LOCUS       NM_020583               1098 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus interferon-stimulated protein (Isg20), transcript
            variant 1, mRNA.
ACCESSION   NM_020583
VERSION     NM_020583.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Jia,M., Li,L., Chen,R., Du,J., Qiao,Z., Zhou,D., Liu,M., Wang,X.,
            Wu,J., Xie,Y., Sun,Y., Zhang,Y., Wang,Z., Zhang,T., Hu,H., Sun,J.,
            Tang,W. and Yi,F.
  TITLE     Targeting RNA oxidation by ISG20-mediated degradation is a
            potential therapeutic strategy for acute kidney injury
  JOURNAL   Mol Ther 31 (10), 3034-3051 (2023)
   PUBMED   37452495
  REMARK    GeneRIF: Targeting RNA oxidation by ISG20-mediated degradation is a
            potential therapeutic strategy for acute kidney injury.
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Weiss,C.M., Trobaugh,D.W., Sun,C., Lucas,T.M., Diamond,M.S.,
            Ryman,K.D. and Klimstra,W.B.
  TITLE     The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity
            through Upregulation of Type I Interferon Response Proteins
  JOURNAL   mSphere 3 (5), e00209-18 (2018)
   PUBMED   30232164
  REMARK    GeneRIF: ISG20 upregulated IFIT1 genes and inhibited translation of
            the alphavirus genome. Furthermore, IFIT1-sensitive alphavirus
            replication was increased in Isg20(-/-) mice compared to the
            replication of wild-type viruses but not in cells ectopically
            expressing ISG20.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Lin,Y., Wang,H., Wang,W., Zeng,S., Zhong,Y. and Li,D.J.
  TITLE     Prevention of embryo loss in non-obese diabetic mice using adoptive
            ITGA2(+)ISG20(+) natural killer-cell transfer
  JOURNAL   Reproduction 137 (6), 943-955 (2009)
   PUBMED   19321657
  REMARK    GeneRIF: Suggest that the recruitment of peripheral
            CXCR4-expressing ITGA2(+)ISG20(+) NK cells into pregnant uteri may
            be important in the regulation of feto-maternal tolerance.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY087214.1, W97502.1, AK136756.1, AK008353.1 and AW122677.1.
            
            On Jan 16, 2008 this sequence version replaced NM_020583.4.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and uses
            an alternate splice junction at the 5' end of the last exon
            compared to variant 4. The resulting isoform (b) has a shorter and
            distinct C-terminus compared to isoform a. Variants 1, 2, and 3 all
            encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136756.1, BC022751.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BY087214.1         2-37
            37-75               W97502.1           1-39
            76-652              AK136756.1         2-578
            653-1036            AK008353.1         465-848
            1037-1098           AW122677.1         1-62                c
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 44.84 cM"
     gene            1..1098
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /note="interferon-stimulated protein"
                     /db_xref="GeneID:57444"
                     /db_xref="MGI:MGI:1928895"
     exon            1..278
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /inference="alignment:Splign:2.1.0"
     exon            279..531
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..849
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /EC_number="3.1.13.1"
                     /note="isoform b is encoded by transcript variant 1;
                     interferon stimulated exonuclease; interferon-stimulated
                     gene 20 kDa protein; promyelocytic leukemia nuclear
                     body-associated protein ISG20"
                     /codon_start=1
                     /product="interferon-stimulated gene 20 kDa protein
                     isoform b"
                     /protein_id="NP_065608.2"
                     /db_xref="CCDS:CCDS21376.1"
                     /db_xref="GeneID:57444"
                     /db_xref="MGI:MGI:1928895"
                     /translation="MAGIPEVVAMDCEMVGLGPQRVSGLARCSIVNIHGAVLYDKYIR
                     PEGEITDYRTQVSGVTPQHMVRATPFGEARLEILQLLKGKLVVGHDLKHDFNALKEDM
                     SKYTIYDTSTDRLLWHEAKLQYYSRVSLRLLCKRLLHKNIQNNWRGHCSVEDARATME
                     LYKISQRLRAQRGLPCPGTSD"
     exon            532..732
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1083
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1059..1064
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /note="hexamer: AATAAA"
     polyA_site      1083
                     /gene="Isg20"
                     /gene_synonym="1600023I01Rik; 2010107M23Rik; 20kDa; DnaQL;
                     HEM45"
                     /note="major polyA site"
ORIGIN      
        1 gaaagggagg agtagggcag ggccagagga gggacagcct gacgcggcca ccagccctga
       61 ctcaacctgc cagccccctt acctggccag ccttgaggag atggaacagc ccaggctaca
      121 aggcctgccc ccactcctca acttcccttg ataatgaacc agaaactgaa actaaaacag
      181 gcaggctccc cgttagagat gagtcacttc ccaaagtgac tgaagtagcc gagaagtgga
      241 aacagagggg cagaagagaa cccagggcac tgagacaggg ctttctgagg gtcgccaagg
      301 agcatggcag gcatcccaga ggtggtggcc atggactgtg agatggtggg gcttgggcct
      361 caaagggtga gtggcctcgc ccgctgcagc attgtgaaca tccatggcgc agtcctgtat
      421 gacaagtaca tccgacccga gggagagatc acggactaca gaacccaagt cagcggggtc
      481 acgcctcagc acatggtgag ggccacgcca tttggtgaag ccaggctaga gatcctgcag
      541 cttctgaaag gcaagctggt ggtgggccat gacctgaagc acgacttcaa tgccctgaag
      601 gaggatatga gcaagtacac catctatgac acgtccacag acaggctgct gtggcatgag
      661 gccaagctgc agtactacag ccgagtgtcc ctgaggctgc tgtgtaagcg cctgctacac
      721 aagaacatcc agaacaactg gcggggccac tgctctgtgg aagatgccag ggccacaatg
      781 gagctctaca aaatctctca gcgactcaga gcccagcgag ggctgccttg ccctgggacg
      841 tcagactgaa cttcatcctc atccagggtt agaagctgcc actcctcaag ttctccatga
      901 atgagacctg tttctaacaa ccactgccac caaccaccgc aatgtgtaaa accaagaaca
      961 ctcccccatt acagcaactc tcttgctttg aggcaaaaac aacaacaaca acaacaacaa
     1021 caacaacagc aaaaccaaaa aaaaaaaaaa actttagtaa taaatggctt tgattttgtc
     1081 taaaaaaaaa aaaaaaaa
//
