LOCUS       NM_019440               3537 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus immunity-related GTPase family M member 2 (Irgm2),
            mRNA.
ACCESSION   NM_019440
VERSION     NM_019440.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3537)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3537)
  AUTHORS   Christgen,S., Place,D.E., Zheng,M., Briard,B., Yamamoto,M. and
            Kanneganti,T.D.
  TITLE     The IFN-inducible GTPase IRGB10 regulates viral replication and
            inflammasome activation during influenza A virus infection in mice
  JOURNAL   Eur J Immunol 52 (2), 285-296 (2022)
   PUBMED   34694641
REFERENCE   3  (bases 1 to 3537)
  AUTHORS   Dockterman,J., Fee,B.E., Taylor,G.A. and Coers,J.
  TITLE     Murine Irgm Paralogs Regulate Nonredundant Functions To Execute
            Host Defense to Toxoplasma gondii
  JOURNAL   Infect Immun 89 (11), e0020221 (2021)
   PUBMED   34338548
  REMARK    GeneRIF: Murine Irgm Paralogs Regulate Nonredundant Functions To
            Execute Host Defense to Toxoplasma gondii.
REFERENCE   4  (bases 1 to 3537)
  AUTHORS   Pradipta,A., Sasai,M., Motani,K., Ma,J.S., Lee,Y., Kosako,H. and
            Yamamoto,M.
  TITLE     Cell-autonomous Toxoplasma killing program requires Irgm2 but not
            its microbe vacuolar localization
  JOURNAL   Life Sci Alliance 4 (7), e202000960 (2021)
   PUBMED   34078740
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3537)
  AUTHORS   Eren,E., Planes,R., Bagayoko,S., Bordignon,P.J., Chaoui,K.,
            Hessel,A., Santoni,K., Pinilla,M., Lagrange,B., Burlet-Schiltz,O.,
            Howard,J.C., Henry,T., Yamamoto,M. and Meunier,E.
  TITLE     Irgm2 and Gate-16 cooperatively dampen Gram-negative
            bacteria-induced caspase-11 response
  JOURNAL   EMBO Rep 21 (11), e50829 (2020)
   PUBMED   33124769
REFERENCE   6  (bases 1 to 3537)
  AUTHORS   Hunn,J.P., Koenen-Waisman,S., Papic,N., Schroeder,N., Pawlowski,N.,
            Lange,R., Kaiser,F., Zerrahn,J., Martens,S. and Howard,J.C.
  TITLE     Regulatory interactions between IRG resistance GTPases in the
            cellular response to Toxoplasma gondii
  JOURNAL   EMBO J 27 (19), 2495-2509 (2008)
   PUBMED   18772884
REFERENCE   7  (bases 1 to 3537)
  AUTHORS   Miyairi,I., Tatireddigari,V.R., Mahdi,O.S., Rose,L.A.,
            Belland,R.J., Lu,L., Williams,R.W. and Byrne,G.I.
  TITLE     The p47 GTPases Iigp2 and Irgb10 regulate innate immunity and
            inflammation to murine Chlamydia psittaci infection
  JOURNAL   J Immunol 179 (3), 1814-1824 (2007)
   PUBMED   17641048
  REMARK    GeneRIF: p47 GTPases Irgb10 and Iigp2 act together to confer
            differential susceptibility against murine chlamydial infection.
REFERENCE   8  (bases 1 to 3537)
  AUTHORS   Martens,S., Parvanova,I., Zerrahn,J., Griffiths,G., Schell,G.,
            Reichmann,G. and Howard,J.C.
  TITLE     Disruption of Toxoplasma gondii parasitophorous vacuoles by the
            mouse p47-resistance GTPases
  JOURNAL   PLoS Pathog 1 (3), e24 (2005)
   PUBMED   16304607
REFERENCE   9  (bases 1 to 3537)
  AUTHORS   Bekpen,C., Hunn,J.P., Rohde,C., Parvanova,I., Guethlein,L.,
            Dunn,D.M., Glowalla,E., Leptin,M. and Howard,J.C.
  TITLE     The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of
            the cell autonomous resistance mechanism in the human lineage
  JOURNAL   Genome Biol 6 (11), R92 (2005)
   PUBMED   16277747
REFERENCE   10 (bases 1 to 3537)
  AUTHORS   Boehm,U., Guethlein,L., Klamp,T., Ozbek,K., Schaub,A., Futterer,A.,
            Pfeffer,K. and Howard,J.C.
  TITLE     Two families of GTPases dominate the complex cellular response to
            IFN-gamma
  JOURNAL   J Immunol 161 (12), 6715-6723 (1998)
   PUBMED   9862701
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142291.1 and AJ007972.1.
            
            [WARNING] On Feb 5, 2025 this sequence was replaced by NM_019440.4.
            
            On Sep 20, 2008 this sequence version replaced NM_019440.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142291.1, AK165347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2041              AK142291.1         3-2043
            2042-3537           AJ007972.1         1843-3338
FEATURES             Location/Qualifiers
     source          1..3537
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 36.07 cM"
     gene            1..3537
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="immunity-related GTPase family M member 2"
                     /db_xref="GeneID:54396"
                     /db_xref="MGI:MGI:1926262"
     exon            1..194
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..3514
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1403
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="interferon inducible GTPase 2; interferon-g induced
                     GTPase; interferon-gamma-inducible GTPase Ifggd2 protein"
                     /codon_start=1
                     /product="immunity-related GTPase family M protein 2"
                     /protein_id="NP_062313.3"
                     /db_xref="CCDS:CCDS48803.1"
                     /db_xref="GeneID:54396"
                     /db_xref="MGI:MGI:1926262"
                     /translation="MEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEG
                     EVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRT
                     TQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHV
                     KLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFL
                     VSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNL
                     HTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDD
                     WVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSI
                     PHP"
     regulatory      3483..3488
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="hexamer: AATAAA"
     regulatory      3487..3492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="hexamer: AATAAT"
     polyA_site      3506
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="major polyA site"
     polyA_site      3510
                     /gene="Irgm2"
                     /gene_synonym="GTPI; Ifggd2; Iigp2"
                     /note="major polyA site"
ORIGIN      
        1 ctagaagttg gggacttaca tctgggccaa catagataga gcagggtctg agaggaaacc
       61 taggagctca ggctgccctt cagctgctcc tgcctcttct aatcgctctt ccccacagga
      121 ccctgcccca ccacacttct ctctctcctg accgtcctga gcctggattg cagttttgta
      181 aggcttctga gcaggttgcc ccgttgctcg acaacatgga agaggcagtt gagtcacctg
      241 aggttaaaga atttgaatac ttctccgacg ctgtattcat tcccaaagac ggcaatactt
      301 tatctgtagg cgtcattaag agaattgaga ctgccgtgaa agaaggggag gtagtgaaag
      361 tggtttctat agttaaagag atcatacaga acgtttccag aaacaaaata aagatcgctg
      421 tgactgggga ctctggcaat ggcatgtcat ctttcatcaa tgcccttagg ctcatcggac
      481 acgaagagaa agattcagct cccactgggg tggtgagaac cacccagaaa ccaacctgtt
      541 acttttcctc ccactttccc tatgtggagc tgtgggacct gcctggctta ggggccacag
      601 cccagagtgt ggagagctac ctggaagaga tgcagatcag catatacgac cttatcatca
      661 tcgtagcttc tgagcagttc agcttaaatc atgtgaagct ggccataacc atgcagagga
      721 tgagaaagag gttctatgtc gtctggacca agctggacag ggacctcagc acaagtacct
      781 tccctgaacc ccagctactg cagagtatcc aaaggaatat ccgggatagt cttcagaagg
      841 agaaagtgaa ggagcacccc atgttcctgg tatctgtctt taagcctgaa tcacatgact
      901 tcccaaagct tagggagaca ctacaaaaag acctccctgt catcaagtac cacggcctcg
      961 tcgaaaccct ttaccaagtc tgtgagaaaa ctgttaatga gagagtagag tccattaaaa
     1021 agagtataga tgaagataac ctacacacag agtttgggat ctcggatccg ggtaacgcga
     1081 tagagattcg gaaagccttc caaaaaacct ttggtttgga tgacatatct ctccacctgg
     1141 ttgctctgga aatgaaaaat aaacatttca acactagtat ggagtcccag gagacccaga
     1201 ggtaccaaca agatgactgg gtgctggctc ggttgtatcg cactggaacc cgggttggct
     1261 ctataggttt tgactacatg aagtgctgct ttacctctca tcacagtcga tgcaaacaac
     1321 agaaagatat acttgatgaa actgctgcca aagccaagga agttctgtta aaaatcctga
     1381 gactctccat tcctcatcct taggaaggtt tagacaactg gagtcttctc cccagccctg
     1441 taccccatgt gtacccccag ttgagataac acccctctcc cccacgccat ggggtccaag
     1501 ttccttgagg ttactaggcc gactgtctta atgggtatcc ctctcgtgag acaccataat
     1561 gggttttgct aactgaatta cctgggatct gactatagga taagtttccc tgttctaatt
     1621 gtttggaatg ccatgtttga cacatgctca ccttagcgcc aacgacgagg ggcctcttgg
     1681 tctactcctg tctctttttg tctcttttcg tccttgactc tggagatgga gtatctctta
     1741 gggaatgggg aagagcttgt ctttggctat tgtctgaaaa acgtggccag cagaggcctg
     1801 ttctccaacc cctcctctga tgtgtaaaga ggagaggggc attaactccg gcattactag
     1861 taataggatt cacacagtgc tgaagagaat gattctcagc accctacact acccttgatg
     1921 gtgtcaatgg tatcatgatt agtcctggcc cttcacactc tgggctctca gtcttatatt
     1981 ggacttcaac ttcttcagca gcccctaatt ctgcaggctg cacctccatc cagacacaca
     2041 aggacccttc tccctttgcc atgaagcact cacatttgaa tctgtgtgtg tgactttgca
     2101 tttaagacag gtgccgctcc gtgttctgtc atgctccttt ctctcagccc tgctttcgat
     2161 agatatcagt actgtcagcc caacttccct agcggtctca ggcctctgtc ctccccttct
     2221 cccctttcac ctctttggca caatgttaaa tgctttcttt cttttttctc tgtgtagccc
     2281 tggctgtcct ggaactcact ctgtagacca ggctggcctc aaactcagaa atccacctgc
     2341 ctctgccaac tgttaccagc atcacaccgg agcgtttagt ttgggctcat agtttgctag
     2401 tacagtccat cacagctgaa agtcatcaca gtgggagcac agagcagctg atcccgtgtg
     2461 tccgctatca gggagcagag agagatgaat agggctcttt ggcacacatt ctccttttca
     2521 ttcagcccaa gaccagccta tagaatgata tcatccacgt tcagagtggg tcttccaacc
     2581 ttcatgaacc aagtccagag actccttcat agacacgccc aaaggtctct ttgcatagtg
     2641 attctagatc ctgccaacct gccaaccaat attaactaca caggcactca ggggatctag
     2701 gacttttatt ggttaatagt gggaagaagg ttgggtgtgg cttagtagta caatgttttc
     2761 ctagcacatg gaaggctatg gttttgatac ctagaaagaa acaaaatctg ttctgaaatg
     2821 gaaggaaaat gccaattata tttgttgaga aaatacaatt aaattatatt attggcacag
     2881 gcacttcaaa aaaagaatca cttaaatgta aaaggtgggt ttactgtata tgctgtgggt
     2941 aaggatagga tggactaaga agtctcacga tggtgggatt gggggtgagc caagttctgc
     3001 taagactcac cttccacctg cttgttcttt ggttaatgtg gtgccatgga agtcacagga
     3061 gaggtctgca aagaaaccgc agaggttttg tctgtcgtcc ttatgacatt cgtgtgtact
     3121 cagaaataat tcctgaggtc aaggttatgg catagatgct gctccgcaat gtcagctgta
     3181 aataagaaag cgagtttgct ctttaaaagc tcgcctgagg ttgtatgtgt tggtcacagg
     3241 gtatctcacc tggccccagc actgaggaaa ctgtgatctc actgttggcc gggctggaga
     3301 agcagggtgt gaattctctc cgtgtcttag gtcatagaca tagattttct ctttgctggt
     3361 tgtatgtaca tacctatcta tatacagata cagaagtata tgtacacaga tattatatat
     3421 tcatcacaca catttattat gcattgtatg taacatacat gtagtgttga tctttgtgat
     3481 ggaataaata atcacagtat attatataaa tagaaaaaaa aaaaaaaaaa aaaaaaa
//
