LOCUS       NM_001294278            2227 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus intestine specific homeobox (Isx), transcript variant
            1, mRNA.
ACCESSION   NM_001294278 XM_006531370
VERSION     NM_001294278.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Kim,Y.K., Giordano,E., Hammerling,U., Champaneri,D., von Lintig,J.,
            Hussain,M.M. and Quadro,L.
  TITLE     The intestine-specific homeobox (ISX) modulates
            beta-carotene-dependent regulation of microsomal triglyceride
            transfer protein (MTP) in a tissue-specific manner
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1870 (2), 159584 (2025)
   PUBMED   39645027
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Thomas,L.D., Ramkumar,S., Golczak,M. and von Lintig,J.
  TITLE     Genetic deletion of Bco2 and Isx establishes a golden mouse model
            for carotenoid research
  JOURNAL   Mol Metab 73, 101742 (2023)
   PUBMED   37225015
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Widjaja-Adhi,M.A.K., Ramkumar,S. and von Lintig,J.
  TITLE     Protective role of carotenoids in the visual cycle
  JOURNAL   FASEB J 32 (11), fj201800467R (2018)
   PUBMED   29882710
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 2227)
  AUTHORS   Mori,K., Nakamura,H., Kurooka,H., Miyachi,H., Tamada,K., Sugai,M.,
            Takumi,T. and Yokota,Y.
  TITLE     Id2 Determines Intestinal Identity through Repression of the
            Foregut Transcription Factor Irx5
  JOURNAL   Mol Cell Biol 38 (9), e00250-17 (2018)
   PUBMED   29463648
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2227)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   7  (bases 1 to 2227)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2227)
  AUTHORS   Seino,Y., Miki,T., Kiyonari,H., Abe,T., Fujimoto,W., Kimura,K.,
            Takeuchi,A., Takahashi,Y., Oiso,Y., Iwanaga,T. and Seino,S.
  TITLE     Isx participates in the maintenance of vitamin A metabolism by
            regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression
  JOURNAL   J Biol Chem 283 (8), 4905-4911 (2008)
   PUBMED   18093975
  REMARK    GeneRIF: Isx participates in the maintenance of vitamin A
            metabolism by regulating Bcmo1 expression in the intestine.
REFERENCE   9  (bases 1 to 2227)
  AUTHORS   Li,X., Madison,B.B., Zacharias,W., Kolterud,A., States,D. and
            Gumucio,D.L.
  TITLE     Deconvoluting the intestine: molecular evidence for a major role of
            the mesenchyme in the modulation of signaling cross talk
  JOURNAL   Physiol Genomics 29 (3), 290-301 (2007)
   PUBMED   17299133
REFERENCE   10 (bases 1 to 2227)
  AUTHORS   Choi,M.Y., Romer,A.I., Hu,M., Lepourcelet,M., Mechoor,A.,
            Yesilaltay,A., Krieger,M., Gray,P.A. and Shivdasani,R.A.
  TITLE     A dynamic expression survey identifies transcription factors
            relevant in mouse digestive tract development
  JOURNAL   Development 133 (20), 4119-4129 (2006)
   PUBMED   16971476
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603782.5.
            
            On Feb 1, 2022 this sequence version replaced NM_001294278.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128289.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1160              AL603782.5         25459-26618         c
            1161-1312           AL603782.5         9201-9352           c
            1313-1388           AL603782.5         7442-7517           c
            1389-2227           AL603782.5         5810-6648           c
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 35.54 cM"
     gene            1..2227
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /note="intestine specific homeobox"
                     /db_xref="GeneID:71597"
                     /db_xref="MGI:MGI:1918847"
     exon            1..1160
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             944..1672
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pancreas-intestine homeodomain transcription factor"
                     /codon_start=1
                     /product="intestine-specific homeobox isoform 1"
                     /protein_id="NP_001281207.1"
                     /db_xref="CCDS:CCDS80899.1"
                     /db_xref="GeneID:71597"
                     /db_xref="MGI:MGI:1918847"
                     /translation="MAGPTIHRDMEKSSGYCEAPENLGLSFSIEAILKKPTERRSLPR
                     PQSICKEDSRQTTIPGSKLERPPQDQPQEEKKNKRRVRTTFTTEQLQELEKLFHFTHY
                     PDIHVRSQLASRINLPEARVQIWFQNQRAKWRKQEKSGNLSAPQQPGSCADTHCYDYI
                     GTSHRMLPTLSDSAPFKLVPYTDSPCPMAPMGPTAPAWPSHPASLCPYLHVPTPTPQV
                     GQHLCNFNIGTDFSLSKQATLLSQ"
     exon            1161..1312
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1388
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2227
                     /gene="Isx"
                     /gene_synonym="9130012O13Rik; Pix-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacatttct ctgagcagaa ttcctggcaa gatagagcag tgactgtcag ctccaagccc
       61 agagtttact ggactgggaa tctttgtggc tgtcttgaag acagtaaagg gtgatcaagc
      121 aggaaaaatt aataaggaaa ccccaaaaga aggagaaacg agtggctaaa gaatttacta
      181 tgtgactgga agtcagggag aagagaacag aataaagcca acaccagccc agagagcact
      241 ggcctcagac cacaggcctg aggtaaaagt gagcacagac ccccgcaggg agccagcatc
      301 gaccttagcc tctacctgaa gatctgcaga ggcacaggag ccctggaagt ctcattcctg
      361 agactggaag ctgggttgag gaagtccaga agggcctctg agaagacctt tcagccacaa
      421 agaggctcag ggttcacttg gccatctagg gcccataggt ggcagcctag cctcccaggg
      481 actgcctgaa gccagcagga aggggacaca agtcagagag aggacaaagg tggatgctgg
      541 ctccaaacct catcccacca accctgcctg ttttctcttt gttttctggt accattactc
      601 agttcgctcc aggatccttg cctaggctgg taactgtgaa agcctccacc accaagaaga
      661 tcctctctgg aaaattgaac ctctatttgg tgacaactat agacctgtgg atagaggaca
      721 agtgcctacc agctcttctg ctggaagcca cctcctagtc ttaaaggtgt tcaaggtcca
      781 tggaagtccc tgtgtccaag gaattgtggc tgaattaccc agcatcagga ttcccaatca
      841 ccacctctgt gtccccagaa gctccgggaa gaaaatatac caccctctgc tggcatctcc
      901 ctgggcacac acagagtgtt cctcctagca gcagggctag gccatggcag gccctacgat
      961 ccacagggac atggagaaga gttcaggata ctgtgaagcc ccagagaatc tgggcttgtc
     1021 cttctccatt gaggcaatcc tgaagaaacc cacagaaaga agaagtttgc ccagaccaca
     1081 aagcatttgt aaagaggact ccaggcagac aactatccca ggttccaagc tggagaggcc
     1141 cccacaggat cagccccaag aagagaaaaa gaacaagcgg agagttcgca ctaccttcac
     1201 cacagagcag ctacaggagc tggagaagct cttccacttc acccattacc ctgacatcca
     1261 tgtccgttcc caattggctt ccaggattaa cctgcctgaa gctcgagtac agatctggtt
     1321 ccagaatcag agagccaagt ggaggaagca ggagaagagt gggaacctca gtgccccaca
     1381 gcagcctggg tcctgtgctg acacccactg ctatgactac attggtacct cccacagaat
     1441 gctgcctact ctctcagact cagctccctt caagctggtt ccctacacag attccccttg
     1501 tcccatggca cccatgggac ctacagcccc tgcctggccc tctcacccag catccttgtg
     1561 tccctacctt catgttccca cccctacacc ccaagtgggg cagcatctgt gcaacttcaa
     1621 catagggact gatttttctc tttccaagca agcaactctc ctctctcagt gatggcaggc
     1681 agccctggac ctcagagaaa atcactccac aatccatcaa tgacccacag tccaggaagc
     1741 tacccagagc ttgccattaa agactgtact ggctatggaa gacatcaaag gacagctcga
     1801 gtctcaccag ccagtcagtc tcctaatgct gaagactggc tgactaaggg ctggggatga
     1861 agtccagaat aagctgctct tcttttaccc ctctggacat catctgtaac caagcagcca
     1921 tttctgtgga cccctttctc ctttacttag gagagccttg ggaaatacaa ggcatggaga
     1981 ggggctgcac atccgtgtac ttgttcatga tgtccatact gaacactgag cattgtgcac
     2041 ttgaaaatag atgttgagat gcacaggtta gattctgccc aggttagctg aaaggtgatc
     2101 ctgacctcta cctgcagatg gatattgatg acattgcact gggctagtgt ctagaacact
     2161 ctgtatgact ttgatatgag aaatctcaga ctgggagaga aatggaagaa atattttaat
     2221 ttaaatg
//
