LOCUS       NM_008393               2349 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus Iroquois related homeobox 3 (Irx3), transcript variant
            2, mRNA.
ACCESSION   NM_008393
VERSION     NM_008393.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2349)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2349)
  AUTHORS   Yan,X.Y., Luo,Y.Y., Chen,H.J., Hu,X.Q., Zheng,P., Fang,H.T.,
            Ding,F., Zhang,L., Li,Z. and Yan,Y.E.
  TITLE     IRX3 promotes adipose tissue browning and inhibits fibrosis in
            obesity-resistant mice
  JOURNAL   Int J Biochem Cell Biol 175, 106638 (2024)
   PUBMED   39173825
  REMARK    GeneRIF: IRX3 promotes adipose tissue browning and inhibits
            fibrosis in obesity-resistant mice.
REFERENCE   3  (bases 1 to 2349)
  AUTHORS   Miao,L., Lu,Y., Nusrat,A., Zhao,L., Castillo,M., Xiao,Y., Guo,H.,
            Liu,Y., Gunaratne,P., Schwartz,R.J., Burns,A.R., Kumar,A.,
            DiPersio,C.M. and Wu,M.
  TITLE     beta1 integrins regulate cellular behaviour and cardiomyocyte
            organization during ventricular wall formation
  JOURNAL   Cardiovasc Res 120 (11), 1279-1294 (2024)
   PUBMED   38794925
REFERENCE   4  (bases 1 to 2349)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   5  (bases 1 to 2349)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2349)
  AUTHORS   Bosse,A., Stoykova,A., Nieselt-Struwe,K., Chowdhury,K.,
            Copeland,N.G., Jenkins,N.A. and Gruss,P.
  TITLE     Identification of a novel mouse Iroquois homeobox gene, Irx5, and
            chromosomal localisation of all members of the mouse Iroquois gene
            family
  JOURNAL   Dev Dyn 218 (1), 160-174 (2000)
   PUBMED   10822268
REFERENCE   7  (bases 1 to 2349)
  AUTHORS   Cohen,D.R., Cheng,C.W., Cheng,S.H. and Hui,C.C.
  TITLE     Expression of two novel mouse Iroquois homeobox genes during
            neurogenesis
  JOURNAL   Mech Dev 91 (1-2), 317-321 (2000)
   PUBMED   10704856
REFERENCE   8  (bases 1 to 2349)
  AUTHORS   Bulfone,A., Gattuso,C., Marchitiello,A., Pardini,C., Boncinelli,E.,
            Borsani,G., Banfi,S. and Ballabio,A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
REFERENCE   9  (bases 1 to 2349)
  AUTHORS   Bellefroid,E.J., Kobbe,A., Gruss,P., Pieler,T., Gurdon,J.B. and
            Papalopulu,N.
  TITLE     Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes
            and functions in neural specification
  JOURNAL   EMBO J 17 (1), 191-203 (1998)
   PUBMED   9427753
REFERENCE   10 (bases 1 to 2349)
  AUTHORS   Bosse,A., Zulch,A., Becker,M.B., Torres,M., Gomez-Skarmeta,J.L.,
            Modolell,J. and Gruss,P.
  TITLE     Identification of the vertebrate Iroquois homeobox gene family with
            overlapping expression during early development of the nervous
            system
  JOURNAL   Mech Dev 69 (1-2), 169-181 (1997)
   PUBMED   9486539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067195.1, BC085500.1 and AK143023.1.
            
            On Dec 7, 2011 this sequence version replaced NM_008393.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. It encodes isoform 2, which has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067195.1, BC085500.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               BC067195.1         1-280
            281-2335            BC085500.1         1-2055
            2336-2349           AK143023.1         2252-2265
FEATURES             Location/Qualifiers
     source          1..2349
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.55 cM"
     gene            1..2349
                     /gene="Irx3"
                     /note="Iroquois related homeobox 3"
                     /db_xref="GeneID:16373"
                     /db_xref="MGI:MGI:1197522"
     exon            1..690
                     /gene="Irx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             415..1938
                     /gene="Irx3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     iroquois-class homeodomain protein IRX-3; homeodomain
                     protein IRXB1; iroquois homeobox protein 3"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-3 isoform
                     2"
                     /protein_id="NP_032419.2"
                     /db_xref="CCDS:CCDS57631.1"
                     /db_xref="GeneID:16373"
                     /db_xref="MGI:MGI:1197522"
                     /translation="MSFPQLGYQYIRPLYPPERPGAAGGGGGGSSAGGRSGPGAGASE
                     LAASGSLSNVLSSVYGAPYAAAAAAAAAAQGYGAFLPYATELPIFPQLGAQYELKDSP
                     GVQHPATAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTK
                     GEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDE
                     EEDEEESKRELEMEEEELAGEEEDTGGEGLADDDEDEEIDLENLDSAAAGSELTLAGA
                     AHRNGDFGLGPISDCKTSDSDDSSEGLEDRPLSVLSLAPPPPPVARAPASPPSPPSSL
                     DPCAPAPAPSSALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPPTLQLSPAA
                     AAAAAAAHRLVSAPLGKFPAWTNRPFPGPPAGPRPHPLSMLGSAPQHLLGLPGAAGHP
                     AAAAAAYARPAEPESGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS"
     exon            691..1816
                     /gene="Irx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1883
                     /gene="Irx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2349
                     /gene="Irx3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2304..2309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irx3"
                     /note="hexamer: AATAAA"
     polyA_site      2335
                     /gene="Irx3"
                     /note="major polyA site"
ORIGIN      
        1 ggagaggaca ggacaggagg agagtgtaaa ctagaggagg gcgaaggaag cgaggcgcga
       61 cacagctccc ggagaggagg gcagaactga gcgcctagcg cagagcggct cgcccggcct
      121 agaggaggga gtgctgcgca gagaggaggg gcttgaggcc ccgtagaaat gtcaatcaga
      181 gcccggagcc cagggaatct cggccaatct gttcggacct gacctgactc ctcgctgccg
      241 ccgctgccgc cgccgccgcc cgccgcggag cagatcaata ggcgaacgcg gagcgcgacg
      301 cagcgcggcc cgggctcggc ccagcccccg atgcgctccg gagccggggt ccggagctga
      361 gcacggcggc tcgggggtcc gggcccccag tccgtaggtg cgccgcgggc caccatgtcc
      421 ttcccccagc tcggatacca gtacatccgc cctctctacc cacccgaacg cccgggagct
      481 gcgggcggcg gtggaggcgg cagtagcgct gggggccgga gcggtcccgg cgccggagcc
      541 tccgagttgg ccgcctctgg gtccctatcc aatgtgcttt catcagtgta cggggcaccc
      601 tacgccgctg ccgcagctgc cgccgccgcc gctcagggtt acggcgcctt cctgccctac
      661 gccacggagc tgcccatctt cccacagctg ggcgctcagt atgagctgaa ggacagccct
      721 ggcgtccagc atccggccac ggccgccgcg ttcccgcacc cgcaccccgc cttctacccc
      781 tatggccagt accagttcgg ggacccgtcc cgtcccaaga acgccacccg ggaaagcacg
      841 agcacgctca aggcctggct caacgagcac cgcaagaacc cgtaccccac caagggcgag
      901 aagatcatgt tggccatcat caccaagatg accctcaccc aggtgtccac ctggttcgcc
      961 aacgcgcgcc ggcgcctcaa gaaggagaac aagatgacgt gggctccccg tagtcgcacg
     1021 gacgaggagg gcaatgctta tgggagcgag cgggaggagg aggacgaaga ggaagacgag
     1081 gaagagagca aacgcgagct ggagatggag gaggaggagc tcgcaggaga ggaggaggac
     1141 acggggggcg aggggctggc cgacgacgac gaggatgagg agatcgattt ggaaaactta
     1201 gacagcgcgg cagccgggtc ggagctgacc ctggctgggg cggcgcacag gaacggcgac
     1261 ttcggcctgg gacccatttc ggactgcaaa actagcgact cggacgacag ctccgaaggc
     1321 ttggaggacc gaccactgtc ggtcctgagc ctggccccac cgccaccgcc cgtggccagg
     1381 gctcctgcat ctccaccttc tccaccctcc agcctggatc cctgcgctcc ggccccggcg
     1441 ccctcctccg ccctccagaa gcccaagatc tggtcactgg ccgagacggc caccagcccg
     1501 gacaacccac gccgctcgcc tcccggagcc ggaggttcgc ctcccggcgc agccgttgcg
     1561 cccccgacgc tgcagctctc gcccgcggcc gctgcagcgg ctgcagcggc acacagactc
     1621 gtgtcggcgc cgcttggcaa attccccgct tggaccaaca ggcctttccc agggccgccg
     1681 gccggtccgc ggccgcaccc gctgtccatg ctgggctcgg ccccacagca cctgctggga
     1741 cttcccggag ccgcaggtca tcccgctgcg gccgcagccg cctatgctcg gcctgccgag
     1801 ccggagagtg gaacagatcg ctgtagtgcc ttggaagtgg agaaaaagtt actcaagaca
     1861 gctttccagc cggtgccaag gcggccacag aaccatctgg acgctgctct ggtcttatca
     1921 gctctctcct cgtcttaact tttcaaccat ttttaaatcg ttgtactaat tgtaaaaaac
     1981 aaaacaaaac aaaatcgctc tgtatagtga cgagttgcaa gcatgtctgt gtatgattac
     2041 cttaaaagaa acactaaaca acaacaacaa caacaacaac aacaggaaag gacaaaagaa
     2101 agaaagaaag ccagtccccc caccttggcc ctcccccaag tcaccccaca tttagattgt
     2161 gaggttcctt cgttgtgttg atttcggggg gggggggagt ggggttacgg agagaacaag
     2221 cctgtctgac tctttttgta tatacgggaa aatgtacata cgtgtgaacc aaattgtaca
     2281 agaaagtatc tattttttgg ctaaataaat gagctgttgc cacttttgac tataaccggc
     2341 aggtctgcc
//
