LOCUS       NM_133927               2314 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus integrin alpha FG-GAP repeat containing 2 (Itfg2),
            mRNA.
ACCESSION   NM_133927
VERSION     NM_133927.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Al-Shami,A., Crisostomo,J., Wilkins,C., Xu,N., Humphries,J.,
            Chang,W.C., Anderson,S.J. and Oravecz,T.
  TITLE     Integrin-alpha FG-GAP repeat-containing protein 2 is critical for
            normal B cell differentiation and controls disease development in a
            lupus model
  JOURNAL   J Immunol 191 (7), 3789-3798 (2013)
   PUBMED   23997217
  REMARK    GeneRIF: These results identify Itfg2 as a novel contributor to B
            cell differentiation and a negative regulator of the autoimmune
            response during lupus.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC014833.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014833.1, AK134630.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 62.99 cM"
     gene            1..2314
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /note="integrin alpha FG-GAP repeat containing 2"
                     /db_xref="GeneID:101142"
                     /db_xref="MGI:MGI:1915450"
     exon            1..193
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1429
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /note="integrin-alpha FG-GAP repeat-containing protein 2"
                     /codon_start=1
                     /product="KICSTOR complex protein ITFG2"
                     /protein_id="NP_598688.1"
                     /db_xref="CCDS:CCDS20572.1"
                     /db_xref="GeneID:101142"
                     /db_xref="MGI:MGI:1915450"
                     /translation="MRSVSYVQRVALDFSGSLFPHAICLGDVDNDALNELVVGDTSGK
                     LSVYKNDDSRPWLTCMCQGMLTCVGVGDVCNKGKNLVVAVSAEGWLHLFDLTPTKALD
                     ASGHHETLGEEQRPVFKQHIPANTKVMLISDIDGDGCYELVVGYTDRVVRAFRWEELA
                     EGPEHLAGQLVSLKKWMLEGQVDSLSVTPGPLGVPELVVSQPGCAYAVLLCTWNKDTG
                     SPPASEEATGDSRETPAARDVVLHQTSGRIHNKNVSTHLIGNIRQGHNPEGGNAGLFA
                     LCTLDGTLKLMQEADKLLWSVQVDHQLFALEKLDVTGNGLEEVVACAWDGQTYIIDHN
                     RTVVRFQVDENIRAFCAGQYACKEGRNSPCLVYVTFNQKIYVYWEVQLERMESTNLLK
                     LLEAEPEYHRLLQELRVDPEDLPAVCTLLHQTLYHPDQPLQCTPSSFQDPT"
     exon            194..289
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            290..331
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..500
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            501..640
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            641..789
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            790..887
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            888..941
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1033
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1151
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1325
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..2299
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /note="hexamer: AACAAA"
     polyA_site      2299
                     /gene="Itfg2"
                     /gene_synonym="2700050P07Rik"
                     /note="major polyA site"
ORIGIN      
        1 cttccggttc ggtggcctga cacgcgtgca cggctgtcct gagggctcgg gggtcgtttt
       61 ggtgcagtgg cccggcacct cagccctcca gagtgccatg aggtcggtta gttatgtgca
      121 gcgcgtggcg ctggatttca gcgggagtct cttcccgcac gccatctgcc tcggagacgt
      181 ggataacgac gcgttaaatg agctagttgt gggagacacc agcgggaaac tgtccgtgta
      241 taagaatgac gacagccggc catggcttac ctgcatgtgc cagggaatgt tgacttgtgt
      301 tggggtcgga gatgtctgta ataaagggaa gaacctggtg gtagcagtca gcgcagaagg
      361 ctggctgcac ttgtttgacc tgacacccac caaggctctg gatgcctctg ggcaccatga
      421 gacacttgga gaggagcagc gacctgtctt caagcagcac atcccggcca acacaaaggt
      481 catgctgatc agcgacatcg atggagatgg gtgttacgag ctggtggtag gatacacaga
      541 ccgtgtggtg cgggccttcc gctgggaaga actggctgag gggcctgaac acctggcagg
      601 gcagttggtg tccctcaaga agtggatgct ggagggtcag gtagacagtc tctctgtgac
      661 cccagggcct ctgggtgtgc ctgagttggt tgtgtcgcag ccagggtgtg cttatgcagt
      721 tctgctgtgc acctggaaca aggacactgg ctcccctcct gcctctgagg aggccacagg
      781 agacagtagg gagaccccag ctgcccgaga tgtagtcctg caccagacat ctggccggat
      841 ccacaacaag aacgtctcca ctcacctaat tggcaacatc agacaaggtc ataaccctga
      901 aggtggtaac gcaggcctct tcgccctgtg caccctggat gggacactga agctgatgca
      961 ggaagcagac aagttgctgt ggtctgtgca ggtggatcac cagctttttg ccctagagaa
     1021 gctggatgtc acgggcaatg ggcttgagga ggtggtagct tgtgcctggg atggacagac
     1081 atatatcatc gatcacaacc gcaccgttgt gcgcttccaa gtggatgaaa atatccgtgc
     1141 cttctgtgca ggccagtacg cctgcaaaga gggccgcaac agtccctgct tggtatatgt
     1201 caccttcaat cagaagatct acgtgtactg ggaggtgcag ctggagcgca tggagtccac
     1261 taaccttctg aagctgctgg aggctgagcc cgagtaccac cgcctactgc aggagctgcg
     1321 tgtggatcct gaagatctcc ctgcagtctg taccctgctt catcagactc tctaccatcc
     1381 ggaccagcca ctacagtgta ccccctcaag cttccaggac cccacctagc tgggctcgac
     1441 cacttagctg gtgaaggatc cttccgagcc cccaacccta ccccagagcg atccatgacc
     1501 ttggaggatg gggagtgtgt attacagagg aaggagcaga actgggttct cagagaggat
     1561 ggatgtgccc cccccccccc cccgagagcc tgtgatgaag agatccatcg gttgcccctc
     1621 tgctcgtggc tccttctcat gctccctgct ctcactgcag gaaaccgact tgtgtgtgag
     1681 acaaggcagc aaacctttgc tatgttccaa cacctgaaag gcttcaggcc tgaggaactg
     1741 agggagcatg gggtgagccc ccctccccct gctgagtgcc gattttcaca gcatagctcc
     1801 aggcagctga cactcgcagt tattgcagga atgaacggca gagtatttat tcttttaggg
     1861 tattttcctg tctcatcttc ctgtgttctt ccatttactg aagcaactag gtcagggctt
     1921 tctcattttg tcatcatctc tctctggttt tgtttttgtt tgttggtttt gttttgtatg
     1981 tctctgtgtg caaaggagga accaggggtg ttcacacacc agccaagtgc tctgccattc
     2041 agctgtatcc agcactgccg ttctctaaag taccgtgctg cttgagagcc tcacccacct
     2101 gcttcccaaa catgactgcc tgtcggaaac tagatgctca cagtttgtct tacatgatgg
     2161 tgcaccagtg tactcccagt tcttgagaga aagatcatga gtccaaagcc agccaaggct
     2221 ccatagcaag tttgagacca gcgtgggtca catttggaga tctgatctca aataaaacaa
     2281 aaaggcgtta acaatctgaa aaaaaaaaaa aaaa
//
