LOCUS       NM_027397               1868 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus insulin related protein 2 (islet 2) (Isl2), mRNA.
ACCESSION   NM_027397
VERSION     NM_027397.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   Nord,C., Jones,I., Garcia-Maestre,M., Hagglund,A.C. and Carlsson,L.
  TITLE     Reduced mTORC1-signaling in progenitor cells leads to retinal
            lamination deficits
  JOURNAL   Dev Dyn 253 (10), 922-939 (2024)
   PUBMED   38546215
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1868)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1868)
  AUTHORS   Mehta,K., Daghsni,M., Raeisossadati,R., Xu,Z., Davis,E.,
            Naidich,A., Wang,B., Tao,S., Pi,S., Chen,W., Kostka,D., Liu,S.,
            Gross,J.M., Kuwajima,T. and Aldiri,I.
  TITLE     A cis-regulatory module underlies retinal ganglion cell genesis and
            axonogenesis
  JOURNAL   Cell Rep 43 (6), 114291 (2024)
   PUBMED   38823017
REFERENCE   5  (bases 1 to 1868)
  AUTHORS   Engelhardt,D., Marean,A., McKean,D., Petersen,J. and Niswander,L.
  TITLE     RSG1 is required for cilia-dependent neural tube closure
  JOURNAL   Genesis 62 (3), e23602 (2024)
   PUBMED   38721990
REFERENCE   6  (bases 1 to 1868)
  AUTHORS   Ozaki,S. and Snider,W.D.
  TITLE     Initial trajectories of sensory axons toward laminar targets in the
            developing mouse spinal cord
  JOURNAL   J Comp Neurol 380 (2), 215-229 (1997)
   PUBMED   9100133
REFERENCE   7  (bases 1 to 1868)
  AUTHORS   Ahlgren,U., Pfaff,S.L., Jessell,T.M., Edlund,T. and Edlund,H.
  TITLE     Independent requirement for ISL1 in formation of pancreatic
            mesenchyme and islet cells
  JOURNAL   Nature 385 (6613), 257-260 (1997)
   PUBMED   9000074
REFERENCE   8  (bases 1 to 1868)
  AUTHORS   Tremblay,P., Pituello,F. and Gruss,P.
  TITLE     Inhibition of floor plate differentiation by Pax3: evidence from
            ectopic expression in transgenic mice
  JOURNAL   Development 122 (8), 2555-2567 (1996)
   PUBMED   8756299
REFERENCE   9  (bases 1 to 1868)
  AUTHORS   Keller-Peck,C.R. and Mullen,R.J.
  TITLE     Patterns of neuronal differentiation in neural tube mutant mice:
            curly tail and Pax3 splotch-delayed
  JOURNAL   J Comp Neurol 368 (4), 516-526 (1996)
   PUBMED   8744440
REFERENCE   10 (bases 1 to 1868)
  AUTHORS   Pfaff,S.L., Mendelsohn,M., Stewart,C.L., Edlund,T. and Jessell,T.M.
  TITLE     Requirement for LIM homeobox gene Isl1 in motor neuron generation
            reveals a motor neuron-dependent step in interneuron
            differentiation
  JOURNAL   Cell 84 (2), 309-320 (1996)
   PUBMED   8565076
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116699.9, AK013964.1, BC120880.2 and BE953935.1.
            
            On Jul 28, 2007 this sequence version replaced NM_027397.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013964.1, SRR7345562.3640446.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC116699.9         177548-177605
            59-601              AK013964.1         2-544
            602-603             AC116699.9         179017-179018
            604-683             AK013964.1         547-626
            684-1778            BC120880.2         364-1458
            1779-1868           BE953935.1         1-90                c
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.13 cM"
     gene            1..1868
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /note="insulin related protein 2 (islet 2)"
                     /db_xref="GeneID:104360"
                     /db_xref="MGI:MGI:109156"
     exon            1..190
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1212
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /note="islet 2"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-2"
                     /protein_id="NP_081673.2"
                     /db_xref="CCDS:CCDS23205.1"
                     /db_xref="GeneID:104360"
                     /db_xref="MGI:MGI:109156"
                     /translation="MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSP
                     DLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAQCQVGFSSSDLV
                     MRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGP
                     LPGARGLHLPDAGSGRQPSLRTHVHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDA
                     LMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKASLQGLTGTPLV
                     AGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSS
                     GSDVTSLSSQLPDTPNSMVPSPVET"
     exon            191..380
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            381..643
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            644..927
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1095
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1851
                     /gene="Isl2"
                     /gene_synonym="3110001N10Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcgtgcggg ccggtgcgga atcgctcctt caactccgcg gggcaggagt tagttagcaa
       61 agagcagagg ctgggcgctc gaccctggtc cttctgtccc cggccgcaag ctttgctcac
      121 atctctctct gcatggtgga tattattttt cattatcctt ttctgggtgc tatgggggat
      181 cattccaaga agaagcccgg gacggccatg tgcgtgggct gcgggagtca gatccacgac
      241 cagtttatcc ttcgcgtgtc gcccgacctc gagtggcacg ccgcctgcct caagtgcgcg
      301 gagtgcagcc agtacctgga cgagacgtgc acgtgcttcg tgagagacgg gaaaacctac
      361 tgcaagcggg actacgtcag gctgttcggc atcaagtgtg cccagtgcca ggtgggcttc
      421 agcagcagtg acctggtgat gcgggcgcgg gacagcgtgt accacatcga gtgcttccgc
      481 tgctccgtgt gcagccgcca gctgctccct ggagacgagt tctcgctgcg ggagcatgag
      541 ctgctctgcc gagctgacca cggcctcctg ctggagcgcg ctgcggctgg cagcccgcgc
      601 agccccggcc cgctccccgg cgcccgcggc ctgcatctgc cagacgctgg gtccggacga
      661 cagccctcac tgcgcacgca cgtgcacaag caggcggaga agacaacccg ggtacggact
      721 gtgctcaacg agaagcaact gcataccctg cggacgtgct acgccgccaa tccgcggcca
      781 gacgcgctca tgaaagagca gctagtagag atgaccggct tgagcccgcg ggtcatccgc
      841 gtgtggtttc agaacaagcg ttgcaaggac aagaagaagt ccattctcat gaagcagcta
      901 cagcagcagc aacacagtga caaggcgagc ctccagggac tgactgggac gcctctggtg
      961 gcaggcagcc ccatccgcca tgagaacgcg gtgcagggca gcgcagtcga ggtgcagacg
     1021 taccagccgc cctggaaagc actcagcgag tttgcactcc agagcgacct ggaccaaccc
     1081 gcctttcaac agctggtttc cttctccgag tcaggctccc taggcaactc ttccggtagc
     1141 gacgtgacct ctctgtcctc gcagctcccg gacaccccca acagtatggt acctagtccg
     1201 gtggagacgt gagcgaggac ccctccctgc cagcccgcgg acctcgcatg ctccctgcat
     1261 gagacgcacc catgctcagg ccattccagc tctgaaaaat ctccggccct tgtaattatt
     1321 gttgttattt aaagcgagcg ggcagaggca cgcgaccgcg acgggacggc cagcagcgct
     1381 ggggcgcagc ctgcaccgct gagactggag actccggctc caaggacttt tttttttctt
     1441 tctcataact agaatttggg acattctggg ttagctccgc cctcgcctct ccctcgctgc
     1501 gtggggaact gtcactgtct ctctgcgcct tgctcgcccg ggaacccatc tgatggggtc
     1561 ctacagggcc ctaccggtga ggacgcctgc tccgaactcg cctgcgctga cccgaggctt
     1621 tgttctggac ctggcagcga ggacggaaca attccaagaa acagacataa cccccaaagc
     1681 gcatgactgc cggacagagt agaaaccaga ctgtctttta aaaagtgttt taaattatca
     1741 gtcgacggag gacagtgaga gcctttgccg aacaaacgta agttattgtt atttattgtg
     1801 aggcgaatag tgggacgaat attttgatct taataaaaca caacccgatg caaaaaaaaa
     1861 aaaaaaaa
//
