LOCUS       NM_022428               3369 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Iroquois homeobox 6 (Irx6), transcript variant 1,
            mRNA.
ACCESSION   NM_022428
VERSION     NM_022428.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3369)
  AUTHORS   Narwidina,A., Miyazaki,A., Iwata,K., Kurogoushi,R., Sugimoto,A.,
            Kudo,Y., Kawarabayashi,K., Yamakawa,Y., Akazawa,Y., Kitamura,T.,
            Nakagawa,H., Yamaguchi-Ueda,K., Hasegawa,T., Yoshizaki,K.,
            Fukumoto,S., Yamamoto,A., Ishimaru,N., Iwasaki,T. and Iwamoto,T.
  TITLE     Iroquois homeobox 3 regulates odontoblast proliferation and
            differentiation mediated by Wnt5a expression
  JOURNAL   Biochem Biophys Res Commun 650, 47-54 (2023)
   PUBMED   36773339
REFERENCE   3  (bases 1 to 3369)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3369)
  AUTHORS   Qu,X., Harmelink,C. and Baldwin,H.S.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3369)
  AUTHORS   Kojima,Y., Koguchi,T., Mizuno,K., Sato,Y., Hoshi,S., Hata,J.,
            Nishio,H., Hashimoto,D., Matsushita,S., Suzuki,K., Miyagawa,S.,
            Hui,C.C., Tanikawa,C., Murakami,Y., Yamada,G., Hayashi,Y. and
            Matsuda,K.
  TITLE     Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk
            Factors for Hypospadias
  JOURNAL   J Urol 201 (2), 386-392 (2019)
   PUBMED   30063927
  REMARK    GeneRIF: In mouse embryos there was no significant upregulation of
            Haao expression in the developing male external genitalia. Irx6 was
            expressed in the ectodermal epithelium, demonstrating prominent
            dorsal ectodermal expression without expression in the ventral
            ectoderm adjacent to the urethral plate during the same period.
REFERENCE   6  (bases 1 to 3369)
  AUTHORS   Mummenhoff,J., Houweling,A.C., Peters,T., Christoffels,V.M. and
            Ruther,U.
  TITLE     Expression of Irx6 during mouse morphogenesis
  JOURNAL   Mech Dev 103 (1-2), 193-195 (2001)
   PUBMED   11335133
REFERENCE   7  (bases 1 to 3369)
  AUTHORS   Erkman,L., Yates,P.A., McLaughlin,T., McEvilly,R.J., Whisenhunt,T.,
            O'Connell,S.M., Krones,A.I., Kirby,M.A., Rapaport,D.H.,
            Bermingham,J.R., O'Leary,D.D. and Rosenfeld,M.G.
  TITLE     A POU domain transcription factor-dependent program regulates axon
            pathfinding in the vertebrate visual system
  JOURNAL   Neuron 28 (3), 779-792 (2000)
   PUBMED   11163266
REFERENCE   8  (bases 1 to 3369)
  AUTHORS   Peters,T., Dildrop,R., Ausmeier,K. and Ruther,U.
  TITLE     Organization of mouse Iroquois homeobox genes in two clusters
            suggests a conserved regulation and function in vertebrate
            development
  JOURNAL   Genome Res 10 (10), 1453-1462 (2000)
   PUBMED   11042145
REFERENCE   9  (bases 1 to 3369)
  AUTHORS   Jorde,L.B.
  TITLE     Linkage disequilibrium and the search for complex disease genes
  JOURNAL   Genome Res 10 (10), 1435-1444 (2000)
   PUBMED   11042143
  REMARK    Review article
REFERENCE   10 (bases 1 to 3369)
  AUTHORS   Branscomb,A., Seger,J. and White,R.L.
  TITLE     Evolution of odorant receptors expressed in mammalian testes
  JOURNAL   Genetics 156 (2), 785-797 (2000)
   PUBMED   11014824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035140.1 and AK053729.1.
            
            On Jul 23, 2014 this sequence version replaced NM_022428.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035140.1, AK053729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AK035140.1         2-114
            114-2493            AK053729.1         2-2381
            2494-3369           AK035140.1         2497-3372
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     gene            1..3369
                     /gene="Irx6"
                     /note="Iroquois homeobox 6"
                     /db_xref="GeneID:64379"
                     /db_xref="MGI:MGI:1927642"
     exon            1..791
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
     exon            792..1040
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1150
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1455
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..2058
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..3369
                     /gene="Irx6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctctcct ccctcgccgc cccgcttgcc tcttgcctcc tcgggggccg caggggagga
       61 ggcgagcacg ctgcaccctg ggcccgcacg gctcgccggg aggcgtattt cccacttctc
      121 ccggggaatt tggagagggt ctgtgtgcgc gcgcgcgcgt gagctgcagg cgaaagaggg
      181 taggatctag cggcgagtcg agggtcaggg tctttgacgt ttctcgcccg ttgcacaaac
      241 ctcgcagagc aagaacgagt gtatccgaga gtgcgtgcat gtacacgggc tggctgccct
      301 tggcacactc ggtggcccgg ggccccgggg cccgcggtcc cctctggcgg ccggggatta
      361 ccgtgacgtc acgttgagcc tctggccacc ttggactggg acacctcggg aacctcacag
      421 cccgacgctg cgctgtacct caccttgccc ctgcgcgcct ttggcaccct actccttctt
      481 cctaattctg ccgccgatcc atgggcccct ctgccttctg gaacccacag gccgtagggg
      541 tgccttacca atcgcagaac tcggcagccc ctctgccttt gattctgcct cccgtctctc
      601 ccctcctgcc aacgaactgg cggccagctc ctgcagccct gtaagaaaac cagacgctgc
      661 gctgcgctgc tggggtcatc gaatcacaga gctgagcaag ggactcgaaa ggaaagaggg
      721 actcaagtcc ctgaagacgc cctgctatgg ccttttcacc ttttggacac ccgtatggca
      781 gcacatccca gtttctggtg tctgcaagtt ccagtgccac ttgctgcgaa acggcccctc
      841 ggccagtgtc agatgtggcc tcagcctcca cctctgcctc tactctttgc tgtacaccct
      901 atgacagtcg gctgctgggc agtgctcggc cagagctggg agctgccttg ggcatctatg
      961 gagcacccta tgcagctgcc cagagttacc ctgggtacct gacctatggc ccagagccac
     1021 ccacactgtg tggcgcactg aatcctcagt atgagttcaa ggatgctgca ggaagctttg
     1081 cccccagcct gacccagcca ggggcctact acccctatga aacaactctg gggcagtatc
     1141 aatacgacag gtatggcgga gtggaattga gcagtgctgg ccgcaggaag aatgccacaa
     1201 gggagagcac cagcgcactg aaggcctggc tccacgagca ccgcaagaac ccgtacccca
     1261 ccaagggcga gaagatcatg ctggccatca tcaccaagat gaccctcacc caggtgtcca
     1321 cctggttcgc caacgcgcgc cggcgcctca agaaggagaa caagatgaca tgggcgccca
     1381 agaacaaggg aggggaggag aggaaagcag acagtggaga agactctctg ggatgcctga
     1441 atggtgacac caaagatgct actgccagcc aggaagcccg ggggctgagg ctgagtgacc
     1501 tggaagacct ggaggaagag gaggaagagg aagaagcaga ggaggaggca gcggtctcag
     1561 cagcacgcag gctggcggat tttcagaaga gcacgcaacc cctgcctgct ccctgcgccg
     1621 ccgcccagga gagatgcttg gagagcagag agtgcggcct ggggctaccc cgtttctctt
     1681 ttactgaggc cccacaatca ggggaagctg acttcatcac agcagagcca ggcggcccca
     1741 cgatgatctt acactaccca agtggccaca aaccccgcat ttggtcctta gctcacactg
     1801 cggcagccag cgctgtcgaa agtgctccct caactccgcc cagggcacaa agtccagagt
     1861 gccacatgat tcccagacag cccagttcta tcaggcgact cctggtaccc agagactccg
     1921 aaggcgaaga ggattctcct gcagccaaag cttttggaaa ctccacgttc accctgcagg
     1981 ggctgccact gaactgtgca ccatacccga ggcggagaga gcctgaagtg cggttccagt
     2041 acccatctgg agcagaagca ggttagtgca atggctgcgg tttgcagaag acttttggaa
     2101 atggctgctt ccggatccac attcatatta agaagtttcc agaccttggc atggactggg
     2161 agctctcact ttgcctgtga caaacacaca gaaccatcct agctgtatct tgcacgcagg
     2221 actggggaca ggccagatga cacacacctc atcagacttg gaggagagaa ggtgggagac
     2281 cttgggggaa agccctgtgt gtgctcacag gatactttga ccaagtctct cttcctccca
     2341 tgaatggagg ccctgagcag catctcctcc tgctcaccca cccctgccca gcccactcac
     2401 tgtgtaactt tcttgctgaa atggtctcca aggactgtct gtgtctcctt cctcttcccc
     2461 ggctctacct tcaaaaataa cttagctgag tccaaggtgt gtagcctatc aatgccagcg
     2521 accctgggag aggtctggtg cagctggagt gggactccgt actgccatga aggcttctgg
     2581 gagtggggtc ttgggctgca gacctcagtt ctgttaatca cagagagaga aatggaggaa
     2641 gtcacccaca atgcccagga cacagggccc cccccccacc ctggaactaa acaagctgaa
     2701 cagcaggatg acatcagaat atttgctgat gatcaacgtt tgttccctgg tggtcctggg
     2761 gctgtaaatg tgtgtgctag ggacccatga gaggaaacct gacagtccct ttggccactg
     2821 cttccctgat acccatccaa gaagtaggca gtttggtggg atgggaagag accatagagg
     2881 gcatattatc tacttaatct taagctccag tctcttccag tacaggccag ccagtgggag
     2941 gtgagcatca gggcggggct ttgccccctt gtccctttgt gattctgtct gaacgggagt
     3001 agggtgagag gtctgaagat tgcccacagg atgcagtatg aggctgcctg agtcttgggt
     3061 tctagctcta gaaaacctca acctcagcca aggagcaaac tcacacctgc ccacctaggc
     3121 aatgagacag gcagaggcct ggagggagtc tgggaagtca tggtggttaa cagggagagt
     3181 tggtatgaat tggagaaagt cactctgaag gcagtctcca gggctggacc actcatctac
     3241 ctgcaggtgg tagaaaggaa gcagcctcac ctagctgatt ttaaggcctt tagaagctgc
     3301 ggagacaaaa ttggaaggac attaaaggaa agatgaaaac aaaacaaaac aataaaacct
     3361 ttggaatgg
//
