LOCUS       NM_010575               3437 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus integrin alpha 2b (Itga2b), mRNA.
ACCESSION   NM_010575
VERSION     NM_010575.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3437)
  AUTHORS   Liu N, Kawahira N, Nakashima Y, Nakano H, Iwase A, Uchijima Y, Wang
            M, Wu SM, Minamisawa S, Kurihara H and Nakano A.
  TITLE     Notch and retinoic acid signals regulate macrophage formation from
            endocardium downstream of Nkx2-5
  JOURNAL   Nat Commun 14 (1), 5398 (2023)
   PUBMED   37669937
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3437)
  AUTHORS   Severin S, Consonni A, Chicanne G, Allart S, Payrastre B and
            Gratacap MP.
  TITLE     SHIP1 Controls Internal Platelet Contraction and alphaIIbbeta3
            Integrin Dynamics in Early Platelet Activation
  JOURNAL   Int J Mol Sci 24 (2), 958 (2023)
   PUBMED   36674478
  REMARK    GeneRIF: SHIP1 Controls Internal Platelet Contraction and
            alphaIIbbeta3 Integrin Dynamics in Early Platelet Activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3437)
  AUTHORS   Haji S, Ito T, Guenther C, Nakano M, Shimizu T, Mori D, Chiba Y,
            Tanaka M, Mishra SK, Willment JA, Brown GD, Nagae M and Yamasaki S.
  TITLE     Human Dectin-1 is O-glycosylated and serves as a ligand for C-type
            lectin receptor CLEC-2
  JOURNAL   Elife 11, e83037 (2022)
   PUBMED   36479973
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3437)
  AUTHORS   Rodriguez A, Epperly M, Filiatrault J, Velazquez M, Yang C, McQueen
            K, Sambel LA, Nguyen H, Iyer DR, Juarez U, Ayala-Zambrano C,
            Martignetti DB, Frias S, Fisher R, Parmar K, Greenberger JS and
            D'Andrea AD.
  TITLE     TGFbeta pathway is required for viable gestation of Fanconi anemia
            embryos
  JOURNAL   PLoS Genet 18 (11), e1010459 (2022)
   PUBMED   36441774
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3437)
  AUTHORS   Van Deren DA, De S, Xu B, Eschenbacher KM, Zhang S and Capecchi MR.
  TITLE     Defining the Hoxb8 cell lineage during murine definitive
            hematopoiesis
  JOURNAL   Development 149 (8) (2022)
   PUBMED   35452096
REFERENCE   6  (bases 1 to 3437)
  AUTHORS   Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt
            P, Saris CJ and Orkin SH.
  TITLE     Transcription factor NF-E2 is required for platelet formation
            independent of the actions of thrombopoietin/MGDF in megakaryocyte
            development
  JOURNAL   Cell 81 (5), 695-704 (1995)
   PUBMED   7774011
REFERENCE   7  (bases 1 to 3437)
  AUTHORS   Denarier E, Martin F, Martineau S and Marguerie G.
  TITLE     PCR cloning and sequence of the murine GPIIb gene promoter
  JOURNAL   Biochem Biophys Res Commun 195 (3), 1360-1364 (1993)
   PUBMED   8216269
REFERENCE   8  (bases 1 to 3437)
  AUTHORS   Morse HC 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 3437)
  AUTHORS   Chen YQ, Gao X, Timar J, Tang D, Grossi IM, Chelladurai M, Kunicki
            TJ, Fligiel SE, Taylor JD and Honn KV.
  TITLE     Identification of the alpha IIb beta 3 integrin in murine tumor
            cells
  JOURNAL   J Biol Chem 267 (24), 17314-17320 (1992)
   PUBMED   1512266
REFERENCE   10 (bases 1 to 3437)
  AUTHORS   Phillips DR, Charo IF and Scarborough RM.
  TITLE     GPIIb-IIIa: the responsive integrin
  JOURNAL   Cell 65 (3), 359-362 (1991)
   PUBMED   2018971
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY204133.1, AL596258.15, BC120493.1 and AF170316.1.
            
            [WARNING] On Jan 9, 2024 this sequence was replaced by NM_010575.3.
            
            On Nov 2, 2007 this sequence version replaced NM_010575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154619.1, AF170316.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY204133.1         2-11
            11-11               AL596258.15        111718-111718       c
            12-150              BY204133.1         13-151
            151-3349            BC120493.1         1-3199
            3350-3437           AF170316.1         3211-3298
FEATURES             Location/Qualifiers
     source          1..3437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.29 cM"
     gene            1..3437
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /note="integrin alpha 2b"
                     /db_xref="GeneID:16399"
                     /db_xref="MGI:MGI:96601"
     exon            1..359
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..3273
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /note="integrin alpha-IIb; GPalpha IIb; platelet membrane
                     glycoprotein IIb; platelet glycoprotein IIb of IIb/II Ia
                     complex; GP IIb; alpha IIb"
                     /codon_start=1
                     /product="integrin alpha-IIb precursor"
                     /protein_id="NP_034705.2"
                     /db_xref="CCDS:CCDS25500.1"
                     /db_xref="GeneID:16399"
                     /db_xref="MGI:MGI:96601"
                     /translation="MARASCAWHSLWLLQWTPLFLGPSAVPPVWALNLDSEKFSVYAG
                     PNGSHFGFSVDFHKDKHGSVSIVVGAPRALNASQEETGAVFLCPWKANGGKCNPLLFD
                     LRDETRNLGFQIFQTFKTGQGLGASVVSWNDVIVACAPWQHWNVLEKRDEAEKTPVGG
                     CFLAQLQSGGRAEYSPCRANTMSSVYAESFRGDKRYCEAGFSLAVTQAGELVLGAPGG
                     YFFLGLLARVPIENIISSYRPGTLLWHVSNQRFTYDNSNPVFFDGYRGYSVAVGEFDG
                     DPSTTEYVSGAPTWSWTLGAVEILDSYYQPLHRLHGEQMASYFGHSVAVTDVNGDGRH
                     DLLVGAPLYMESRADRKLAEVGRVYLFLQPKGPQALSTPTLLLTGTQLYGRFGSAIAP
                     LGDLNRDGYNDIAVAAPYGGPSGQGQVLIFLGQSEGLSPRPSQVLDSPFPTGSGFGFS
                     LRGAVDIDDNGYPDLIVGAYGASKVAVYRAQPVVMATVQLMVQDSLNPTLKNCVLDQT
                     KTPVSCFNIQMCVGATGHNIPQKLHLKAELQLDLQKPRQGRRVLLLASQQASLTLSLD
                     LGGRDKPICHTTGAFLRDEADFRDKLSPIVLSLNVSLPPEETGGAPAVVLHGETHVQE
                     QTRIILDCGEDDLCVPQLRLTATAGDSPLLIGADNVLELKIEAANDGEGAYEAELAVH
                     LPPGAHYMRALSNIEGFERLVCTQKKENESRVALCELGNPMKKDTRIGITMLVSVENL
                     EEAGESVSFQLQVRSKNSQNPNSKVVMLPVAIQAEATVELRGNSFPASLVVAAEEGDR
                     EQEDLDRWVSRLEHTYELHNIGPGTVNGLRLLIHIPGQSQPSDLLYILDVQPQGGLLC
                     STQPSPKVDWKLSTPSPSSIRPVHHQRERRQAFLQGPKPGQQDPVLVSCDGSASCTVV
                     ECELREMVRGQRAMVTVQVMLGLSSLRQRPQEQFVLQSHAWFNVSSLPYSVPVVSLPS
                     GQARVQTQLLRALEERAIPVWWVLVGVLGGLLLLTLLVLAMWKAGFFKRNRPPLEEDE
                     EEE"
     exon            360..481
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            482..579
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            580..742
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            743..792
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            793..838
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            839..967
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1015
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1059
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1113
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1166
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1378
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1561
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1607
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1712
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1768
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1920
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2046
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2114
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2262
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2355
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2435
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2516
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2616
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2760
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2880
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..2997
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3099
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            3100..3216
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3437
                     /gene="Itga2b"
                     /gene_synonym="alphaIIb; CD41; CD41B; GpIIb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggtgggcc ctcccccgtc ctagtcgacg tctagaggct attgccctct gccatgcctg
       61 ctgctcagcc atgagctcca gtctgataag ctgaaacttc cggtggtggg aacttcaggg
      121 aaagggaaag agctggccca ttcctgttta ggacgtttgg gaagaaggaa gatggccaga
      181 gcctcctgcg catggcattc cctgtggctt ctgcagtgga caccactgtt cttgggtcct
      241 agtgctgttc ctccagtctg ggccttgaac ctggactctg agaagttctc cgtctatgca
      301 ggtcccaatg gcagccactt tggcttctca gtggactttc ataaggacaa acatggaagc
      361 gtgtccatcg tggtgggcgc ccccagggcc ctaaacgcaa gtcaagagga gactggagcc
      421 gtattcctgt gcccctggaa ggccaatggt ggcaagtgca acccgttgct cttcgacctc
      481 agggatgaga cacgaaacct aggcttccaa attttccaaa ccttcaagac cgggcaagga
      541 cttggggcgt cggtcgtcag ctggaatgac gtcattgtgg cctgtgcccc ctggcagcac
      601 tggaatgtcc tggaaaagcg cgatgaggca gagaagactc cggtaggagg ctgcttcttg
      661 gctcagctcc aaagcggggg ccgcgcagag tactcgccct gtcgcgccaa caccatgagc
      721 tccgtttacg cagagagttt tcgcggagac aagcgatact gtgaagcagg cttcagcttg
      781 gcggtgaccc aggctgggga gctagtgctt ggagcccctg gaggctactt ttttttaggt
      841 ctcctggctc gcgttccaat tgagaacatc atctccagct accgcccggg tacccttttg
      901 tggcatgttt ccaaccagcg cttcacctac gacaacagca acccagtgtt tttcgatggt
      961 taccggggat attcggtagc cgtgggcgag tttgatgggg atccgagcac tacagagtac
     1021 gtatcgggtg cccccacttg gagctggacc ttgggagcgg tggaaatttt ggactcctac
     1081 taccagcccc tgcaccggct tcatggagaa cagatggctt catatttcgg gcactcggtg
     1141 gcagtcactg acgtcaacgg ggacgggagg catgacctac tggtgggggc tccattgtat
     1201 atggagagca gggcagaccg caagctggcc gaggtgggcc gcgtttattt gtttctgcag
     1261 cctaagggcc cccaagctct gagcacaccc actctcctgc tgactggcac ccagctctat
     1321 gggagatttg gatctgccat tgcacccctg ggtgacctca accgagacgg ctataatgat
     1381 attgctgtgg ctgcccccta tgggggtccc agtggtcagg gccaagtgct gatattcctg
     1441 ggtcagagtg aagggctgag tccacgcccc tcccaggttc tggacagccc cttccccaca
     1501 ggctctggct ttggcttctc ccttcgtggt gctgtagaca tcgatgacaa tggataccca
     1561 gacctgattg tgggagcata tggagctagc aaggtggctg tgtacagagc tcagcctgtg
     1621 gtgatggcca ctgtccaact gatggttcaa gactccctga atccaacact gaagaactgt
     1681 gtcctggatc agaccaagac accagtcagc tgcttcaaca tccagatgtg tgtgggagcc
     1741 acaggacaca acattcctca gaagctgcat ctaaaggcag agctgcagct ggacttacag
     1801 aagccccgtc agggccgccg ggtgctcctg ctggcatccc aacaggcgag cctcaccctg
     1861 agcctggacc tgggcggaag agacaagcct atctgccaca ccacgggggc cttccttcgg
     1921 gatgaggccg acttccggga caagctgagc ccaattgtgc taagcctcaa cgtgtcgctg
     1981 cccccagaag agactggagg agcccctgcc gtggtattgc atggagaaac ccatgtccag
     2041 gagcagacac ggatcatcct ggattgtggg gaagacgacc tgtgtgtgcc acagctccgg
     2101 ctcacagcta ctgcggggga ctccccactc ctaatcggtg ctgacaatgt gttggagctg
     2161 aagattgaag cagccaatga tggtgaggga gcctatgaag cggagctggc tgtgcatctg
     2221 cctccaggtg cccactacat gcgggctctc agcaacattg agggctttga gaggcttgtc
     2281 tgcactcaga agaaagagaa tgagtccagg gtggccctct gtgagctggg caaccccatg
     2341 aaaaaggaca cccggatagg aatcacaatg ctggtgagtg tggagaacct ggaagaagct
     2401 ggcgagtccg tgtccttcca gctgcaggtc aggagcaaga acagccagaa tccaaacagt
     2461 aaggtcgtga tgttgcctgt ggcaatccaa gctgaagcca cagtggagct tcgagggaat
     2521 tccttccctg cctccctggt ggtggcagca gaagaaggtg acagggagca ggaagacttg
     2581 gacagatggg tctccaggct ggagcacacc tatgagctcc acaacattgg ccctggcact
     2641 gtgaatggcc tcagacttct catccacatt cctggccagt cccagccctc ggatctgctc
     2701 tacatcctgg atgtgcagcc gcagggaggt ctcctttgct ccacacagcc atctcccaag
     2761 gtggactgga aactatccac gcccagccct tcttccattc gccccgtcca tcaccagcgt
     2821 gagcgcagac aggcattcct gcaggggccc aagccagggc agcaggaccc agttctggtg
     2881 agctgcgacg gctcagcgtc ctgtacggtg gtggagtgtg agctgcggga gatggtgcgc
     2941 gggcagcggg ccatggttac tgtgcaggtc atgctggggc tgtccagcct ccgccagagg
     3001 ccgcaggagc agtttgtgct gcagtcgcac gcctggttca acgtctcctc cctaccttac
     3061 tcggtgccgg tggtcagctt gcccagtggg caagctcggg tgcagacaca gctgcttcgg
     3121 gccttggagg agagggccat tcctgtctgg tgggtgctgg tgggcgtgct gggcggtctg
     3181 ctgctgctga ccctgctagt tttggccatg tggaaggctg gcttcttcaa gcggaatcga
     3241 ccgcctctgg aggaagatga agaggaagag tgacagcaga gggggcgggg ttcctggtgg
     3301 gaaagctggg tacctgcttc ctgtttccag ccagttgcct ttgctcagaa ctccatgggg
     3361 gtcttccctt tccagcagac cgggtgcatc ccttttccta atacctaata aagagcttga
     3421 cagtgatatc cgccatg
//
