LOCUS       NM_023627               1850 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus myo-inositol 1-phosphate synthase A1 (Isyna1), mRNA.
ACCESSION   NM_023627 XM_979527
VERSION     NM_023627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Seelan,R.S., Lakshmanan,J., Casanova,M.F. and Parthasarathy,R.N.
  TITLE     Identification of myo-inositol-3-phosphate synthase isoforms:
            characterization, expression, and putative role of a 16-kDa
            gamma(c) isoform
  JOURNAL   J Biol Chem 284 (14), 9443-9457 (2009)
   PUBMED   19188364
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Buccafusca,R., Venditti,C.P., Kenyon,L.C., Johanson,R.A., Van
            Bockstaele,E., Ren,J., Pagliardini,S., Minarcik,J., Golden,J.A.,
            Coady,M.J., Greer,J.J. and Berry,G.T.
  TITLE     Characterization of the null murine sodium/myo-inositol
            cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is
            independent of expression of its cognate mitochondrial ribosomal
            protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels
            in neonatal brain
  JOURNAL   Mol Genet Metab 95 (1-2), 81-95 (2008)
   PUBMED   18675571
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Li,X.Y., Cui,X.S. and Kim,N.H.
  TITLE     Transcription profile during maternal to zygotic transition in the
            mouse embryo
  JOURNAL   Reprod Fertil Dev 18 (6), 635-645 (2006)
   PUBMED   16930510
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Chauvin,T.R. and Griswold,M.D.
  TITLE     Characterization of the expression and regulation of genes
            necessary for myo-inositol biosynthesis and transport in the
            seminiferous epithelium
  JOURNAL   Biol Reprod 70 (3), 744-751 (2004)
   PUBMED   14613899
  REMARK    GeneRIF: Isyna1 is highly expressed in two types of germ cells,
            pachytene spermatocytes and round spermatids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF288525.1.
            
            On May 4, 2006 this sequence version replaced XM_979527.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288525.1, AK005029.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..1850
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /note="myo-inositol 1-phosphate synthase A1"
                     /db_xref="GeneID:71780"
                     /db_xref="MGI:MGI:1919030"
     exon            1..63
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            64..192
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1746
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /EC_number="5.5.1.4"
                     /note="L-myo-inositol 1-phosphate isomerase; similar to
                     Homo sapiens myo-inositol-1-phosphate synthase encoded by
                     GenBank Accession numbers AF220530, AF251265 and AF218361;
                     MIP synthase; MI-1-P synthase"
                     /codon_start=1
                     /product="inositol-3-phosphate synthase 1"
                     /protein_id="NP_076116.1"
                     /db_xref="CCDS:CCDS22373.1"
                     /db_xref="GeneID:71780"
                     /db_xref="MGI:MGI:1919030"
                     /translation="MEPAAEILVDSPDVVYSPETIEARYEYRTTRVSREGGVLRVQPR
                     ATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSL
                     TQAGTVNLGLDENGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCG
                     LQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSA
                     GLDKVIVLWTANTERFCEVVPGRNDTAENLLHTIQLGLEVSPSTLFAVASILEDCAFL
                     NGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNH
                     LGNNDGQNLSAPLQFRSKEVTKSSVVDDMVHSNHVLYAPGERPDHCVVIKYVPYVGDS
                     KRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEP
                     QGFHTVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKM
                     ERPGPGIKPGEVVATSPLPCKKEPTPATNGCTGDANGHPQAPTPKLSTA"
     exon            193..354
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            355..487
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..681
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            682..831
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1047
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1212
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1326
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1544
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1838
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1818..1823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /note="hexamer: AATAAA"
     polyA_site      1838
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /note="major polyA site"
ORIGIN      
        1 cgctgcccca gagccctcgg gcccacgctg tccgctgccg cagtctgatc caactctggg
       61 ccgctcgcca cgatggagcc cgccgccgag atcctcgtgg atagcccgga cgtggtctac
      121 agccccgaaa ccatcgaggc gcgctacgag taccggacaa cgcgcgtcag ccgcgagggc
      181 ggcgtgctgc gggtgcagcc cagggctacg cgtttcacct tccgcaccgc ccggcaggtg
      241 ccccgactcg gggtcatgtt ggtcggctgg ggcgggaaca acggctccac gctcactgct
      301 gctgttctgg ccaatcggct gcgcctaacc tggcccacgc gcacaggtcg caaggaggca
      361 aactattatg gatcgttgac ccaggcgggc accgtgaact tgggtctgga tgagaacggc
      421 cgggaggtgt ttgtgccctt cagtgcgctg ctacccatgg tggcccccaa cgacctggtg
      481 tttgatggct gggatatctc gtcgctgaac ctggccgagg ccatgcggcg cgcgcaggtc
      541 ctggactgcg gtctgcagga acagctgtgg ccccacatgg agagcctgcg tccgcggccc
      601 tcagtctaca ttcctgagtt catcgctgcc aaccagacag cacgtgcgga caacctcatc
      661 cctggcacac gtgcccaaca gttggagcaa atccgaaagg acattagaga tttccgatcc
      721 agtgcgggat tggataaggt catcgtgctg tggaccgcca atacggagcg cttctgcgag
      781 gtggtcccag gtcgcaatga cacagcagaa aacttgctac atactatcca gcttggcctg
      841 gaggtgtcac cgtccacact ttttgctgtg gccagcatcc tggaggactg cgccttcctc
      901 aatggatccc cacagaacac actggtaccc ggtgccctgg aactggcttc gcagcgccat
      961 gtgtttgtag gtggtgatga cttcaagtca gggcagacta aggtcaagtc tgtcctggtg
     1021 gacttcctca tcggctctgg gctcaagacc atgtccatcg tgagctataa ccacctgggc
     1081 aacaacgacg ggcagaacct gtctgcaccg ctgcagttcc gctccaagga ggtgacaaag
     1141 agcagtgtgg tggacgacat ggttcacagc aaccatgtgc tctacgcgcc tggagagcgg
     1201 ccagaccact gtgtggtgat caaatatgtg ccctatgttg gcgacagcaa gcgtgccttg
     1261 gacgagtaca cctccgagct gatgctgggt gggacaaaca ccttggtgct ccataatacc
     1321 tgcgaggatt cgctcctggc cgcgcccatc atgctggacc tagtgctgct cacagagctg
     1381 tgtcagcgcg tgagcttctg cacagactcg gaccccgagc ctcagggctt ccacacagtg
     1441 ctgtccctgc ttagcttcct gtttaaggcc ccgcttgtgc ccccgggcag ccctgtagtg
     1501 aatgccctct tccgccagcg cagctgtatc gagaatattt tcagggcttg cgtggggctc
     1561 ccgccccaga accacatgct attagagcac aagatggagc gtccaggccc aggcatcaag
     1621 ccaggagagg tggtggccac cagcccactg ccttgcaaga aagagcccac acctgccacc
     1681 aatggctgca ccggcgatgc caatgggcac ccgcaggcac caacaccaaa gctgtccact
     1741 gcttaaatca agtgaccgga ccggaccctt ctacccccaa tgcctccaac catagtactt
     1801 cagcccttgc caaagacaat aaagcaagtc tcaagcaaaa aaaaaaaaaa
//
