            of progressive muscular dystrophy, impaired axonal regeneration and
            cerebral vascular defects. [provided by RefSeq, Aug 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157612.1, SRR12282455.32452832.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AC122380.4         91449-91830
            383-510             AC122380.4         96676-96803
            511-590             AC122380.4         96904-96983
            591-846             AC122380.4         98318-98573
            847-978             AC122380.4         99081-99212
            979-1186            AC122380.4         100444-100651
            1187-1380           AC122380.4         100754-100947
            1381-1469           AC122380.4         101189-101277
            1470-1597           AC122380.4         101387-101514
            1598-1693           AC122380.4         101641-101736
            1694-1755           AC122380.4         101877-101938
            1756-1925           AC122380.4         102040-102209
            1926-2075           AC122380.4         103041-103190
            2076-2191           AC122380.4         103923-104038
            2192-2384           AC122380.4         104435-104627
            2385-2465           AC122380.4         106453-106533
            2466-2545           AC122380.4         106619-106698
            2546-2620           AC122380.4         106797-106871
            2621-2723           AC122380.4         107010-107112
            2724-2900           AC122380.4         107599-107775
            2901-3029           AC122380.4         107940-108068
            3030-3143           AC122380.4         111079-111192
            3144-3242           AC122380.4         111396-111494
            3243-3368           AC122380.4         111582-111707
            3369-4034           AC122380.4         115257-115922
FEATURES             Location/Qualifiers
     source          1..4034
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 77.2 cM"
     gene            1..4034
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /note="integrin alpha 7"
                     /db_xref="GeneID:16404"
                     /db_xref="MGI:MGI:102700"
     exon            1..382
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            383..510
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            511..590
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            591..846
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            847..978
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1186
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1380
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1469
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1597
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1693
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1755
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1925
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2075
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..2191
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2384
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2465
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2545
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2620
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2723
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..2900
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3029
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            3030..3143
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3242
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3368
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..4034
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4028..4033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /note="hexamer: AATAAA"
     polyA_site      4034
                     /gene="Itga7"
                     /gene_synonym="alpha7; [a]7"
                     /note="major polyA site"
ORIGIN      
        1 gtacttagct ggtcctgggg cagcagcggg aagggactga agaggggtgc tgaggtgaaa
       61 gattggaaga cccggaaaga tcagctagat ttcggaaacc agaaacaccc tcggggagac
      121 ctggggctcc cggcgcgcga cgatttcctc gcactagctg ggagagcgtt gatcccatgg
      181 ccaggattcc gaggtgcgat tttctccggc cccccggaat ctactatctt attacttcct
      241 tgctcgctgg actgttctta ccaccggcta tcgccttcaa tctggatgtg atgggtgcca
      301 tacgcaagga gggagaaccc ggcagcctat tcggcttttc ggtggccctg caccgacaat
      361 tacagccccg accccagagc tggctgctgg tgggcgctcc ccaggccctg gctcttcctg
      421 gacagcaggc aaaccgcacc ggaggcctct ttgcttgtcc cctgagccta gaggagacag
      481 attgctacag agtggacatt gacaggggag ctaacgtgca gaaggagagc aaggagaacc
      541 aatggctggg agtcagtgtc cggagccagg ggccaggggg caagattgtt acgtgtgcac
      601 accgatatga gtctcgacag agagtggacc aggctttgga gactcgggat gtgattggcc
      661 gctgctttgt gctaagccag gacctggcca tccgtgatga gctggatggt ggggagtgga
      721 agttctgtga ggggcgcccc cagggccatg aacagtttgg gttctgtcag cagggcacag
      781 ctgccacctt ctcccctgac agtcactacc tcgtctttgg ggctccagga acctataact
      841 ggaagggcac ggccagggtg gagctctgtg cgcagggctc gccggacctg gcacacctgg
      901 atgacgggcc ctacgaggcg gggggcgaga aggagcaaga cccccgcctc atcccggtcc
      961 ctgccaacag ctaccttggt ttctccatcg attctgggaa gggtcttatg cgctcagaag
     1021 agctgagttt tgtggcaggg gccccacgtg ccaaccacaa aggggctgtg gtcattctgc
     1081 gcaaggatag cgccagccgc ttgatacctg aggttgtgct gtctggggag cgcctgacct
     1141 ctggctttgg ctactcactg gctgtgactg atctcaacaa tgatggctgg gcagacctga
     1201 ttgtgggtgc cccctacttc tttgaacgcc aagaagagct gggaggtgct gtgtatgtgt
     1261 acatgaacca gggtggccat tgggcagata tctctcctct ccgaatctgt ggctcccctg
     1321 attccatgtt tgggatcagt ttggctgtat tgggggacct caaccaagat ggcttcccag
     1381 acattgccgt gggagctccc tttgacggag atgggaaggt ctttatctac catgggagca
     1441 gccttggggt ggttgtcaaa ccttcacagg tgctggaggg cgaggcggtg ggtatcaaga
     1501 gctttggtta ctccctgtct ggtggcctgg atgtggatgg aaatcactac ccagacctgc
     1561 ttgtgggctc cctggctgat accgctgctc tgttcagggc cagacctgtt ctacatgtct
     1621 cccaagagat cttcattgac cccagagcca tcgatctgga acaacccaac tgtgccgatg
     1681 gacgcttggt ctgtgtggac ataaagatct gtttcagcta tgtcgctgtg cccagcagct
     1741 acagccctag tgtggcctta gattatatgt tagatgggga cacagaccgg aggctccggg
     1801 gccaggttcc acgtgtgacg tttctgagcc gaggcctgga tgacctcagg catcagtcct
     1861 ccggcaccgt gtggctgaag caccaacatg accgagtctg tggagatact gtgttccagc
     1921 tgcaggaaaa cgtcaaagac aagctacggg ccattgtggt gaccctgtca tatggtctcc
     1981 gaacccctcc attagggagg caagcacctg gccaggagct ccccactgtg gctcccatcc
     2041 tcaatgctca ccagcccagc acccagagga ctgagatcca ctttctgaag caaggctgcg
     2101 gtgaagataa gatctgtcag agcaacctcc agctcgagcg gtaccagttc tgttccagga
     2161 tcagcgacac agagttccag gctctgccca tggatctgga tggaaggacc gccctgttcg
     2221 cattgagtgg gcagccgttc ataggcctgg aactgacagt caccaacctg ccctctgacc
     2281 ctgcccggcc tcaggcagat ggggatgatg ctcatgaagc acagctcttg gtcactctcc
     2341 cagcctctct acggtactca ggagtccgtg ctctggactc tgtggagaag ccgctctgcc
     2401 tgtccaatga cagcgcctct catgtcgagt gtgagctggg gaaccctatg aagagaggcg
     2461 ctcaggtcac tttttacctc atcctcagca cctctgggat cactattgag accacagagc
     2521 tggaggtgaa attgctgtta gccacgatca gtgagcagga gctggatccg gtctccgttc
     2581 gggctcatgt cttcattgaa ttgccactgt ccatttcagg ggtggccact ccccagcaac
     2641 tcttcttctc tggcgaggtg aagggcgaaa gtgccatgcg atctgagagg gacgtgggca
     2701 gcaaagtcaa gtatgaggtc acggtctcca atcaaggcca gtctctcaat actctgggct
     2761 ctgcgttcct caacatcatg tggccccacg agatcgccaa tggaaagtgg ctgctgtacc
     2821 ccatgcgggt agagctggag ggcggacagg ggcctggcaa gagagggatc tgttccccaa
     2881 gacccaacat cctccagctg gatgtggaca gcagggatag gaggcggcga gagctggggc
     2941 agccggagcc gcaggagcct ccagagaagg tggagcctag cacatcctgg tggccagtgt
     3001 cctctgctga gaagagaaac gtgactctgg actgcgccca gggcacggcc aagtgtgtgg
     3061 tgttcagctg cccactctac agctttgatc gtgcagccgt gcttcacgtc tggggccgcc
     3121 tctggaacag cacctttctg gaggagtaca tggccgtgaa atccctggaa gtgatcgtcc
     3181 gagccaacat cacagtgaaa tcctccatta agaacttgtt gctcagagat gcatccacag
     3241 tgattccagt gatggtgtac ttggacccca tggccgtggt tgtggaagga gtcccctggt
     3301 gggtcatcct cctggcagtg ctggctgggc tgttagtcct ggccttgctg gtactgctgc
     3361 tgtggaagct gggattcttc aagcgggcga agcaccccga ggccaccgtg ccccagtacc
     3421 acgcagtgaa gatccctcgg gaagaccgac agcagttcaa ggaggagaag acaggcacca
     3481 tccagaggag taactggggc aactcccagt gggagggctc cgacgcacac cccatcttgg
     3541 ctgccgactg gcatcctgag ctgggtcctg atggacatcc ggtgccagcc actgcctaac
     3601 atctgctgtc ccaagcccag cccgtgggtt ccttccgccc ttttcccaag atggctcctt
     3661 gggatggaga tagtggagta agttgctagc atcacgttga gatatggcag gctctgcttt
     3721 ctcaggagca cagatctttc tcccaccagg agaaccaccc ctccatcttc cccatacaat
     3781 gctgtgagac gagggggcat ggctggaagg gcaggcatgt cctgatacag ggtggggaga
     3841 aggggttctg agctccctct cacccaccct gtaaaacctg tcttccccaa agtgccttag
     3901 acagagggtc agggaagaga ctgtgtcact gtctcagggc cctttactcc caagtctccc
     3961 ctgccctctg gccttactgt gctgtaccag tccagtggtt ttgtctattt attaaaaagt
     4021 atttgacaat aaaa
//
