LOCUS       NM_018885               2601 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus Iroquois homeobox 4 (Irx4), mRNA.
ACCESSION   NM_018885
VERSION     NM_018885.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2601)
  AUTHORS   Narwidina A, Miyazaki A, Iwata K, Kurogoushi R, Sugimoto A, Kudo Y,
            Kawarabayashi K, Yamakawa Y, Akazawa Y, Kitamura T, Nakagawa H,
            Yamaguchi-Ueda K, Hasegawa T, Yoshizaki K, Fukumoto S, Yamamoto A,
            Ishimaru N, Iwasaki T and Iwamoto T.
  TITLE     Iroquois homeobox 3 regulates odontoblast proliferation and
            differentiation mediated by Wnt5a expression
  JOURNAL   Biochem Biophys Res Commun 650, 47-54 (2023)
   PUBMED   36773339
REFERENCE   2  (bases 1 to 2601)
  AUTHORS   Cattaneo P, Hayes MGB, Baumgarten N, Hecker D, Peruzzo S, Aslan GS,
            Kunderfranco P, Larcher V, Zhang L, Contu R, Fonseca G, Spinozzi S,
            Chen J, Condorelli G, Dimmeler S, Schulz MH, Heinz S,
            Guimaraes-Camboa N and Evans SM.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2601)
  AUTHORS   de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga
            HT, Schricker A, Del Sol A, Gifford CA and Srivastava D.
  TITLE     Single-cell analysis of cardiogenesis reveals basis for organ-level
            developmental defects
  JOURNAL   Nature 572 (7767), 120-124 (2019)
   PUBMED   31341279
REFERENCE   4  (bases 1 to 2601)
  AUTHORS   Wang Y, Lu P, Wu B, Morrow BE and Zhou B.
  TITLE     NOTCH maintains developmental cardiac gene network through WNT5A
  JOURNAL   J Mol Cell Cardiol 125, 98-105 (2018)
   PUBMED   30347193
REFERENCE   5  (bases 1 to 2601)
  AUTHORS   Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH
            and Mao CA.
  TITLE     Essential roles of mitochondrial biogenesis regulator Nrf1 in
            retinal development and homeostasis
  JOURNAL   Mol Neurodegener 13 (1), 56 (2018)
   PUBMED   30333037
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2601)
  AUTHORS   Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D,
            Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ,
            Conner DA, Rosenthal N, Cepko CL, Seidman CE and Seidman JG.
  TITLE     Cardiomyopathy in Irx4-deficient mice is preceded by abnormal
            ventricular gene expression
  JOURNAL   Mol Cell Biol 21 (5), 1730-1736 (2001)
   PUBMED   11238910
REFERENCE   7  (bases 1 to 2601)
  AUTHORS   Peters T, Dildrop R, Ausmeier K and Ruther U.
  TITLE     Organization of mouse Iroquois homeobox genes in two clusters
            suggests a conserved regulation and function in vertebrate
            development
  JOURNAL   Genome Res 10 (10), 1453-1462 (2000)
   PUBMED   11042145
REFERENCE   8  (bases 1 to 2601)
  AUTHORS   Christoffels VM, Keijser AG, Houweling AC, Clout DE and Moorman AF.
  TITLE     Patterning the embryonic heart: identification of five mouse
            Iroquois homeobox genes in the developing heart
  JOURNAL   Dev Biol 224 (2), 263-274 (2000)
   PUBMED   10926765
REFERENCE   9  (bases 1 to 2601)
  AUTHORS   Christoffels VM, Habets PE, Franco D, Campione M, de Jong F, Lamers
            WH, Bao ZZ, Palmer S, Biben C, Harvey RP and Moorman AF.
  TITLE     Chamber formation and morphogenesis in the developing mammalian
            heart
  JOURNAL   Dev Biol 223 (2), 266-278 (2000)
   PUBMED   10882515
  REMARK    Erratum:[Dev Biol 2000 Sep 1;225(1):266]
REFERENCE   10 (bases 1 to 2601)
  AUTHORS   Bruneau BG, Bao ZZ, Tanaka M, Schott JJ, Izumo S, Cepko CL, Seidman
            JG and Seidman CE.
  TITLE     Cardiac expression of the ventricle-specific homeobox gene Irx4 is
            modulated by Nkx2-5 and dHand
  JOURNAL   Dev Biol 217 (2), 266-277 (2000)
   PUBMED   10625552
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132571.1, AC154266.2 and BB675268.1.
            
            [WARNING] On Dec 19, 2023 this sequence was replaced by
            NM_018885.3.
            
            On Dec 16, 2009 this sequence version replaced NM_018885.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132571.1, AF124732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-287               AK132571.1         1-287
            288-288             AC154266.2         56684-56684
            289-1110            AK132571.1         289-1110
            1111-1111           AC154266.2         63637-63637
            1112-2571           AK132571.1         1112-2571
            2572-2601           BB675268.1         378-407
FEATURES             Location/Qualifiers
     source          1..2601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 39.64 cM"
     gene            1..2601
                     /gene="Irx4"
                     /note="Iroquois homeobox 4"
                     /db_xref="GeneID:50916"
                     /db_xref="MGI:MGI:1355275"
     exon            1..380
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..512
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            513..764
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            765..877
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1206
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2601
                     /gene="Irx4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccgcggcg cctggggacg ccggcgcgct ctgctctcca ggtgctccgc ctggaaatgt
       61 ctccattagt tgtcgcttgc tccccgccgg agcgcgcgcg cccagcggcc gcgcagagcc
      121 ctagcgggca gccaggagtg gcccggcgcc actgcaggta ggcaaggtcc ccacgcccgc
      181 cccctcccgg ggttccgaga cccctccccc cctttcgagg aggcggagga ggcagaggct
      241 ccgcgcggcc gccgaggggc gcgggcggcg gaggcggcgg cggcagcggc ggcggtgact
      301 ccccggtgcg tcccgggctg cgcgctgctc ccggaggccc tggcgcctaa gcggcgcggg
      361 ccggctcttt cctggcgcag agcctaggat cctacaactc cggagcagtg cccacgctgt
      421 gcacaggacc ccaacggccc ctcagacctt cttaggccgc acccgccatg tcctacccgc
      481 agtttggata cccctattcc tctgctcctc agttcctgat gaccaccaac tccctgagca
      541 cgtgctgcga gtcgggcggc cgcacactgg ctgattccgg gcctgcagcc tcggcacagg
      601 cgcccgtcta ctgccctgtc tacgagagcc ggctgctggc cactgcacgc cacgaactca
      661 attctgccgc cgcgctcggc gtctacggga gcccctatgg cagctcgcag ggctatggca
      721 actacgtgac ctatggctct gaggcatctg ctttctactc tctgaacagc ttcgagtcca
      781 aggatggcac aggatcttca cacgccggcc taccacccac tgcagctgca gcctactacc
      841 cgtatgagcc agctctgagc cagtacccat atgacaggta cgggaccgtg gacagcggca
      901 cgcggcgcaa gaatgccacc cgggagacca ccagcacact gaaggcctgg ctgcaggagc
      961 accggaagaa cccgtacccc accaaaggag agaagatcat gctggccatc atcaccaaga
     1021 tgaccctcac acaggtttcc acctggtttg ccaacgcacg tcggcgcctc aagaaggaga
     1081 acaagatgac ctggccacct agaaataaat gtgcagatga gaagcgcccc tatggggagg
     1141 gggaggagga ggaggctgga gaggaggagt cacgggagga gcctctcaag agtgccaaga
     1201 gcgaaggtca tgctggcaaa gacgacaagg agctagaact cagtgacttg gaagacttcg
     1261 accctctaga tgcagagacc tcagaatgtg agctgaagac gcccttccag tccctggata
     1321 gtggaccaga gaggattcct gcttcatctg atggtcccgg cacaggcaag gaggcctcca
     1381 ccacactccg gatgcccctg ggcaccgctg gtggagctgt tatggatggg gatctggaga
     1441 gggcaaggaa ctgcctccgg agcacagtgg tcgttcctga ctctggcgcc gagggcggcc
     1501 cacctgcttg cgaagccaaa ctgacctttg ctcaggcggg agcgccgccg aacctggaga
     1561 ccaagccccg catctggtcc ttggcacaca cagccaccgc tgctgcagcc acagctctga
     1621 gccagactga gtttccctcc tgcatgctga aacgccaagg tccaacgggt gtatctgcga
     1681 cgacgccagc gtcctcacct gcagtcacgg ccccttctgg ggctctggat aggcaccagg
     1741 actccccagt aactagcctc agaaactggg tggatggggt atttcacgat cccatcctta
     1801 gacacagcac tttgaaccag gcctgggcca ccgctaaggg cgcacttctg gatcccggcc
     1861 ctctaggacg caatctgggg gcgggtacta acgtactgac gacgcccctt gcttgctcct
     1921 tcccgcccac ggtgccccaa gacgtcccac ctgcaggggc ctcccgggag ctgctggcta
     1981 cgcccaaggc cggtggcaaa cccttctgca cttaacaccc acctgcacag tggagaaggg
     2041 aactggcgct caggctgcag gcgctgactc tgaactgctt taaatgggtt tccaaaagaa
     2101 gggggaattt ccaagccaag attgccaacc cacttgagac agaggatttg aactcaacct
     2161 ccagggctat ggaggaactc ctcgcgttct atcaccaggt tttacctgat gttgcgtcca
     2221 cctgagccat cccttaactc caggaagatg agaagaccgg agagcacagc cgatgggagg
     2281 ccccctgaag cataaagttt acgtccaaag tttacatgga gaaggcattt gggtactgag
     2341 gcttgttttg tgtcgctgtc tccttctggg tttgaggcat gccggtgttc gtgcgaagag
     2401 tcttcagccc gtttttcttc ggacttcatc ctcagcacgt agagctcacc gccaacactt
     2461 ccaccgagtt tacactgttg cacactcttg actcgacaaa attatgtttt ctaaaatgta
     2521 tattcacacc agtaattgcc tgtttcagag ggaggctaat ataacaaaac taataaattt
     2581 tcgtgtttgc attgcggaag g
//
