LOCUS       NP_076116                557 aa            linear   ROD 30-APR-2024
DEFINITION  inositol-3-phosphate synthase 1 [Mus musculus].
ACCESSION   NP_076116 XP_984621
VERSION     NP_076116.1
DBSOURCE    REFSEQ: accession NM_023627.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 557)
  AUTHORS   Seelan,R.S., Lakshmanan,J., Casanova,M.F. and Parthasarathy,R.N.
  TITLE     Identification of myo-inositol-3-phosphate synthase isoforms:
            characterization, expression, and putative role of a 16-kDa
            gamma(c) isoform
  JOURNAL   J Biol Chem 284 (14), 9443-9457 (2009)
   PUBMED   19188364
REFERENCE   3  (residues 1 to 557)
  AUTHORS   Buccafusca,R., Venditti,C.P., Kenyon,L.C., Johanson,R.A., Van
            Bockstaele,E., Ren,J., Pagliardini,S., Minarcik,J., Golden,J.A.,
            Coady,M.J., Greer,J.J. and Berry,G.T.
  TITLE     Characterization of the null murine sodium/myo-inositol
            cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is
            independent of expression of its cognate mitochondrial ribosomal
            protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels
            in neonatal brain
  JOURNAL   Mol Genet Metab 95 (1-2), 81-95 (2008)
   PUBMED   18675571
REFERENCE   4  (residues 1 to 557)
  AUTHORS   Li,X.Y., Cui,X.S. and Kim,N.H.
  TITLE     Transcription profile during maternal to zygotic transition in the
            mouse embryo
  JOURNAL   Reprod Fertil Dev 18 (6), 635-645 (2006)
   PUBMED   16930510
REFERENCE   5  (residues 1 to 557)
  AUTHORS   Chauvin,T.R. and Griswold,M.D.
  TITLE     Characterization of the expression and regulation of genes
            necessary for myo-inositol biosynthesis and transport in the
            seminiferous epithelium
  JOURNAL   Biol Reprod 70 (3), 744-751 (2004)
   PUBMED   14613899
  REMARK    GeneRIF: Isyna1 is highly expressed in two types of germ cells,
            pachytene spermatocytes and round spermatids
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF288525.1.
            
            On May 4, 2006 this sequence version replaced XP_984621.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288525.1, AK005029.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..557
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     Protein         1..557
                     /product="inositol-3-phosphate synthase 1"
                     /EC_number="5.5.1.4"
                     /note="L-myo-inositol 1-phosphate isomerase; similar to
                     Homo sapiens myo-inositol-1-phosphate synthase encoded by
                     GenBank Accession numbers AF220530, AF251265 and AF218361;
                     MIP synthase; MI-1-P synthase"
                     /calculated_mol_wt=60801
     Region          9..507
                     /region_name="NAD_binding_5"
                     /note="Myo-inositol-1-phosphate synthase; cl00554"
                     /db_xref="CDD:469819"
     Site            279
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NPH2; propagated from
                     UniProtKB/Swiss-Prot (Q9JHU9.1)"
     Site            357
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NPH2; propagated from
                     UniProtKB/Swiss-Prot (Q9JHU9.1)"
     Region          512..557
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JHU9.1)"
     Site            524
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6AYK3; propagated from
                     UniProtKB/Swiss-Prot (Q9JHU9.1)"
     CDS             1..557
                     /gene="Isyna1"
                     /gene_synonym="1300017C10Rik; IPS 1"
                     /coded_by="NM_023627.1:73..1746"
                     /db_xref="CCDS:CCDS22373.1"
                     /db_xref="GeneID:71780"
                     /db_xref="MGI:MGI:1919030"
ORIGIN      
        1 mepaaeilvd spdvvyspet iearyeyrtt rvsreggvlr vqpratrftf rtarqvprlg
       61 vmlvgwggnn gstltaavla nrlrltwptr tgrkeanyyg sltqagtvnl gldengrevf
      121 vpfsallpmv apndlvfdgw disslnlaea mrraqvldcg lqeqlwphme slrprpsvyi
      181 pefiaanqta radnlipgtr aqqleqirkd irdfrssagl dkvivlwtan terfcevvpg
      241 rndtaenllh tiqlglevsp stlfavasil edcaflngsp qntlvpgale lasqrhvfvg
      301 gddfksgqtk vksvlvdfli gsglktmsiv synhlgnndg qnlsaplqfr skevtkssvv
      361 ddmvhsnhvl yapgerpdhc vvikyvpyvg dskraldeyt selmlggtnt lvlhntceds
      421 llaapimldl vlltelcqrv sfctdsdpep qgfhtvlsll sflfkaplvp pgspvvnalf
      481 rqrscienif racvglppqn hmllehkmer pgpgikpgev vatsplpckk eptpatngct
      541 gdanghpqap tpklsta
//
