LOCUS       NM_021459               2526 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus ISL1 transcription factor, LIM/homeodomain (Isl1),
            mRNA.
ACCESSION   NM_021459 XM_354773
VERSION     NM_021459.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2526)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2526)
  AUTHORS   Zhang,C., Zheng,Y., Qu,Y., Huang,R., Huang,H., Li,J., Qiu,M. and
            Li,F.
  TITLE     Transcriptional factor ISL1 regulates palate development by tuning
            the SHH cascade
  JOURNAL   FEBS J 292 (4), 851-863 (2025)
   PUBMED   39704783
REFERENCE   3  (bases 1 to 2526)
  AUTHORS   Amato,C.M., Xu,X. and Yao,H.H.
  TITLE     An extragenital cell population contributes to urethra closure
            during mouse penis development
  JOURNAL   Sci Adv 10 (49), eadp0673 (2024)
   PUBMED   39642224
REFERENCE   4  (bases 1 to 2526)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2526)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   6  (bases 1 to 2526)
  AUTHORS   Gunther,T., Struwe,M., Aguzzi,A. and Schughart,K.
  TITLE     Open brain, a new mouse mutant with severe neural tube defects,
            shows altered gene expression patterns in the developing spinal
            cord
  JOURNAL   Development 120 (11), 3119-3130 (1994)
   PUBMED   7720556
REFERENCE   7  (bases 1 to 2526)
  AUTHORS   Weinstein,D.C., Ruiz i Altaba,A., Chen,W.S., Hoodless,P.,
            Prezioso,V.R., Jessell,T.M. and Darnell,J.E. Jr.
  TITLE     The winged-helix transcription factor HNF-3 beta is required for
            notochord development in the mouse embryo
  JOURNAL   Cell 78 (4), 575-588 (1994)
   PUBMED   8069910
REFERENCE   8  (bases 1 to 2526)
  AUTHORS   Dickinson,M.E., Krumlauf,R. and McMahon,A.P.
  TITLE     Evidence for a mitogenic effect of Wnt-1 in the developing
            mammalian central nervous system
  JOURNAL   Development 120 (6), 1453-1471 (1994)
   PUBMED   8050356
REFERENCE   9  (bases 1 to 2526)
  AUTHORS   Thor,S., Ericson,J., Brannstrom,T. and Edlund,T.
  TITLE     The homeodomain LIM protein Isl-1 is expressed in subsets of
            neurons and endocrine cells in the adult rat
  JOURNAL   Neuron 7 (6), 881-889 (1991)
   PUBMED   1764243
REFERENCE   10 (bases 1 to 2526)
  AUTHORS   Karlsson,O., Thor,S., Norberg,T., Ohlsson,H. and Edlund,T.
  TITLE     Insulin gene enhancer binding protein Isl-1 is a member of a novel
            class of proteins containing both a homeo- and a Cys-His domain
  JOURNAL   Nature 344 (6269), 879-882 (1990)
   PUBMED   1691825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC170086.2, AK090263.1 and CF725499.1.
            
            On Dec 11, 2007 this sequence version replaced NM_021459.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090263.1, BC132263.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC170086.2         100848-100850
            4-442               AK090263.1         5-443
            443-863             CF725499.1         78-498
            864-1506            AK090263.1         865-1507
            1507-2526           AC170086.2         111247-112266
FEATURES             Location/Qualifiers
     source          1..2526
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 64.87 cM"
     gene            1..2526
                     /gene="Isl1"
                     /note="ISL1 transcription factor, LIM/homeodomain"
                     /db_xref="GeneID:16392"
                     /db_xref="MGI:MGI:101791"
     exon            1..294
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1316
                     /gene="Isl1"
                     /note="Lim-homeodomain protein Islet1; islet-1; insulin
                     related protein; Islet 1"
                     /codon_start=1
                     /product="insulin gene enhancer protein ISL-1"
                     /protein_id="NP_067434.3"
                     /db_xref="CCDS:CCDS26790.1"
                     /db_xref="GeneID:16392"
                     /db_xref="MGI:MGI:101791"
                     /translation="MGDMGDPPKKKRLISLCVGCGNQIHDQYILRVSPDLEWHAACLK
                     CAECNQYLDESCTCFVRDGKTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHI
                     ECFRCVACSRQLIPGDEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAA
                     EPISARQPALRPHVHKQPEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMT
                     GLSPRVIRVWFQNKRCKDKKRSIMMKQLQQQQPNDKTNIQGMTGTPMVAASPERHDGG
                     LQANPVEVQSYQPPWKVLSDFALQSDIDQPAFQQLVNFSEGGPGSNSTGSEVASMSSQ
                     LPDTPNSMVASPIEA"
     exon            295..484
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..744
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1031
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1199
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..2526
                     /gene="Isl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2226..2231
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Isl1"
                     /note="hexamer: AATAAA"
     polyA_site      2245
                     /gene="Isl1"
                     /note="major polyA site"
     regulatory      2492..2497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Isl1"
                     /note="hexamer: AATAAA"
     polyA_site      2522
                     /gene="Isl1"
                     /note="major polyA site"
ORIGIN      
        1 tttgagtaag agataaggaa gagaggtgcc ccgagccgtg cgagtccgcc gctgctgctg
       61 cgcctccgct ctgccaactc cgccggctta aatcggactc ccagatctgc gagggcgcgg
      121 cgcagccggg cagctgtttc ccccagtttt ggcaaccccg ggggccacta tttgccacct
      181 agccacagca ccagcatcct ctctgtgggc tattcaccaa ttgtccaacc accatttcac
      241 tgtggacatt actccctctt acagatatgg gagacatggg cgatccacca aaaaaaaaac
      301 gtctgatttc cctgtgtgtt ggttgcggca atcaaattca cgaccagtat attctgaggg
      361 tttctccgga tttggagtgg catgcagcat gtttgaaatg tgcggagtgt aatcagtatt
      421 tggacgaaag ctgtacgtgc tttgttaggg atgggaaaac ctactgtaaa agagattata
      481 tcaggttgta cgggatcaaa tgcgccaagt gcagcatagg cttcagcaag aacgacttcg
      541 tgatgcgtgc ccgctctaag gtgtaccaca tcgagtgttt ccgctgtgta gcctgcagcc
      601 gacagctcat cccgggagac gaattcgccc tgcgggagga tgggcttttc tgccgtgcag
      661 accacgatgt ggtggagaga gccagcctgg gagctggaga ccctctcagt cccttgcatc
      721 cagcgcggcc tctgcaaatg gcagccgaac ccatctcggc taggcagcca gctctgcggc
      781 cgcacgtcca caagcagccg gagaagacca cccgagtgcg gactgtgctc aacgagaagc
      841 agctgcacac cttgcggacc tgctatgccg ccaaccctcg gccagatgcg ctcatgaagg
      901 agcaactagt ggagatgacg ggcctcagtc ccagagtcat ccgagtgtgg tttcaaaaca
      961 agcggtgcaa ggacaagaaa cgcagcatca tgatgaagca gctccagcag cagcaaccca
     1021 acgacaaaac taatatccag gggatgacag gaactcccat ggtggctgct agtccggaga
     1081 gacatgatgg tggtttacag gctaacccag tagaggtgca aagttaccag ccgccctgga
     1141 aagtactgag tgacttcgcc ttgcaaagcg acatagatca gcctgctttt cagcaactgg
     1201 tcaatttttc agaaggagga ccaggctcta attctactgg cagtgaagta gcatcgatgt
     1261 cctcgcagct cccagataca cccaacagca tggtagccag tcctattgag gcatgaggaa
     1321 cattcattca gatgttttgt tttgttttgt tttgtttttt tcccctgttg gagaaagtgg
     1381 gaaatgacgt tgaactccga aataaaaagt atttaacgac ccagtcaatg gaaactgaat
     1441 caagaaatga acgctccagg aagcgcatga agtctgttct aatgacaaag tgatatggta
     1501 gcaacactgt gaagacaatc atgggatttt actagaataa aaacaaacaa acaaacaaaa
     1561 ccctaagccc aacatatgct attcaatgac cttaggagta cttaaaaaag aaaaagaaaa
     1621 aaaaaagaga gagagaccgt ttttaaaacg tagaggattt atattcaagg atctcaaaaa
     1681 atgcgcgttt tcatttcact gcacatctag aggaagagca gaaacagaga atttcctagt
     1741 ccatcctatt ctgaatggtg ctgtttctat attggtcact gccttgccaa acaggagctc
     1801 cggcacagag cggaagaaac cagcctcagt gacttgaaag tgtcctttca ggaaggcgga
     1861 gctgcgttgg tttgcaatgt ttttagttga ctttgacaag gggttacgtg aaattctggg
     1921 tctcttaagc atgccctgta gctggtttct cttttacgtt tgcctctcct cccatccttt
     1981 tctttccttt tctttatttc tctttacaat ttttttgaga tccatcctct atcaagaagt
     2041 ctgaagcgac tttaaaggtt tttaaatttg tatttaaaaa ccaacttata aagcattgca
     2101 acaaggttac ctctattttg ccacaagcgt ctcgggattg tgtttgactc ctgtctgtcc
     2161 aagaactttt cccccaaaga tgtgtatagt tattggttaa aatgactgtt ttcgctcttt
     2221 ctggaaataa agaggaaaaa ggaaactttt tttgtttgct cttgcattgc aaaaattata
     2281 aaagtaattt attatttatt gtcaggagac ttgccacttt tcatgtcatt tgactttttt
     2341 tttgtttgct gaagtaaaaa gaagataaag gttgtaccgt ggtctttgaa ttatatgtct
     2401 aagtttatgt gttttgtctt ttttttttct ttaaatatta tgtgaaatca aagcgccata
     2461 tgtagaatta tatcttcagg actatttcac taataaacgt ttggcataga taattaaata
     2521 aacgca
//
