LOCUS       NP_034703                480 aa            linear   ROD 13-MAY-2025
DEFINITION  iroquois-class homeodomain protein IRX-1 [Mus musculus].
ACCESSION   NP_034703 XP_127441
VERSION     NP_034703.2
DBSOURCE    REFSEQ: accession NM_010573.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 480)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (residues 1 to 480)
  AUTHORS   Catela,C., Assimacopoulos,S., Chen,Y., Tsioras,K., Feng,W. and
            Kratsios,P.
  TITLE     The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets
            involved in motor neuron development
  JOURNAL   iScience 28 (4), 112210 (2025)
   PUBMED   40230530
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 480)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 480)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 480)
  AUTHORS   Sepp,M., Leiss,K., Murat,F., Okonechnikov,K., Joshi,P.,
            Leushkin,E., Spanig,L., Mbengue,N., Schneider,C., Schmidt,J.,
            Trost,N., Schauer,M., Khaitovich,P., Lisgo,S., Palkovits,M.,
            Giere,P., Kutscher,L.M., Anders,S., Cardoso-Moreira,M.,
            Sarropoulos,I., Pfister,S.M. and Kaessmann,H.
  TITLE     Cellular development and evolution of the mammalian cerebellum
  JOURNAL   Nature 625 (7996), 788-796 (2024)
   PUBMED   38029793
REFERENCE   6  (residues 1 to 480)
  AUTHORS   Christoffels,V.M., Keijser,A.G., Houweling,A.C., Clout,D.E. and
            Moorman,A.F.
  TITLE     Patterning the embryonic heart: identification of five mouse
            Iroquois homeobox genes in the developing heart
  JOURNAL   Dev Biol 224 (2), 263-274 (2000)
   PUBMED   10926765
REFERENCE   7  (residues 1 to 480)
  AUTHORS   Bosse,A., Stoykova,A., Nieselt-Struwe,K., Chowdhury,K.,
            Copeland,N.G., Jenkins,N.A. and Gruss,P.
  TITLE     Identification of a novel mouse Iroquois homeobox gene, Irx5, and
            chromosomal localisation of all members of the mouse Iroquois gene
            family
  JOURNAL   Dev Dyn 218 (1), 160-174 (2000)
   PUBMED   10822268
REFERENCE   8  (residues 1 to 480)
  AUTHORS   Cohen,D.R., Cheng,C.W., Cheng,S.H. and Hui,C.C.
  TITLE     Expression of two novel mouse Iroquois homeobox genes during
            neurogenesis
  JOURNAL   Mech Dev 91 (1-2), 317-321 (2000)
   PUBMED   10704856
REFERENCE   9  (residues 1 to 480)
  AUTHORS   Bosse,A., Zulch,A., Becker,M.B., Torres,M., Gomez-Skarmeta,J.L.,
            Modolell,J. and Gruss,P.
  TITLE     Identification of the vertebrate Iroquois homeobox gene family with
            overlapping expression during early development of the nervous
            system
  JOURNAL   Mech Dev 69 (1-2), 169-181 (1997)
   PUBMED   9486539
REFERENCE   10 (residues 1 to 480)
  AUTHORS   Ptacek,L.J., Tawil,R., Griggs,R.C., Meola,G., McManis,P.,
            Barohn,R.J., Mendell,J.R., Harris,C., Spitzer,R., Santiago,F. et
            al.
  TITLE     Sodium channel mutations in acetazolamide-responsive myotonia
            congenita, paramyotonia congenita, and hyperkalemic periodic
            paralysis
  JOURNAL   Neurology 44 (8), 1500-1503 (1994)
   PUBMED   8058156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133937.1, AW491133.1 and CO043226.1.
            
            On Mar 30, 2007 this sequence version replaced NP_034703.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133937.1, AF165984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..480
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 38.43 cM"
     Protein         1..480
                     /product="iroquois-class homeodomain protein IRX-1"
                     /note="homeodomain protein IRXA1; iroquois homeobox
                     protein 1; Iroquois related homeobox 1"
                     /calculated_mol_wt=50038
     Region          146..184
                     /region_name="Homeobox_KN"
                     /note="Homeobox KN domain; pfam05920"
                     /db_xref="CDD:428673"
     Region          190..285
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     Region          <195..257
                     /region_name="DNA_pol_phi"
                     /note="DNA polymerase phi; pfam04931"
                     /db_xref="CDD:461488"
     Site            241
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P81068.4)"
     Region          309..326
                     /region_name="IRO"
                     /note="Motif in Iroquois-class homeodomain proteins
                     (only). Unknown function; smart00548"
                     /db_xref="CDD:214716"
     Region          318..354
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     Region          401..480
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P81068.4)"
     CDS             1..480
                     /gene="Irx1"
                     /coded_by="NM_010573.2:236..1678"
                     /db_xref="CCDS:CCDS26627.1"
                     /db_xref="GeneID:16371"
                     /db_xref="MGI:MGI:1197515"
ORIGIN      
        1 msfpqlgypq ylsaagpgay ggerpgvlaa aaaaaaaass grpgtaelga gagaaavtsv
       61 lgmyaaagpy agapnysafl pyaadlslfs qmgsqyelkd npgvhpatfa ahttpayypy
      121 gqfqygdpgr pknatrests tlkawlnehr knpyptkgek imlaiitkmt ltqvstwfan
      181 arrrlkkenk vtwgarskdq edgalfgsdt egdpekaedd eeidlesidi dqiderdgdq
      241 snedeedkae aprarvappa sardqsspls aaetlksqds plglvkevse pgstrllspg
      301 aaavglqgap hskpkiwsla etatspdgap kasppppssh asahgppsgs plqhpaflps
      361 hglytchigk fsnwtngafl aqgsllnmrs flgvsaphaa phgphltapp ppqppvqvat
      421 gvlhgekasa rsspalperd lvtrpdsppq qlkspfqpvr dnslapqegt prilaalpsa
//
