LOCUS       NM_010573               2080 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus Iroquois homeobox 1 (Irx1), mRNA.
ACCESSION   NM_010573 XM_127441
VERSION     NM_010573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2080)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2080)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2080)
  AUTHORS   Xu,J., Zhou,X., Zhang,T., Zhang,B. and Xu,P.X.
  TITLE     Smarca4 deficiency induces Pttg1 oncogene upregulation and
            hyperproliferation of tubular and interstitial cells during kidney
            development
  JOURNAL   Front Cell Dev Biol 11, 1233317 (2023)
   PUBMED   37727504
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2080)
  AUTHORS   Huang,R., Zhang,C., Zheng,Y., Zhang,W., Huang,H., Qiu,M., Li,J. and
            Li,F.
  TITLE     ISL1 regulates lung branching morphogenesis via Shh signaling
            pathway
  JOURNAL   J Biol Chem 299 (8), 105034 (2023)
   PUBMED   37442233
REFERENCE   6  (bases 1 to 2080)
  AUTHORS   Christoffels,V.M., Keijser,A.G., Houweling,A.C., Clout,D.E. and
            Moorman,A.F.
  TITLE     Patterning the embryonic heart: identification of five mouse
            Iroquois homeobox genes in the developing heart
  JOURNAL   Dev Biol 224 (2), 263-274 (2000)
   PUBMED   10926765
REFERENCE   7  (bases 1 to 2080)
  AUTHORS   Bosse,A., Stoykova,A., Nieselt-Struwe,K., Chowdhury,K.,
            Copeland,N.G., Jenkins,N.A. and Gruss,P.
  TITLE     Identification of a novel mouse Iroquois homeobox gene, Irx5, and
            chromosomal localisation of all members of the mouse Iroquois gene
            family
  JOURNAL   Dev Dyn 218 (1), 160-174 (2000)
   PUBMED   10822268
REFERENCE   8  (bases 1 to 2080)
  AUTHORS   Cohen,D.R., Cheng,C.W., Cheng,S.H. and Hui,C.C.
  TITLE     Expression of two novel mouse Iroquois homeobox genes during
            neurogenesis
  JOURNAL   Mech Dev 91 (1-2), 317-321 (2000)
   PUBMED   10704856
REFERENCE   9  (bases 1 to 2080)
  AUTHORS   Bosse,A., Zulch,A., Becker,M.B., Torres,M., Gomez-Skarmeta,J.L.,
            Modolell,J. and Gruss,P.
  TITLE     Identification of the vertebrate Iroquois homeobox gene family with
            overlapping expression during early development of the nervous
            system
  JOURNAL   Mech Dev 69 (1-2), 169-181 (1997)
   PUBMED   9486539
REFERENCE   10 (bases 1 to 2080)
  AUTHORS   Ptacek,L.J., Tawil,R., Griggs,R.C., Meola,G., McManis,P.,
            Barohn,R.J., Mendell,J.R., Harris,C., Spitzer,R., Santiago,F. et
            al.
  TITLE     Sodium channel mutations in acetazolamide-responsive myotonia
            congenita, paramyotonia congenita, and hyperkalemic periodic
            paralysis
  JOURNAL   Neurology 44 (8), 1500-1503 (1994)
   PUBMED   8058156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133937.1, AW491133.1 and CO043226.1.
            
            On Mar 30, 2007 this sequence version replaced NM_010573.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133937.1, AF165984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               AK133937.1         1-452
            453-453             AW491133.1         58-58
            454-1962            AK133937.1         454-1962
            1963-2080           CO043226.1         1-118               c
FEATURES             Location/Qualifiers
     source          1..2080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 38.43 cM"
     gene            1..2080
                     /gene="Irx1"
                     /note="Iroquois homeobox 1"
                     /db_xref="GeneID:16371"
                     /db_xref="MGI:MGI:1197515"
     exon            1..511
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1678
                     /gene="Irx1"
                     /note="homeodomain protein IRXA1; iroquois homeobox
                     protein 1; Iroquois related homeobox 1"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-1"
                     /protein_id="NP_034703.2"
                     /db_xref="CCDS:CCDS26627.1"
                     /db_xref="GeneID:16371"
                     /db_xref="MGI:MGI:1197515"
                     /translation="MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPG
                     TAELGAGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNP
                     GVHPATFAAHTTPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEK
                     IMLAIITKMTLTQVSTWFANARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAE
                     DDEEIDLESIDIDQIDERDGDQSNEDEEDKAEAPRARVAPPASARDQSSPLSAAETLK
                     SQDSPLGLVKEVSEPGSTRLLSPGAAAVGLQGAPHSKPKIWSLAETATSPDGAPKASP
                     PPPSSHASAHGPPSGSPLQHPAFLPSHGLYTCHIGKFSNWTNGAFLAQGSLLNMRSFL
                     GVSAPHAAPHGPHLTAPPPPQPPVQVATGVLHGEKASARSSPALPERDLVTRPDSPPQ
                     QLKSPFQPVRDNSLAPQEGTPRILAALPSA"
     exon            512..1547
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1620
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..2062
                     /gene="Irx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2040..2045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irx1"
                     /note="hexamer: AATAAA"
     polyA_site      2058
                     /gene="Irx1"
                     /note="major polyA site"
ORIGIN      
        1 gagcggaggg cggccgccgc agtcggcgcg cgatctcgga tacgggcgca gccgggagcc
       61 gggcgccgcc agcgagcact gggccgagga acagcgagcg gcccccgccc ccgggccggc
      121 cggagcgcgc ccggcccgcg gcccgcagcc cccgagtcgc gcctcctcgg atcgccagcc
      181 ggtcttcttg cccgcgcagt tagtgttgcc ctccgccacc accgagcccg cggacatgtc
      241 cttcccgcag ctgggctacc cgcaatacct aagcgccgcg ggcccgggcg cctatggtgg
      301 agagcgccct ggggtgctgg ctgcggccgc ggctgctgcg gccgccgcct cgtcgggccg
      361 tcccgggact gcggagctgg gagcgggcgc gggagcggcc gcggtcacct cggtgctagg
      421 catgtatgcc gcggcgggac cgtacgcggg cgcacccaac tacagcgcct tcttgcccta
      481 tgccgcggac ctcagcctct tctcgcagat gggctctcag tatgaactga aggacaaccc
      541 cggggtgcac ccagcgacct tcgcagccca cacaacgcct gcttattatc cctatggtca
      601 gtttcaatac ggggatcccg gacggcccaa gaacgccacg cgggagagca ccagcacgct
      661 gaaagcctgg ctcaacgaac accgcaagaa cccgtacccc accaaaggag agaagattat
      721 gctggccatt atcaccaaga tgaccctcac acaggtctcc acctggttcg ccaatgcgcg
      781 ccggcgcctc aagaaggaga acaaggtgac ttggggggcg cgcagcaagg accaggaaga
      841 cggcgccctc tttggcagcg acaccgaggg cgaccccgag aaggccgagg acgacgagga
      901 gatcgacctg gagagcattg acatcgatca gatcgacgag cgtgatggcg accagagcaa
      961 cgaagacgaa gaggacaagg cggaggctcc tagggcgcgc gtagcccctc ccgcctcagc
     1021 tcgggaccag agctccccat tgtcggctgc tgagacactc aagtctcaag attcgccctt
     1081 gggcctggtt aaggaggtct cagagcccgg cagcacacgc ctgctgagtc ctggcgccgc
     1141 ggcggtcggc ctgcagggcg cgccgcacag caagcccaag atctggtctc tggctgagac
     1201 agccactagc cccgatggtg cgcctaaggc gtctccaccg ccaccctcaa gccacgccag
     1261 cgcacacggg ccgcccagcg gctcacccct gcaacacccg gcctttctac ccagccacgg
     1321 actgtacacc tgtcacatag gcaagttttc caactggacc aacggcgcgt tcctagcaca
     1381 gggctcgctg ctgaacatgc gatctttcct gggcgtcagc gcgccgcatg cagcacctca
     1441 cggcccacac ctgacagcac caccacctcc acagccgcca gtccaggttg ccaccggggt
     1501 gctccatggt gagaaggcct ccgcacgcag cagtcctgca cttccagaga gagacctagt
     1561 caccagaccg gattcgcccc cacaacagtt aaagtcgccc ttccagccgg tgcgcgacaa
     1621 ctcgctggcc ccgcaggagg gaacgcctcg gatcctcgca gccctcccgt ctgcctgatt
     1681 aaggggggtc atcttttact tttgcggggg gaggggaggg ggaggggttg ggggggagga
     1741 gacgagggaa gaattaagac aaatatttga gacttgtgta aaggacaaac gtgacggcag
     1801 cgtcagtgat tctcacacat cgctctctgc agaaaggggc tcatcctgcc taagcgcttg
     1861 ggaagggggg agtaaggctc agcctgccgc tcggattgat tatccgattc ggtaaatgcc
     1921 cccctcccac ttctgtgttt gtgtcttctt tgtttctttt ttcccctttc tgtatatagc
     1981 gtgatttcag attgtaaata gcgcgtcagc gaacttgttt aaatcatata tttttgtcta
     2041 ataaactaaa tgaaacgatg tcaaaaaaaa aaaaaaaaaa
//
