LOCUS       NM_177193               4129 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus immunoglobulin superfamily containing leucine-rich
            repeat 2 (Islr2), transcript variant 4, mRNA.
ACCESSION   NM_177193
VERSION     NM_177193.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Werren,E.A., LaForce,G.R., Srivastava,A., Perillo,D.R., Li,S.,
            Johnson,K., Baris,S., Berger,B., Regan,S.L., Pfennig,C.D., de
            Munnik,S., Pfundt,R., Hebbar,M., Jimenez-Heredia,R.,
            Karakoc-Aydiner,E., Ozen,A., Dmytrus,J., Krolo,A., Corning,K.,
            Prijoles,E.J., Louie,R.J., Lebel,R.R., Le,T.L., Amiel,J.,
            Gordon,C.T., Boztug,K., Girisha,K.M., Shukla,A., Bielas,S.L. and
            Schaffer,A.E.
  TITLE     TREX tetramer disruption alters RNA processing necessary for
            corticogenesis in THOC6 Intellectual Disability Syndrome
  JOURNAL   Nat Commun 15 (1), 1640 (2024)
   PUBMED   38388531
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Astrof,S., Arriagada,C., Saijoh,Y., Francou,A., Kelly,R.G. and
            Moon,A.
  TITLE     Aberrant differentiation of second heart field mesoderm prefigures
            cellular defects in the outflow tract in response to loss of FGF8
  JOURNAL   Dev Biol 499, 10-21 (2023)
   PUBMED   37060937
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Hiver,S., Shimizu-Mizuno,N., Ikawa,Y., Kajikawa,E., Sai,X.,
            Nishimura,H., Takaoka,K., Nishimura,O., Kuraku,S., Tanaka,S. and
            Hamada,H.
  TITLE     Gse1, a component of the CoREST complex, is required for placenta
            development in the mouse
  JOURNAL   Dev Biol 498, 97-105 (2023)
   PUBMED   37019373
REFERENCE   5  (bases 1 to 4129)
  AUTHORS   Petitpre,C., Faure,L., Uhl,P., Fontanet,P., Filova,I.,
            Pavlinkova,G., Adameyko,I., Hadjab,S. and Lallemend,F.
  TITLE     Single-cell RNA-sequencing analysis of the developing mouse inner
            ear identifies molecular logic of auditory neuron diversification
  JOURNAL   Nat Commun 13 (1), 3878 (2022)
   PUBMED   35790771
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4129)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   7  (bases 1 to 4129)
  AUTHORS   Visel,A., Carson,J., Oldekamp,J., Warnecke,M., Jakubcakova,V.,
            Zhou,X., Shaw,C.A., Alvarez-Bolado,G. and Eichele,G.
  TITLE     Regulatory pathway analysis by high-throughput in situ
            hybridization
  JOURNAL   PLoS Genet 3 (10), 1867-1883 (2007)
   PUBMED   17953485
REFERENCE   8  (bases 1 to 4129)
  AUTHORS   Gejima,R., Okafuji,T. and Tanaka,H.
  TITLE     The LRR and Ig domain-containing membrane protein SST273 is
            expressed on motoneurons
  JOURNAL   Gene Expr Patterns 6 (3), 235-240 (2006)
   PUBMED   16378755
REFERENCE   9  (bases 1 to 4129)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 4129)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA328406.1, BC059068.1 and BY079125.1.
            
            On Jun 4, 2009 this sequence version replaced NM_177193.4.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream
            translational start codon, compared to variant 1. The encoded
            isoform (b) is shorter than isoform a. Variants 2-8 encode the same
            isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA328406.1, BC059068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               CA328406.1         1-147
            148-4109            BC059068.1         1-3962
            4110-4129           BY079125.1         211-230
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..4129
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /note="immunoglobulin superfamily containing leucine-rich
                     repeat 2"
                     /db_xref="GeneID:320563"
                     /db_xref="MGI:MGI:2444277"
     exon            1..334
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /inference="alignment:Splign:2.1.0"
     exon            335..427
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /inference="alignment:Splign:2.1.0"
     exon            428..4114
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..2673
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /note="isoform b precursor is encoded by transcript
                     variant 4; immunoglobulin superfamily containing
                     leucine-rich repeat protein 2; leucine-rich repeat domain
                     and immunoglobulin domain containing axon extension
                     protein"
                     /codon_start=1
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein 2 isoform b precursor"
                     /protein_id="NP_796167.2"
                     /db_xref="CCDS:CCDS23238.1"
                     /db_xref="GeneID:320563"
                     /db_xref="MGI:MGI:2444277"
                     /translation="MGPFGALCLAWALLGVVRACPEPCACVDKYAHQFADCAYKELRE
                     VPEGLPANVTTLSLSANKITVLRRGAFVNVTQVTSLWLAHSEVRTVESGALAVLSQLK
                     NLDLSHNLISNFPWSDLRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLR
                     TLEPGTFDALSALSHLQLYHNPFHCSCGLVWLQAWAASTRVSLPEPDSIACASPPELQ
                     GVPVHRLPALPCAPPSVRLSAEPPPEAPGTPLRAGLAFMLHCVAEGHPTPRLQWQLQI
                     PGGTVVLVPPVLSKEEDGGDKVEDGEGDGDEDLPTQTEAPTPTPAPAWPAPPATPRFL
                     ALANGSLLVPLLSAKEAGIYTCRAHNELGTNSTSLRVTVAAAGPPKHAPGTGEEPDAQ
                     VPTSERKATTKGRSNSVLPFKPEGKTKGQGLARVSVLGEIEAELEETDEGEQMEGQIP
                     ADPMGEKHCGHGDPSRYVSNHAFNQSSDLKPHVFELGVIALDVAEREARVQLTPLAAR
                     WGPGPDGASGARRPGRRPLRLLYLCPAGGGTAVQWSRVEEGVNAYWFRGLRPGTNYSV
                     CLALAGEACHVQVVFSTKKELPSLLVIVTVSVFLLVLATVPLLGAACCHLLAKHPGKP
                     YRLILRPQAPDPMEKRIAADFDPRASYLESEKSYPARGEAGGEEPEEVPEEGLDEDVE
                     QGDPSGDLQREESLAGCSLVESQSKANQEEFEAGSEYSDRLPLGAEAVNIAQEINGNY
                     RQTAG"
     regulatory      4090..4095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /note="hexamer: AATAAA"
     polyA_site      4109
                     /gene="Islr2"
                     /gene_synonym="B930052A04Rik; Linx; Mbu-3; mKIAA1465"
                     /note="major polyA site"
ORIGIN      
        1 agagggtgag gcgttctgct aacactatca attatgcatc gtgttgaacg aagcttcggg
       61 gagggggagg ctagcaggcg gcaggaggaa aagggtccgg gagagccagg cagcgcagtt
      121 cagcaggtcc cactggaggt ctttctgcgc cactgcttgc tttggagagg ggggaaaaaa
      181 gtgtttaaag gcaaagacac gcccctccag tcctatgctt ttctttctcc caaattcctc
      241 aaagatggtt tgtctcacgt gttgcggggc gtagaacggc tcgcattcaa ttagaagcga
      301 agctcgcggg cgctggcggg acgggcgcgt gaggcaacag atgccagaag ctcccttaga
      361 ctgtcacctg agtctggaga ccggctcgca gccccacagc atcacactgc aagtcagaga
      421 gcagcaggag tcacgatggg gccctttgga gccctgtgtt tggcctgggc tttgctagga
      481 gtggtcagag cgtgtcccga gccttgcgcc tgtgttgaca agtacgccca ccagtttgca
      541 gactgtgcct acaaggagct gcgcgaggtc ccagaaggac tgccagccaa cgtgaccacg
      601 cttagtctgt ctgccaacaa gattacggta ctaaggcggg gggccttcgt caacgtcacg
      661 caggtcactt cgctgtggct ggctcacagt gaggtacgca cggtagagtc aggggcattg
      721 gcagtgctga gtcagctcaa gaacctcgac ctaagccaca accttatatc caacttccct
      781 tggagcgacc ttcgtaactt gagcgcgctg cagctgctga aaatgaacca caaccgtctg
      841 ggatcgctgc cccgggatgc actcggcgcg ctcccggacc tgcgctctct gcgcatcaac
      901 aacaaccggc tgcgtaccct ggagcccggc acgttcgacg cactaagcgc gctgtctcac
      961 ctgcaactct atcacaaccc cttccactgc agctgtggtc tcgtgtggct gcaggcctgg
     1021 gcagcgagca cccgggtctc cttaccggag cccgattcta tagcgtgcgc ctcgccccct
     1081 gagctgcagg gcgtgcccgt gcaccgcctg cccgccctgc cctgcgcacc ccccagcgtg
     1141 cgtctgagcg cagagccgcc gcctgaggca cctggcaccc ctctgcgcgc aggcttggct
     1201 ttcatgttac attgcgtcgc cgaaggccac cccacacccc gcctgcaatg gcaacttcag
     1261 atcccgggtg gcactgtagt cttagtgcca ccggttctca gcaaggaaga agatggagga
     1321 gataaggtgg aggatggaga gggtgacgga gatgaggacc tgcctacgca gactgaagcg
     1381 ccaaccccaa ctccagcacc tgcttggcca gcgcctccag ccaccccgcg cttcttggcc
     1441 ctcgcaaatg gctctctgtt ggtgcccctt ctgagtgcca aggaggcagg catctacact
     1501 tgtcgtgcac acaatgagct gggcaccaac tcaacgtcct tacgggtgac ggtggctgca
     1561 gcggggccgc caaaacacgc tcctggaaca ggggaagaac ctgatgcgca ggtcccgacc
     1621 tctgagcgca aggccaccac taagggccgt agcaacagcg tcctgccctt caagcctgaa
     1681 ggcaaaacca aaggccaagg tcttgcccga gtcagcgtgc ttggggaaat cgaggcagag
     1741 ctggaggaga cagatgaagg agagcagatg gaaggtcaga tccctgcaga tccgatggga
     1801 gagaagcact gtggccatgg ggacccctct cgctatgtgt ctaaccatgc attcaaccag
     1861 agctcagatc tcaagccgca cgtttttgag ttgggcgtca tcgcgctgga tgtagcagag
     1921 cgtgaggctc gggtgcagct gacgcctctt gctgcgcgct ggggccctgg gccagatggt
     1981 gctagcggag cgcggcggcc ggggaggcgg ccactgcgcc tactctatct gtgtcctgcg
     2041 gggggtggca cggcagttca gtggtcacga gtggaagagg gggtcaatgc ctactggttt
     2101 cgcggcctgc ggcctggcac caactactcc gtatgcctgg cactggcggg cgaggcgtgt
     2161 cacgtgcagg tggtgttttc taccaagaaa gaactgccgt ccctgctggt tatcgtgacc
     2221 gtgagtgttt ttctcctggt gctggccacc gtgcccctgc tgggtgccgc ctgctgccat
     2281 ctgctggcca aacatccggg caaaccctac cgtttaatcc tgaggccaca ggccccggac
     2341 cctatggaga aacgcatcgc ggccgatttc gatccgcgtg cttcctacct tgagtctgag
     2401 aaaagctacc ctgctcgtgg cgaggcggga ggtgaggagc cagaggaggt cccggaggaa
     2461 ggcctggatg aagatgtgga gcagggggac ccaagcgggg accttcagag agaggaaagc
     2521 ctggcgggtt gctcattggt ggagtctcag tccaaggcca accaagagga gttcgaggct
     2581 ggctcggagt acagcgatcg gctgcccctg ggagcggaag cagtcaacat cgcccaggaa
     2641 ataaacggca actacaggca gacagcgggc tgagccccca gcacgcctgg cctgcccacc
     2701 tccaccttgg gtacctcgta gcctagggac ggcaggactt taacaccctc gcgggactcc
     2761 gccctacccc ccaagccttc agttactctg cctccttagc cctccccagg ggtcactact
     2821 agggatttct aggagtgggc cgaattcagg ggtcattctt ttggtgggct tgaatcccca
     2881 tccccaccca aagcacagag tcaggctcct acctcctcta agacaccacc catgggcggc
     2941 gagaaaccgt ctatgccttc catttcatca cggcgatcca cgaaacccat cgcgcacccc
     3001 atctggtgga acttggagac aaggggagag cgccacgcca gtcgttgacc acatttggtg
     3061 ataataatag ggttggtcca gcgtttgcct gggatcccca ggacaggtcc ccagcgtgga
     3121 gcgctgtgac tctcactttg atcccactct gccttttcaa ggatgcatgt gccagaagcc
     3181 cgctaatttt tattctcacc gctcctttcc tataatgatc caaatccgcg cgtcccccct
     3241 ccccattcct accccacccc atttctgtct agttggagcc aaactggggt cctggtaggc
     3301 ctttcaactc agcgcactga ttttcttatt ttcgttgttt taaaaagcag cgacatttct
     3361 gggtctggtg ctaatacccc cttcccacct tctgggaaat tgggtgtgag tgtgtcaggt
     3421 gtgagtgtcg gaatctcttt gcttccggct ctctcctaat ttcaagcgct ccggaactgc
     3481 gcgccctttt cctcgcaggg tgcggccttg gttcccgggc cagtttcgtc gtcaatgtct
     3541 tgcagatgcc agaggctggt gcgtgccaca gtgactcttg ctactccatg gggttcagac
     3601 cccagcagga acgtgctggt gggtacaggg agctgtgact cccgggcgca tctcacgaat
     3661 gggcctgcct caggcctgac cgaggcagca ggggggttgc gaagcccggg agggacaccc
     3721 tagttcccca cgtctcccct caccccagga atatagagtt tgctcagcgt gtagtccccg
     3781 ccgagcgtgg gctatagact tctgtgtccg taaagtgtgc cggtgtagtg tagcggagct
     3841 gggggtgggg gatggggagc gggtgggcag gtggacgagg aaggagggag ggagagggcg
     3901 ggagtggcga ggggactcgg gtggggtttt agttctttta ggaaaaggtc agggggtggg
     3961 gtttcaggcg tctggaccaa ggctctggct ctggctctgg gcgaagtgca gcacaaacgt
     4021 gggtgacccg gggaggagtt gaccccggag cccatgtcct tttctaaatg cttctgtatg
     4081 taaactgtca ataaaataat cgatttgaac aggaaaaaaa aaaaaaaaa
//
