LOCUS       NM_001081212            6794 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus insulin receptor substrate 2 (Irs2), mRNA.
ACCESSION   NM_001081212 XM_357863
VERSION     NM_001081212.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6794)
  AUTHORS   Mathew,D., Barillas-Cerritos,J., Nedeljkovic-Kurepa,A., Abraham,M.,
            Taylor,M.D. and Deutschman,C.S.
  TITLE     Phosphorylation of insulin receptor substrates (IRS-1 and IRS-2) is
            attenuated following cecal ligation and puncture in mice
  JOURNAL   Mol Med 29 (1), 106 (2023)
   PUBMED   37550630
  REMARK    GeneRIF: Phosphorylation of insulin receptor substrates (IRS-1 and
            IRS-2) is attenuated following cecal ligation and puncture in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6794)
  AUTHORS   Yang,W., Liao,W., Li,X., Ai,W., Pan,Q., Shen,Z., Jiang,W. and
            Guo,S.
  TITLE     Hepatic p38alpha MAPK controls gluconeogenesis via FOXO1
            phosphorylation at S273 during glucagon signalling in mice
  JOURNAL   Diabetologia 66 (7), 1322-1339 (2023)
   PUBMED   37202506
REFERENCE   3  (bases 1 to 6794)
  AUTHORS   Wang,Z., Yi,B., Gan,L., Li,X., Liu,X., Lv,Q. and Yang,L.
  TITLE     Expression of IRS2 in the female reproductive system during the
            estrous cycle in mice
  JOURNAL   Biotech Histochem 98 (3), 187-192 (2023)
   PUBMED   36472073
  REMARK    GeneRIF: Expression of IRS2 in the female reproductive system
            during the estrous cycle in mice.
REFERENCE   4  (bases 1 to 6794)
  AUTHORS   Shvadchenko,A.M., Volobueva,M.N., Ivanova,V.O., Beletskiy,A.P.,
            Smirnova,G.R., Bal,N.V. and Balaban,P.M.
  TITLE     New Context Significantly Changes Expression of Irs2 Gene in
            Hippocampal Areas
  JOURNAL   Biochemistry (Mosc) 87 (11), 1243-1251 (2022)
   PUBMED   36509718
  REMARK    GeneRIF: New Context Significantly Changes Expression of Irs2 Gene
            in Hippocampal Areas.
REFERENCE   5  (bases 1 to 6794)
  AUTHORS   Riehle,C., Weatherford,E.T., McCarty,N.S., Seei,A., Jaishy,B.P.,
            Manivel,R., Galuppo,P., Allamargot,C., Hameed,T., Boudreau,R.L.,
            Bauersachs,J., Weiss,R.M. and Abel,E.D.
  TITLE     Insulin and Insulin-Like Growth Factor 1 Signaling Preserves
            Sarcomere Integrity in the Adult Heart
  JOURNAL   Mol Cell Biol 42 (10), e0016322 (2022)
   PUBMED   36125265
REFERENCE   6  (bases 1 to 6794)
  AUTHORS   Sun,X.J., Pons,S., Wang,L.M., Zhang,Y., Yenush,L., Burks,D.,
            Myers,M.G. Jr., Glasheen,E., Copeland,N.G., Jenkins,N.A.,
            Pierce,J.H. and White,M.F.
  TITLE     The IRS-2 gene on murine chromosome 8 encodes a unique signaling
            adapter for insulin and cytokine action
  JOURNAL   Mol Endocrinol 11 (2), 251-262 (1997)
   PUBMED   9013772
REFERENCE   7  (bases 1 to 6794)
  AUTHORS   Welham,M.J., Bone,H., Levings,M., Learmonth,L., Wang,L.M.,
            Leslie,K.B., Pierce,J.H. and Schrader,J.W.
  TITLE     Insulin receptor substrate-2 is the major 170-kDa protein
            phosphorylated on tyrosine in response to cytokines in murine
            lymphohemopoietic cells
  JOURNAL   J Biol Chem 272 (2), 1377-1381 (1997)
   PUBMED   8995447
REFERENCE   8  (bases 1 to 6794)
  AUTHORS   Yamauchi,T., Tobe,K., Tamemoto,H., Ueki,K., Kaburagi,Y.,
            Yamamoto-Honda,R., Takahashi,Y., Yoshizawa,F., Aizawa,S.,
            Akanuma,Y., Sonenberg,N., Yazaki,Y. and Kadowaki,T.
  TITLE     Insulin signalling and insulin actions in the muscles and livers of
            insulin-resistant, insulin receptor substrate 1-deficient mice
  JOURNAL   Mol Cell Biol 16 (6), 3074-3084 (1996)
   PUBMED   8649419
REFERENCE   9  (bases 1 to 6794)
  AUTHORS   Sun,X.J., Wang,L.M., Zhang,Y., Yenush,L., Myers,M.G. Jr.,
            Glasheen,E., Lane,W.S., Pierce,J.H. and White,M.F.
  TITLE     Role of IRS-2 in insulin and cytokine signalling
  JOURNAL   Nature 377 (6545), 173-177 (1995)
   PUBMED   7675087
REFERENCE   10 (bases 1 to 6794)
  AUTHORS   Tobe,K., Tamemoto,H., Yamauchi,T., Aizawa,S., Yazaki,Y. and
            Kadowaki,T.
  TITLE     Identification of a 190-kDa protein as a novel substrate for the
            insulin receptor kinase functionally similar to insulin receptor
            substrate-1
  JOURNAL   J Biol Chem 270 (11), 5698-5701 (1995)
   PUBMED   7534300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113484.14 and AC138677.8.
            
            On Jun 16, 2018 this sequence version replaced NM_001081212.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147580.1, AK155277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4460              AC113484.14        94085-98544         c
            4461-6794           AC138677.8         194809-197142       c
FEATURES             Location/Qualifiers
     source          1..6794
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.35 cM"
     gene            1..6794
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /note="insulin receptor substrate 2"
                     /db_xref="GeneID:384783"
                     /db_xref="MGI:MGI:109334"
     exon            1..4460
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             500..4465
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /note="4PS"
                     /codon_start=1
                     /product="insulin receptor substrate 2"
                     /protein_id="NP_001074681.1"
                     /db_xref="CCDS:CCDS52477.1"
                     /db_xref="GeneID:384783"
                     /db_xref="MGI:MGI:109334"
                     /translation="MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGH
                     KRFFVLRGPGTGGDEASAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNIN
                     KRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSC
                     SASLPGVLGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCL
                     SARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVV
                     AQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTG
                     LVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPV
                     RAPLSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSG
                     HGSGSYPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLR
                     AFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRG
                     LRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSFPASSPKVAYNPY
                     PEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAP
                     KQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYKASSPAESSPEDSGYMRMWCG
                     SKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALRGGSEGLKGIPGHCYSSLP
                     RSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHHSAV
                     PSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINI
                     DFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMN
                     LDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQPLPPAPGD
                     LYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVA
                     SPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTT
                     VTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAVPPVP
                     QARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQPG
                     DKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVK
                     E"
     exon            4461..6794
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6773..6778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /note="hexamer: AATACA"
     polyA_site      6794
                     /gene="Irs2"
                     /gene_synonym="Irs-2"
                     /note="major polyA site"
ORIGIN      
        1 gttactcact gtgcggcggg gaccgcgaca agcccgggtc gtcgttggtg gcagcagcag
       61 cagcggcagc aacggcagca gcggccccag tggcagtgtg ggccccgagt gtccggacgc
      121 agaccgtcgt cgcgcagtgc agaacggtgg cagcagacgg gccgcgcgcg ttctaagctc
      181 ggccccgcga ctcggggacc ccgactctcg acccagccag ccagtccccg ggcgccgccc
      241 gagagcccgg gaagcagcgg cagcggacag tcgaagcggg ggggtggcca tcgcccgcac
      301 cgagcatcct tcggagcggc ggagggccct gcgccaccga gccgcgcgcg cctcctagcc
      361 caccgcctgg gcccggggga cgcgcgcgcg tggccgggcg gccgggcgac gggtggcggg
      421 gagccgcccc cgcccgcgcc cctcggccct cgccatcccc tgttcgccca gccgggcaga
      481 gagacctgaa gcggcggcga tggctagcgc gcccctgcct gggccccccg cgtcggcggg
      541 cggggacggc ccgaacctca ataacaacaa caacaacaac aaccacagcg tgcgcaagtg
      601 cggctacctg cgcaagcaga agcacggcca caagcgcttt ttcgtgttgc gcggccccgg
      661 cacgggcggc gacgaggcat ccgcggctgg ggggtcgccg ccgcagcctc cgcggctgga
      721 gtactacgag agcgagaaga agtggaggag caaggcgggc gcgccgaagc gagtgatcgc
      781 gctcgactgc tgtctgaaca tcaacaagcg cgcggacgcc aagcacaagt acctgatcgc
      841 cctctacacc aaggacgagt acttcgctgt agcggcggag aacgagcagg agcaggaggg
      901 ctggtaccgc gcactcaccg acttggtcag cgaaggccgc tctggcgagg ggggctcggg
      961 caccaccgga ggctcttgca gcgcctctct cccgggcgtc ctgggcggct cagcgggcgc
     1021 cgctggctgc gatgacaact acgggctcgt gacacccgcc acggccgtct accgcgaggt
     1081 gtggcaggtg aacctgaaac ctaagggact gggccagagc aagaacctga ctggtgtata
     1141 ccgcctatgc ctgtctgcgc gcaccatcgg cttcgtgaag ctcaattgcg aacagccgtc
     1201 ggtgacgctg cagcttatga acattcgccg ctgcggccac tcggacagct tcttcttcat
     1261 cgaggtgggc cgttcggccg tcaccggtcc cggggagctg tggatgcaag ccgacgactc
     1321 ggtggtggcg cagaacatcc atgagaccat cctagaagct atgaaggcac tcaaagagct
     1381 cttcgagttc cggcctcgca gcaagagtca gtcgtccggg tcgtcagcca cgcatcccat
     1441 cagcgtgccg ggcgcgcgcc gccaccacca cctagtcaac ctacccccta gccagaccgg
     1501 cctggtgcgc cgctcgcgca ctgacagcct ggcggccacc cccccagcag ccaagtgcac
     1561 ttcgtgccgg gttcgtacgg ccagcgaggg cgacggcggc gcggcaggcg gggccgggac
     1621 ggcaggaggc aggccgatgt cggtggcagg gagccccctg agtcccgggc cggtgcgcgc
     1681 gccccttagc cgctcgcaca ccctgagcgc cggctgcgga ggccgcccga gcaaagtgac
     1741 tctggcgccg gcagggggag ccctgcaaca cagccgctcc atgtccatgc ccgtggcgca
     1801 ctcacctcct gcagccacca gcccaggcag cctgtcctcc agcagtgggc acggctcggg
     1861 ctcctacccg ctgccacctg gctcccaccc gcacctgcct catccactgc atcaccccca
     1921 aggccagcgt ccgtccagcg gtagtgcctc cgcctcgggc tcccccagcg acccgggttt
     1981 catgtccctt gacgagtatg gctccagccc tggcgacctg agagccttca gtagccacag
     2041 gagcaacaca cccgagtcaa tagcggagac cccgccagcc agagatggca gtgggggcga
     2101 actctatggg tacatgagca tggatagacc cctgagccac tgtggccgcc cttaccgtag
     2161 ggtctcaggg gatggggccc aggacctgga tagaggactg aggaagagga cttattccct
     2221 aaccacgcct gccaggcagc ggcaggtacc tcagccttcc tctgcctctc tagatgaata
     2281 cactctcatg agggccacct tctctggtag ttcaggtcgc ctctgcccat ccttccctgc
     2341 gtcctctccc aaagtggcct acaaccctta cccagaggac tatggagaca ttgagattgg
     2401 ttctcacaag agttccagca gtaacctggg ggcagatgat ggctacatgc ccatgacccc
     2461 tggggcagcc cttaggagtg gtggtcccaa tagctgcaag agcgatgact acatgcccat
     2521 gagccccaca agcgtgtctg ctcccaagca gatcctgcag ccacgcttgg cagcggcctt
     2581 gcccccttcc ggagcagccg tgccagcacc cccttcaggg gtgggcagga ccttcccagt
     2641 aaacggaggt ggctacaaag ccagctcccc agcggagagc tccccagaag acagtgggta
     2701 catgcgaatg tggtgtggct ccaagctgtc tatggagaac ccagacccta agctactccc
     2761 caacggggac tacctcaaca tgtcccccag cgaggcaggc actgcaggga ccccacctga
     2821 cttctcagca gctttgcgtg gaggcagtga aggcctcaaa ggcatcccgg gccactgcta
     2881 cagctctttg ccccgctctt ataaggctcc ctgttcctgc agcggagaca atgaccagta
     2941 tgtgctcatg agctcccctg tgggccggat cttggaagag gagagactgg agccccaggc
     3001 caccccaggg gctggcacct ttggggcagc tggtggtagt catacccagc ctcatcactc
     3061 agcagtgcct tcctccatga ggccgagtgc catcggtggc cgccctgagg gcttcctggg
     3121 ccagcgatgt cgggcagtgc ggcctacacg cctatcgcta gagggactgc agacccttcc
     3181 cagcatgcaa gagtaccctc tacccacaga gcccaagagc cctggcgagt acatcaacat
     3241 tgactttggt gaggcaggta cccgtctgtc tccgcctgcc cccccactac tggcatccgc
     3301 ggcctcatct tcttcactgc tctcagctag tagtcctgct tcatccctgg gttcaggaac
     3361 cccaggcacc agcagcgaca gccggcagcg ctctccactc tctgactata tgaacctgga
     3421 cttcagttct cccaagtccc ccaagcctag cacccgcagt ggggacacag taggctccat
     3481 ggatggcctt ctctctccag aggcttcatc cccataccca ccactgcccc cacgtccttc
     3541 cacttcccct tcctccttac agcagcctct gccacctgcc ccgggagacc tataccgcct
     3601 gcctccagca tcagctgcca cttcccaggg tcccactgct ggctcctcaa tgtcctccga
     3661 gcctggggat aatggtgact ataccgagat ggcctttggt gtggctgcaa ccccgccaca
     3721 acctatcgtg gcacctccaa agccagaagg tgcccgagtg gccagtccca catcgggctt
     3781 gaagcggcta agtctcatgg atcaggtatc tggggtggag gctttccttc aagtcagcca
     3841 gccccctgac ccccaccggg gtgctaaggt catccgtgca gacccacagg ggggacgtcg
     3901 tcgccacagt tcagagacct tttcctctac caccaccgtc accccagtgt ccccatcctt
     3961 tgcccacaat tccaagcgcc acaattcggc ctctgtggaa aatgtctcac tcaggaaaag
     4021 cagtgaaggc agcagtaccc tgggaggagg tgatgagccg cccacatccc caggacaggc
     4081 acagcccttg gtggctgtgc ccccagtgcc acaggctagg ccgtggaacc ccggtcagcc
     4141 cggagctttg attggctgtc ctggaggcag cagttctccc atgcgcagag agacctccgt
     4201 gggtttccag aacggcctca actatatcgc catcgatgtg agaggcgagc aggggtcctt
     4261 ggcgcagtct cagccgcagc caggagacaa gaactcctgg agccggaccc gtagccttgg
     4321 ggggctcctc ggcaccgtcg gaggctctgg cgccagcgga gtgtgtgggg gtccaggcac
     4381 tggagctttg ccctctgcca gcacctatgc aagcatcgac ttcctgtccc atcacttgaa
     4441 ggaagccaca gtcgtgaaag agtgaagcgc taccagcccc atcgccgcca tgttgaaaaa
     4501 aacaaaaaca aaaacaaaac aaaaaaaaca aaactctgaa tccattcgaa ggagatgctt
     4561 ggcatgtttc cgaccaacgc tgctgctcac tttcctatca acgggagcaa ttctacattt
     4621 tgagacttct gtgaattaga taaggaacca agaggcaggt ctgcctctca gctgtcccca
     4681 cacaccagcc ctcatcgcac ggtttgtgtt gcattttgtt tcctttgtga actgacgggc
     4741 tgatggcgta cactccggga gattggacgt ttccaccgcc gccggcctcc ataagtcctg
     4801 gccatcgctg tcatttttct cttgttactt tcattttggc aaagtggatt aatccctcag
     4861 catgcaagga gatgctataa tatacatgga agtggtcaaa tctggtattt actggcttac
     4921 agtcaaaact accacagtcc tacctcagtt cagggtgaag ccggattgtt tggcagggta
     4981 cagggcgact ctgccccagg atcacatgct gacctccgtc tctctgttaa gtcgatgtgg
     5041 actccagtcc aggtacctga atggtttacc tacgcacaga gcccggtgtg ggactgaata
     5101 ttctccgtgg gattggactt gaagatggat taatcctaaa aattcctaaa tgtgactgga
     5161 gcagcctcct tttggagatc atcagccgta tttgggggta ggggtgggga tgggtggatc
     5221 tctctttgtg tctacaacag gcttgttgac tcctctctct gtagatgttc gtgtaagtcc
     5281 ttcagattgc aagagccttt tctcccctcc acaagcctcc tggctgtgac tcttagctca
     5341 ccatcctcaa acctaaaact caacacaggc acgcttgtag ctcaagactg gcttgggctt
     5401 ttgtttttta aatatattat ctctggcaca atgttacttt tgttggccaa caaggttgcc
     5461 ctgaacagga ggggaggcat tccagccatt gtactatgaa tggcaaaaga ggaaaaacat
     5521 ctctccccct acactttcct gtcaacggtt cttgacagag actaccctgg ttctgttgtc
     5581 agtgttctgg aaatgtcagt gttgtggaac tgtttcatat gtcacctaga agggctgagc
     5641 ttgccggcag aatcgccgtc acctcgctgc tccgtcacag ggctggaggc cctgcctccc
     5701 tgaccccccc acttcccagt gcctgtctcc atagtcctgt agaggctaca ctaataactc
     5761 ttggaaatgt gagttgctgg tttatttttt aatcattgtt ttgtttttgt ttgggatgta
     5821 tatatatata tatatatatg tgtcactata gaataatgca ttggtaaggt aagaatgggc
     5881 ttttagagga tgaccaaaaa aaattccatg tcttaaaaaa tatatttaat ggcaatgcag
     5941 ctgtcttcct gcttccgttg ctgagcttgt agaagaaggc tgtattgcaa gacaaagttg
     6001 aatgtaaatt gatctcccca caccccgcgc caattctcaa ggtttacctt gctgcagttg
     6061 tgcatcttaa gcagtttggg ccacatagca ctgtgtgtgc tatcctttac tgagctgtta
     6121 aaggatctcc ggaaatcttc tccagtgttg atgaggaacc tgcgctgcat ttgctgtgta
     6181 gctgaatccc ccagggacag taggactgat ctgctgacta cagcacgtcg aggcagatgt
     6241 gacacaccct ccatgctggg agtggtcacc acaggacaca gatggcatat gtccctgatg
     6301 cagctgacat gaacaagaag agaaatcgag aatacactaa atccccctcc tcctgtacat
     6361 ttcaagaaga gcaggcatat gcaatattta catccttaat ttagtttaca gaatggaacc
     6421 aaaatgtgta agtgttacgt tcgccacact tcatgctgta cattgggtct ttgtacattt
     6481 tgcttgactt aatcttaaat ttaaactatt ttttgctata taaactttaa cagttattaa
     6541 acagtgtttt ctttgggtac atgtttcctg gataccaaga tgttaaatat atttctcgct
     6601 attgtgtttc aacaagagac ttgccctccc tgttgtcttc cactgtacat gctgtatata
     6661 ggggtcacgt gatgccgctg aagacaagaa taaactggag tagattagtt tgctgtattt
     6721 agtctgtatt gaccatggat gccctcctta atagccatat gcaataaaat aaaatacatt
     6781 atttatgaaa tgaa
//
