LOCUS       NM_010572               6269 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus insulin receptor substrate 4 (Irs4), mRNA.
ACCESSION   NM_010572 XM_907989
VERSION     NM_010572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6269)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6269)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6269)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 6269)
  AUTHORS   Lopez-Gonzalez,L., Alonso,A., Garcia-Calero,E., de Puelles,E. and
            Puelles,L.
  TITLE     Tangential Intrahypothalamic Migration of the Mouse Ventral
            Premamillary Nucleus and Fgf8 Signaling
  JOURNAL   Front Cell Dev Biol 9, 676121 (2021)
   PUBMED   34095148
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6269)
  AUTHORS   Gan,P., Patterson,M., Watanabe,H., Wang,K., Edmonds,R.A.,
            Reinholdt,L.G. and Sucov,H.M.
  TITLE     Allelic variants between mouse substrains BALB/cJ and BALB/cByJ
            influence mononuclear cardiomyocyte composition and cardiomyocyte
            nuclear ploidy
  JOURNAL   Sci Rep 10 (1), 7605 (2020)
   PUBMED   32371981
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6269)
  AUTHORS   Laustsen,P.G., Michael,M.D., Crute,B.E., Cohen,S.E., Ueki,K.,
            Kulkarni,R.N., Keller,S.R., Lienhard,G.E. and Kahn,C.R.
  TITLE     Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice
  JOURNAL   Genes Dev 16 (24), 3213-3222 (2002)
   PUBMED   12502742
REFERENCE   7  (bases 1 to 6269)
  AUTHORS   Krebs,D.L., Uren,R.T., Metcalf,D., Rakar,S., Zhang,J.G., Starr,R.,
            De Souza,D.P., Hanzinikolas,K., Eyles,J., Connolly,L.M.,
            Simpson,R.J., Nicola,N.A., Nicholson,S.E., Baca,M., Hilton,D.J. and
            Alexander,W.S.
  TITLE     SOCS-6 binds to insulin receptor substrate 4, and mice lacking the
            SOCS-6 gene exhibit mild growth retardation
  JOURNAL   Mol Cell Biol 22 (13), 4567-4578 (2002)
   PUBMED   12052866
REFERENCE   8  (bases 1 to 6269)
  AUTHORS   Xiao,H., Yin,T., Wang,X.Y., Uchida,T., Chung,J., White,M.F. and
            Yang,Y.C.
  TITLE     Specificity of interleukin-2 receptor gamma chain superfamily
            cytokines is mediated by insulin receptor substrate-dependent
            pathway
  JOURNAL   J Biol Chem 277 (10), 8091-8098 (2002)
   PUBMED   11788580
  REMARK    GeneRIF: These data suggest that IRS-dependent signaling pathways
            work by recruiting different signaling molecules to determine
            specificity of IL-2R gamma superfamily cytokines.
REFERENCE   9  (bases 1 to 6269)
  AUTHORS   Fantin,V.R., Wang,Q., Lienhard,G.E. and Keller,S.R.
  TITLE     Mice lacking insulin receptor substrate 4 exhibit mild defects in
            growth, reproduction, and glucose homeostasis
  JOURNAL   Am J Physiol Endocrinol Metab 278 (1), E127-E133 (2000)
   PUBMED   10644546
REFERENCE   10 (bases 1 to 6269)
  AUTHORS   Fantin,V.R., Lavan,B.E., Wang,Q., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Keller,S.R. and Lienhard,G.E.
  TITLE     Cloning, tissue expression, and chromosomal location of the mouse
            insulin receptor substrate 4 gene
  JOURNAL   Endocrinology 140 (3), 1329-1337 (1999)
   PUBMED   10067860
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060235.1 and AK045172.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_907989.1, NM_010572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060235.1, BC150782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3768              BC060235.1         1-3768
            3769-4672           AK045172.1         1517-2420
            4673-5146           BC060235.1         4673-5146
            5147-6269           BC060235.1         5148-6270
FEATURES             Location/Qualifiers
     source          1..6269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 62.43 cM"
     gene            1..6269
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /note="insulin receptor substrate 4"
                     /db_xref="GeneID:16370"
                     /db_xref="MGI:MGI:1338009"
     exon            1..3687
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..3670
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /note="pp160; phosphoprotein of 160 kDa"
                     /codon_start=1
                     /product="insulin receptor substrate 4"
                     /protein_id="NP_034702.2"
                     /db_xref="CCDS:CCDS30445.1"
                     /db_xref="GeneID:16370"
                     /db_xref="MGI:MGI:1338009"
                     /translation="MASCSFSGHQALRRLRASAAAAASAALAAVATTPLLSSGTRTAL
                     IGTGSSCPGAMWLSTATGSRSDSESEEEDLPVGDEVCKRGYLRKQKHGHRRYFVLKLE
                     TADAPARLEYYRNARKFRHSVRAAAAAAEAAASGAAVPALIPPRRVIILYQCFSVSQR
                     ADARYRHLIALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGALPDGEP
                     AALAAAAAAEPPFYKDVWQVVVKPRGLGHRKELSGVFRLCLTDEEVVFVRLNTEVASV
                     VVQLLSIRRCGHSEQYFFLEVGRSTVIGPGELWMQVDDSVVAQNMHELFLEKMRALCA
                     DEYRARCRSYSISIGAHLLTLLSTRRHLGLLPLEPGGWLRRYGLEQFCRLRAIREREE
                     MLFTRRFISPREPPPPFRRGRGHLPRARRSRRAASVPPSLFRRSAPSPGRIPQPEDVP
                     NDRAREASGSSSGNTEEKDKEGEEGNRGDCIPMNNWGSGNGRGSGGGRGSSGQGSSSQ
                     GSGGRQGSGGGQGSGGQGAGGNQCSGNGQGTAGGHGSGGGGHGSGGGQRPGDGHGSGG
                     GKNSGSGKNSDDGDRGKSVKKRSYFGKFTQSKQQQTLPPPPPPPPAAGATGGKGKSGG
                     RFRLYFCADRGTKERKEAKEVRDMETSGGATRGPYRARAFDEDEDDPYVPMRPGVAAP
                     LACSSDYMPMAPQNSSASTKRHSRSPFEDSRGYMMMFPRVSPPPPVPSAPKAPDTNKG
                     DDSKDNDSDSDYMFMAPGAGAIPKNPPNAQGGSSSKSWSSYFSLPSPFQSSPLGQSDH
                     SEYVPMLPGKFLGSGLHKEASFSQGTKNVSSKPSTEASFSKPEDKGSSAKPSDDVPPM
                     NKAKEPNHLSFIAKGTQVKPKPLNPTQERREAAGSRDYINIDFIKRERLVLPSSAQGL
                     PDMRGVVTDPAPTAFSGYLNVEFGVPFPNPTIRLSDLLRVLPGANSIPLAGTRWPFPG
                     SAIGSIVEAGEYIEVIFNPAMTPAMSFADSAICYDAQTGQIYVVDPFSECCMDVSLSP
                     GRCSEPPPVARLRREEAQERRRPQSRSQSLFASTRAAVSAFPTDSLDRDFPAASAVIA
                     APAEAPLLAVSRALAVVSALAAAPSIGDVFAGFRAAAGVDSASARGFQPVAGAQAVRE
                     FQDLAAGWNPGALNHRARGEDLAAGAAAPPPPPRQIWVLRPQERADSEDDDDDDDDIY
                     VRMDFARRDYRK"
     exon            3688..6248
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6230..6235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /note="hexamer: AATAAA"
     polyA_site      6248
                     /gene="Irs4"
                     /gene_synonym="IRS-4"
                     /note="major polyA site"
ORIGIN      
        1 aaaaccacgg tgcatcacca tggcgagttg ctccttctct ggccaccaag cgcttaggag
       61 actgagagcc tcagcagcag cagcagcctc cgcagctcta gcagcagtgg cgaccacccc
      121 gctcctttcc tcgggaaccc ggaccgcact cattgggacc gggtcgtcct gtccgggagc
      181 catgtggctc tccacagcca ctggctcccg gtcagactcg gaatccgaag aggaggacct
      241 ccccgtcggg gatgaagtct gcaaacgcgg ctacctgagg aagcagaagc atgggcatag
      301 gcgttacttc gtgctcaaac tcgagaccgc agacgctcca gctcgactcg aatactaccg
      361 aaatgccagg aagttccggc acagtgtccg cgccgcggcg gctgcagcag aggcggccgc
      421 ctccggtgct gcggtccccg cgctcatccc accacggcgc gtgatcatcc tgtaccaatg
      481 cttctccgtg agccagcgcg ccgatgccag gtaccgacac ctcattgccc tttttaccca
      541 ggacgaatac ttcgcgatgg tggccgagaa cgagtcggaa caagaaagct ggtacttgct
      601 cctcagccgc ctcatcctcg agagcaagcg ccgccgctgc ggcacgctag gcgcactgcc
      661 ggacggagag ccggcagccc tggcggccgc agcggcggcg gagccaccct tctacaaaga
      721 tgtgtggcag gtagtagtga aacccagggg gctggggcac agaaaagagc tgagcggcgt
      781 gttccggctg tgtcttaccg acgaagaggt agtgtttgta aggctcaata ccgaagtggc
      841 cagtgtggtc gtccagctgc tgagcattcg tcgctgtggg cactcggagc agtacttctt
      901 cttggaagtc ggcagatcca ctgtcatagg tccgggggag ctgtggatgc aagtggatga
      961 ctccgtggtg gcccaaaata tgcatgagct gtttctggag aagatgagag ccttgtgcgc
     1021 agatgaatac agagcccgat gccgcagcta cagcatcagt attggcgccc acctgttaac
     1081 cctgctgtcc actaggaggc acctgggctt gctcccgctg gagcctggtg gctggctcag
     1141 aagatacggc ttggagcagt tttgccgcct cagagctatc cgtgagaggg aagagatgct
     1201 attcaccagg cgcttcatct cacccagaga gcctccgcct ccctttaggc gaggaagagg
     1261 gcacctgccc agagcccgca ggtccaggag agccgcgtca gtaccaccca gccttttccg
     1321 acgctcagca cctagcccgg gaaggatccc acagcctgaa gatgtcccca acgacagagc
     1381 ccgtgaagcc tccggttcca gctctggcaa cactgaagaa aaagacaagg agggtgagga
     1441 aggaaaccga ggtgattgca tacctatgaa caactggggc tcaggaaatg gccggggctc
     1501 aggaggtgga cggggctcaa gtggccaagg ttccagtagc cagggctcag gtgggagaca
     1561 gggatctgga ggtggccagg gctcaggagg ccagggtgcc ggaggaaacc agtgttcagg
     1621 aaatggccag ggcacagcag gtggccatgg ctcaggtgga ggtggccatg gctcaggcgg
     1681 tggccagaga cctggagatg gtcatggctc aggtggtggc aagaactcag gaagtgggaa
     1741 aaattctgac gatggtgacc gtggaaaatc tgtgaagaaa agatcctact ttggtaaatt
     1801 cactcaaagc aagcagcagc aaacactgcc tccaccccca ccgccaccgc cagcagctgg
     1861 agcaactggt ggcaaaggga agtctggagg aagattccga ctttattttt gcgcagacag
     1921 aggcacaaaa gaacgcaaag aagccaaaga ggtaagagat atggagacct caggaggtgc
     1981 tacccggggg ccttacagag ccagagcttt cgatgaagat gaggatgacc cgtatgtgcc
     2041 aatgagacca ggggtggctg cccctcttgc gtgttccagt gattatatgc caatggctcc
     2101 tcaaaattcc tctgcttcaa caaaacgcca ctctaggtca ccctttgaag actccagagg
     2161 gtacatgatg atgtttccca gagtgagccc cccaccacct gtgccaagtg ctccgaaagc
     2221 accggacacc aataaagggg atgactcaaa ggacaatgac agtgacagtg attacatgtt
     2281 tatggctccc ggagcaggtg cgattcctaa aaatcctccc aatgcgcagg gaggctcttc
     2341 ctccaaaagc tggagctcgt atttctctct gccaagtcct tttcagagtt cacctttggg
     2401 acagagtgac cacagtgagt atgttcctat gttacctgga aaattcctgg ggagcggtct
     2461 acacaaagaa gcctccttta gccagggcac caaaaatgtg tcttcaaagc cttcaactga
     2521 ggcgtcattc tcaaaacccg aagataaagg gtcatctgca aagccttcag atgatgtgcc
     2581 cccaatgaac aaggctaagg aacctaacca cctttctttt attgcaaaag gaactcaagt
     2641 aaagcccaaa ccgctaaacc ccacacagga gcggagagaa gctgctggct cccgtgacta
     2701 tatcaacatt gactttatta agagagagcg ccttgtgcta ccttcctctg ctcaaggact
     2761 gccagacatg cggggcgtag ttactgaccc cgcacccaca gctttttctg gctacctgaa
     2821 tgttgaattc ggggtgccct tcccaaatcc aacaatccgc ctctcagatc ttttaagagt
     2881 tctaccaggt gccaactcca tccctctggc cggtactagg tggcccttcc caggcagtgc
     2941 tataggtagc attgtggaag cgggagaata cattgaagtt attttcaacc cggctatgac
     3001 accagccatg tcttttgctg acagtgccat ttgctatgat gctcaaacag gtcaaatcta
     3061 tgtcgtcgac ccattttctg agtgctgtat ggacgtttct ctctctcctg gtcgatgctc
     3121 tgaaccgcca cctgtagcta ggctgcggcg ggaggaagcg caggagagaa gacgcccaca
     3181 aagccgctcc caaagtttat ttgccagcac tcgagccgcg gtctcggctt tcccgactga
     3241 cagcttggac agagactttc ccgccgcttc tgcggtgatt gctgctccag ctgaggcgcc
     3301 tctcttggca gtgagccggg ctttagccgt ggtctctgcg ctcgcagcgg cccccagcat
     3361 aggcgacgtc tttgcaggct tccgcgctgc ggcaggagtt gactccgcct ccgctcgcgg
     3421 gttccaacct gttgcgggtg cccaggctgt aagagaattc caggaccttg ccgcaggctg
     3481 gaatcctgga gcccttaacc acagggcccg aggtgaggac ctggccgccg gcgcagcggc
     3541 tcccccgccg ccacctcgcc agatttgggt gctgagaccc caagagagag cggattctga
     3601 ggacgacgac gatgatgacg acgacattta cgtgagaatg gactttgcca gacgagacta
     3661 caggaagtga ccactctccg aaatgagagt tattacactg ccaccaaaac caaacacatt
     3721 ttagaagaaa agtgacacag aacttcatct ttgtctactc cagatctgcc taaaagaaag
     3781 aaaattctga aacttctgaa tagaaagcag ccttgatttc taccagtcaa cgagcagact
     3841 gtggcggctg aatgagcatg ctaatggagt ttattcttag gactgcctcc tgcatccatt
     3901 gattgactta aatatgtgca cactgtacgt ttgctttgct tcctaggttc cctgatgtgt
     3961 ctgtttaaaa ggaatgagat gctataagtt agtgtctcat aacacttccc ctttcctcta
     4021 taaaaaatat gtaaatatag ccagcatata atacttggga ggattttcaa tgagaatatc
     4081 tttaaacaat ggtagacaaa gagacatcta tgtaaatgag aaggtaggta tgatctggag
     4141 aatctttttg ctgaacattc acatacttaa aacatttctt gatcaaggaa ttaatgtgaa
     4201 ttgaacctct atcttgacag gacattttca gtattttaaa gacaagacta aagggcaaat
     4261 tatctcagag tttgctcatt aacaagacta caacattcta tcaacactaa ccatcaacta
     4321 aagtgatatc ttgacagagt tgttctagca ttttaaaggc agaaccaagg agcaggttgt
     4381 ctacttctat gtgtagaacc tggtgatgtt ctgctatcga attgaacata tccaagccta
     4441 ttgtttttat tttattttga aatctacatt tatccctgca aagaggcaag tatccatttc
     4501 acaagaccct ttctggctct ctggggcctc ctctttccag ctctttaaac tgcctccccc
     4561 tctttctggc tttcccacag taaccattct ccctcccatg tccaggatgc ccagggtgcc
     4621 tataatgaca ttgcttaccc attttcagaa attggtgtat acctataaga ttaatcaacc
     4681 aatcaactga tgcctaaaac tcaagccaaa aggaacctct tataaggccc tgtttccttc
     4741 tggacaatgg agccaatata agatgtacaa aatttaaaat aaagaaaaat cagagcaagc
     4801 cccccccccc agttttgctt gcttctgatg gaaactgaat taagattttt ggaacctgga
     4861 cctttgagaa tatgataaca gcaggttgtg accacacagg ataggtacaa aggtcttgaa
     4921 gcttgcttag agctttgtta tgtggtggca cccagctctt ggatctcgta ccatcactgg
     4981 caaaactctc atctcacaga tgggtgtgag tgtttgagca agtgtctgca aaagtgtgtg
     5041 agtgctagtg tgtgtgtgca cacatttgtg tgtatgtaca cctttgtgta cctgtgaaca
     5101 tgtgattata gacgtaccta ttgtgtgtaa ctgtgtttaa aaaaaattgc ttcgcattta
     5161 acgtgcaact ttcaactagt gtgaaactta cctgaagttc tttgccactc ggttcctaca
     5221 tctttgaacg tgtgcttcta tcgttgagca ggcttctagt acatgtggct aaactaactt
     5281 tccaaaggac cgagttgatt tctattgttt ctccctgcct actaagcaaa gggatggggt
     5341 ggggtgtgtg tgtgctcctt ttcccccacg tgaattgtgc tgaggagagg atgtggcttc
     5401 agtgccagtc actgaaccag tttctggtca ttgctagggt atcacttgct ttcatcagtc
     5461 ccttcaggct cctctcttgt tcttacctaa ttcagtactg cagtgtgtgg cttttgttca
     5521 ttgtaacagt gtactcttta ggcagccttt cttcaggcct tctattacca ttttatattc
     5581 aagtaagttg tcataatcgt tcagaattga agcaagaaaa gatttgaggg aaaatgctgt
     5641 gttattttgt tcatgtattc attcagtttg aaggctgcca atagacaggg tacagaaggt
     5701 agagcacaga gatagcacac ttgctgaata aatgaatgga aatctcatac acagccggac
     5761 acacaattag tcacaggtac aaatagtcac aggtactgca taacacatat gcaatctctt
     5821 aaacacaact tcttagttta cagatataat taatttattc agtattgtgc tggaagaatc
     5881 tatggaatat gtgtaccgac atatcacttg ccttccagtg gtcagtttat gctgctgaga
     5941 aaaataccga tggaacgatt tgtgtgtgtg agcactacat tagtttggtg tcatacatag
     6001 ttacttggtc agtaaaacaa ctagagcttt acagttccaa cagttcatta catttgctac
     6061 ttctgcttca cagacctgct ttgagttgct ctgtgtttgt cttcctttgt aaataccctt
     6121 aaaccttctt gtttgtaagc atctggtttg cagttttggg agacgaccgt gcaactctgt
     6181 atagtgttta tatatatatc tgacttgctt tttccttaga gctacttgca ataaatgtgt
     6241 tcatgtaaaa aaaaaaaaaa aaaaaaaaa
//
