LOCUS       NM_001306162            4723 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus integrin alpha 3 (Itga3), transcript variant 3, mRNA.
ACCESSION   NM_001306162
VERSION     NM_001306162.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4723)
  AUTHORS   Moye,A.L., Dost,A.F., Ietswaart,R., Sengupta,S., Ya,V., Aluya,C.,
            Fahey,C.G., Louie,S.M., Paschini,M. and Kim,C.F.
  TITLE     Early-stage lung cancer is driven by a transitional cell state
            dependent on a KRAS-ITGA3-SRC axis
  JOURNAL   EMBO J 43 (14), 2843-2861 (2024)
   PUBMED   38755258
  REMARK    GeneRIF: Early-stage lung cancer is driven by a transitional cell
            state dependent on a KRAS-ITGA3-SRC axis.
REFERENCE   2  (bases 1 to 4723)
  AUTHORS   Abou Nader,N., Charrier,L., Meisnsohn,M.C., Banville,L.,
            Deffrennes,B., St-Jean,G., Boerboom,D., Zamberlam,G.,
            Brind'Amour,J., Pepin,D. and Boyer,A.
  TITLE     Lats1 and Lats2 regulate YAP and TAZ activity to control the
            development of mouse Sertoli cells
  JOURNAL   FASEB J 38 (9), e23633 (2024)
   PUBMED   38690712
REFERENCE   3  (bases 1 to 4723)
  AUTHORS   Zhang,X., Li,H., Wang,H., Zhang,Q., Deng,X., Zhang,S., Wang,L.,
            Guo,C., Zhao,F., Yin,Y., Zhou,T., Zhong,J., Feng,H., Chen,W.,
            Zhang,J., Feng,H. and Hu,R.
  TITLE     Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural
            stem cell pool contributes to cognitive impairment after
            hemorrhagic stroke
  JOURNAL   Redox Biol 71, 103086 (2024)
   PUBMED   38367510
  REMARK    GeneRIF: Iron/ROS/Itga3 mediated accelerated depletion of
            hippocampal neural stem cell pool contributes to cognitive
            impairment after hemorrhagic stroke.
REFERENCE   4  (bases 1 to 4723)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4723)
  AUTHORS   Bosquetti,B., Santana,A.A., Gregorio,P.C., Cunha,R.S.D.,
            Miniskiskosky,G., Budag,J., Franco,C.R.C., Ramos,E.A.S.,
            Barreto,F.C. and Stinghen,A.E.M.
  TITLE     The Role of alpha3beta1 Integrin Modulation on Fabry Disease
            Podocyte Injury and Kidney Impairment
  JOURNAL   Toxins (Basel) 15 (12), 700 (2023)
   PUBMED   38133204
  REMARK    GeneRIF: The Role of alpha3beta1 Integrin Modulation on Fabry
            Disease Podocyte Injury and Kidney Impairment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4723)
  AUTHORS   Shakibaei,M., Zimmermann,B. and Merker,H.J.
  TITLE     Changes in integrin expression during chondrogenesis in vitro: an
            immunomorphological study
  JOURNAL   J Histochem Cytochem 43 (10), 1061-1069 (1995)
   PUBMED   7560884
REFERENCE   7  (bases 1 to 4723)
  AUTHORS   Stepp,M.A., Zhu,L., Sheppard,D. and Cranfill,R.L.
  TITLE     Localized distribution of alpha 9 integrin in the cornea and
            changes in expression during corneal epithelial cell
            differentiation
  JOURNAL   J Histochem Cytochem 43 (4), 353-362 (1995)
   PUBMED   7534781
REFERENCE   8  (bases 1 to 4723)
  AUTHORS   Takeuchi,K., Hirano,K., Tsuji,T., Osawa,T. and Irimura,T.
  TITLE     cDNA cloning of mouse VLA-3 alpha subunit
  JOURNAL   J Cell Biochem 57 (2), 371-377 (1995)
   PUBMED   7759572
REFERENCE   9  (bases 1 to 4723)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   10 (bases 1 to 4723)
  AUTHORS   Tamura,R.N., Cooper,H.M., Collo,G. and Quaranta,V.
  TITLE     Cell type-specific integrin variants with alternative alpha chain
            cytoplasmic domains
  JOURNAL   Proc Natl Acad Sci U S A 88 (22), 10183-10187 (1991)
   PUBMED   1946438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ089026.1 and BC096741.1.
            
            Summary: This gene encodes a subunit of integrin family of cell
            surface proteins. The encoded protein undergoes post-translational
            processing to form a disulfide bond-linked dimer comprised of heavy
            and light chains. At the cell surface, the encoded protein
            non-covalently associates with the integrin beta-1 subunit to form
            a heterodimer that interacts with many extracellular matrix
            proteins including fibronectin and laminin. Mice lacking the
            encoded protein die during the first day after birth due to severe
            abnormalities in kidneys. Mice lacking the encoded protein
            specifically in the basal layer of epidermis display several skin
            defects and accelerated wound healing. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an alternate exon the 3' coding region, compared to variant
            1. It encodes isoform 3, which has a longer and distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096741.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CJ089026.1         2-11
            11-3057             BC096741.1         1-3047
            3058-4723           BC096741.1         3049-4714
FEATURES             Location/Qualifiers
     source          1..4723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..4723
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /note="integrin alpha 3"
                     /db_xref="GeneID:16400"
                     /db_xref="MGI:MGI:96602"
     exon            1..44
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            45..572
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..3573
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; galactoprotein B3; CD49 antigen-like family
                     member C; VLA-3 receptor, alpha 3 subunit"
                     /codon_start=1
                     /product="integrin alpha-3 isoform 3 precursor"
                     /protein_id="NP_001293091.1"
                     /db_xref="CCDS:CCDS83878.1"
                     /db_xref="GeneID:16400"
                     /db_xref="MGI:MGI:96602"
                     /translation="MGPGPCRVPRAPGWLLRALALMVAACGRVAFAFNLDTRFLVVKE
                     AVNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVGDDYTNRTGAVYLCPLTAHKDD
                     CERMDISEKSDPDHHIIEDMWLGVTVASQGPAGRVLVCAHRYTKVLWSGLEDQRRMVG
                     KCYVRGNDLQLDPGDDWQTYHNEMCNSNTDYLQTGMCQLGTSGGFTQNTVYFGAPGAY
                     NWKGNSYMIQRKDWDLSEYSYRGSEEQGNLYIGYTVQVGNAILHPTDIITVVTGAPRH
                     QHMGAVFLLKQESGGDLQRKQVLKGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFE
                     RKEEVGGAVYVFMNQAGASFPDQPSLLLHGPSRSAFGISIASIGDINQDGFQDIAVGA
                     PFEGLGKVYIYHSSSGGLLRQPQQIIHGEKLGLPGLATFGYSLSGKMDVDENLYPDLL
                     VGSLSDHIVLLRARPVINILHRTLVARPAVLDPALCTATSCVQVELCFAYNQSAGNPN
                     YRRNITLAYTLEADRDRRPPRLRFARSQSSVFHGFFSMPETHCQTLELLLMDNVRDKL
                     RPIVIAMNYSLPLRMPDRLKLGLRSLDAYPVLNQAQAMENHTEVHFQKECGPDNKCDS
                     NLQMRAAFLSEQLQPLSRLQYSRDTKKLFLSINVTNSPSSQRAGEDAHEALLTLEVPS
                     ALLLSSVRPSGTCQANNETILCELGNPFKRNQRMELLIAFEVIGVTLHTRDLPVLLQL
                     STSSHQDNLQPVLLTLQVDYTLQASLSLMNHRLQSFFGGTVMGEAAMKTAEDVGSPLK
                     YEFQVSPVGDGLAALGTLVLGLEWPYEVTNGKWLLYPTEITIHSNGSWPCQPSGNLVN
                     PLNLTLSDPGVTPLSPQRRRRQLDPGGDQSSPPVTLAAAKKAKSETVLTCSNGRARCV
                     WLECPLPDTSNITNVTVKARVWNSTFIEDYKDFDRVRVDGWATLFLRTSIPTINMENK
                     TTWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCDFFKPTRYYRIM
                     PKYHAVRIREEDRYPPPGSTLPTKKHWVTSWQIRDRYY"
     exon            573..700
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            701..780
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1030
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1117
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1328
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1525
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1614
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1751
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1838
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1906
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2043
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2193
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2291
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2439
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2511
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2591
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2669
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2772
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2955
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3078
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3192
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3193..3291
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3417
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     exon            3418..4706
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4685..4690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /note="hexamer: AATAAA"
     polyA_site      4706
                     /gene="Itga3"
                     /gene_synonym="CD49C; GAPB3"
                     /note="major polyA site"
ORIGIN      
        1 ctctttcccc ggaaggaaag cggagcccgg actgggcgcg caagccgagg tccaaagagc
       61 taacacctcc aagggggcgc ggccgggacc atctagggtg tggggtgctc ggagctcgga
      121 acggtgaccc gtccaccgaa ccaacgtgag agtagatcca cggatctgga aaacggattg
      181 gaaaagcacc cggagcagac gtgaaagtga cccggactag ggtaaaaaat tgcctgacta
      241 ccggtgcagc ggctctgcgg gctcgggtgt cctctggtgg cgcctggagc aggtgaaccg
      301 ttcatcactc ccggtgctga gccctctagc gatttcgccc ggccccttac ggcccggccc
      361 gcagccatgg gccccggccc ctgccgcgtg ccccgcgccc ctggctggct gctccgcgct
      421 ctggccttga tggtggcggc ttgcggccgg gtcgccttcg ccttcaacct ggacacccga
      481 ttcctggtgg tgaaggaggc ggtgaacccc ggtagcctct tcggctactc ggtcgccctc
      541 catcggcaga ctgagcgaca acagcgctac ctccttctgg ccggggctcc ccgggacctc
      601 gctgtgggtg atgactatac caaccggact ggtgctgtgt acctgtgtcc cctcacggcc
      661 cacaaggacg actgtgaacg gatggacatt tcagagaaaa gtgaccctga ccatcacatt
      721 attgaggata tgtggcttgg agtgactgtg gccagccagg gccctgcagg tagagtcctg
      781 gtctgtgccc atcggtacac caaggtgctg tggtctgggc tagaagacca gcggcgcatg
      841 gtgggcaagt gctatgtgcg tggcaatgac ctacagctcg accccggcga tgactggcag
      901 acataccaca acgagatgtg taacagcaac actgactact tgcagaccgg catgtgccag
      961 ctgggcacca gcggcggctt cacccagaac accgtatact tcggtgcccc tggtgcctac
     1021 aactggaaag gaaacagcta catgattcag cggaaggact gggatttatc tgaatatagc
     1081 tacaggggct cagaggagca aggaaacctt tatattgggt acacggtgca ggtaggcaac
     1141 gccatcctac atcccacgga catcatcact gttgtgacgg gtgccccacg gcaccaacat
     1201 atgggcgctg tcttcttgct gaagcaagag tcaggtggag acctgcagag gaagcaggtg
     1261 ctgaagggca cgcaggtggg cgcttatttt ggcagtgcca ttgccctggc agacctgaac
     1321 aatgatgggt ggcaggacct cctggtgggt gctccctact acttcgaacg gaaagaggag
     1381 gtagggggtg ccgtctatgt cttcatgaac caggcgggcg catccttccc tgatcaacct
     1441 tccctcctgc ttcacggccc cagccgctct gcctttggca tctctatagc cagcatcggt
     1501 gacatcaacc aggatggatt ccaggacatc gctgtgggag ccccatttga gggcttgggc
     1561 aaagtctaca tctaccacag cagctccggg gggctcctca ggcagcccca gcagataatc
     1621 catggagaga aactcggact gccaggcttg gccaccttcg gctactccct gagcgggaag
     1681 atggatgtgg atgaaaacct ttacccagac ctgctagtag ggagcctgtc ggaccacatc
     1741 gtgctgctgc gggcccggcc tgtcatcaat atcctccata ggaccttggt ggccaggcca
     1801 gctgtgttgg accctgcgct ttgtacagct acctcctgtg ttcaggtgga gctgtgtttt
     1861 gcctacaacc agagcgctgg gaaccccaac tacaggcgga acatcaccct ggcttacaca
     1921 ctggaggctg acagggaccg acgcccaccc aggctccgat ttgcccgcag ccagtcatct
     1981 gtcttccacg gcttcttctc catgccagag acacattgcc agacactgga gttactgctg
     2041 atggacaatg ttcgcgataa actccgtcct atcgtcattg ccatgaacta ctccttacct
     2101 ctgcgcatgc ctgatcgcct caagctcggc ttgcggtctc tggatgccta cccagtcctc
     2161 aaccaggcac aggctatgga gaatcacact gaggtccact tccagaaaga gtgcgggcca
     2221 gacaacaagt gcgacagcaa cctgcagatg cgagcagcct tcctgtctga gcagctgcag
     2281 cctctaagca ggctccagta cagcagagac actaagaaac tgtttttgag catcaatgtg
     2341 accaattcac cgagcagcca acgggctggg gaagatgcgc atgaggcatt gctcacccta
     2401 gaggtgccat ccgccctgct actgtcctcc gtgcgcccgt ctgggacctg ccaagctaat
     2461 aacgagacca tcctgtgtga gctaggaaac cccttcaaac ggaaccagag gatggagctg
     2521 ctcattgcct ttgaggtcat cggggtaacg ttgcacacga gggacctccc agtacttctt
     2581 cagctgtcca cgtcgagtca ccaggacaac ttgcagcccg tactcctgac tttgcaggtg
     2641 gactacaccc tccaggcctc gctcagctta atgaatcatc ggttgcagag cttctttggt
     2701 ggcacagtga tgggtgaggc tgccatgaaa actgcggagg atgtgggaag tcccctgaaa
     2761 tatgaattcc aggtgagccc agtgggagat gggctggcag ccttgggcac actggttcta
     2821 ggtctggagt ggccctatga agttaccaat ggcaagtggc tgctgtaccc cacggagatc
     2881 accatccata gcaatggttc ctggccctgc cagccgtctg gaaaccttgt caaccctctc
     2941 aaccttactc tctctgaccc tggagtcaca ccactgtcgc cacagcgccg ccggcggcaa
     3001 ctggatccag ggggagacca gagttccccg cctgtcacac tagctgctgc caaaaaagcc
     3061 aagtctgaga ctgtgttgac ctgctccaat ggccgtgccc gctgtgtgtg gctggagtgc
     3121 ccccttccag acacctccaa cattaccaat gtgaccgtga aagcacgggt gtggaacagc
     3181 accttcattg aggactacaa agactttgac agagtcaggg tagatggctg ggctaccctg
     3241 ttcctgagaa ccagcatccc taccatcaac atggagaaca agaccacatg gttctctgtg
     3301 gacattgact cagagctggt ggaggagctg ccggctgaga ttgagctgtg gttggtgctt
     3361 gtggccgtgg gtgctgggtt gctgctgctg gggctcatca tcctcctctt gtggaagtgt
     3421 gacttcttta agccgacccg ctactaccgg attatgccca agtaccatgc agtgcgtatc
     3481 cgggaggagg accgctaccc acctccaggg agcacgctac ccaccaagaa gcactgggtc
     3541 accagctggc agattcggga ccgatactac tgatgccctc cccgacaaac cttccggcgc
     3601 tcccttcctt cctatttatc ataaattatg actccgacag tccaaagggg gccacgccct
     3661 tggctggcac cagcaggctc aggcatctat ccctcttcag tgcaggcatg ttttctgggg
     3721 ccctggaatc tccttcaaga ccttgcaatg ctgagcccag cacagccctt gcacagtgga
     3781 cacacacaca gggcctactg ctaatggcct gctctgatat atcatggagg gtgccgtatc
     3841 caagtctctg tctgtgccaa aaccaagcca aagcgcctct actgggagac aggaggaaaa
     3901 ggtccctgat gtggggacac ggctcctcca cactgaatcc cccttgagcc attgtcaatg
     3961 gatggagttt actgtccaga ataaaactac tgatgcggag gagacagtca ggctcagctg
     4021 caattcctgc caggcactgg agcgcagggc tacactaaag gctacccagg ggatgttctt
     4081 acgacctgcg tgctcagacg caagagcaat gaactagaaa gcaggtcgcc ggaatgggct
     4141 ttatgggtgc atctctaaaa tcgtggctac agagagagct ggcaagaaac gcagcccgaa
     4201 ggaacaaaga gagaccgtgg gcagcctgga cgcacacact gtgctgggac tgacctggag
     4261 catggcggca tccttcagag agcagggtcc tggcgcagca gacattggta ggatgaagag
     4321 gagagacttc tgatccatcc tgaccacctc agcctgggca aggcctggag atccccacga
     4381 gaccacgtgg ggtgtgatac ttgaatgtag catggcaggg gagggcccag cccctgcccc
     4441 agttggccag acttaactct gctcccttga ccacagagat gagattctga gctgcctgtg
     4501 gctttcttcc cctcccccag gggctgcatc cccattctag cagtggaggc tgatttccca
     4561 ggtcctctcc ccatcccggt ccacaggcag gcccactccc cagctctgtc ccctccaccc
     4621 cacggtacta taacaacttc cccgatcctg tgccttcttt gtatatgggc ttctcactaa
     4681 aataaataaa ctgttcccag tttgtaaaaa aaaaaaaaaa aaa
//
