LOCUS       NP_071873                439 aa            linear   ROD 30-APR-2024
DEFINITION  iroquois-class homeodomain protein IRX-6 isoform 1 [Mus musculus].
ACCESSION   NP_071873
VERSION     NP_071873.2
DBSOURCE    REFSEQ: accession NM_022428.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 439)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 439)
  AUTHORS   Narwidina,A., Miyazaki,A., Iwata,K., Kurogoushi,R., Sugimoto,A.,
            Kudo,Y., Kawarabayashi,K., Yamakawa,Y., Akazawa,Y., Kitamura,T.,
            Nakagawa,H., Yamaguchi-Ueda,K., Hasegawa,T., Yoshizaki,K.,
            Fukumoto,S., Yamamoto,A., Ishimaru,N., Iwasaki,T. and Iwamoto,T.
  TITLE     Iroquois homeobox 3 regulates odontoblast proliferation and
            differentiation mediated by Wnt5a expression
  JOURNAL   Biochem Biophys Res Commun 650, 47-54 (2023)
   PUBMED   36773339
REFERENCE   3  (residues 1 to 439)
  AUTHORS   Catela,C., Chen,Y., Weng,Y., Wen,K. and Kratsios,P.
  TITLE     Control of spinal motor neuron terminal differentiation through
            sustained Hoxc8 gene activity
  JOURNAL   Elife 11, e70766 (2022)
   PUBMED   35315772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 439)
  AUTHORS   Qu,X., Harmelink,C. and Baldwin,H.S.
  TITLE     Tie2 regulates endocardial sprouting and myocardial trabeculation
  JOURNAL   JCI Insight 5 (13), 96002 (2019)
   PUBMED   31112136
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 439)
  AUTHORS   Kojima,Y., Koguchi,T., Mizuno,K., Sato,Y., Hoshi,S., Hata,J.,
            Nishio,H., Hashimoto,D., Matsushita,S., Suzuki,K., Miyagawa,S.,
            Hui,C.C., Tanikawa,C., Murakami,Y., Yamada,G., Hayashi,Y. and
            Matsuda,K.
  TITLE     Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk
            Factors for Hypospadias
  JOURNAL   J Urol 201 (2), 386-392 (2019)
   PUBMED   30063927
  REMARK    GeneRIF: In mouse embryos there was no significant upregulation of
            Haao expression in the developing male external genitalia. Irx6 was
            expressed in the ectodermal epithelium, demonstrating prominent
            dorsal ectodermal expression without expression in the ventral
            ectoderm adjacent to the urethral plate during the same period.
REFERENCE   6  (residues 1 to 439)
  AUTHORS   Mummenhoff,J., Houweling,A.C., Peters,T., Christoffels,V.M. and
            Ruther,U.
  TITLE     Expression of Irx6 during mouse morphogenesis
  JOURNAL   Mech Dev 103 (1-2), 193-195 (2001)
   PUBMED   11335133
REFERENCE   7  (residues 1 to 439)
  AUTHORS   Erkman,L., Yates,P.A., McLaughlin,T., McEvilly,R.J., Whisenhunt,T.,
            O'Connell,S.M., Krones,A.I., Kirby,M.A., Rapaport,D.H.,
            Bermingham,J.R., O'Leary,D.D. and Rosenfeld,M.G.
  TITLE     A POU domain transcription factor-dependent program regulates axon
            pathfinding in the vertebrate visual system
  JOURNAL   Neuron 28 (3), 779-792 (2000)
   PUBMED   11163266
REFERENCE   8  (residues 1 to 439)
  AUTHORS   Peters,T., Dildrop,R., Ausmeier,K. and Ruther,U.
  TITLE     Organization of mouse Iroquois homeobox genes in two clusters
            suggests a conserved regulation and function in vertebrate
            development
  JOURNAL   Genome Res 10 (10), 1453-1462 (2000)
   PUBMED   11042145
REFERENCE   9  (residues 1 to 439)
  AUTHORS   Jorde,L.B.
  TITLE     Linkage disequilibrium and the search for complex disease genes
  JOURNAL   Genome Res 10 (10), 1435-1444 (2000)
   PUBMED   11042143
  REMARK    Review article
REFERENCE   10 (residues 1 to 439)
  AUTHORS   Branscomb,A., Seger,J. and White,R.L.
  TITLE     Evolution of odorant receptors expressed in mammalian testes
  JOURNAL   Genetics 156 (2), 785-797 (2000)
   PUBMED   11014824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK035140.1 and AK053729.1.
            
            On Jul 1, 2005 this sequence version replaced NP_071873.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035140.1, AK053729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.99 cM"
     Protein         1..439
                     /product="iroquois-class homeodomain protein IRX-6 isoform
                     1"
                     /note="iroquois-class homeodomain protein IRX-6;
                     homeodomain protein IRXB3; iroquois homeobox protein 6;
                     Iroquois related homeobox 6"
                     /calculated_mol_wt=47292
     Region          <142..232
                     /region_name="COG5576"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]"
                     /db_xref="CDD:227863"
     Site            order(146..148,150,170,176,189,191..192,195..196,198..200,
                     202..203)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(146,149,192,195..196,199)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     Region          162..200
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     Region          205..270
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9ER75.2)"
     CDS             1..439
                     /gene="Irx6"
                     /coded_by="NM_022428.3:747..2066"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS40428.1"
                     /db_xref="GeneID:64379"
                     /db_xref="MGI:MGI:1927642"
ORIGIN      
        1 mafspfghpy gstsqflvsa sssatcceta prpvsdvasa stsastlcct pydsrllgsa
       61 rpelgaalgi ygapyaaaqs ypgyltygpe pptlcgalnp qyefkdaags fapsltqpga
      121 yypyettlgq yqydryggve lssagrrkna trestsalka wlhehrknpy ptkgekimla
      181 iitkmtltqv stwfanarrr lkkenkmtwa pknkggeerk adsgedslgc lngdtkdata
      241 sqearglrls dledleeeee eeeaeeeaav saarrladfq kstqplpapc aaaqercles
      301 recglglprf sfteapqsge adfitaepgg ptmilhypsg hkpriwslah taaasavesa
      361 pstppraqsp echmiprqps sirrllvprd segeedspaa kafgnstftl qglplncapy
      421 prrrepevrf qypsgaeag
//
