LOCUS       NM_010577               4440 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus integrin alpha 5 (fibronectin receptor alpha) (Itga5),
            transcript variant 1, mRNA.
ACCESSION   NM_010577
VERSION     NM_010577.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Ezzo,M., Spindler,K., Wang,J.B., Lee,D., Pecoraro,G., Cowen,J.,
            Pakshir,P. and Hinz,B.
  TITLE     Acute contact with profibrotic macrophages mechanically activates
            fibroblasts via alphavbeta3 integrin-mediated engagement of Piezo1
  JOURNAL   Sci Adv 10 (43), eadp4726 (2024)
   PUBMED   39441936
  REMARK    GeneRIF: Acute contact with profibrotic macrophages mechanically
            activates fibroblasts via alphavbeta3 integrin-mediated engagement
            of Piezo1.
REFERENCE   3  (bases 1 to 4440)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   4  (bases 1 to 4440)
  AUTHORS   Wang,X., Zhang,Y., Chi,K., Ji,Y., Zhang,K., Li,P., Fu,Z., Wang,X.,
            Cui,S., Shen,W., Cai,G., Chen,X., Zhu,H. and Hong,Q.
  TITLE     IGFBP2 induces podocyte apoptosis promoted by mitochondrial damage
            via integrin alpha5/FAK in diabetic kidney disease
  JOURNAL   Apoptosis 29 (7-8), 1109-1125 (2024)
   PUBMED   38796567
  REMARK    GeneRIF: IGFBP2 induces podocyte apoptosis promoted by
            mitochondrial damage via integrin alpha5/FAK in diabetic kidney
            disease.
REFERENCE   5  (bases 1 to 4440)
  AUTHORS   Benwell,C.J., Johnson,R.T., Taylor,J.A.G.E., Lambert,J. and
            Robinson,S.D.
  TITLE     A proteomics approach to isolating neuropilin-dependent alpha5
            integrin trafficking pathways: neuropilin 1 and 2 co-traffic alpha5
            integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells
  JOURNAL   Commun Biol 7 (1), 629 (2024)
   PUBMED   38789481
  REMARK    GeneRIF: A proteomics approach to isolating neuropilin-dependent
            alpha5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic
            alpha5 integrin through endosomal p120RasGAP to promote polarised
            fibronectin fibrillogenesis in endothelial cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4440)
  AUTHORS   Watt,F.M. and Hodivala,K.J.
  TITLE     Cell adhesion. Fibronectin and integrin knockouts come unstuck
  JOURNAL   Curr Biol 4 (3), 270-272 (1994)
   PUBMED   7522915
  REMARK    Review article
REFERENCE   7  (bases 1 to 4440)
  AUTHORS   Yang,J.T., Rayburn,H. and Hynes,R.O.
  TITLE     Embryonic mesodermal defects in alpha 5 integrin-deficient mice
  JOURNAL   Development 119 (4), 1093-1105 (1993)
   PUBMED   7508365
REFERENCE   8  (bases 1 to 4440)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 4440)
  AUTHORS   Brannan,C.I., Gilbert,D.J., Ceci,J.D., Matsuda,Y., Chapman,V.M.,
            Mercer,J.A., Eisen,H., Johnston,L.A., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     An interspecific linkage map of mouse chromosome 15 positioned with
            respect to the centromere
  JOURNAL   Genomics 13 (4), 1075-1081 (1992)
   PUBMED   1354638
REFERENCE   10 (bases 1 to 4440)
  AUTHORS   Holers,V.M., Ruff,T.G., Parks,D.L., McDonald,J.A., Ballard,L.L. and
            Brown,E.J.
  TITLE     Molecular cloning of a murine fibronectin receptor and its
            expression during inflammation. Expression of VLA-5 is increased in
            activated peritoneal macrophages in a manner discordant from major
            histocompatibility complex class II
  JOURNAL   J Exp Med 169 (5), 1589-1605 (1989)
   PUBMED   2523953
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131721.4, BC050943.1 and
            AK142241.1.
            
            On Sep 26, 2015 this sequence version replaced NM_010577.3.
            
            Summary: The product of this gene belongs to the integrin alpha
            chain family. Integrins are heterodimeric integral membrane
            proteins composed of an alpha chain and a beta chain. This gene
            encodes the integrin alpha 5 chain, which is proteolytically
            processed to generate light and heavy chains that join with beta 1
            to form a fibronectin receptor. In addition to adhesion, integrins
            are known to participate in cell-surface mediated signaling.
            Integrin alpha 5 and integrin alpha V chains are produced by
            distinct genes. Homozygous knockout mice for this gene exhibit
            embryonic lethality. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059829.1, AK142241.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC131721.4         49977-50004         c
            29-82               BC050943.1         1-54
            83-2891             BC050943.1         56-2864
            2892-2920           AK142241.1         2692-2720
            2921-4440           BC050943.1         2894-4413
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.9 cM"
     gene            1..4440
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /note="integrin alpha 5 (fibronectin receptor alpha)"
                     /db_xref="GeneID:16402"
                     /db_xref="MGI:MGI:96604"
     exon            1..492
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..3427
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; integrin alpha-5; integrin alpha-F; CD49
                     antigen-like family member E; fibronectin receptor subunit
                     alpha; fibronectin receptor alpha polypeptide"
                     /codon_start=1
                     /product="integrin alpha-5 isoform 1 preproprotein"
                     /protein_id="NP_034707.5"
                     /db_xref="CCDS:CCDS27903.1"
                     /db_xref="GeneID:16402"
                     /db_xref="MGI:MGI:96604"
                     /translation="MGSWTPRSPRSPLHAVLLRWGPRRLPPLLPLLLLLWPPPLQVGG
                     FNLDAEAPAVLSGPPGSLFGFSVEFYRPGRDGVSVLVGAPKANTSQPGVLQGGAVYVC
                     PWGTSPIQCTTIQFDSKGSRILESSLYSAKGEEPVEYKSLQWFGATVRAHGSSILACA
                     PLYSWRTEKDPQNDPVGTCYLSTENFTRILEYAPCRSDFGSAAGQGYCQGGFSAEFTK
                     TGRVVLGGPGSYFWQGQILSATQEQISESYYPEYLINPVQGQLQTRQASSVYDDSYLG
                     YSVAVGEFSGDDTEDFVAGVPKGNLTYGYVTVLNGSDIHSLYNVSGEQMASYFGYAVA
                     ATDTNGDGLDDLLVGAPLLMERTADGRPQEVGRVYIYLQRPAGIDPTPTLTLTGQDEF
                     SRFGSSLTPLGDLDQDGYNDVAIGAPFGGEAQQGVVFIFPGGPGGLSTKPSQVLQPLW
                     AAGRTPDFFGSALRGGRDLDGNGYPDLIVGSFGVDKALVYRGRPIISASASLTIFPSM
                     FNPEERSCSLEGNPVSCINLSFCLNASGKHVPNSIGFEVELQLDWQKQKGGVRRALFL
                     TSKQATLTQTLLIQNGAREDCREMKIYLRNESEFRDKLSPIHIALNFSLDPKAPMDSH
                     GLRPVLHYQSKSRIEDKAQILLDCGEDNICVPDLQLDVYGEKKHVYLGDKNALNLTFH
                     AQNLGEGGAYEAELRVTAPLEAEYSGLVRHPGNFSSLSCDYFAVNQSRQLVCDLGNPM
                     KAGTSLWGGLRFTVPHLQDTKKTIQFDFQILSKNLNNSQSNVVSFPLSVEAQAQVSLN
                     GVSKPEAVIFPVSDWNPQDQPQKEEDLGPAVHHVYELINQGPSSISQGVLELSCPQAL
                     EGQQLLYVTKVTGLSNCTSNYTPNSQGLELDPETSPHHLQKREAPGRSSTASGTQVLK
                     CPEAKCFRLRCEFGPLHRQESRSLQLHFRVWAKTFLQREYQPFSLQCEAVYEALKMPY
                     QILPRQLPQKKLQVATAVQWTKAEGSNGVPLWIIILAILFGLLLLGLLIYVLYKLGFF
                     KRSLPYGTAMEKAQLKPPATSDA"
     exon            493..623
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            624..736
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            737..857
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            858..919
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            920..965
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1091
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1136
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1180
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1237
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1290
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1499
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1691
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1737
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1839
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1895
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2050
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2188
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2256
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2407
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2500
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2580
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2661
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2767
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2920
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            2921..3004
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            3005..3118
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3220
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3343
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..4410
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4378..4383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /note="hexamer: AATAAA"
     polyA_site      4405
                     /gene="Itga5"
                     /gene_synonym="Cd49e; Fnra; VLA5"
                     /note="major polyA site"
ORIGIN      
        1 agtctgagcc aggccagacc accggcctcc agctggggcc ggagccaggg ttcagaggtg
       61 cggcccccca cgccccttcg ggtgcggggc gcggcctcgg cgtccccggg acccaggaat
      121 gcccccccgc cagccggccc ggcggccggg gggagggccc agccgggagt ttggcaaact
      181 cctccccgcg ttgagtcatt cgcctctggg aggtttagga agcggctccg ggtcggtggc
      241 cccaggacag ggaagagcgg gcactatggg gagctggacg ccacggtcgc ctcgatctcc
      301 tctccacgcg gtgctgctgc gctgggggcc ccgacgccta ccgccgctgc tgcctctgct
      361 gctgctactg tggccgccac cactccaggt tgggggcttc aacctagacg cggaggcccc
      421 ggcggtgctc tccgggcccc ccggctccct ttttggcttc tccgtggagt tttaccggcc
      481 gggaagggac ggagtcagtg tgctggttgg ggcacccaag gctaacacta gccagccagg
      541 tgtactgcaa ggtggtgctg tctatgtgtg tccctggggc accagtccta tccagtgcac
      601 caccattcaa tttgacagca aaggctcccg gattctggag tcctcactgt acagtgccaa
      661 gggagaggag cctgtggagt acaagtcctt gcagtggttc ggagcaacag ttcgggccca
      721 tggctcctcc atcttggcat gtgctccact gtatagctgg cgcacagaaa aggacccaca
      781 gaatgaccca gtgggcacct gctacctctc cacagaaaac ttcacccgga ttctggagta
      841 cgcaccttgc cgctcagatt ttggcagtgc agcagggcag ggctactgcc aagggggctt
      901 cagtgctgag ttcaccaaga ctggccgtgt ggtcctgggt ggacctggaa gctacttctg
      961 gcaaggccag atcctgtccg ccactcaaga gcagatctcg gagtcctatt acccagagta
     1021 tctcatcaac cctgttcagg ggcagctgca gacccgccag gccagctccg tctatgatga
     1081 cagctacttg ggatactctg tggctgtggg tgaattcagt ggtgatgaca cagaagactt
     1141 tgttgctggc gtgcccaagg ggaacctcac ctatggctat gtcaccgtcc ttaatggctc
     1201 agacatccac tccctctaca acgtctcagg agaacagatg gcctcctact tcggctatgc
     1261 tgtggctgcc actgatacca atggagatgg gctagatgac ctactggtag gggcacccct
     1321 gctcatggag cggacagctg atgggagacc tcaggaggtg ggcagggtct acatctatct
     1381 gcagcgccca gcgggcatag atcccacacc caccctcacc ctcactgggc aagatgagtt
     1441 cagccgattc ggcagctcct tgacaccctt gggggacctg gaccaagacg gctacaatga
     1501 tgtcgccatt ggggctccat ttggtgggga ggcccagcag ggagtcgtat ttatattccc
     1561 gggaggccca ggaggactga gcactaaacc ttcccaggtt ttgcagcctc tttgggcagc
     1621 tggccgtacc ccagacttct ttggctctgc ccttcgagga ggacgagatc tggatggcaa
     1681 tggataccct gatctaatcg ttggatcctt tggtgtggac aaggctctgg tgtacagagg
     1741 gcggcccatc atatctgcca gcgcatctct caccatcttc ccctccatgt tcaacccaga
     1801 ggagcgcagt tgcagcctgg aagggaaccc tgtgtcctgc atcaacctta gcttctgcct
     1861 caatgcctct ggaaaacatg tccccaactc tataggcttc gaggtggaac tccaactgga
     1921 ctggcagaag caaaagggag gggtccggcg ggcactgttc ctgacttcca agcaggccac
     1981 ccttacccag accctgctta tccagaatgg ggctcgggag gactgcaggg agatgaagat
     2041 ctacctcagg aatgaatcag aattcagaga caaactctcc ccaattcaca ttgccctcaa
     2101 cttctccttg gaccccaaag ctcccatgga cagccatggc ctccggccag ttctacacta
     2161 ccaaagcaaa agcaggatag aggacaaggc ccagatcttg ctggactgtg gtgaagacaa
     2221 tatctgtgtg cctgacctgc agctggatgt gtatggggag aagaaacatg tgtacctggg
     2281 tgacaagaac gcactgaacc tgacattcca tgcccaaaat ctgggtgagg gcggtgccta
     2341 tgaagccgag cttcgggtca cagcccctct agaggccgag tactcaggac ttgtcagaca
     2401 cccagggaac ttctccagcc tgagctgtga ctactttgct gtgaaccaga gccgccagct
     2461 ggtgtgtgac ctgggcaacc ccatgaaggc aggcaccagt ctctggggtg gccttcggtt
     2521 cactgttcct catcttcaag acacaaagaa aaccatccag tttgactttc agatcctcag
     2581 caagaacctg aacaactcac aaagcaacgt ggtctccttc ccactctcgg tggaggctca
     2641 agcccaggtc tcccttaatg gtgtctccaa gcctgaagct gtgattttcc cagtcagcga
     2701 ctggaatcct caagaccagc ctcagaagga ggaagacttg ggcccagctg tccaccatgt
     2761 ctacgagctc atcaaccagg ggcccagctc catcagccag ggtgtgctgg agctcagctg
     2821 tccacaggct ctggaaggcc aacagctcct ctatgtgacc aaggtgacag gactcagcaa
     2881 ctgcacctcc aactacaccc ccaactcaca gggcctggag ttggatccag agacctctcc
     2941 acaccacctg cagaaacgag aggctccagg gaggagttct actgcctcag gaacacaagt
     3001 tctgaaatgc cctgaagcca agtgtttcag gctgcgctgt gagtttgggc cactgcaccg
     3061 ccaagagagc cgtagtctgc agctgcattt ccgagtctgg gccaagacct tcttgcagcg
     3121 ggaataccag ccatttagcc ttcagtgtga ggctgtatat gaagctctga agatgcccta
     3181 ccagatcctg cctcggcagc ttccccaaaa gaaacttcag gtggccacag ccgtgcagtg
     3241 gaccaaggca gaaggcagca atggtgtccc gttgtggatc atcatcctag ccattctttt
     3301 tggcctcctg ctcctaggtc tgctcatcta cgtcctctac aagctcggct tcttcaaacg
     3361 ttccctcccc tacggcacag ccatggaaaa agctcagctc aagcctccag ccacctcaga
     3421 tgcctgagcc ctcctgatct cagactcatg atcccgaaga gccagtccaa taccttccga
     3481 cagggaggga ctaggcactt cctgaaggtg ctgagggctg gggagaagct cttcttccta
     3541 gcccagagac atacttgaag ggccagagct ggggggcaag aagcttgtgg atccttcccc
     3601 ccatgcactg tgaaggaccc tcgtttacac atgccctctc gtggatgggg gcctcaggtc
     3661 cagggacaga agctccagct ttccttcagc ctttgcattt tggagacttt tctgaaatca
     3721 acttggaacc ataattaggg aatccagttg tggttctctg ggccgggcat gccaacagga
     3781 cttcccatct gactccggcc tgcaaagatg catctttggt cttgccagag aaccaaagga
     3841 agtctgcagc taagagcctg agacttgggg agtgagacct ggcaactcca acagccccca
     3901 tcctggaagg ccaatgaaga acactaaccg tggatggtgc tgcaggacca gctcaggaca
     3961 aatcccaaac aaaggtcgat gctggcccag acccagatcc atggaagtca gaaagagaat
     4021 ggagccagac ccagtctggg gcctagggtt gatctggagc ccagtctcgg attctaagaa
     4081 cctatgctag cagacccaag gtggcatttg ggtcagctgc agacctgggc ttagaaacct
     4141 atttatccct gacttaggac aagtcaggaa ttgcccagga ccctaaccag gccacattgg
     4201 caaacagacc tggaacctca gcctggccac tcattcccca gagagaacgg gaagccccag
     4261 gcctgtatga cctgggttct gcccaccagc tgcactgacg ctgcccctct ctccctagcc
     4321 aaccctcccc tctcctccag aacccacccc aacttattta aactctgttg caagtgcaat
     4381 aaaccccacc cactgccccc actgaccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
