LOCUS       NM_001277970            5878 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus integrin alpha 6 (Itga6), transcript variant 2, mRNA.
ACCESSION   NM_001277970
VERSION     NM_001277970.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5878)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   2  (bases 1 to 5878)
  AUTHORS   Faraldo,M.M., Romagnoli,M., Wallon,L., Dubus,P., Deugnier,M.A. and
            Fre,S.
  TITLE     Alpha-6 integrin deletion delays the formation of
            Brca1/p53-deficient basal-like breast tumors by restricting luminal
            progenitor cell expansion
  JOURNAL   Breast Cancer Res 26 (1), 91 (2024)
   PUBMED   38835038
  REMARK    GeneRIF: Alpha-6 integrin deletion delays the formation of
            Brca1/p53-deficient basal-like breast tumors by restricting luminal
            progenitor cell expansion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5878)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   4  (bases 1 to 5878)
  AUTHORS   Georges-Labouesse,E., Messaddeq,N., Yehia,G., Cadalbert,L.,
            Dierich,A. and Le Meur,M.
  TITLE     Absence of integrin alpha 6 leads to epidermolysis bullosa and
            neonatal death in mice
  JOURNAL   Nat Genet 13 (3), 370-373 (1996)
   PUBMED   8673141
REFERENCE   5  (bases 1 to 5878)
  AUTHORS   Hierck,B.P., Thorsteinsdottir,S., Niessen,C.M., Freund,E.,
            Iperen,L.V., Feyen,A., Hogervorst,F., Poelmann,R.E., Mummery,C.L.
            and Sonnenberg,A.
  TITLE     Variants of the alpha 6 beta 1 laminin receptor in early murine
            development: distribution, molecular cloning and chromosomal
            localization of the mouse integrin alpha 6 subunit
  JOURNAL   Cell Adhes Commun 1 (1), 33-53 (1993)
   PUBMED   8081870
  REMARK    Erratum:[Cell Adhes Commun 1993 Sep;1(2):following 190]
REFERENCE   6  (bases 1 to 5878)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 5878)
  AUTHORS   Wadsworth,S., Halvorson,M.J. and Coligan,J.E.
  TITLE     Developmentally regulated expression of the beta 4 integrin on
            immature mouse thymocytes
  JOURNAL   J Immunol 149 (2), 421-428 (1992)
   PUBMED   1385605
REFERENCE   8  (bases 1 to 5878)
  AUTHORS   Cooper,H.M., Tamura,R.N. and Quaranta,V.
  TITLE     The major laminin receptor of mouse embryonic stem cells is a novel
            isoform of the alpha 6 beta 1 integrin
  JOURNAL   J Cell Biol 115 (3), 843-850 (1991)
   PUBMED   1833411
REFERENCE   9  (bases 1 to 5878)
  AUTHORS   Sonnenberg,A., Linders,C.J., Daams,J.H. and Kennel,S.J.
  TITLE     The alpha 6 beta 1 (VLA-6) and alpha 6 beta 4 protein complexes:
            tissue distribution and biochemical properties
  JOURNAL   J Cell Sci 96 (Pt 2), 207-217 (1990)
   PUBMED   1698797
REFERENCE   10 (bases 1 to 5878)
  AUTHORS   Sonnenberg,A., Modderman,P.W. and Hogervorst,F.
  TITLE     Laminin receptor on platelets is the integrin VLA-6
  JOURNAL   Nature 336 (6198), 487-489 (1988)
   PUBMED   2973567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928963.8.
            
            On May 11, 2022 this sequence version replaced NM_001277970.1.
            
            Summary: This gene encodes a protein that is a member of the
            integrin superfamily. Integrins are transmembrane receptors
            involved cell adhesion and signaling, and they are subdivided based
            on the heterodimer formation of alpha and beta chains. This protein
            has been shown to heterodimerize with beta 4 to bind laminin and to
            form the main component of hemidesmosomes, which mediate attachment
            of epithelia to basement membranes. In mouse, deficiency of this
            gene is associated with absence of hemidesmosomes, severe skin
            blistering, and early post-natal death. In humans mutations of this
            gene are associated with epidermolysis bullosa. Alternative
            splicing results in multiple transcript variants that encode
            different protein isoforms. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (2) lacks an alternate penultimate
            exon, compared to variant 1, resulting in a novel 3' coding region
            and shorter 3' UTR. It encodes isoform 2 which has a distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.1833.1,
                                           SRR10223971.2098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AL928963.8         52987-53368
            383-507             AL928963.8         82678-82802
            508-587             AL928963.8         84529-84608
            588-843             AL928963.8         86047-86302
            844-975             AL928963.8         88486-88617
            976-1186            AL928963.8         91557-91767
            1187-1380           AL928963.8         92438-92631
            1381-1469           AL928963.8         92771-92859
            1470-1588           AL928963.8         93944-94062
            1589-1687           AL928963.8         99744-99842
            1688-1749           AL928963.8         100057-100118
            1750-1910           AL928963.8         104316-104476
            1911-2054           AL928963.8         104626-104769
            2055-2170           AL928963.8         106610-106725
            2171-2360           AL928963.8         106834-107023
            2361-2444           AL928963.8         107115-107198
            2445-2524           AL928963.8         107297-107376
            2525-2602           AL928963.8         107527-107604
            2603-2705           AL928963.8         107692-107794
            2706-2879           AL928963.8         109177-109350
            2880-2978           AL928963.8         111831-111929
            2979-3089           AL928963.8         112021-112131
            3090-3188           AL928963.8         112212-112310
            3189-3314           AL928963.8         115429-115554
            3315-5878           AL928963.8         121902-124465
FEATURES             Location/Qualifiers
     source          1..5878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 42.79 cM"
     gene            1..5878
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="integrin alpha 6"
                     /db_xref="GeneID:16403"
                     /db_xref="MGI:MGI:96605"
     exon            1..382
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..3476
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; CD49 antigen-like family member F"
                     /codon_start=1
                     /product="integrin alpha-6 isoform 2 precursor"
                     /protein_id="NP_001264899.1"
                     /db_xref="CCDS:CCDS71074.1"
                     /db_xref="GeneID:16403"
                     /db_xref="MGI:MGI:96605"
                     /translation="MAVAGQLCLLYLSAGLLARLGTAFNLDTREDNVIRKSGDPGSLF
                     GFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITSRGPCTRIEFDND
                     ADPMSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQN
                     LRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVR
                     VEQKNNTFFDMNIFEDGPYEVGGETDHDESLVPVPANSYLGFSLDSGKGIVSKDDITF
                     VSGAPRANHSGAVVLLKRDMKSAHLLPEYIFDGEGLASSFGYDVAVVDLNADGWQDIV
                     IGAPQYFDRDGEVGGAVYVYINQQGKWSNVKPIRLNGTKDSMFGISVKNIGDINQDGY
                     PDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTSPYFGYSIAGNMDLDRNSYPDL
                     AVGSLSDSVTIFRSRPVINILKTITVTPNRIDLRQKSMCGSPSGICLKVKACFEYTAK
                     PSGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEET
                     LWLQENIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKE
                     GCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNSP
                     SDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELG
                     NPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQDNLAPITAKAKVVIELLLS
                     VSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLKNLGTATLNIQWP
                     KEISNGKWLLYLMKVESKGLEQIVCEPHNEINYLKLKESHNSRKKRELPEKQIDDSRK
                     FSLFPERKYQTLNCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNSTFLEEYSKLNYLD
                     ILLRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGVAWWIILLAVLAGILMLA
                     LLVFLLWKCGFFKRSRYDDSIPRYHAVRIRKEEREIKDEKHMDNLEKKQWITKWNENE
                     SYS"
     exon            383..507
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            508..587
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            588..843
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            844..975
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1186
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1380
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1469
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1588
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1687
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1749
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1910
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2054
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2170
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2360
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2444
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2524
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2602
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2705
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2879
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..2978
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3089
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3188
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3314
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..5878
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5667..5672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="hexamer: AATAAA"
     polyA_site      5687
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="major polyA site"
     regulatory      5785..5790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="hexamer: AGTAAA"
     polyA_site      5803
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="major polyA site"
     regulatory      5859..5864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
                     /note="hexamer: TATAAA"
     polyA_site      5878
                     /gene="Itga6"
                     /gene_synonym="5033401O05Rik; Cd49f; VLA-6"
ORIGIN      
        1 gggctcattg agcagcagct agctgcgggc gtgggggagc ggccgcacag tgagcgtgag
       61 ccggccgggg gtggggccgc gcgcaggggc gaccgaggcc aagtggccgc agcggcgcgc
      121 caggcagccc ggccccggcc ccgagcccgc gcgcacagag gccgcagcag ctccgcgggt
      181 ccctcccacc gcgcgcgccc atggcggtcg cgggccagtt gtgcctgctc tacctgtccg
      241 cggggcttct agcccggctg ggtacagcct tcaacctgga cacccgcgag gacaacgtga
      301 tccggaaatc gggggatccc gggagcctct tcggcttctc gctcgccatg cactggcagt
      361 tgcagccgga ggacaagcgg ctgttgcttg tgggggcacc tcgggcagaa gcactcccgc
      421 tgcagagggc gaacagaaca gggggcctgt acagctgtga catcacctcc cggggacctt
      481 gtacacggat tgaatttgat aatgacgctg atcctatgtc agaaagcaag gaagaccagt
      541 ggatgggagt cactgttcag agccaaggtc cagggggcaa agtggtgacg tgtgcacatc
      601 gatatgagaa acggcagcac gtcaacacga agcaggagtc gcgggatatc tttggaagat
      661 gttatgtcct aagtcagaat ctcagaattg aagatgatat ggacggagga gactggagtt
      721 tctgcgatgg ccggttgaga ggccatgaaa agtttggctc ctgtcagcaa ggagtagcgg
      781 ctactttcac taaggacttt cattacattg tttttggagc cccagggact tacaactgga
      841 aagggatcgt ccgtgtagaa caaaagaata acactttttt tgacatgaac atctttgaag
      901 atgggcccta tgaagttggt ggagagactg atcatgatga aagtctcgtg cccgttcctg
      961 ctaacagtta cctaggcttt tcactggact cagggaaggg tattgtttct aaagatgaca
     1021 tcacttttgt gtctggtgct ccaagagcca atcacagtgg ggctgtagtt ttgctaaaaa
     1081 gagacatgaa gtccgcgcat ctgctccctg agtatatatt tgacggagaa ggcctggctt
     1141 cctcgtttgg ctatgatgtg gcagtggtgg acctcaatgc agatgggtgg caagacattg
     1201 ttatcggagc tccacagtat tttgataggg atggtgaagt cgggggtgca gtttacgtct
     1261 acattaacca gcaaggcaaa tggagtaatg tgaagccgat tcgtctaaat gggaccaaag
     1321 actcgatgtt tggaatctct gtgaaaaata taggtgatat taaccaagat ggctatccag
     1381 atattgctgt tggagctccc tatgatgatc tggggaaggt ttttatctat catggatccc
     1441 cgactggcat aattaccaag ccaacacagg ttctcgaggg gacatcgcct tacttcggct
     1501 attcaatcgc tgggaatatg gacctggatc ggaattccta ccccgacctt gctgtgggct
     1561 ccctctcaga ctcggtcact attttcagat cccggccagt gattaacatt ctaaaaacca
     1621 tcacagtgac tcctaacaga attgacctcc gccagaagtc catgtgtggc tcacctagcg
     1681 ggatatgcct caaggttaaa gcctgttttg aatatactgc gaaaccttcc ggttataacc
     1741 ctccaatatc aattttgggt attctcgaag ctgaaaaaga aagaagaaag tcagggttgt
     1801 catcgagagt tcagtttcga aaccaaggtt ccgagccaaa gtatactcag gagctgaccc
     1861 tgaatcggca gaagcagcgg gcgtgcatgg aggagaccct ctggctgcag gagaacatca
     1921 gagacaagct gcgtcccatc cccatcacgg cttctgtgga gatccaggag cccagctctc
     1981 gccggcgggt gaactcactc cccgaagttc ttcccatcct gaattcaaat gaagccaaaa
     2041 cggtccagac agatgtccac ttcttaaagg aaggatgtgg agacgacaat gtctgtaaca
     2101 gcaaccttaa gctagagtat aaatttggta cccgagaagg aaatcaagac aaattctctt
     2161 accttccaat tcaaaaaggc atcccagaat tagtcctaaa agatcagaaa gatatagctc
     2221 tggaaataac ggtgaccaac agcccttcgg atccaaggaa tccccggaaa gatggcgacg
     2281 atgcccatga agccaaactc atcgccacgt ttccagacac tctgacatat tccgcttaca
     2341 gagaactgag ggctttccct gagaagcagc tgagctgtgt ggccaaccag aatggctccc
     2401 aagccgactg tgagctcgga aatcctttca agagaaattc cagtgttact ttctatctga
     2461 ttttaagtac aaccgaggtc acctttgaca ccacagatct ggatattaat ctgaagttgg
     2521 aaacaacaag caatcaggat aatttggctc caattacagc gaaggcaaaa gtggttattg
     2581 aattgctttt atcggtctcc ggagtcgcta agccttcgca ggtgtatttt ggaggtacag
     2641 ttgttggtga gcaagctatg aaatctgaag atgaagtagg aagtttaata gagtatgaat
     2701 ttagggtgat taacttaggc aagcctctta aaaacctcgg cacagcaacc ttgaatatac
     2761 agtggcccaa ggagattagc aatggcaaat ggttgcttta tttgatgaaa gttgaatcca
     2821 aaggtttgga gcagattgtt tgtgagccac acaatgaaat aaactacctg aagctgaagg
     2881 agtctcacaa ctcaagaaag aaacgggaac ttcctgaaaa acagatagat gacagcagga
     2941 aattttcttt atttcctgaa agaaaatacc agactctcaa ctgcagcgtc aacgtgaggt
     3001 gtgtgaacat caggtgccca ctgcgagggc tggacagcaa ggcctctctc gttcttcgtt
     3061 ccaggttgtg gaacagcaca tttctagagg aatattccaa actgaactac ttggacattc
     3121 tcctgagggc ttccatagat gtcaccgctg ctgctcagaa tatcaagctc cctcacgcgg
     3181 gcactcaggt tcgagtgacg gtgtttccct caaagactgt agctcagtat tcaggagtag
     3241 cttggtggat catcctcctg gctgttcttg ccgggattct gatgctggct ctattagtgt
     3301 ttttactgtg gaagtgtgga ttctttaagc gctctaggta cgatgacagc attccccgat
     3361 accatgcggt gcggatccgg aaagaagagc gagagatcaa agatgagaaa cacatggata
     3421 acctcgaaaa aaaacagtgg atcaccaagt ggaatgaaaa cgaaagttac tcatagagag
     3481 gagggcacag gaaagaacac ctcacactac ccaaagcccc cccttatttt ttccagctca
     3541 gaaattcagg tggcttcaaa gcctgctcag ctcccccata tatgatttca gactgacgac
     3601 acccagtatg gacctacagt ttcaactgtg gatattgtta cacctaaggc tcctgttttg
     3661 cacagccaaa tttaagactg gtagagtgga tttttcttta actgccttaa tttaactttc
     3721 cggattgcct ttgtttttga cgtggctgac ttccacacgc tggggcaggg cctgcccatc
     3781 tgcactgctg ggatgctctc ccccaggtca cctgtgctaa cagagtggct atcccagcct
     3841 gctcccacaa gcattcttct cataagattg accttggctc aagactgcca atggatagct
     3901 gtgcctctgg tgaaagttct gtcttaaatg tgcaatagaa ggtgatgtta ccctttggcc
     3961 ttctttctcc atctcctaga agtgaggacc cttgctgacg ccaaatgcac acaggttccc
     4021 gtctcccttg tcactaaagc acagggtcga cagacttgaa tgctagttac atttgtttgt
     4081 atatgatatt tatttttttc ttcaagccat cttgctgttg actaataggc caaagatgct
     4141 tctgggtggt ttaagcaatg agaatgagaa cctgggaggt cttgttgttg ttgttgttct
     4201 gaccttactt atttactgca aaaaaaaaaa aagatcttta taaacatgca agggtcattt
     4261 taataactta aactcacctg tacatgatac cgtaattgcc tttctggcag gccttccacc
     4321 aacccagaaa gtttgacaaa gggggttaac tgtaggacat ttcgtccttc cccggcagtg
     4381 gatgtactgt tttgagccct gtgtggaact tctgaacttc gtgctgtaac tttcagaact
     4441 cttagacatg ggtgtgctca ctgaactcta gggtctgtgt gctagatgct gccaacgctg
     4501 tattcaggac ctgaagtgag tacccgtgtg gatccagacc aatccagtgt gagactactg
     4561 aagaacatct gttgccagaa cggccacacc aaacagatgg agtgccccag cacttagctt
     4621 cttaaataac atcggaacca ttcagccagc gagtctgtgt ttgctttttg ttcaaattgt
     4681 tcgccgaatc taaattcctc caaaggactt gtgactactc ttagctcatt gctaaagtgc
     4741 ttgcttaccg tgcctcggcc cgccttggtt ggttgtaaaa atggtaggag ggggaaaaca
     4801 attattttat atatatgttc aacagagatt gaatatatta tcaaatcttt ttttaattgt
     4861 gctttaaaat aatttatatg gagagcaaca acagcaaaca ggtgccaaca gcaaacaggt
     4921 gctaatttgt ttggatatta gttatataag cagttctcta tcttaagact gggtctcaag
     4981 taacccaggc tggccttgaa ctccttaggt aacttgggat agttttgaac ttccgattcc
     5041 cctgcctccc caccccaggg ctgtgattgc aggtgtgcgc ttgggactga ccccaggctt
     5101 tgtcggtgct agggcagcac tctgcgactg aattaggtcc cagccacttc tctgtctttt
     5161 aaaagaacaa aacattgcta aatgtgccat tgttgctttg agttttaatt cttttttttt
     5221 ctttctttca taaaacatta cagtcttaag atattaaaga cctttattct ggttctattt
     5281 ctgtcttttc actcaaaact ggttttacaa atgatgcctt gtttacagaa agctctctac
     5341 cacagggcct agtcatgtgt aaagtctcag tttctctctg gagtatcttg gagcctagca
     5401 cactggcttt aaaggacaca gctaagaagc tgataccttg acagtgtttg tagacctttg
     5461 ttataaaaat gaatgtcctg gaaagggttg ggagggagtt caacaacaaa gaaacaagaa
     5521 tgtcatgttt aaatttaata gttgtctaaa atgtcatctc aagtcaagtc actggtctgt
     5581 ttgcatttga taggttttta tactaactag cattataaga ttatttcaat tagaaaatac
     5641 ctgtggatat ttgtataaaa gtgtgaaata aattttttac aaaagtgctc atcgcttgtt
     5701 aacacagcat catgtatgtg aaagcaaact ctaagattat aaatgacaac ctgagttgcc
     5761 tttctttgta tttcatcaag ccaaagtaaa gctttcaata tttgtttagt gtcccatata
     5821 atttcagaac agctaaagat acctaaagtg tgatacaata taaatgtgat tgaaggtt
//
