LOCUS       NM_008396               7114 bp    mRNA    linear   ROD 11-NOV-2023
DEFINITION  Mus musculus integrin alpha 2 (Itga2), mRNA.
ACCESSION   NM_008396 XM_982915
VERSION     NM_008396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7114)
  AUTHORS   Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE
            and Ravid K.
  TITLE     Characterization of Glycoproteoforms of Integrins alpha2 and beta1
            in Megakaryocytes in the Occurrence of JAK2V617F Mutation-Induced
            Primary Myelofibrosis
  JOURNAL   Mol Cell Proteomics 21 (4), 100213 (2022)
   PUBMED   35182768
  REMARK    GeneRIF: Characterization of Glycoproteoforms of Integrins alpha2
            and beta1 in Megakaryocytes in the Occurrence of JAK2V617F
            Mutation-Induced Primary Myelofibrosis.
REFERENCE   2  (bases 1 to 7114)
  AUTHORS   Galdyszynska M, Bobrowska J, Lekka M, Radwanska P, Piera L,
            Szymanski J and Drobnik J.
  TITLE     The stiffness-controlled release of interleukin-6 by cardiac
            fibroblasts is dependent on integrin alpha2beta1
  JOURNAL   J Cell Mol Med 24 (23), 13853-13862 (2020)
   PUBMED   33124775
REFERENCE   3  (bases 1 to 7114)
  AUTHORS   Agarwal M, Goheen M, Jia S, Ling S, White ES and Kim KK.
  TITLE     Type I Collagen Signaling Regulates Opposing Fibrotic Pathways
            through alpha2beta1 Integrin
  JOURNAL   Am J Respir Cell Mol Biol 63 (5), 613-622 (2020)
   PUBMED   32692932
  REMARK    GeneRIF: Type I Collagen Signaling Regulates Opposing Fibrotic
            Pathways through alpha2beta1 Integrin.
REFERENCE   4  (bases 1 to 7114)
  AUTHORS   Kiouptsi K, Jackel S, Wilms E, Pontarollo G, Winterstein J, Karwot
            C, Gross K, Jurk K and Reinhardt C.
  TITLE     The Commensal Microbiota Enhances ADP-Triggered Integrin
            alphaIIbbeta3 Activation and von Willebrand Factor-Mediated
            Platelet Deposition to Type I Collagen
  JOURNAL   Int J Mol Sci 21 (19), 7171 (2020)
   PUBMED   32998468
  REMARK    GeneRIF: The Commensal Microbiota Enhances ADP-Triggered Integrin
            alphaIIbbeta3 Activation and von Willebrand Factor-Mediated
            Platelet Deposition to Type I Collagen.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7114)
  AUTHORS   Kronenberg D, Michel PA, Hochstrat E, Wei M, Brinckmann J, Muller
            M, Frank A, Hansen U, Eckes B and Stange R.
  TITLE     Increased Collagen Turnover Impairs Tendon Microstructure and
            Stability in Integrin alpha2beta1-Deficient Mice
  JOURNAL   Int J Mol Sci 21 (8), 2835 (2020)
   PUBMED   32325713
  REMARK    GeneRIF: Increased Collagen Turnover Impairs Tendon Microstructure
            and Stability in Integrin alpha2beta1-Deficient Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7114)
  AUTHORS   Keely PJ, Wu JE and Santoro SA.
  TITLE     The spatial and temporal expression of the alpha 2 beta 1 integrin
            and its ligands, collagen I, collagen IV, and laminin, suggest
            important roles in mouse mammary morphogenesis
  JOURNAL   Differentiation 59 (1), 1-13 (1995)
   PUBMED   7589890
REFERENCE   7  (bases 1 to 7114)
  AUTHORS   Wu JE and Santoro SA.
  TITLE     Complex patterns of expression suggest extensive roles for the
            alpha 2 beta 1 integrin in murine development
  JOURNAL   Dev Dyn 199 (4), 292-314 (1994)
   PUBMED   7521231
REFERENCE   8  (bases 1 to 7114)
  AUTHORS   Tarone G, Russo MA, Hirsch E, Odorisio T, Altruda F, Silengo L and
            Siracusa G.
  TITLE     Expression of beta 1 integrin complexes on the surface of
            unfertilized mouse oocyte
  JOURNAL   Development 117 (4), 1369-1375 (1993)
   PUBMED   7691492
REFERENCE   9  (bases 1 to 7114)
  AUTHORS   Morse HC 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   10 (bases 1 to 7114)
  AUTHORS   Takada Y and Hemler ME.
  TITLE     The primary structure of the VLA-2/collagen receptor alpha 2
            subunit (platelet GPIa): homology to other integrins and the
            presence of a possible collagen-binding domain
  JOURNAL   J Cell Biol 109 (1), 397-407 (1989)
   PUBMED   2545729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036572.1, BC065139.1, CT025598.9, AK028540.1 and CJ248007.1.
            
            [WARNING] On Jan 18, 2024 this sequence was replaced by
            NM_008396.4.
            
            On Apr 13, 2018 this sequence version replaced NM_008396.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065139.1, AK156604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AK036572.1         2-60
            60-4277             BC065139.1         1-4218
            4278-4493           CT025598.9         35492-35707         c
            4494-7107           AK028540.1         1-2614
            7108-7114           CJ248007.1         411-417
FEATURES             Location/Qualifiers
     source          1..7114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.61 cM"
     gene            1..7114
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /note="integrin alpha 2"
                     /db_xref="GeneID:16398"
                     /db_xref="MGI:MGI:96600"
     exon            1..225
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3704
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /note="collagen receptor; CD49 antigen-like family member
                     B; platelet membrane glycoprotein Ia; VLA-2 receptor,
                     alpha 2 subunit"
                     /codon_start=1
                     /product="integrin alpha-2 precursor"
                     /protein_id="NP_032422.2"
                     /db_xref="CCDS:CCDS26787.1"
                     /db_xref="GeneID:16398"
                     /db_xref="MGI:MGI:96600"
                     /translation="MGPGQAGGALLLRLLMLVQGILNCLAYNVGLPGAKIFSGPSSEQ
                     FGYSVQQLTNPQGNWLLVGSPWSGFPENRMGDVYKCPVDLPTATCEKLNLQNSASISN
                     VTEIKTNMSLGLTLTRNPGTGGFLTCGPLWAHQCGNQYYATGICSDVSPDFQFLTSFS
                     PAVQACPSLVDVVVVCDESNSIYPWEAVKNFLVKFVTGLDIGPKKTQVALIQYANEPR
                     IIFNLNDFETKEDMVQATSETRQHGGDLTNTFRAIEFARDYAYSQTSGGRPGATKVMV
                     VVTDGESHDGSKLKTVIQQCNDDEILRFGIAVLGYLNRNALDTKNLIKEIKAIASTPT
                     ERYFFNVADEAALLEKAGTLGEQIFSIEGTVQGGDNFQMEMAQVGFSADYAPQNDILM
                     LGAVGAFDWSGTLVQETSHKPVIFPKQAFDQVLQDRNHSSFLGYSVAAISTEDGVHFV
                     AGAPRANYTGQIVLYSVNKQGNVTVIQSHRGDQIGSYFGSVLCSVDVDKDTITDVLLV
                     GAPTYMNDLKKEEGKVYLFTITKGILNQHQFLEGPEGTGNARFGSAIAALSDINMDGF
                     NDVIVGSPVENENSGAVYIYNGHQGTIRTKYSQKILGSNGAFRRHLQFFGRSLDGYGD
                     LNGDSITDVSIGALGQVIQLWSQSIADVAIEALFTPDKITLLNKDAKITLKLCFRAEF
                     RPAGQNNQVAILFNMTLDADGHSSRVTSRGVFRENSERFLQKNMVVNEVQKCSEHHIS
                     IQKPSDVVNPLDLRVDISLENPGTSPALEAYSETVKVFSIPFYKECGSDGICISDLIL
                     DVQQLPAIQTQSFIVSNQNKRLTFSVILKNRGESAYNTVVLAEFSENLFFASFSMPVD
                     GTEVTCEVGSSQKSVTCDVGYPALKSEQQVTFTINFDFNLQNLQNQAAINFQAFSESQ
                     ETNKADNSVSLTIPLLYDAELHLTRSTNINFYEISSDENAPSVIKSVEDIGPKFIFSL
                     KVTAGSAPVSMALVTIHIPQYTKEKNPLLYLTGIQTDQAGDISCTAEINPLKLPHTAP
                     SVSFKNENFRHTKELDCRTTSCSNITCWLKDLHMKAEYFINVTTRVWNRTFAASTFQT
                     VQLTAAAEIDTHNPQLFVIEENAVTIPLMIMKPTEKAEVPTGVIIGSIIAGILLLLAM
                     TAGLWKLGFFKRQYKKMGQNPDEMDETTELNS"
     exon            226..343
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            344..453
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            454..545
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            546..660
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            661..788
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            789..937
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1088
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1254
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1331
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1470
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1616
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1760
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1964
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2101
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2241
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2393
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2504
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2587
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2729
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2822
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2899
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2983
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3086
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3197
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3302
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3416
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..3506
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3623
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..7108
                     /gene="Itga2"
                     /gene_synonym="CD49B; DX5; GPIa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggggcggtt cctagctcag aagctgcaag caacttttcc ttgctctcat tcaggctgga
       61 gagaactcct ccgtacagtt tctggaaagt ctagcctctg ggagccctgg atcgaggata
      121 ctgtgtgcac ccccagagca ctttagattc cccagcgcag acccaagatg ggaccgggac
      181 aggcaggggg cgcgctcctg ctgcggctgc taatgctagt tcaaggtatt ttgaattgtc
      241 tggcgtataa tgttggcctc ccaggagcga aaatattttc cgggccttca agtgaacagt
      301 ttgggtattc agtacagcag cttacgaacc cacaaggcaa ctggctactg gttggttcac
      361 cgtggagtgg cttccctgag aaccgaatgg gagatgtgta caagtgccct gtggacctac
      421 ccactgccac ctgtgaaaag ctgaatctgc aaaattcagc aagcatctca aatgttaccg
      481 agataaagac caacatgagc ctgggattga ccctcaccag gaatccgggg accggaggct
      541 ttctaacctg tggtcctctc tgggcacatc agtgtggaaa tcagtattat gcaactggga
      601 tctgttctga tgttagtcca gactttcagt tcttgaccag cttttcacct gcagttcagg
      661 cttgcccttc cctcgtggat gttgtagttg tatgtgatga atcaaacagt atttatcctt
      721 gggaagcagt aaagaacttt ttggtaaagt ttgtgacagg cctggatata ggacctaaaa
      781 agacacaggt ggcgttaatt caatatgcca atgagccgag aattatattt aacttgaacg
      841 atttcgaaac caaagaggat atggtccagg ccacatctga gacgcgccaa catggtgggg
      901 acctcacaaa caccttcaga gctatcgaat tcgcaagaga ctacgcttat tcacagactt
      961 ctggcgggcg cccgggtgct acaaaagtca tggtagttgt gaccgatggc gagtcccatg
     1021 atgggtcgaa gctgaaaact gtgatccagc aatgcaatga tgacgagata ctgaggttcg
     1081 gcatagcagt tcttgggtat ttaaacagaa atgctcttga tactaaaaat ttaatcaaag
     1141 aaataaaagc aattgctagt actccaaccg agagatactt tttcaatgtg gccgacgaag
     1201 cggctcttct ggagaaggct ggaactctag gggagcaaat attcagcatt gaaggcactg
     1261 ttcaaggagg agacaacttc cagatggaaa tggcacaagt tggattcagt gcagattacg
     1321 ctcctcaaaa tgatattctg atgttaggtg cagtgggggc ttttgactgg agtggaactc
     1381 ttgtccagga gacatctcac aagcccgtga tctttcctaa acaagccttt gaccaggttc
     1441 tgcaggatag aaaccacagt tcgtttttag gttactctgt ggctgcaatt tctactgaag
     1501 acggtgtcca ttttgttgct ggtgctcctc gagcaaatta tactggccag atagtgttgt
     1561 acagcgttaa caagcaaggc aatgtgaccg tgattcagtc tcacagaggg gaccagattg
     1621 gctcctattt tggcagtgtg ctgtgctcag ttgatgtaga taaagacacc attacagacg
     1681 tgctcctggt aggtgctcct acatacatga acgacctcaa gaaagaagag ggaaaagtct
     1741 acctatttac catcacaaag ggcatcttga atcagcacca gtttcttgaa gggccagaag
     1801 gcactggaaa tgctcggttt ggttcagcaa ttgcagccct gtcagacatc aacatggatg
     1861 gctttaatga tgtgattgtc ggttcacctg tagagaatga gaactctgga gctgtgtaca
     1921 tttacaatgg tcaccagggt accattcgca ccaagtactc ccagaaaatc cttgggtcca
     1981 atggagcctt taggagacat ctccagttct ttggaaggtc cctggatggc tatggtgatt
     2041 taaatgggga ttccatcact gatgtatcca ttggtgcttt ggggcaagtg attcaactct
     2101 ggtcacaaag cattgctgac gtggccatag aagctttgtt cactccagac aaaatcactt
     2161 tgctcaacaa ggatgctaag ataaccctaa agctctgctt cagagcagag tttagacctg
     2221 ctgggcaaaa caatcaagta gccatcctgt ttaacatgac gcttgatgcg gacggacatt
     2281 catccagggt aacctccagg ggggtgttca gagaaaacag tgagcgattc ttgcagaaga
     2341 atatggtggt aaacgaagtg cagaagtgtt ctgagcacca cattagcata cagaagccct
     2401 ctgatgttgt caaccctttg gatctgcgtg tggacatcag tttggaaaac ccaggcacta
     2461 gccctgccct cgaagcctat tctgaaactg tcaaagtctt cagtatccct ttctataagg
     2521 agtgtggcag cgatggaatt tgcatctctg acctgatcct ggatgtccaa cagctgccag
     2581 ccattcaaac tcaatccttt attgtcagta accaaaacaa gaggttaaca ttttcagtca
     2641 tcctgaaaaa cagaggggaa agtgcataca acactgtggt cctggccgag ttttctgaga
     2701 acttgttttt tgcttctttc tccatgccgg tcgatggaac agaagtaaca tgtgaggttg
     2761 gttcatcgca gaaatctgtt acctgtgatg tgggataccc tgccttaaag agtgaacagc
     2821 aggtgacttt taccattaac ttcgacttta atcttcaaaa cctccagaac caggcggcca
     2881 tcaatttcca agccttcagt gagagccaag aaacaaacaa agcagacaat tcggtcagtc
     2941 tcacgattcc tctcctgtat gatgccgaac ttcacttaac ccgatccacc aacatcaact
     3001 tctatgagat ctcttcggat gagaacgctc cttctgtcat caagagtgtc gaagatattg
     3061 gtcctaaatt catcttctcc ctcaaggtaa cagccggaag tgccccagtg agcatggcat
     3121 tggtgactat ccacattcct cagtacacca aggaaaagaa cccactcctg tatctgactg
     3181 ggatacaaac agaccaggct ggcgacatca gctgcacagc agaaataaat ccactcaagc
     3241 taccacacac cgccccttct gtatctttca agaatgaaaa cttccggcat acgaaagaat
     3301 tggactgcag aaccacttcc tgcagtaaca tcacctgctg gctgaaagac cttcacatga
     3361 aagcagagta cttcatcaat gtgacaacca gagtttggaa caggaccttt gctgcttcga
     3421 ctttccagac tgtgcagctg acagcagcgg cagagatcga tacacataac cctcagctct
     3481 tcgtgattga ggaaaatgct gtcacgattc ccctcatgat aatgaaaccc acggagaaag
     3541 cagaagtacc gacaggggtt atcataggca gcataattgc gggaatcctt ttgctgttgg
     3601 ctatgactgc aggtttgtgg aagctcggct tcttcaaaag acaatataag aaaatgggcc
     3661 aaaatccaga tgagatggat gagaccacag aactcaacag ctaaaccatc ggcggacagc
     3721 acggtgtggg ggctagcggc atccctgcca gggctcgctg gtgtggtgaa tggacttcta
     3781 ttaaagtcca cctttaaaca atttaatagg taaactagcc tgctcagttg gggatggtaa
     3841 aattgtgggt ggtgtggtta ggggtagaaa gaccaaagac atcatataga aaggggaaaa
     3901 gttatcttca gactggctag tccagcgttt accttctaac agggcgatgg gatacttcta
     3961 gacatgacaa accttcaaga aaatggaaat gtttttcaga tttgggggtg gaaaagtgca
     4021 tagggaatgt tctttttaat ttgcttatca gtaacaatta aagtggaaag tacctggtgt
     4081 gtatattata cataatatat atgttatata ttatcaatat aacatatata ttaaacatat
     4141 ataattgaca taaatgataa taggttatat atttatatgt atgtatatat gtatatgtat
     4201 aaatatactg agtactttct acagacatat aataatattg taatgaaaaa atgaatgttt
     4261 gttgacaaga gagacaacca gcatagattg tttttcaatt tatgctgctc ctcaaaggat
     4321 gccacagaga tagatatctt taattgataa tcttatttat taactaagtt taaaaaaaaa
     4381 aagacagtaa tctcagctac cactcaggaa gctgagacag gacctggagt ctgaggtctc
     4441 cctgagctgt agcatgagtt caaggctatc ctggaggatt taaggagacc ctgtctaaaa
     4501 gcaaaggaag aaatgacccc tgggacttag cttaatggta gagttcttgt ttagtggcat
     4561 cttaaaagaa atgaagtaga taaaaggtat gctttcttac tatgagcatg cttgaaatgc
     4621 tcggataacc aagagaaccc ttttatttaa ctaacctgct cccctttcct gctgcctctg
     4681 tgacagaaac ccctgcagcc tgcctttctc cccggcagtt atccactttc ctctatccac
     4741 cgcctacatc tcctacagca tggataccaa cccaacgcca cccctacaca cacacacaca
     4801 cacacacaca cacacacaca cacacacaat tccaggtgtt gagctgagaa agtcctctgt
     4861 ttatctccca cacctgtgtg attatacacc cctaaacttt agggagctag tttcatttgc
     4921 tgctaaacaa gtaattaaac tacacctgaa tttgtagctg ttacctgtta tatataaaaa
     4981 taatacataa atggaaaggc tcgggagggg ttgtaagctg gagcagcagc agaaatcact
     5041 accttggcag gaacatcctc tgtactgggt tcaggtgggc acaactcttc agccctaact
     5101 cttgaaactc tgggttgaca gaagggccaa cagcctacat tttgacaacc tctcaggcct
     5161 tgtgatgtaa acagactcac tccagggagg agtggtcctt tcctaccgtt tgcccctcat
     5221 ttcccagact agacattctc tagaagagag tgggaacagg ggggttcagg gacagctgta
     5281 aaactcactt tgtcacacac tttatgcaaa aagctttggc ctggtctcta ggaacttcat
     5341 tgttctcctt atgaaagagg aagtcagggt tagggctagc cagtgactca atcttaaaag
     5401 ccacccttaa gaatttctac atcctccaaa aataagacct agagatgtca gagaaaaaaa
     5461 caacttgtcc acgtgtggat ggatggctct gactgccttc gtgccaagcc cctgggtggc
     5521 agtccagagc tacttggacc acttaatggc tcactccagc cttgataaag ccaaataaac
     5581 aaggaaaaaa aatattagct gtaaatgtca gagaggtaca gcaaaaacag cttggtactc
     5641 ttttagttac gtgatccaga ttcttttaac ggctgtgtca ttctaaccaa aattttaaag
     5701 ggtgcagaaa ccagtcatta ggttgctaga gaatatttca cacagcatgt taatttattg
     5761 cacactcgtg tgtatgtgtg tgtgtgtgtg tgtgtgtgtg ttagcctggt tacaactaag
     5821 actcagacac agtcctgtca gccatttctc aacccaccct cagcgctttg agcttagcag
     5881 tattgtagta ttgccatttt gaagcagaca gttttaggag agaaagggct acctcacacc
     5941 ttgcaaggtt ttaagcagcc atccctggcc tctactgact ccttctccca tgattttgac
     6001 aataacaaat atccccaggt cttactaaat gactcctgta tttttcaagg aattttaagc
     6061 aaagatgttt ctaagaaatt attgggggtc aggtagattg tatttgagag gaaattatgt
     6121 ggtccattca accacagctt tgctttatag gactcaaagt tgtcagggta aaatatacat
     6181 ctcataaatg gtagatcaca aaatgtgatc ttaagaacct gagtggcttc ttgcatggcc
     6241 accacacgac agcaacacag tgacacagtc taataaagaa atgggactca cttaaaagtc
     6301 acacagcact cattgtagca gcaagctatg accgtctaac tgggcagatg cctttctagt
     6361 tagcagtgtt atttttacac gacagtgaaa cttgcctctt taactgtgaa gaataaagac
     6421 aactaggcca atttactcta gtcacctcag tgattattcc tgatacatag ctgaacccga
     6481 catgtgaaaa tctcactaag atttcattga acagaaggca ggattctcag ctgagctccc
     6541 tcatctatct ccatgcacac agagaacaac tctacacaca aaagggactc acccttcatg
     6601 tactttcagg aagggcggag ccatcagcag gaaaaacatc cagaggcaaa agataaacat
     6661 ggggggaaag ttggaagtac aatatttact actttaaagt ataaagacat agccattgtg
     6721 taaatatata gattgtattg tttgtacttg attttggcaa aggaagccga gacgtaaatg
     6781 tatatattgc acagctgtat tagaattgtc tattttttaa agaggaaact gtcctatttc
     6841 tcaactgata agtactcctg gtaagatgta atatttgctg gttttaatta aatgtgtctt
     6901 gtcatttttc tctccaccaa aagtatataa gatggatgta tttccttgtg tatcaactta
     6961 gtgaatttat ctgacttctt aaaaacaatc aaactgtagt aattgacata aagaaaagcc
     7021 caagagccag acagaaacgt tttatttaac tgtaaatcat ccttttcata ccctgttgtt
     7081 aagtatcatt aaaagtgttt tgacagtaaa aaaa
//
