LOCUS       NM_001276489            2498 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus isthmin 1, angiogenesis inhibitor (Ism1), mRNA.
ACCESSION   NM_001276489
VERSION     NM_001276489.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2498)
  AUTHORS   Li,J., Tan,M., Yang,T., Huang,Q. and Shan,F.
  TITLE     The paracrine isthmin1 transcriptionally regulated by C/EBPbeta
            exacerbates pulmonary vascular leakage in murine sepsis
  JOURNAL   Am J Physiol Cell Physiol 326 (1), C304-C316 (2024)
   PUBMED   38047305
  REMARK    GeneRIF: The paracrine isthmin1 transcriptionally regulated by
            C/EBPbeta exacerbates pulmonary vascular leakage in murine sepsis.
REFERENCE   2  (bases 1 to 2498)
  AUTHORS   Tee,J.H., Vijayakumar,U., Shanmugasundaram,M., Lam,T.Y.W., Liao,W.,
            Yang,Y., Wong,W.S.F. and Ge,R.
  TITLE     Isthmin-1 attenuates allergic Asthma by stimulating adiponectin
            expression and alveolar macrophage efferocytosis in mice
  JOURNAL   Respir Res 24 (1), 269 (2023)
   PUBMED   37932719
  REMARK    GeneRIF: Isthmin-1 attenuates allergic Asthma by stimulating
            adiponectin expression and alveolar macrophage efferocytosis in
            mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2498)
  AUTHORS   Gao,G., Li,X., Jiang,Z., Osorio,L., Tang,Y.L., Yu,X., Jin,G. and
            Zhou,Z.
  TITLE     Isthmin-1 (Ism1) modulates renal branching morphogenesis and
            mesenchyme condensation during early kidney development
  JOURNAL   Nat Commun 14 (1), 2378 (2023)
   PUBMED   37185772
  REMARK    GeneRIF: Isthmin-1 (Ism1) modulates renal branching morphogenesis
            and mesenchyme condensation during early kidney development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2498)
  AUTHORS   Zhao,M., Banhos Danneskiold-Samsoe,N., Ulicna,L., Nguyen,Q.,
            Voilquin,L., Lee,D.E., White,J.P., Jiang,Z., Cuthbert,N.,
            Paramasivam,S., Bielczyk-Maczynska,E., Van Rechem,C. and
            Svensson,K.J.
  TITLE     Phosphoproteomic mapping reveals distinct signaling actions and
            activation of muscle protein synthesis by Isthmin-1
  JOURNAL   Elife 11, e80014 (2022)
   PUBMED   36169399
  REMARK    GeneRIF: Phosphoproteomic mapping reveals distinct signaling
            actions and activation of muscle protein synthesis by Isthmin-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2498)
  AUTHORS   Nguyen,N., Xu,S., Lam,T.Y.W., Liao,W., Wong,W.S.F. and Ge,R.
  TITLE     ISM1 suppresses LPS-induced acute lung injury and post-injury lung
            fibrosis in mice
  JOURNAL   Mol Med 28 (1), 72 (2022)
   PUBMED   35752760
  REMARK    GeneRIF: ISM1 suppresses LPS-induced acute lung injury and
            post-injury lung fibrosis in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2498)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   7  (bases 1 to 2498)
  AUTHORS   Xiang,W., Ke,Z., Zhang,Y., Cheng,G.H., Irwan,I.D., Sulochana,K.N.,
            Potturi,P., Wang,Z., Yang,H., Wang,J., Zhuo,L., Kini,R.M. and Ge,R.
  TITLE     Isthmin is a novel secreted angiogenesis inhibitor that inhibits
            tumour growth in mice
  JOURNAL   J Cell Mol Med 15 (2), 359-374 (2011)
   PUBMED   19874420
  REMARK    GeneRIF: results demonstrate that Isthmin is a novel endogenous
            angiogenesis inhibitor with functions likely in physiological as
            well as pathological angiogenesis.
REFERENCE   8  (bases 1 to 2498)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   9  (bases 1 to 2498)
  AUTHORS   Leong,K.G., Wang,B.E., Johnson,L. and Gao,W.Q.
  TITLE     Generation of a prostate from a single adult stem cell
  JOURNAL   Nature 456 (7223), 804-808 (2008)
   PUBMED   18946470
REFERENCE   10 (bases 1 to 2498)
  AUTHORS   Pera,E.M., Kim,J.I., Martinez,S.L., Brechner,M., Li,S.Y.,
            Wessely,O. and De Robertis,E.M.
  TITLE     Isthmin is a novel secreted protein expressed as part of the Fgf-8
            synexpression group in the Xenopus midbrain-hindbrain organizer
  JOURNAL   Mech Dev 116 (1-2), 169-172 (2002)
   PUBMED   12128218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928831.11.
            
            On Nov 4, 2022 this sequence version replaced NM_001276489.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077398.1, ERR3363658.3738750.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AL928831.11        36411-36574
            165-395             AL928831.11        89637-89867
            396-660             AL928831.11        97906-98170
            661-804             AL928831.11        103737-103880
            805-894             AL928831.11        107273-107362
            895-2498            AL928831.11        114744-116347
FEATURES             Location/Qualifiers
     source          1..2498
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.06 cM"
     gene            1..2498
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="isthmin 1, angiogenesis inhibitor"
                     /db_xref="GeneID:319909"
                     /db_xref="MGI:MGI:2442963"
     exon            1..164
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1412
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="isthmin 1 homolog"
                     /codon_start=1
                     /product="isthmin-1 precursor"
                     /protein_id="NP_001263418.1"
                     /db_xref="CCDS:CCDS50730.2"
                     /db_xref="GeneID:319909"
                     /db_xref="MGI:MGI:2442963"
                     /translation="MVRLAAELLLLLGLLLLTLHITVLRGSGASDRQDAAAGNVSGSQ
                     LQNNLNLESDSTSETSFPLSKEAPEEHQVVHQPFPRQRFPPETGHPSLQRDGPRSFLL
                     DLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEAEKDQHPENKPSWSLPAPDWRAWWQ
                     RSLSLARTNSGDQDDKYDSTSDDSNFLSVPRGWDRPAPGHRTFETKEQPEYDSTDGEG
                     DWSLWSVCSVTCGNGNQKRTRSCGYACIATESRTCDRPNCPGIEDTFRTAATEVSLLA
                     GSEEFNATKLFEVDMDSCERWMSCKSEFLKKYMHKVINDLPSCPCSYPTEVAYSTADI
                     FDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLIT
                     RGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDED
                     YIKQFQEAREY"
     exon            165..395
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     exon            396..660
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     exon            661..804
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     exon            805..894
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     exon            895..2498
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1746..1751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="hexamer: AATACA"
     polyA_site      1769
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="major polyA site"
     regulatory      2477..2482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="Ism1"
                     /gene_synonym="5430433G21Rik; Ism"
                     /note="major polyA site"
ORIGIN      
        1 gtcctaaagc cgcgcgactc aagaggatgg tgcgcctggc tgcggaactg ctcctgctgc
       61 tggggctact gctgctcacg ctgcacatca cggttctgcg cggatccgga gcctccgacc
      121 ggcaggacgc ggccgccggc aacgtcagcg ggtcccagtt gcagaataac ctcaacctgg
      181 agagtgactc cacgtcagaa accagctttc ctctgtccaa agaagccccg gaggagcacc
      241 aggttgtcca ccaacccttc cccagacagc gattccctcc agagactgga catccttcac
      301 tgcagagaga cggccccaga tcctttctcc ttgacctacc aaactttcca gatctttcca
      361 aagctgatat caatgggcag aatccaaaca ttcaggtcac catagaggtg gttgatggcc
      421 ctgactccga agcagaaaaa gatcagcatc cagagaataa acccagctgg tcgctcccag
      481 ctcccgactg gcgggcctgg tggcagaggt ccttgtcctt ggccaggaca aatagtgggg
      541 accaggatga caagtatgac agtacctcag atgacagcaa cttcctcagt gttcctagag
      601 gatgggaccg tccagcccca ggacaccgga cttttgaaac caaagagcag ccagagtatg
      661 attccacaga cggggagggt gattggagtc tctggtctgt ctgcagcgtc acctgtggaa
      721 atggcaacca gaaacggacc cgttcttgtg gctatgcatg cattgccaca gaatccagga
      781 cctgtgaccg tccaaactgc ccaggaattg aagatacttt caggacagcg gccactgaag
      841 tgagtctgct tgcgggaagt gaggagttta atgccaccaa gttgtttgaa gttgacatgg
      901 acagctgtga gcgatggatg agctgcaaaa gtgagttctt aaagaaatac atgcacaagg
      961 tgatcaacga cctgcccagc tgcccctgct cctaccctac tgaggtggcc tacagcacag
     1021 ctgacatctt tgaccgcatc aagcgcaagg acttccgatg gaaggatgct agtgggccca
     1081 aagagaaact agagatctac aagcctactg ctcggtactg catccgctct atgctgtccc
     1141 tggagagtac cacactggct gcccagcact gttgctatgg tgacaacatg cagctcatca
     1201 ccaggggcaa aggggcaggc actcccaatc tcatcagcac cgagttctct gctgaactcc
     1261 actacaaagt ggatgttctg ccctggatta tctgcaaggg tgactggagc agatataatg
     1321 aggcccggcc tcccaataac ggacagaagt gcacagagag cccttctgat gaggactaca
     1381 tcaaacagtt ccaagaagcc agagagtact aaagcaccac tggtttggag acacaaatgc
     1441 actgcactga tctgccaact gtcacctggt tctttttatc cacaatattt gtatatctgt
     1501 atattccaca tgaatatttt tgtaagtata ataggggtat gcaccaggcc tggaggaccg
     1561 ctatgtccag tactgacaaa ccatgttgga agtcctccta atggctgtgt gggatggaag
     1621 aggcacctgg gagccatagt gggtatgact ctgttcccac ctccatccag tgcagaggag
     1681 catagagact gaggttgtaa acattataag cagtttatat atatataaat atatataact
     1741 tatttaatac aaatgtgact taagcttaac cttttctctg gagttgtcct tattaaaaaa
     1801 attatttaat tgcttctgag agagttaaaa agggaaagga cataggggga tttcgagaaa
     1861 aggaattttg cattggaaat gcaccagagc aatgaaacac ccaccttgca tcaggtgttc
     1921 ttcaggcgtg gagtgctgct agcgtcacag tttccaagac ttcttggtct tagattaggc
     1981 aaggggtggg tagtaagtga atgtgcagag tcaaatctaa gacatcgttt tcaatggctt
     2041 taaagtaaat gaccaacata attgtactga agagcccagc aggagctctg ctctatctta
     2101 acgggctcag aagactgaag gaagttcagg tgtaaagcca ggagtggcac tttccaaaga
     2161 aaaaacacaa gtcgaaaaat aataggggcc ccgttttgtc tattttatct taatagagtg
     2221 acttttcttc accaatatat tcccagtaaa taaatataga agggggtgat gggagctgaa
     2281 gcctgggaaa tcctaatatt tttatgtttt aagaaaaaaa actgcattat ttttgtaaag
     2341 tatttattga gtcgttggat attgtgcatc gtgccgttat gagatgatcc gttctgtggg
     2401 gtagaacttg aggacagatg aagagctgat tcttatgcaa ccttttactt gcaaaactcc
     2461 agggaaagag atagacaata aaatcatgat aaaatgtg
//
