LOCUS       NM_176922               5294 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus integrin alpha 11 (Itga11), mRNA.
ACCESSION   NM_176922
VERSION     NM_176922.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5294)
  AUTHORS   Zheng,H., An,M., Luo,Y., Diao,X., Zhong,W., Pang,M., Lin,Y.,
            Chen,J., Li,Y., Kong,Y., Zhao,Y., Yin,Y., Ai,L., Huang,J., Chen,C.
            and Lin,T.
  TITLE     PDGFRalpha+ITGA11+ fibroblasts foster early-stage cancer
            lymphovascular invasion and lymphatic metastasis via ITGA11-SELE
            interplay
  JOURNAL   Cancer Cell 42 (4), 682-700 (2024)
   PUBMED   38428409
  REMARK    GeneRIF: PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage
            cancer lymphovascular invasion and lymphatic metastasis via
            ITGA11-SELE interplay.
REFERENCE   2  (bases 1 to 5294)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5294)
  AUTHORS   Bieber,K., Bezdek,S., Gupta,Y., Vorobyev,A., Sezin,T., Gross,N.,
            Prussmann,J., Sayegh,J.P., Becker,M., Mousavi,S., Hdnah,A.,
            Kunzel,S., Ibrahim,S.M., Ludwig,R.J., Gullberg,D. and Sadik,C.D.
  TITLE     Forward genetics and functional analysis highlight Itga11 as a
            modulator of murine psoriasiform dermatitis
  JOURNAL   J Pathol 261 (2), 184-197 (2023)
   PUBMED   37565309
  REMARK    GeneRIF: Forward genetics and functional analysis highlight Itga11
            as a modulator of murine psoriasiform dermatitis.
REFERENCE   4  (bases 1 to 5294)
  AUTHORS   Romaine,A., Melleby,A.O., Alam,J., Lobert,V.H., Lu,N.,
            Lockwood,F.E., Hasic,A., Lunde,I.G., Sjaastad,I., Stenmark,H.,
            Herum,K.M., Gullberg,D. and Christensen,G.
  TITLE     Integrin alpha11beta1 and syndecan-4 dual receptor ablation
            attenuate cardiac hypertrophy in the pressure overloaded heart
  JOURNAL   Am J Physiol Heart Circ Physiol 322 (6), H1057-H1071 (2022)
   PUBMED   35522553
  REMARK    GeneRIF: Integrin alpha11beta1 and syndecan-4 dual receptor
            ablation attenuate cardiac hypertrophy in the pressure overloaded
            heart.
REFERENCE   5  (bases 1 to 5294)
  AUTHORS   Song,W., Li,Q., Wang,T., Li,Y., Fan,T., Zhang,J., Wang,Q., Pan,J.,
            Dong,Q., Sun,Z.S. and Wang,Y.
  TITLE     Putative complement control protein CSMD3 dysfunction impairs
            synaptogenesis and induces neurodevelopmental disorders
  JOURNAL   Brain Behav Immun 102, 237-250 (2022)
   PUBMED   35245678
REFERENCE   6  (bases 1 to 5294)
  AUTHORS   Zhu,C.Q., Popova,S.N., Brown,E.R., Barsyte-Lovejoy,D., Navab,R.,
            Shih,W., Li,M., Lu,M., Jurisica,I., Penn,L.Z., Gullberg,D. and
            Tsao,M.S.
  TITLE     Integrin alpha 11 regulates IGF2 expression in fibroblasts to
            enhance tumorigenicity of human non-small-cell lung cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 104 (28), 11754-11759 (2007)
   PUBMED   17600088
REFERENCE   7  (bases 1 to 5294)
  AUTHORS   Popova,S.N., Barczyk,M., Tiger,C.F., Beertsen,W., Zigrino,P.,
            Aszodi,A., Miosge,N., Forsberg,E. and Gullberg,D.
  TITLE     Alpha11 beta1 integrin-dependent regulation of periodontal ligament
            function in the erupting mouse incisor
  JOURNAL   Mol Cell Biol 27 (12), 4306-4316 (2007)
   PUBMED   17420280
REFERENCE   8  (bases 1 to 5294)
  AUTHORS   Leomil Coelho,L.F., Mota,B.E., Sales,P.C., Marques,J.T., de
            Oliveira,J.G., Bonjardim,C.A., Peregrino Ferreira,P.C. and
            Kroon,E.G.
  TITLE     Integrin alpha 11 is a novel type I interferon stimulated gene
  JOURNAL   Cytokine 33 (6), 352-361 (2006)
   PUBMED   16697656
  REMARK    GeneRIF: The in vivo induction of ITGA-11 protein is detected in
            spleen and lungs of type I IFN-treated BALB/c mice.
REFERENCE   9  (bases 1 to 5294)
  AUTHORS   Popova,S.N., Rodriguez-Sanchez,B., Liden,A., Betsholtz,C., Van Den
            Bos,T. and Gullberg,D.
  TITLE     The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated
            chemotaxis of embryonic fibroblasts on collagens
  JOURNAL   Dev Biol 270 (2), 427-442 (2004)
   PUBMED   15183724
REFERENCE   10 (bases 1 to 5294)
  AUTHORS   Zhang,W.M., Kapyla,J., Puranen,J.S., Knight,C.G., Tiger,C.F.,
            Pentikainen,O.T., Johnson,M.S., Farndale,R.W., Heino,J. and
            Gullberg,D.
  TITLE     alpha 11beta 1 integrin recognizes the GFOGER sequence in
            interstitial collagens
  JOURNAL   J Biol Chem 278 (9), 7270-7277 (2003)
   PUBMED   12496264
  REMARK    GeneRIF: the GFOGER sequence in fibrillar collagens is a common
            recognition motif used by integrins, particularly alpha11beta1
            [integrin alpha11]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166097.5 and AC164614.3.
            
            On Nov 9, 2022 this sequence version replaced NM_176922.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058716.1, AY124460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC166097.5         110798-110939
            143-254             AC166097.5         129827-129938
            255-355             AC166097.5         160549-160649
            356-447             AC166097.5         163654-163745
            448-562             AC166097.5         165025-165139
            563-690             AC166097.5         168212-168339
            691-839             AC166097.5         170312-170460
            840-984             AC166097.5         176869-177013
            985-1150            AC166097.5         177425-177590
            1151-1221           AC166097.5         178849-178919
            1222-1366           AC166097.5         184448-184592
            1367-1515           AC166097.5         185187-185335
            1516-1656           AC166097.5         188115-188255
            1657-1860           AC166097.5         188513-188716
            1861-1991           AC166097.5         190548-190678
            1992-2158           AC166097.5         193231-193397
            2159-2301           AC166097.5         194474-194616
            2302-2412           AC166097.5         195750-195860
            2413-2498           AC164614.3         141509-141594       c
            2499-2706           AC164614.3         139551-139758       c
            2707-2805           AC164614.3         138729-138827       c
            2806-2882           AC164614.3         138031-138107       c
            2883-2972           AC164614.3         135920-136009       c
            2973-3063           AC164614.3         134304-134394       c
            3064-3177           AC164614.3         133164-133277       c
            3178-3264           AC164614.3         132970-133056       c
            3265-3375           AC164614.3         130631-130741       c
            3376-3471           AC164614.3         130405-130500       c
            3472-3585           AC164614.3         125305-125418       c
            3586-5294           AC164614.3         123018-124726       c
FEATURES             Location/Qualifiers
     source          1..5294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.82 cM"
     gene            1..5294
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /note="integrin alpha 11"
                     /db_xref="GeneID:319480"
                     /db_xref="MGI:MGI:2442114"
     exon            1..142
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..3657
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /note="integrin a11"
                     /codon_start=1
                     /product="integrin alpha-11 precursor"
                     /protein_id="NP_795896.4"
                     /db_xref="CCDS:CCDS23265.1"
                     /db_xref="GeneID:319480"
                     /db_xref="MGI:MGI:2442114"
                     /translation="MDFPRGLLVAWTLSLWPGFTDTFNMDTRNPRVIAGPSAAFFGYT
                     VQQHDISGKKWLVVGAPMETNGHQKTGDVYKCPVTQGNCTKLNLGRVTLSNVSERKDN
                     MRLGLSLATNPKDNSFLACSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQ
                     TYMDIVIVLDGSNSIYPWVEVQHFLINILKKFYIGPGQIQVGIVQYGEDAVHEFHLND
                     YRSVKDVVEAASHIEQRGGTETRTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHD
                     SPDLEKVIRQSEKDNVTRYAVAVLGYYNRRGINPETFLNEIKYIASDPDDKHFFNVTD
                     EAALKDIVDALGDRIFSLEGTNKNETSFGLEMSQTGFSSHVVEDGILLGAVGAYDWNG
                     AVLKETSAGKVIPHRESYLKEFPEELKNHAAYLGYTVTSVVSSRQGRVYVAGAPRFNH
                     TGKVILFSMHNNRSLTIHQALRGEQIGSYFGSEITSVDVNDDRVTDVLLVGAPMYFSE
                     GRERGKVYVYNLRQNRFVYNGTLKDSHSYQNARFGSCIASVQDLNQDSYNDVVVGAPL
                     EDSHRGAIYIFHGFQTNILKKPMQRITASELAPGLQHFGCSIHGQLDLNEDGLVDLAV
                     GALGNAVVLWARPVVQINASLHFEPSKINIFHKDCKRNGRDATCLAAFLCFIPIFLAP
                     HFQTATVGIRYNATMDERRYMPRAHLDEGGDQFTNRAVLLSSGQEHCQRINFHVLDTA
                     DYVKPVAFSVEYSLEDPDNGPMLDNGWPTTLRVSVPFWNGCNEDEHCVPDLVLDARSD
                     LPTAMEYCQRVLGRPAQDCSSYTLSFDTTVFIIESTRRRVAVEATLENRGENAYSAVL
                     NISQSENLQFASLIQKDDSDNSIECVNEERRLHKKVCNVSYPFFRAKAKVAFRLDFEF
                     SKSVFLHHLQIHLGAGSDSHEQDSTADDNTALLRFHLKYEADVLFTRSSSLSHFEVKA
                     NSSLESYDGIGPPFNCVFKVQNLGFFPIHGVMMKITVPIATRGGNRLLMLRDFFTDQG
                     NTSCNIWGNSTEYRSTPTEEDLSHAPQRNHSNSDVVSIICNLRLAPSQETSFYLVGNL
                     WLTSLKALKYRSLKITVNAALQRQFHSPFIFREEDPSRQVTFEISKQEDWQVPIWIIV
                     GSTLGGLLLLALLVLALWKLGFFKSAKRKREPGLGPIPKELK"
     exon            143..254
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            255..355
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..447
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            448..562
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            563..690
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            691..839
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            840..984
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1150
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1221
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1366
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1515
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1656
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1860
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1991
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2158
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2301
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2412
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2498
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2706
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2805
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..2882
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..2972
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3063
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3177
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3264
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3375
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3471
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3585
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..5294
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4883..4888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      4937
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /note="major polyA site"
     regulatory      5275..5280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
                     /note="hexamer: AACAAA"
     polyA_site      5294
                     /gene="Itga11"
                     /gene_synonym="4732459H24Rik"
ORIGIN      
        1 agtgcaggct caggacgctc gcgaaccgag gctgtggctc tggctctcag ccgcgcgacc
       61 atcgcgacac ccgccgccgc gcagcgggcc atggactttc ccaggggcct cctggtggcc
      121 tggaccctca gcctttggcc aggattcacg gacaccttca atatggatac cagaaatccc
      181 cgggtcattg ctggtcccag tgctgccttc tttggctaca cagtacagca gcatgatatc
      241 agtggcaaga agtggttggt tgtgggtgcc ccaatggaaa ccaatggcca tcagaagaca
      301 ggagacgtat acaaatgtcc ggtaacccag ggcaactgca ccaagctcaa cctgggcagg
      361 gtcactctgt ccaatgtgtc tgagaggaag gacaacatgc gcctcggcct gagccttgcc
      421 accaacccca aggacaacag cttcctggcc tgcagccctc tctggtcgca cgagtgtgga
      481 agctcctact acaccactgg catgtgctca cgggtcaact ccaacttcag attctctaag
      541 acggtagctc cggcacttca gaggtgccag acttacatgg acatcgtcat tgtcttagat
      601 ggctccaaca gcatctaccc ctgggtggag gtccaacact tcctcatcaa tatcctcaaa
      661 aagttctaca ttggccccgg ccagatccag gtcggaatag tccagtatgg agaagatgcc
      721 gtccatgagt tccaccttaa tgactacagg tctgtaaaag atgtggtgga agccgccagc
      781 cacattgagc agagaggagg gacagagacc cgcacggcat ttggcattga atttgcacgc
      841 tcggaggctt tccagaaggg tggaagaaaa ggggccaaga aagtgatgat tgtcatcacg
      901 gacggggaat cccacgacag cccagacctg gagaaggtga tccggcagag cgagaaggac
      961 aacgtgacca gatacgctgt ggccgttttg ggctactaca accgcagggg gatcaatcca
     1021 gagacttttc taaatgaaat caaatacatc gccagcgacc ctgacgacaa gcacttcttc
     1081 aacgtcacag atgaggcggc cctgaaggac attgttgatg cccttgggga caggatcttc
     1141 agcttggaag gcaccaacaa gaatgagacc tcttttgggc tggagatgtc gcagactggc
     1201 ttttcttcac atgtggtaga ggatgggatc ctgctgggag ctgtgggagc ctatgactgg
     1261 aacggggcgg tgctgaagga gacaagtgct ggcaaggtga ttcctcaccg agagtcctac
     1321 cttaaggagt ttccagagga gctgaagaac catgcagcat acctagggta cacggtgacg
     1381 tcggttgtgt cctccaggca ggggcgggtg tatgtggctg gagcccccag attcaaccat
     1441 actggcaagg tcattctatt cagcatgcac aacaaccgga gcctcaccat ccaccaggct
     1501 cttcggggcg agcagatagg ctcctacttt gggagtgaga ttacctcagt ggacgtcaat
     1561 gatgacagag tgacagatgt gctgctggtg ggtgcaccca tgtacttcag cgagggccga
     1621 gagcgaggca aggtgtatgt ctacaacctg agacagaacc ggtttgttta taatggcact
     1681 ctgaaggatt cccacagcta ccagaacgcc cggttcgggt cctgcatcgc ctctgttcaa
     1741 gacctcaacc aagattccta caatgatgtg gtggtggggg cccctctgga ggacagccac
     1801 agaggggcca tctacatctt ccatggcttc caaaccaata tcctgaagaa gcccatgcag
     1861 agaataacag cctcggagct ggctcctggc ctgcagcatt ttggctgcag catccacgga
     1921 caactggacc tcaatgagga tgggcttgtg gacctagcag tgggcgccct gggcaacgct
     1981 gtggttttgt gggcccgccc tgtagttcaa atcaacgcca gcctccactt tgagccttcc
     2041 aagatcaaca tcttccacaa ggactgcaag cgcaatggca gggatgccac ctgcctggcc
     2101 gccttcctct gcttcatacc catcttcctg gcaccccact tccaaacagc aaccgtcggc
     2161 atcaggtaca atgcaaccat ggatgagagg cggtatatgc cgcgggcaca tctggacgag
     2221 ggcggagacc agttcaccaa cagagccgtc ctgctctcct ctggccagga acactgtcaa
     2281 aggatcaact tccatgtcct ggacactgca gactacgtga agccagtggc cttctccgtg
     2341 gagtactccc tagaggaccc tgacaacggc cccatgctgg acaacggctg gcccactacg
     2401 ctcagagtgt cggtgccctt ctggaatggc tgtaatgagg atgaacactg tgtccctgac
     2461 cttgtactgg atgctcggag tgacctgccc actgccatgg agtactgcca gcgggtgctg
     2521 gggaggccgg cgcaggactg ctccagctac accctgtcct tcgacaccac tgtcttcatc
     2581 atagagagca cgcgccgccg ggtggcagtg gaggccacgc tggagaacag aggagagaat
     2641 gcttacagcg ccgtcctcaa catctcccag tcagagaacc ttcagtttgc cagcctgatc
     2701 cagaaggatg actcagacaa cagcatcgag tgtgtgaacg aggagaggcg gcttcacaag
     2761 aaagtctgca acgtcagcta ccccttcttc agagccaagg ccaaggtggc tttccgtctg
     2821 gatttcgagt tcagcaagtc tgtgtttctg caccatcttc agatccatct gggtgccggc
     2881 agtgacagtc acgagcaaga cagcaccgca gacgataaca cggccctcct gcgcttccac
     2941 ctcaaatatg aagcagacgt cctctttacc agaagcagca gcctgagcca cttcgaggtc
     3001 aaggcaaaca gctcacttga gagctatgat ggcatcggac ctccgttcaa ctgtgttttc
     3061 aaggtgcaga acctgggctt tttccccatc cacggggtga tgatgaagat cactgtgccc
     3121 atcgccacca ggggtggcaa ccgcctgctg atgttgaggg acttcttcac cgaccagggc
     3181 aacacatcct gtaacatctg ggggaacagc acagagtaca ggagtacccc aactgaggaa
     3241 gatctgagcc atgccccaca gaggaatcac agcaactccg acgtggtctc catcatctgc
     3301 aacctgaggc tggcccccag ccaggagacc agcttctacc tggtgggaaa cctgtggctg
     3361 acatctctga aagcactcaa gtacaggtct ctgaagatca cagtcaacgc cgccttgcag
     3421 aggcagttcc acagcccctt catcttccga gaggaagacc ctagccgcca ggtcacattt
     3481 gagatctcca agcaagaaga ctggcaggtc cccatctgga tcatcgtggg cagcactctg
     3541 gggggcctct tgctgctggc cctgctggtc ctggcactgt ggaagctcgg tttttttaaa
     3601 agtgccaagc gcaagaggga acctggccta ggccccatcc ccaaagagct caagtgagga
     3661 tccagaggaa gcttcaagtt gttgggggcc cgacaccagt ccgggggtgt gcaggcccgg
     3721 gctatggcct cagagctgga gcaaagagga cacccatgga ctttacattg agttcatctc
     3781 tggagcaatg gcaactgatc gctgtgggat ggacctccag cccgtgttcg gagtgacttc
     3841 tctactagag gccaagacct ccagtacaga tccctaagga ctaaaaggga ccctccaaga
     3901 cccaccggtg gccttccccc aaggctctgt ggagggaatc tgctgcccca aacactaagg
     3961 tgctagggtt ttgttgtctt gcccacctct gaagaaactc aaggggaagc tagcaaatac
     4021 gagcccactg tgcacgccct atctggacct atagcttcag gactccatgg cccgggagca
     4081 taacctccgc cgcacccctt acccttgctc ttggttccca aaccacagcc atcccttctc
     4141 cacagataga ccccaaagat ctctatgagt gacccagagt tgtgtggctt gatatgccag
     4201 ctgcaggcca gtgatggaaa cacatccagg gactgtgcca aatgaactgg agggaatcag
     4261 gatgctgggt accttccaaa catcagaaag cagcagggct ctccagcagt aaccaccacc
     4321 cactcaatcc tgctctccag cctcccccgc agctcctctc agccgctttg gttgctaggc
     4381 aactcgtgct agggagcctg aggaggatga taaaaatccg tggctctccg taccctcttg
     4441 tctgacaact gcagcttgtc cctggtagat gcactgtgat agggagcctc tgtttcttac
     4501 atcagcacct acacacacac acacacacac acacacacac acacacacac acacacacac
     4561 gcacgcacct cccaaccatc agcgtgtggg agaagggctc ctgtaggggg cgctgtgggg
     4621 ggccttctag gcatgcactg aacaaagccc atgcaaggcc cctgggaacc ttaaacctca
     4681 gaggcagata ggcatctcgc cggccagctc tgggataagc cccaaggaca aggggcatgc
     4741 cggatgccca gcagagtaat ttatgcctta accttttgtt gagatggaaa tggacacatc
     4801 agtgtcccct gtcatctgtt tcatctgaac aatgtcatct gttcccctat gcggtacgac
     4861 ctttactgtc agaaatatat ttaagaaaat gttctaaacg gtatttaaaa acaaccaaca
     4921 acagacattc cactctgtga cagagcaagg ctgcattctg ttttaaagaa gaaagggagg
     4981 agggtgtctg ctcggatcta aatgtcgcgg ggacagtctt gtccattata cagccagtcc
     5041 tctcccaagg tctacctggc ctctcttgcg gtgacatctc tgcatctagg tagtgggcac
     5101 tgctcacccc accattgcca cccaccccat ctttggccag gggctgcccc cactcaggtt
     5161 ccccgaccct ccaggctggg ccttcagtgc tgacccacac actgacttag gccattctcg
     5221 aaacaaagca tctccattct atgctcctac tggtaattca ctttttcaca gcctaacaaa
     5281 taatttagaa agta
//
