LOCUS       NM_018826               2421 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus Iroquois homeobox 5 (Irx5), mRNA.
ACCESSION   NM_018826
VERSION     NM_018826.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2421)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   2  (bases 1 to 2421)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   3  (bases 1 to 2421)
  AUTHORS   Jiang,B., Zheng,J., Yao,H., Wang,Y., Song,F. and Huang,C.
  TITLE     IRX5 suppresses osteogenic differentiation of hBMSCs by inhibiting
            protein synthesis
  JOURNAL   J Cell Physiol 239 (6), e31286 (2024)
   PUBMED   38666481
  REMARK    GeneRIF: IRX5 suppresses osteogenic differentiation of hBMSCs by
            inhibiting protein synthesis.
REFERENCE   4  (bases 1 to 2421)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   5  (bases 1 to 2421)
  AUTHORS   Li,Y., Xiao,D., Chen,H., Zheng,X.F.S. and Xiang,M.
  TITLE     Maf1 controls retinal neuron number by both RNA Pol III- and Pol
            II-dependent mechanisms
  JOURNAL   iScience 26 (12), 108544 (2023)
   PUBMED   38089586
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2421)
  AUTHORS   Jorde,L.B.
  TITLE     Linkage disequilibrium and the search for complex disease genes
  JOURNAL   Genome Res 10 (10), 1435-1444 (2000)
   PUBMED   11042143
  REMARK    Review article
REFERENCE   7  (bases 1 to 2421)
  AUTHORS   Christoffels,V.M., Keijser,A.G., Houweling,A.C., Clout,D.E. and
            Moorman,A.F.
  TITLE     Patterning the embryonic heart: identification of five mouse
            Iroquois homeobox genes in the developing heart
  JOURNAL   Dev Biol 224 (2), 263-274 (2000)
   PUBMED   10926765
REFERENCE   8  (bases 1 to 2421)
  AUTHORS   Christoffels,V.M., Habets,P.E., Franco,D., Campione,M., de Jong,F.,
            Lamers,W.H., Bao,Z.Z., Palmer,S., Biben,C., Harvey,R.P. and
            Moorman,A.F.
  TITLE     Chamber formation and morphogenesis in the developing mammalian
            heart
  JOURNAL   Dev Biol 223 (2), 266-278 (2000)
   PUBMED   10882515
  REMARK    Erratum:[Dev Biol 2000 Sep 1;225(1):266]
REFERENCE   9  (bases 1 to 2421)
  AUTHORS   Bosse,A., Stoykova,A., Nieselt-Struwe,K., Chowdhury,K.,
            Copeland,N.G., Jenkins,N.A. and Gruss,P.
  TITLE     Identification of a novel mouse Iroquois homeobox gene, Irx5, and
            chromosomal localisation of all members of the mouse Iroquois gene
            family
  JOURNAL   Dev Dyn 218 (1), 160-174 (2000)
   PUBMED   10822268
REFERENCE   10 (bases 1 to 2421)
  AUTHORS   Cohen,D.R., Cheng,C.W., Cheng,S.H. and Hui,C.C.
  TITLE     Expression of two novel mouse Iroquois homeobox genes during
            neurogenesis
  JOURNAL   Mech Dev 91 (1-2), 317-321 (2000)
   PUBMED   10704856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056994.1.
            
            On Feb 9, 2004 this sequence version replaced NM_018826.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056994.1, AF230074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.93 cM"
     gene            1..2421
                     /gene="Irx5"
                     /note="Iroquois homeobox 5"
                     /db_xref="GeneID:54352"
                     /db_xref="MGI:MGI:1859086"
     exon            1..634
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..1843
                     /gene="Irx5"
                     /note="homeodomain protein IRXB2; iroquois homeobox
                     protein 5; iroquois related homeobox 5"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-5"
                     /protein_id="NP_061296.1"
                     /db_xref="CCDS:CCDS22522.1"
                     /db_xref="GeneID:54352"
                     /db_xref="MGI:MGI:1859086"
                     /translation="MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSA
                     FSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYA
                     APLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVS
                     TWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPESG
                     GAEQKATAGCERLQGPLSPAGKETEGSLSDSDFKESSSEGRHDELPRPPRAGESSPAG
                     PATARLAEDAGPHYPASVPAPGPHPSAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPK
                     LWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPMGGQTLGGSRASPAPAPARSPSAQCP
                     FPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPSPTAGPGSHFNGLNQTVLNR
                     ADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI"
     exon            635..1040
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..2403
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2382..2387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irx5"
                     /note="hexamer: ATTAAA"
     polyA_site      2403
                     /gene="Irx5"
                     /note="major polyA site"
ORIGIN      
        1 agtcccccca ccgactacac cccgggaagg aggagcttcg cgcgcacaca aggcgtcaga
       61 atcctcaatt tccaacttag catcttggca ggacctttgc aaagccaaaa gcagagcccc
      121 ccggtgcaaa gagcgaggga ggggggtggg gggagagaaa gcctagcccg ggcaagcggg
      181 gcgcgcagag gagcgggcgc ggcggtcgca gccagaggcg cgcgggaagc caaccaggag
      241 gcgccgcggg ccggagcccg ggagccgggg ctcgaagagc tgcggcccgg ggcagccaga
      301 agccaggtgc cctctcgctc gccctcgcag ggcgccgccc ggctcgttgg ccgccgcggc
      361 gcggcgcgcc ccatgcccgt gtgtggccat gtcctacccg cagggctact tgtaccagcc
      421 gtccgcctcg ctggcgctct actcgtgccc cgcatacagc accagcgtca tttcggggcc
      481 ccgcacggat gagctcggcc gctcttcttc gggctccgcg ttctcgccct acgctggctc
      541 cactgccttc acggctccct cgcccggcta caactcgcac ctccagtacg gcgccgaccc
      601 cgcggctgcg gccgccgctg ccttctctta cgtgggctct ccctacgacc acactcccgg
      661 tatggcaggt tccttgggat atcaccctta tgcagcacct ctgggctcct atccttatgg
      721 ggaccccgcg taccggaaga atgccactcg ggacgctaca gccactctca aggcctggct
      781 caacgagcac cgcaagaacc cgtaccccac caagggagag aagatcatgc tggccattat
      841 caccaagatg accctcaccc aggtgtccac ctggtttgcc aacgcgcgcc ggcgcctcaa
      901 gaaagagaac aagatgacgt ggacgccacg gaaccgcagc gaggacgagg aggaggagga
      961 gaacatcgat ctggagaaga acgacgagga cgagccacag aagcccgagg acaagggcga
     1021 cctcgagggc cccgaatcag gaggagcaga gcagaaggcg actgcgggct gcgaacggct
     1081 gcaggggccg ctcagccccg ccggcaagga gaccgaaggc agcctcagcg actcggattt
     1141 taaggagtcg tcctccgaag gccgccacga tgagctgccc aggcccccgc gcgcgggcga
     1201 gtcctccccg gctgggcccg caaccgctcg tctggcggaa gacgcgggtc ctcactaccc
     1261 cgcgagtgtg ccggctcccg gcccgcaccc atcagccgga gagctgcccc ccggctcggg
     1321 cggatcctcg gtcatccact cgccaccgcc acctccgcca ccgcctccgg ccgtgctagc
     1381 caagcccaaa ctgtggtctc tggccgagat cgccacatcc tcggacaagg tcaaggacgg
     1441 gggcggaggg agcgagggct ctccatgccc accgtgccca gggcccatgg gcgggcaaac
     1501 gcttggaggc agccgcgcgt ctcctgcccc agcgcccgca cgctcaccct ccgcgcagtg
     1561 tccctttccg ggcgggacgg tgctgtcccg gcctctttat tacacggcgc ccttctatcc
     1621 gggctacacg aactatggct ccttcggaca tcttcacggc cacccagggc cagggccaag
     1681 ccctacagcg ggtcctggct ctcatttcaa tggattaaac cagacggtgt tgaatcgtgc
     1741 ggacgttttg gctaaagacc cgaaaatgtt gcggagccag tctcagctag acctgtgcaa
     1801 agactccccc tatgagttga agaaaggtat gtccgacatt taactctggt gcggtatccc
     1861 cggactttcc taatttatta aaaccatggc cttggcagtt atttttccat caccaagaga
     1921 gagaaagaaa aaagaaataa actacccctc ttattcagaa gtttatagtt tatggagatg
     1981 gatggcataa aaatgtatac atctccacac tcgaaaaaat tgttttagcc aactgaaaag
     2041 aaaaaaaaac ttaaaaggat ttgtattaaa tcttattctg tatatttaat gtagcatttt
     2101 tgtatttaaa ttgataattc agtatctttg aagtaaatta tgaaatcaag acacctgtac
     2161 aggcatttaa tgtttttgta atataaatat atacatttgt gttcccccaa aactgtttca
     2221 tagtttaaaa atacaagttt aatttaattt tttacaccta ttgatttttt tcctgggtat
     2281 gagctaaaat attattacag aaaggaagca ggttatacgc ttagatttaa aaaaaaaagt
     2341 aagagaaact gcagtggtct ttgtaaaatg caaaatattt aattaaagga gattttaaca
     2401 taaaaaaaaa aaaaaaaaaa a
//
