LOCUS       NM_001195431            2111 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus immunoglobulin superfamily containing leucine-rich
            repeat (Islr), transcript variant 2, mRNA.
ACCESSION   NM_001195431
VERSION     NM_001195431.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2111)
  AUTHORS   Liu,F., Cao,Y., Wang,X., Zhang,K., Li,N., Su,Y., Zhang,Y. and
            Meng,Q.
  TITLE     Islr regulates satellite cells asymmetric division through the
            SPARC/p-ERK1/2 signaling pathway
  JOURNAL   FASEB J 38 (7), e23534 (2024)
   PUBMED   38597911
  REMARK    GeneRIF: Islr regulates satellite cells asymmetric division through
            the SPARC/p-ERK1/2 signaling pathway.
REFERENCE   2  (bases 1 to 2111)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2111)
  AUTHORS   Ando,R., Shiraki,Y., Miyai,Y., Shimizu,H., Furuhashi,K.,
            Minatoguchi,S., Kato,K., Kato,A., Iida,T., Mizutani,Y., Ito,K.,
            Asai,N., Mii,S., Esaki,N., Takahashi,M. and Enomoto,A.
  TITLE     Meflin is a marker of pancreatic stellate cells involved in
            fibrosis and epithelial regeneration in the pancreas
  JOURNAL   J Pathol 262 (1), 61-75 (2024)
   PUBMED   37796386
  REMARK    GeneRIF: Meflin is a marker of pancreatic stellate cells involved
            in fibrosis and epithelial regeneration in the pancreas.
REFERENCE   4  (bases 1 to 2111)
  AUTHORS   Zhang,Y., Lan,M., Liu,C., Wang,T., Liu,C., Wu,S. and Meng,Q.
  TITLE     Islr regulates insulin sensitivity by interacting with Psma4 to
            control insulin receptor alpha levels in obese mice
  JOURNAL   Int J Biochem Cell Biol 159, 106420 (2023)
   PUBMED   37116777
  REMARK    GeneRIF: Islr regulates insulin sensitivity by interacting with
            Psma4 to control insulin receptor alpha levels in obese mice.
REFERENCE   5  (bases 1 to 2111)
  AUTHORS   Liu,C., Liu,J., Wang,T., Su,Y., Li,L., Lan,M., Yu,Y., Liu,F.,
            Xiong,L., Wang,K., Chen,M., Li,N., Xu,Q., Hu,Y., Jia,Y. and Meng,Q.
  TITLE     Immunoglobulin Superfamily Containing Leucine-Rich Repeat (Islr)
            Participates in IL-6-Mediated Crosstalk between Muscle and Brown
            Adipose Tissue to Regulate Energy Homeostasis
  JOURNAL   Int J Mol Sci 23 (17), 10008 (2022)
   PUBMED   36077405
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2111)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   7  (bases 1 to 2111)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   8  (bases 1 to 2111)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   9  (bases 1 to 2111)
  AUTHORS   Fenske,T.S., McMahon,C., Edwin,D., Jarvis,J.C., Cheverud,J.M.,
            Minn,M., Mathews,V., Bogue,M.A., Province,M.A., McLeod,H.L. and
            Graubert,T.A.
  TITLE     Identification of candidate alkylator-induced cancer susceptibility
            genes by whole genome scanning in mice
  JOURNAL   Cancer Res 66 (10), 5029-5038 (2006)
   PUBMED   16707424
REFERENCE   10 (bases 1 to 2111)
  AUTHORS   Nagasawa,A., Kudoh,J., Noda,S., Mashima,Y., Wright,A., Oguchi,Y.
            and Shimizu,N.
  TITLE     Human and mouse ISLR (immunoglobulin superfamily containing
            leucine-rich repeat) genes: genomic structure and tissue expression
  JOURNAL   Genomics 61 (1), 37-43 (1999)
   PUBMED   10512678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160976.2, AC158996.2 and AI838480.1.
            
            Transcript Variant: This variant (2) uses a different segment for
            its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024538.1, SRR7345562.964301.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC160976.2         174966-175093
            129-390             AC160976.2         175290-175551
            391-2086            AC158996.2         1-1696
            2087-2111           AI838480.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..2111
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /note="immunoglobulin superfamily containing leucine-rich
                     repeat"
                     /db_xref="GeneID:26968"
                     /db_xref="MGI:MGI:1349645"
     exon            1..128
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /inference="alignment:Splign:2.1.0"
     exon            129..2095
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1423
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /note="immunoglobulin superfamily containing leucine-rich
                     repeat protein; mesenchymal stromal cell- and
                     fibroblast-expressing Linx paralogue"
                     /codon_start=1
                     /product="immunoglobulin superfamily containing
                     leucine-rich repeat protein precursor"
                     /protein_id="NP_001182360.1"
                     /db_xref="CCDS:CCDS23237.1"
                     /db_xref="GeneID:26968"
                     /db_xref="MGI:MGI:1349645"
                     /translation="MRALCLLCWAVLLNLVRACPEPCDCGEKYGFQIADCAYRDLEGV
                     PPGFPANVTTLSLSANRLPGLPEGAFREVPLLQSLWLAHNEIRSVAIGALAPLSHLKS
                     LDLSHNLLSEFAWSDLHNLSALQLLKMDSNELAFIPRDAFSSLSALRSLQLNHNRLHA
                     LAEGTFAPLTALSHLQINDNPFDCTCGIVWFKTWALASAVSIPEQDNIACTTPHVLKG
                     IPLGRLPPLPCSAPSVQLSYQPSQDGAELRPGFVLALHCDVDGQPVPQLHWHIHTPGG
                     TVEIASPNVGTDGRALPGALATSGQPRFQAFANGSLLIPDFGKLEEGTYSCLATNELG
                     SAESSVNVALATPGEGGEDAVGHKFHGKAVEGKGCYTVDNEVQPSGPEDNVVIIYLSR
                     AGPPEAAIAADGRPAQQFSGILLLGQSLLVLSFFYF"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /note="hexamer: AATAAA"
     polyA_site      2070
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /note="major polyA site"
     regulatory      2073..2078
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Islr"
                     /gene_synonym="Meflin"
                     /note="hexamer: AATAAA"
     polyA_site      2086
                     /gene="Islr"
                     /gene_synonym="Meflin"
     polyA_site      2095
                     /gene="Islr"
                     /gene_synonym="Meflin"
ORIGIN      
        1 tggaaaacag atttcaagtc ataaagtcag ctaggaacag gccaaggcag aaagagctgt
       61 gtgcaaagga gaagctgggg tccacttcca tcttgtcttc atcctgactg actgcacaca
      121 cgaccttgga cgtaccatgc gggcactgtg cctgctttgt tgggctgttc tcctgaacct
      181 ggtgcgagct tgtccagagc cctgtgactg tggggagaag tatggcttcc agattgcaga
      241 ctgtgcctat cgtgacctag agggtgtgcc accgggcttc ccggccaatg tgaccacact
      301 gagcctgtca gccaacaggc tgccaggcct gccggaggga gccttcaggg aagtgcccct
      361 attgcagtcg ctgtggctgg cacacaatga gatccgctcg gtggctattg gtgctctggc
      421 ccctctgagc catctcaaga gtctggacct cagccacaac ctcctctctg agtttgcctg
      481 gagcgacctg cacaacctca gcgctctgca gctgctcaag atggacagca acgagttagc
      541 cttcatccct cgggacgcct ttagcagcct cagcgccctg cgttccctgc agctcaacca
      601 caaccgcctg cacgcgttgg ccgagggcac cttcgcaccg ctcaccgcgc tgtcccactt
      661 gcagatcaat gacaaccctt tcgactgcac ctgtggcatc gtgtggttca agacatgggc
      721 cctggcctca gcggtgtcta ttccagaaca ggacaacatt gcctgtacta caccccacgt
      781 cctgaagggt atcccactag gccgcctgcc acccctgccc tgctcagctc cctcagtgca
      841 actaagctac cagcccagcc aagatggagc agagctacgg cctggcttcg tgctggcact
      901 ccactgtgac gtggatggac agccagtccc ccagctccat tggcacattc acaccccggg
      961 cggcacggtg gagatcgcca gtcctaatgt aggcactgat ggacgtgccc tgcctggtgc
     1021 ccttgcaacc agtgggcagc cacgcttcca ggcctttgcc aatggcagcc tgcttatccc
     1081 tgactttggc aagctggagg agggcaccta tagctgcctg gccaccaatg agctaggcag
     1141 tgccgaaagc tctgtaaatg tggcattggc caccccaggt gaggggggag aggatgctgt
     1201 ggggcacaag ttccatggca aagcagtgga gggcaagggc tgctatacgg ttgacaacga
     1261 ggtacagcca tccggaccgg aagacaacgt ggttatcatt tacctcagcc gtgctgggcc
     1321 cccagaagct gcaatagcag cagacgggag gcctgcgcag cagttctctg gcatacttct
     1381 gctaggccaa agcctgcttg ttctctcctt tttctacttc taactacacc ctgccctggt
     1441 tggctagagc agctccaggg ccttcctaac tccccctgat cacgttcctg ccaatgttcc
     1501 gtcttaacac cacgaggtct ggaattggtg aggcctgagg ttagcctggg gacttcacat
     1561 tttcctatca ccttttctaa gctcatccag gccgctcatt actccaattt gcagatctgc
     1621 tcagaactag cagctaggat agaactatat cccaaaactc atcatctcta gtgctagttg
     1681 ctgctaacag cattgcctgt gctcctagca ggggcagcct gctaacaggg caacaacaat
     1741 gtcttaacct gacctacttt gagagttcta gccatggagg taaagagctt gtggaggcca
     1801 tccaggtggg cactggggct gggctagaag ggggtctgga gtggccagta caggatctgg
     1861 aaaggaggta ccacgggcca tggctgggca ggctaaaagc tttcctgttt ttagatgctc
     1921 tctgatgaga tatggaaatc atccctcact gggcctttct ctcctctcac cccaagcccc
     1981 acagcatgtg cctgcctctt gagacactta ctccccctcc tcctctgaag aggctagcca
     2041 gtctgggtag cagaaaaata aataaataaa taaataaata aataaacaaa cagcaaaaaa
     2101 aaaaaaaaaa a
//
