LOCUS       NM_010576               9832 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus integrin alpha 4 (Itga4), mRNA.
ACCESSION   NM_010576
VERSION     NM_010576.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9832)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9832)
  AUTHORS   Ryu,S., Kim,K.A., Kim,J., Lee,D.H., Bae,Y.S., Lee,H., Kim,B.C. and
            Kim,H.Y.
  TITLE     The protective roles of integrin alpha4beta7 and
            Amphiregulin-expressing innate lymphoid cells in lupus nephritis
  JOURNAL   Cell Mol Immunol 21 (7), 723-737 (2024)
   PUBMED   38806623
  REMARK    GeneRIF: The protective roles of integrin alpha4beta7 and
            Amphiregulin-expressing innate lymphoid cells in lupus nephritis.
REFERENCE   3  (bases 1 to 9832)
  AUTHORS   Parte,S., Kaur,A.B., Nimmakayala,R.K., Ogunleye,A.O.,
            Chirravuri,R., Vengoji,R., Leon,F., Nallasamy,P., Rauth,S.,
            Alsafwani,Z.W., Lele,S., Cox,J.L., Bhat,I., Singh,S., Batra,S.K.
            and Ponnusamy,M.P.
  TITLE     Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell
            Transdifferentiation and Pancreatic Cancer Initiation Via
            LAMA5/ITGA4 Axis
  JOURNAL   Gastroenterology 166 (5), 842-858 (2024)
   PUBMED   38154529
  REMARK    GeneRIF: Cancer-Associated Fibroblast Induces Acinar-to-Ductal Cell
            Transdifferentiation and Pancreatic Cancer Initiation Via
            LAMA5/ITGA4 Axis.
REFERENCE   4  (bases 1 to 9832)
  AUTHORS   Mak,S. and Hammes,A.
  TITLE     Canonical and Non-Canonical Localization of Tight Junction Proteins
            during Early Murine Cranial Development
  JOURNAL   Int J Mol Sci 25 (3), 1426 (2024)
   PUBMED   38338705
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9832)
  AUTHORS   Rohila,D., Park,I.H., Pham,T.V., Jones,R., Tapia,E., Liu,K.X.,
            Tamayo,P., Yu,A., Sharabi,A.B. and Joshi,S.
  TITLE     Targeting macrophage Syk enhances responses to immune checkpoint
            blockade and radiotherapy in high-risk neuroblastoma
  JOURNAL   Front Immunol 14, 1148317 (2023)
   PUBMED   37350973
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9832)
  AUTHORS   Renz,M.E., Chiu,H.H., Jones,S., Fox,J., Kim,K.J., Presta,L.G. and
            Fong,S.
  TITLE     Structural requirements for adhesion of soluble recombinant murine
            vascular cell adhesion molecule-1 to alpha 4 beta 1
  JOURNAL   J Cell Biol 125 (6), 1395-1406 (1994)
   PUBMED   7515889
REFERENCE   7  (bases 1 to 9832)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 9832)
  AUTHORS   Gurish,M.F., Bell,A.F., Smith,T.J., Ducharme,L.A., Wang,R.K. and
            Weis,J.H.
  TITLE     Expression of murine beta 7, alpha 4, and beta 1 integrin genes by
            rodent mast cells
  JOURNAL   J Immunol 149 (6), 1964-1972 (1992)
   PUBMED   1381390
REFERENCE   9  (bases 1 to 9832)
  AUTHORS   Neuhaus,H., Hu,M.C., Hemler,M.E., Takada,Y., Holzmann,B. and
            Weissman,I.L.
  TITLE     Cloning and expression of cDNAs for the alpha subunit of the murine
            lymphocyte-Peyer's patch adhesion molecule
  JOURNAL   J Cell Biol 115 (4), 1149-1158 (1991)
   PUBMED   1840602
REFERENCE   10 (bases 1 to 9832)
  AUTHORS   Holzmann,B. and Weissman,I.L.
  TITLE     Peyer's patch-specific lymphocyte homing receptors consist of a
            VLA-4-like alpha chain associated with either of two integrin beta
            chains, one of which is novel
  JOURNAL   EMBO J 8 (6), 1735-1741 (1989)
   PUBMED   2670559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844590.3.
            
            On Aug 17, 2018 this sequence version replaced NM_010576.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068313.1, X53176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AL844590.3         33852-34282
            432-553             AL844590.3         34604-34725
            554-660             AL844590.3         51214-51320
            661-790             AL844590.3         51419-51548
            791-858             AL844590.3         56188-56255
            859-988             AL844590.3         57509-57638
            989-1074            AL844590.3         59000-59085
            1075-1137           AL844590.3         59920-59982
            1138-1275           AL844590.3         60072-60209
            1276-1387           AL844590.3         63166-63277
            1388-1482           AL844590.3         65431-65525
            1483-1573           AL844590.3         66633-66723
            1574-1619           AL844590.3         67248-67293
            1620-1774           AL844590.3         67663-67817
            1775-1929           AL844590.3         70411-70565
            1930-2079           AL844590.3         79411-79560
            2080-2156           AL844590.3         81709-81785
            2157-2307           AL844590.3         92119-92269
            2308-2403           AL844590.3         93341-93436
            2404-2483           AL844590.3         94051-94130
            2484-2573           AL844590.3         94401-94490
            2574-2664           AL844590.3         96529-96619
            2665-2772           AL844590.3         98908-99015
            2773-2898           AL844590.3         99819-99944
            2899-3018           AL844590.3         101061-101180
            3019-3117           AL844590.3         103493-103591
            3118-3237           AL844590.3         104001-104120
            3238-9832           AL844590.3         104946-111540
FEATURES             Location/Qualifiers
     source          1..9832
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 47.38 cM"
     gene            1..9832
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /note="integrin alpha 4"
                     /db_xref="GeneID:16401"
                     /db_xref="MGI:MGI:96603"
     exon            1..431
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..3333
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /note="integrin alpha-IV; LPAM subunit alpha; VLA-4
                     subunit alpha; CD49 antigen-like family member D;
                     lymphocyte Peyer patch adhesion molecules subunit alpha;
                     VLA-4 receptor, alpha 4 subunit; integrin alpha4B"
                     /codon_start=1
                     /product="integrin alpha-4 precursor"
                     /protein_id="NP_034706.3"
                     /db_xref="CCDS:CCDS16168.1"
                     /db_xref="GeneID:16401"
                     /db_xref="MGI:MGI:96603"
                     /translation="MAAEARCRPRSRGIALREAVMLLLYFGVPTGHSYNLDPENALLY
                     QGPSGTLFGYSVVLHSHGSKRWLIVGAPTASWLSNASVVNPGAIYRCGIRKNPNQTCE
                     QLQLGSPSGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYMKSDNKL
                     PTGICYVMPSDLRTELSKRMAPCYKDYTRKFGENFASCQAGISSFYTQDLIVMGAPGS
                     SYWTGTVFVYNITTNQYKAFVDRQNQVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHE
                     QIGKAYIFSIDENELNIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIR
                     EEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQ
                     EDDLRGAVYIYNGRVDGISSTYSQRIEGQQISKSLRMFGQSISGQIDADNNGYVDVAV
                     GAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLPSVCMHLTLCFSYKGKE
                     VPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDVITGSIRVSSSGEKCRTHQAFMRK
                     DVRDILTPIHVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDVIRKMINFARFCAY
                     ENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTG
                     LYFIKILDLEEKQINCEVTESSGIVKLACSLGYIYVDRLSRIDISFLLDVSSLSRAHE
                     DLSISVHASCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLVNPTSFVYGSSEENEPE
                     TCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNVLDVQTTTGQCHFKH
                     YGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQHCLDFLCNFGKMESGKEAS
                     VHIQLEGRPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAHVFLEGLHHQRP
                     KRHFTIIIITISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVNSKSN
                     DD"
     exon            432..553
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            554..660
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            661..790
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            791..858
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            859..988
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1074
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1137
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1275
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1387
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1482
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1573
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1619
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1774
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1929
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2079
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2156
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2307
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2403
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2483
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2573
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2574..2664
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2772
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2898
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3018
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3019..3117
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3237
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..9832
                     /gene="Itga4"
                     /gene_synonym="CD49D; Itga4B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaacggggc gtgggccaga gcctgaagca tccctggcca ctacgatcgc tccgcctgtg
       61 gccaccaatt cccctcctct tctggcgtcc ctctctccgc ccctgtcgcc tgccagcacc
      121 ggacacgctg ctgcacttca tctcttgggg cgctcttctc tttggccaac cgtcgcatcc
      181 tgtgcaactc tggtcagtgg ccgttttgtg ttgaatgttc tccaccaaga gcgcatggct
      241 gcggaagcga ggtgcagacc gaggtcccga gggatcgccc tccgggaagc ggtgatgctg
      301 ttgttgtact tcggggtgcc aaccgggcac tcctacaacc tggacccgga gaatgcactg
      361 ctgtaccagg gcccctccgg cacgctgttt ggctactcgg tggtgctgca cagccacggg
      421 tcgaagcgct ggctcatcgt gggggctccc actgccagct ggctctctaa tgcctcagtg
      481 gtcaatcctg gggcgattta cagatgcggg atcagaaaga atccaaacca gacctgcgaa
      541 cagctccagc tgggtagccc cagtggagag ccttgtggga agacatgcct ggaggagagg
      601 gataaccagt ggctgggggt caccctttcc agacagcctg gagaaaatgg ctctatcgtg
      661 acttgtgggc acaggtggaa aaatattttt tacatgaaga gcgataacaa actccccact
      721 ggcatttgct acgtcatgcc ttctgatttg cggacagaac tgagtaaaag gatggccccg
      781 tgttacaaag attatacgag aaaatttgga gaaaattttg catcatgtca agctggaata
      841 tctagttttt acacacagga tttaattgtg atgggggccc cgggatcatc gtactggact
      901 ggcaccgtct ttgtctacaa tataactaca aaccaataca aagcatttgt agacagacag
      961 aaccaagtaa aatttggaag ctacttaggc tactcagttg gagctggaca ttttcgaagt
     1021 ccacatacta ccgaagtcgt gggaggagcc cctcaacacg aacagatagg aaaagcatat
     1081 atatttagca ttgatgaaaa cgaactgaac atcgtatatg aaatgaaagg taaaaagctt
     1141 ggctcatact ttggagcttc tgtctgcgct gtggacctca atgcagatgg cttctcagat
     1201 ctccttgttg gagctcccat gcagagcacc atcagggagg aaggaagagt attcgtgtac
     1261 atcaactctg gcatgggagc tgtgatggtt gaaatggaaa gggtccttgt cggaagtgac
     1321 aaatatgctg caagatttgg ggagtctata gcgaatcttg gcgacattga caatgacggc
     1381 tttgaagata ttgctattgg tgcaccacaa gaagacgact tgagaggtgc tgtctacatt
     1441 tacaatggcc gagtcgatgg aatctcctcc acctactcac agagaattga aggacagcaa
     1501 atcagcaaat cattaaggat gtttggacaa tctatctcag gacaaattga tgcagacaac
     1561 aatggatatg ttgatgtagc cgttggtgca tttcaatctg attctgcagt gttgctaagg
     1621 acaaggcctg tagtgattgt tgaagcatct ttaagccatc ctgagtctgt aaataggaca
     1681 aagtttgact gtactgaaaa tggacttcca tctgtgtgca tgcatcttac actgtgtttc
     1741 tcatataaag gcaaagaggt cccaggctac atcgttttgt tttacaatgt gagcttggat
     1801 gtgcacagga aggcagagtc tccgtcaaga ttttatttct tctctaatgg gacttctgac
     1861 gtgattacag gaagcatacg agtttcaagc agtggagaga aatgtaggac acaccaggca
     1921 ttcatgcgga aagacgtgcg agacatcctt acccccattc atgtagaggc cacataccac
     1981 cttgggcatc atgtgatcac caaacgaaac actgaggaat ttccaccact ccagccgatc
     2041 cttcagcaga agaaagaaaa agacgttatt agaaaaatga taaactttgc aaggttttgt
     2101 gcctatgaaa attgctctgc tgatctccaa gtttctgcaa aagttggatt tttgaagcca
     2161 tatgaaaata aaacctatct tgctgttggg agcatgaaga ccataatgct aaacgtgtcc
     2221 ttgttcaacg ctggcgatga tgcttacgaa accactctga atgtccaact ccccacaggc
     2281 ctttatttca ttaagatctt agacctggaa gagaaacaaa taaactgcga agtgactgag
     2341 agctcaggca tagtgaagct tgcctgcagc ctaggttaca tatatgtgga tcgcctctca
     2401 aggatagaca ttagctttct cctggatgtg agctcactca gcagggcaca tgaggacctc
     2461 agcatcagtg tgcatgcctc ctgtgaaaac gagggcgaat tggaccaagt gagggacaac
     2521 agagtgacct taacgatacc tctaaggtat gaggttatgc tgactgttca tgggcttgtg
     2581 aacccaactt catttgtgta tggatctagc gaagaaaacg agccagaaac atgcatggcc
     2641 gagaagctga acctcacttt ccatgttata aacactggga ttagcatggc tccaaatgtt
     2701 agtgtgaaaa taatggtacc aaattctttt ctccctcaag atgataagtt gttcaacgtt
     2761 ttggatgtcc agacaactac agggcaatgc cattttaaac actatggaag agagtgtaca
     2821 tttgcacagc aaaaaggcat agcggggacg ttgaccgata tagtcaaatt cctatcaaag
     2881 actgataaga gactcctgta ttgcatgaaa gctgatcaac actgtttaga tttcttatgc
     2941 aatttcggaa aaatggaaag tgggaaggaa gccagcgttc atattcagct ggagggcagg
     3001 ccatccatct tggaaatgga tgagacctca tcactcaagt ttgaaataaa agcaacagct
     3061 tttccagagc cacacccaaa agttattgaa ctaaataaag atgagaacgt ggcccatgtt
     3121 ttcttggaag ggctccatca tcaaagaccc aaacgacatt tcaccatcat tattattacc
     3181 atcagcttgc tacttggact tattgtactt ttattaattt catgtgttat gtggaaggct
     3241 ggattcttta aaagacagta caaatctatc ctacaagaag aaaacaggag agacagctgg
     3301 agttatgtca acagcaaaag caatgatgac tgaagacttc tacactgaga gaactgaaaa
     3361 actcaggtta ggaaaaagaa atcctgttca gaagacccgt cagaatttct tctttttttc
     3421 catgtgctta tgattttgtg acatactctt agtgcagggg aaatcttcaa gaaagaagct
     3481 acccaaaggt ggcttgtcag cttcggtgga tgagtgaagc aaaacactaa agctctggat
     3541 gtaccggaga ggtgacctgt ttaagacaac ttaaagctag agagaatcca gactcagcag
     3601 ggccgactta aagggaatga tttttcaaca tcactgatga agtggctcat ctcagtgaaa
     3661 tggatgccat gatgtggaaa cttgttggct tcaaatactt ttgatttatc ttcaaactat
     3721 gatcatgatc tttgaattca ctgagactct ttcaaatggc tgttccaaga ttgtctaatg
     3781 gataagtcat tttttattag atattttctt tatttacatt tcaaatgtta tcccctttcc
     3841 tagtttccac tccaaaaatc ccctatcctc tcccctgtcc cctgctcccc aatcgaccca
     3901 ctcccgcttc ctggccaagg cgttccccta tactggggaa tagaaccttc acaggaccaa
     3961 gggcctctcc tcctattgac agagcacagg gtccccaatg aaggagttag agaaaatacc
     4021 caaggagctg aaggggtttg cagccccata ggaggaacaa caatatgaac taaccagtaa
     4081 ccccagagct tcttgggact aaaccaccaa ccaaagaaaa cacacggaga gacgcatggc
     4141 tctagctgga tcaatcattt taaagcagag gacctgaaga ctgctcttgg tggtgctgca
     4201 tccctgggct gtgtccctac agccctttta ctctgcagat aggaactgta aaatcctaaa
     4261 gaacaaaatc cgtttgcagc aggatggctt ctggggaaat ggtcagctgc ggactcttgt
     4321 gtgtatgtac atatactttt ttaaaggata aaaatctcaa tctacttctt tattaagaac
     4381 acccaggaat agtttgcatc ttctaagctt cacctttaat accaattctt aagaatttta
     4441 tcctcatagc agattataaa tatcgcactt tagctgatac acactgatac aacatgaact
     4501 gcagctcact gatgatcgaa aattgtgtga agagagattt aggaaccaat atttcataaa
     4561 acattcactg catcaaatta tgcaaacatg agtatctgct aggatattgt tgtttctctt
     4621 ggtctggttg aatatacata aactaggact ctaaaacacc acattctgtc atagaaatgg
     4681 agacacaaaa atcatagttg gaactgcaaa tcactgatca agtttgtgtg cagtggcatc
     4741 aaaattccca tgcgataatg catgcttgat gttgttgaac aagatactat tttaaaatga
     4801 aatagcttct acctgggttt cacataattt gtctgtaatt acaatcattt ttgtagtatt
     4861 tatttcatat atgtagtttg ataaatgtaa gttttcattt gaatctgtta tgtgtaagca
     4921 agctaaggcc agactttgaa catgtgctgg gtaaaagggg cagccttcag tgttgtgaag
     4981 aaagatcgct ttacaggaag ggtttgatgc cagctggccc ttcctcagat ttcctgactt
     5041 gtgaggatgg cttgttcaca agcctctggc tggagccgtg gagggaggtt ttgagtgctg
     5101 aaacttgagc atagagcatc agatctgggt gagcagaaac catatttaat tagatgctta
     5161 tatttttaag ggatgctttt ttgtgtaaaa ggtttaagtt gatggttttc ttataaaaat
     5221 tcaagtagtt atttcatgag gatgccaaag ttaatagatg agaaatcaat atcattttag
     5281 acctaccgtt tcaaggaatg gtctctgagg agagttaaat gtggatcatt gcactgaaaa
     5341 ccgactcctg cctttcaggt acaaaagaac gtagctacct cctgggccac attttgccca
     5401 attagaaaga aatattttta tatttattaa taaaacttag aattttatat aagctttaaa
     5461 atgtagttat ttcaaaagat gctgttatgg gatgggtagt agaatagtag cctaagagga
     5521 aagaatgttt tttaagtggg tgttcgtggt tatgttacta tctcactgtg aagtctgaga
     5581 ttttacagaa gttttgtttt actaggttac aggagatact aaagaattat cttcaacagt
     5641 attgagagag cacaatgttg ttaaaattag atctaacaaa caccttccaa aaatcaaaac
     5701 tttgattttt ttcattaatt tcatattttt tgattttcaa atacctggct actattttaa
     5761 ttatattaaa atattttaat tgcattaaag tagatacttt aattatatta aatagatagc
     5821 ttcattaaaa tgtgttgcag taaatctctc caacccaaat atgccttggc aatgaaaaca
     5881 caacacagtt aatatgattg catgctgtgc gcctagattg ggcagatcta ctgctacact
     5941 actgtcttcc acagcttatg agacccctta gaacttgcgg tttctccagg ccatgtgctt
     6001 ctgctctgct tcacttcatc ttcctccccc tctgcatcct ctccctcttc cattttctcc
     6061 ttcttttctc tccctacctt cggctccgcc ttccctttta tctgcccaaa tatcagctct
     6121 cctttatttt acaaattaag gtgggaatca ggtttacagg aaatcacctg agtgctgact
     6181 cattccttgt tcacaaccgc tcatgggaga acagaattaa catcaaatat aattagcccc
     6241 agggctatcc tcaacattta cccctttctg tccaattaaa agactatttt atctcagata
     6301 taattgaaca taacaattat tattttgtaa tttataaagt acaggagacc taacacccag
     6361 tccatcatct ttgttaatta aataaaaatc tctgtcatct atccttactt aaaagactat
     6421 agttctgcac ctggctagtt ctgcatctga aaaccatcct ctcaaatcta ttcctctcaa
     6481 agtgaaaagc ctgggctcgc ctgagactat gtagtttttc aacctcaaca taaatccaag
     6541 aatgactgat attaactgaa aatatatagg aagcctaaca tagcttccaa aatttagata
     6601 atttgttgag accactggtc acttggacag tcccttactt caacagggtg gagctttgat
     6661 cttcaggcta ctggccttag tcatctgaca agacttagag aaacaagaat attaaggact
     6721 agcctactgt ctcggcagaa tcaagctgtc ctaacctgta gttgtgtcct ttctttggac
     6781 agtattatat ctgtagatga aatgagccaa ttcttgccta gtgactttca ccacaactag
     6841 agtaactcaa agatgctcag tttcttcttt gaatccaaga cagggaaagc tgtcaggagc
     6901 agactagtct caacaacaag tgaataaata acatcaaact tcacattctg tggacttctg
     6961 atgtttttgg aaaaccaatt atctatatga agtaatctga actgttctct gaacctctct
     7021 cagccatttc tgattaaaat aactgaaaac accctaacaa taaactcaga gccaagaatt
     7081 tcctatctga cccttaactc acaggcttaa acatctcagc tctgtttatc ataacagcaa
     7141 ttgaaggact gggtctaagc cttgtacttc aaaattttta gtatcaaaga caacctataa
     7201 taaccacccg cagccgcaaa gcttagggaa ctgggatgat gaatcttcat aacttcttca
     7261 agctgatatg ggcgttgaga tatttttgaa ggaaggggga agaataggga aagggggagt
     7321 tagttggcct taggaaggcc ccaccatgat tgtattagtt tctgatgtct ctgtcctgac
     7381 tggatccgga tgaaaaacca agatatcagt tcaggcaagt cagttcagca tgtctgatga
     7441 tgaaattcac caaggctgta tattctgtaa tatataaatc tcaaaaaaaa aatttagtat
     7501 catcaatata acctttttgt ttgattctca ggaatctagt tctcaggggg tctccttcta
     7561 tcaaatctga tccatataac tctagaatgt gtaaatacct taatcacctt ttccaaaaac
     7621 acaaagataa aacctttccc caaatcagca tatccttcag ctggtaacca ggaaaacctg
     7681 taacttgcgc tctgtcccag aggaacaata aaacaaccac aacacacaaa atcacacaca
     7741 ttttagccta tttaggcctt tctaatttgt catgtcagga tattaaccca aaatttccat
     7801 ggagtccacg ttagacagaa tatgaatctc ttgcagactt tattatacca tcttacaaca
     7861 attgattcat acttctattt tcctttcctt ttcctttcct ctcctctttc ctttcctctc
     7921 ctctttcctt ttctttctat acctggtttt aagaagcagt ttgtcaaacc aggatttaaa
     7981 cccaaaattc ccgtgcagcc cacattagac agaatatgag tatcctgtaa gacttattaa
     8041 agcaatatat ctttatacca tctttaaagc aattaattca aacttctact aatacctgtt
     8101 ataccgtcta tctgttgtgc tctctaccag gagccacaga catttattta attaatacct
     8161 attataacat gtatctgtta tgctctctac ctggagacat agactttatt aattaatact
     8221 tgttcatagc aggcaattat cactgctgtc tctacttgga gtcagtaact aataatccct
     8281 atatagttcc aaatcacagg taaaatttcc catctttaag tactatacct gcttataaga
     8341 ggcagcttga caaaccagga tttaaactaa aaactccagt ggagcccatg ttagacagaa
     8401 tatgagtatc ctgtaagact tactagagca atatatcgtt atactatctt taagtatcaa
     8461 aaggttatat ttttctcttt atatcaatga gttatttggt ctggagacct ttgtaccttt
     8521 gcctcccaat tttttattca tggggagaag ctgaatgtaa aaagacccct gttgtctgtg
     8581 tccctgtttg gaagtggggg aggcagggta gggaacaaag gacataggga agcaaacagg
     8641 gaaggctctc tctggtgtag atgcttctct gctgttctct gtaggcccct caaatcaaat
     8701 tcatactgct acagcctagg tcactgccca agcccctttc aggtgttggg gggcagtgaa
     8761 tttttatctt agttagttga gttcaaatca atatgttggg cgccattttg ttgtgttaaa
     8821 tctccatccc aaataagccc cggcaatgaa agcatgattt aattcatatg cttacaagct
     8881 gtgcacctag attgggcaga tctaccacta cactaccatc ttccacagtt tatgagaccc
     8941 cttagaacct gtggtttctc caggccatgt gcttctgctc tgcttcactt catcttcctc
     9001 ctcctctgca tcctctccct cttccatttt ctccttcttt tctctgcccc accttccctt
     9061 ttatctgccc aatcatcagc tctcctttgt tttacaaatt aaggtggaat caagtttaca
     9121 gacaatcacc tgaatgctga ctcattcctt gttcacaacc actcacagga gaacagaatt
     9181 aacatcaaat ataattagcc ccagggctat ccacaacaaa aatgcatttt ctatttgtat
     9241 atatcttgca tgccagattc cttcataata aatttctgct tacatacttc tttcatatgc
     9301 aatcacatgc tactttgcaa tcattcattt cttccaggct tcctccatag agcctgatca
     9361 gtcttgggtg cagcctataa ggaataacaa gggtttgatg atttcatttc tgggccacta
     9421 tgatttttca catacctcac aagtgtggtg cataaatcac acatacagat tggcatatac
     9481 tcctagctga gccacaagcc agcaaggacc taaaacacca acatctgtga ccattccaaa
     9541 gcactcttaa ccacctttcc tgcctggtta atatccgcta gtgcctctgt gaagagacag
     9601 ttacttaaga acaccccacc tagcagagga ccctgtccct ccctcccagc acacttcagc
     9661 ctgctgagac attaagcttg ctaagattga gtatgagtat tgagtttcta caactttata
     9721 cccattgctc attcttgttg atatatatgt acagtgtgtg gaatgcatta taaagatcta
     9781 acagtcaact ccattacttt gtgtgctgaa ttaaataaaa aaggattttg at
//
