LOCUS       NM_001309430            2124 bp    mRNA    linear   ROD 17-OCT-2021
DEFINITION  Mus musculus immune system associated SCR family kinase partner
            (Israa), mRNA.
ACCESSION   NM_001309430
VERSION     NM_001309430.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2124)
  AUTHORS   Al-Awadi AMI, AlJawder AI, Mousa A, Taha S and Bakhiet M.
  TITLE     A role for the immune system-released activating agent (ISRAA) in
            the ontogenetic development of brain astrocytes
  JOURNAL   PLoS One 16 (5), e0248455 (2021)
   PUBMED   33970944
  REMARK    GeneRIF: A role for the immune system-released activating agent
            (ISRAA) in the ontogenetic development of brain astrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2124)
  AUTHORS   Ben Khalaf N, Al-Mashoor W, Saeed A, Al-Mehatab D, Taha S, Bakhiet
            M and Fathallah MD.
  TITLE     The mouse intron-nested gene, Israa, is expressed in the lymphoid
            organs and involved in T-cell activation and signaling
  JOURNAL   Mol Immunol 111, 209-219 (2019)
   PUBMED   31096062
  REMARK    GeneRIF: Israa gene product regulates the expression of a pool of
            genes involved in T-cell activation.
REFERENCE   3  (bases 1 to 2124)
  AUTHORS   Ben Khalaf N, Taha S, Bakhiet M and Fathallah MD.
  TITLE     A Central Nervous System-Dependent Intron-Embedded Gene Encodes a
            Novel Murine Fyn Binding Protein
  JOURNAL   PLoS One 11 (2), e0149612 (2016)
   PUBMED   26901312
  REMARK    GeneRIF: observations highlight ISRAA as a novel Fyn binding
            protein that is likely to be involved in a signaling pathway driven
            by the nervous system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2124)
  AUTHORS   Taha S, Fathallah MD and Bakhiet M.
  TITLE     An interspecies conserved motif of the mouse immune system-released
            activating agent (ISRAA) induces proliferative effects on human
            cells
  JOURNAL   Mol Med Rep 10 (1), 75-81 (2014)
   PUBMED   24821660
REFERENCE   5  (bases 1 to 2124)
  AUTHORS   Bakhiet M and Taha S.
  TITLE     A novel nervous system-induced factor inducing immune responses in
            the spleen
  JOURNAL   Immunol Cell Biol 86 (8), 688-699 (2008)
   PUBMED   18779837
  REMARK    GeneRIF: after parasitic challenge in experimental African
            trypanosomiasis, a dramatic expression of a novel gene, ISRAA,in
            the spleen together with uppregualtion of its encoding protein was
            depicted;autonomic nervous system was critically involved in this
            process
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154455.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR7345562.1612539.1, BG916570.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2124              AC154455.2         47079-49202         c
FEATURES             Location/Qualifiers
     source          1..2124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14"
     gene            1..2124
                     /gene="Israa"
                     /gene_synonym="Gm45915"
                     /note="immune system associated SCR family kinase partner"
                     /db_xref="GeneID:100188919"
                     /db_xref="MGI:MGI:5825552"
     exon            1..2124
                     /gene="Israa"
                     /gene_synonym="Gm45915"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..412
                     /gene="Israa"
                     /gene_synonym="Gm45915"
                     /codon_start=1
                     /product="immune system released activating agent"
                     /protein_id="NP_001296359.1"
                     /db_xref="GeneID:100188919"
                     /db_xref="MGI:MGI:5825552"
                     /translation="MAGETVLQGCPLCPDHAEGDRSPRIGGSQRQSPLLEVTHTQCCH
                     LILSCLYVWCPVTQSLYGAPEQHSFLSPLVLLHASQRPGTHPLAISLLTLPSQLVPEY
                     TEVTSLQVIRILVNPSESANCLG"
ORIGIN      
        1 agtaagaggg actcatcagg gctgagaaag gagaatggca ggggaaacag tgctacaagg
       61 atgtcctttg tgtcctgacc atgcagaagg agacagaagc cccaggattg gtggttccca
      121 gaggcagagc ccactcctgg aggtgactca cactcagtgt tgtcatttga tccttagctg
      181 tctgtatgtc tggtgccctg tgacccagtc tctttatggt gctccggagc agcattcctt
      241 tctgtccccc cttgttcttc tccacgcttc ccaacgacca ggtacacacc cacttgccat
      301 ctccctgtta accctacctt cccagttagt gcctgagtac acagaagtga catctctcca
      361 ggtcatcaga attcttgtca atccctctga gtcagcaaac tgcctgggtt agaagtctgg
      421 gacttctctg ggactcagaa cccagtgccc agaatctgag ccacatcaag gctggttgtt
      481 ctccctctcc tcatcttgag agtttggctt gtgcatgaca ggcctgcctg cccacttagt
      541 tagccttcct tcctttcttc ctaacttcct gatggccttc gaagccccta gacttaccat
      601 atcactacca aaagaaaaaa gaaaaagaaa aagctgtaag tgggaagtga cccacttttg
      661 acccctggta catgcatccc aggtagatgc cttggtccct tgtcttattg gaactgattc
      721 tagctcatcc atgagctgaa ggaagtcagt cctttgaccc aagcttggga ctgtggtgtc
      781 ctggctacat tatctccctt ctcacccctc ctctagaggg tccttcaggg ggcgggctcc
      841 ccactgccag aggataaagc atccccgact ccggagccag ccagccatgc cacagcactg
      901 tatttattgg cggctcctct tcactcaggc ccacgacagg agttcagacc cccgcgagaa
      961 aagccacccg ctattgatcc ttagtcaggt ctccggagcc tggcagacat tcatcaagga
     1021 gccacagcat ggggctacag ctcgcccttt ctttcttctt cctttcttct accccccaag
     1081 tcattccccc cccccccggg ggggggggtc cgagggaggc gggtgagggg gcttgccgag
     1141 gtcactccaa gagctgcaga gcgtctggaa gtggagtcgc aggatgcctt tgtctgctgc
     1201 ctctttttgt agatccttat caaggcaagc actgcggggt ggggtggggt ggggtggggt
     1261 tggctgtggg ccccgggctt ttgagcaagt ctttggaagt tagagatgtg gaacttggag
     1321 cgagtcaggg aaagcccttc taacgaagat agtgtgtgga gtgccggcat ttctgtagac
     1381 tccaatacta aaaagaggct gctaaccaag agggccttga gggatttgat tccagagaag
     1441 agagcctaga aattagcaag tgaaaggggc cagtttggac tgatgaatgg gtgcttgaaa
     1501 acaatttgtt ttcttaagta tgtaaatatg ctagtgaaga gtatttactt tttgggttac
     1561 cttggaaaac cctgtatctt gaatattatt tccatcctca gggtcccact caggagcttc
     1621 tgaagtgggt cccgaggaga actaagaggt aggaggacga ggaggcaaaa caacgggaag
     1681 ctgtctttat aatttctaaa ggattaccac caccaagtcc ctgcccctaa ggtgtaaact
     1741 ttgctcagtt ccagcctgaa tgttcactca acctgcagga atgatctttc ttaatatatg
     1801 tatttcaaaa tatatgtata ttttatttat atatgtatat ttcatgtatg aatatgtttg
     1861 cttgcttata tgtccgtgtt ccacttgtgt gtctggtgcc ctcggactag aagagggtgt
     1921 tgaatttccc taaacctgga gtttcagatg attgtgagct gccacatggg tgccaaggag
     1981 agaattctgg ccctctgcaa gagcaagaaa cctcttttaa ccactgagcc atctctcctg
     2041 ccccaggact atctttgtaa agttagttct ttctgctact gtgtgtgtaa gcccttggcc
     2101 actgaacagg ccctatgaat caga
//
