LOCUS       NM_010571               2337 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus insulin receptor substrate 3 (Irs3), mRNA.
ACCESSION   NM_010571
VERSION     NM_010571.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Zhuang L, Jang Y, Park YK, Lee JE, Jain S, Froimchuk E, Broun A,
            Liu C, Gavrilova O and Ge K.
  TITLE     Depletion of Nsd2-mediated histone H3K36 methylation impairs
            adipose tissue development and function
  JOURNAL   Nat Commun 9 (1), 1796 (2018)
   PUBMED   29728617
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Lee S, Lynn EG, Kim JA and Quon MJ.
  TITLE     Protein kinase C-zeta phosphorylates insulin receptor substrate-1,
            -3, and -4 but not -2: isoform specific determinants of specificity
            in insulin signaling
  JOURNAL   Endocrinology 149 (5), 2451-2458 (2008)
   PUBMED   18202124
  REMARK    GeneRIF: Protein kinase C-zeta phosphorylates insulin receptor
            substrate-1, -3, and -4 but not -2.
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Escribano O, Arribas M, Valverde AM and Benito M.
  TITLE     IRS-3 mediates insulin-induced glucose uptake in differentiated
            IRS-2(-/-) brown adipocytes
  JOURNAL   Mol Cell Endocrinol 268 (1-2), 1-9 (2007)
   PUBMED   17316975
  REMARK    GeneRIF: These results provide evidences suggesting that IRS-3/PI
            3-kinase/PKC zeta signaling is the main responsible for the
            insulin-induced glucose uptake observed upon differentiation of
            brown adipocytes lacking IRS-2.
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Tseng YH, Kriauciunas KM, Kokkotou E and Kahn CR.
  TITLE     Differential roles of insulin receptor substrates in brown
            adipocyte differentiation
  JOURNAL   Mol Cell Biol 24 (5), 1918-1929 (2004)
   PUBMED   14966273
  REMARK    GeneRIF: These data indicate that both insulin receptor substrate
            (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the
            differentiation of brown adipocytes.
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Arribas M, Valverde AM and Benito M.
  TITLE     Role of IRS-3 in the insulin signaling of IRS-1-deficient brown
            adipocytes
  JOURNAL   J Biol Chem 278 (46), 45189-45199 (2003)
   PUBMED   12944402
  REMARK    GeneRIF: IRS-3 has a role in the insulin signaling of
            IRS-1-deficient brown adipocytes but not at the same level as IRS-1
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Poltilove RM, Jacobs AR, Haft CR, Xu P and Taylor SI.
  TITLE     Characterization of Drosophila insulin receptor substrate
  JOURNAL   J Biol Chem 275 (30), 23346-23354 (2000)
   PUBMED   10801879
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Liu SC, Wang Q, Lienhard GE and Keller SR.
  TITLE     Insulin receptor substrate 3 is not essential for growth or glucose
            homeostasis
  JOURNAL   J Biol Chem 274 (25), 18093-18099 (1999)
   PUBMED   10364263
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Fantin VR, Lavan BE, Wang Q, Jenkins NA, Gilbert DJ, Copeland NG,
            Keller SR and Lienhard GE.
  TITLE     Cloning, tissue expression, and chromosomal location of the mouse
            insulin receptor substrate 4 gene
  JOURNAL   Endocrinology 140 (3), 1329-1337 (1999)
   PUBMED   10067860
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM,
            Tsushima T, Akanuma Y, Komuro I, Tobe K, Yazaki Y and Kadowaki T.
  TITLE     Growth hormone and prolactin stimulate tyrosine phosphorylation of
            insulin receptor substrate-1, -2, and -3, their association with
            p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly
            PI3-kinase activation via JAK2 kinase
  JOURNAL   J Biol Chem 273 (25), 15719-15726 (1998)
   PUBMED   9624169
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Sciacchitano S and Taylor SI.
  TITLE     Cloning, tissue expression, and chromosomal localization of the
            mouse IRS-3 gene
  JOURNAL   Endocrinology 138 (11), 4931-4940 (1997)
   PUBMED   9348224
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124730.5.
            
            On Apr 28, 2007 this sequence version replaced NM_010571.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030311.1, AK040947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-624               AC124730.5         106203-106826       c
            625-2337            AC124730.5         104144-105856       c
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.59 cM"
     gene            1..2337
                     /gene="Irs3"
                     /note="insulin receptor substrate 3"
                     /db_xref="GeneID:16369"
                     /db_xref="MGI:MGI:1194882"
     exon            1..624
                     /gene="Irs3"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1682
                     /gene="Irs3"
                     /codon_start=1
                     /product="insulin receptor substrate 3"
                     /protein_id="NP_034701.1"
                     /db_xref="CCDS:CCDS19773.1"
                     /db_xref="GeneID:16369"
                     /db_xref="MGI:MGI:1194882"
                     /translation="MKPAGTGPTVSSGGECTDVSLGSPFPWPCLPDVRLCGHLRKQKS
                     QRRRFFVLRADPPRLECYESEKKFLASGCRPPRPRRTVSLEGACTISKRADARQRHLI
                     VIYTSDSSLGVAAASEAEQQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAPFQ
                     DVWPVTLRSKGLGRAQGLSSGSYRLCLGSGALSLLRKPGSKGSRDSRATPPPVLRLSL
                     LSVRRCGHADSFFFLELGRSAPIGPGELWLQAPDAVVAQSIHETVLAAMKRLGSNAAG
                     KAEPPPQGNPPKSVPAAPTPTPYEIPASAAQARSPSERAKQDYFKPLERMGSTHSYKG
                     LDLGGNYITMGVRNDYVHMGGGEAGDYMWMAPPGLPPTPARADPNKQLEDCESTEYVP
                     MNRFLPGPFYYELKARESELGHPGAHCSLRDRWRPTVAQPRSSQGSELSGDYMSIPDY
                     VGTDSARLGSLDSCLNYVDLDLVPPLEVPGAAPGKSPHSYASIKF"
     exon            625..2337
                     /gene="Irs3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccactggg acacacgcac tcctgtgtac aggctccttg ttcactccaa gtcaggagag
       61 ggcgtggaga gatgcagggc agctaggccg gctgcagttt cccagggcta cttgttccaa
      121 gcgggtggta gctcaggggg ccagacccat tcaaatcagt ccttctgggg acagtttact
      181 gtctttggct ggaaatgaag cctgcaggta cgggccccac agtctcctcc gggggcgagt
      241 gcaccgacgt gtccctcggc tcaccgtttc cttggccctg cctgcccgac gtgcggctct
      301 gtggccatct gaggaagcag aagtcccagc gccgccgctt tttcgtgctg cgcgctgacc
      361 caccacgcct ggagtgctac gagagcgaga agaagttctt ggccagcggc tgccgcccac
      421 ctagaccccg gcgtaccgtt agcctggagg gtgcctgcac tattagcaag cgcgcggatg
      481 cccgtcagcg ccacctgatc gtcatctata ccagcgacag cagcctgggc gtggcggcgg
      541 ccagcgaagc agagcagcaa gcatggtaca gcgccctgct cgaggtgcgc gccaccgccg
      601 cagccgctgc tgctactgct atgggtttca gtccccaaga ggcccctgag tcttggatct
      661 tcgccccatt ccaggacgtc tggcctgtga cactgcggtc caaggggctg gggagagcac
      721 aaggcctgag cagcggcagc tatcgcctgt gcctgggttc tggggccctg agcctcctgc
      781 gaaagcctgg aagcaaaggt tccagagaca gccgggcaac gccaccacca gtcctgcgct
      841 tgtccttgct cagtgtgcgc cgctgtggcc acgcagactc ttttttcttc ctggaactcg
      901 ggcgctcagc gcccattggt cctggtgagc tctggctgca ggctcctgat gcagtggtgg
      961 cccaaagcat tcatgagaca gtcctggctg ccatgaagcg gctggggagc aatgcagctg
     1021 gcaaagctga gccaccgcca cagggaaatc ctccaaagag tgttcctgca gctcctaccc
     1081 cgacaccata tgaaatccct gcatcggcag cacaagcaag aagccccagt gagcgagcaa
     1141 agcaggacta cttcaagccc ctggaaagga tggggtcaac acactcctac aagggactag
     1201 atctgggcgg gaactacatc accatgggag tcaggaatga ctatgtccac atggggggag
     1261 gagaagcagg tgactatatg tggatggcgc ccccaggcct tcctcccacc cctgccaggg
     1321 cagatcctaa taagcagctc gaggattgtg agagcacaga gtatgtgccc atgaatagat
     1381 ttttacctgg gcctttttac tacgagctca aggccaggga gtctgaactt gggcatccgg
     1441 gtgcccattg tagccttaga gacagatgga gacccacagt ggctcagccc cgctcttccc
     1501 aagggtcaga gctctctggg gactacatgt ccatccccga ctatgtagga acggacagtg
     1561 ctaggctggg gtctctggac agctgcctca actatgtgga cctggacctg gtccctcccc
     1621 tggaggttcc tggagcagcc ccagggaaga gtccacatag ctatgccagc atcaagttct
     1681 agaacttttg ggaggtagtc aggtgaggag acccaggcat tggtcaggga agagaggaaa
     1741 agaagagacc ttagtactgt tcagctcagc tcctgcacac aggacccagg aaccctgagg
     1801 ccaccatgag ctgctctgct gcccccttgc ctgctctgtt ccttccagct gtaccaccta
     1861 ggaagccctc aggaagccat gctcgaggaa ccagactctt cagagaaaac actagaactt
     1921 ctctctgccc tgccagccct ccccccactc gcaatccaag caacaaacaa ataaaaccct
     1981 tctcagatga atgcccacag aatcagtctc aggctagctg tggcccaagc ctggatgaag
     2041 actctcatcc tggtttggga cagctctgtc ccctcacatg ttggcagcta gatgtcattg
     2101 tgtctcctca gccaaaacat tatcctaacc ctgttttttt tcaagccaga gcggaattcc
     2161 taaggctcag aaacaatggg aggagcatca gggatcatga cggtgctcct caagcagcca
     2221 gtgctcccca agcagccagt cctcacctga cctttctctg ggcccagcag acacaaacga
     2281 gttcctcact tcccagagtg cagcccaacc cacccattaa aggtgccctt ctccctg
//
