LOCUS       NM_008326               2321 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus immunity-related GTPase family M member 1 (Irgm1),
            transcript variant 1, mRNA.
ACCESSION   NM_008326
VERSION     NM_008326.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2321)
  AUTHORS   Cai,H., Ma,G., Zhang,Z., Liu,G., Lu,R., Liu,Y., Wang,J., Wang,S.,
            Sun,S., E,M., Li,Z., Fang,S. and Yu,B.
  TITLE     A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (6), 167238 (2024)
   PUBMED   38759815
  REMARK    GeneRIF: A potential early-atheroprotective target: Irgm1 mediates
            lymphangiogenesis through LEC autophagy by Tfeb translocation.
            Erratum:[Biochim Biophys Acta Mol Basis Dis. 2024 Dec 11:167610.
            doi: 10.1016/j.bbadis.2024.167610.. PMID: 39665974]
REFERENCE   2  (bases 1 to 2321)
  AUTHORS   Dockterman,J., Reitano,J.R., Everitt,J.I., Wallace,G.D.,
            Hendrix,M., Taylor,G.A. and Coers,J.
  TITLE     Irgm proteins attenuate inflammatory disease in mouse models of
            genital Chlamydia infection
  JOURNAL   mBio 15 (4), e0030324 (2024)
   PUBMED   38501887
  REMARK    GeneRIF: Irgm proteins attenuate inflammatory disease in mouse
            models of genital Chlamydia infection.
REFERENCE   3  (bases 1 to 2321)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2321)
  AUTHORS   Chauhan,N.R., Kundu,S., Bal,R., Chattopadhyay,D., Sahu,R.,
            Mehto,S., Yadav,R., Krishna,S., Jena,K.K., Satapathy,S., Pv,A.,
            Murmu,K.C., Singh,B., Patnaik,S., Jena,S., Harshan,K.H., Syed,G.H.,
            Idris,M.M., Prasad,P. and Chauhan,S.
  TITLE     Transgenic mouse models support a protective role of type I IFN
            response in SARS-CoV-2 infection-related lung immunopathology and
            neuroinvasion
  JOURNAL   Cell Rep 42 (11), 113275 (2023)
   PUBMED   37874678
REFERENCE   5  (bases 1 to 2321)
  AUTHORS   Rai,P., Sharpe,M., Ganta,C.K., Baker,P.J., Mayer-Barber,K.D.,
            Fee,B.E., Taylor,G.A. and Fessler,M.B.
  TITLE     IRGM1 supports host defense against intracellular bacteria through
            suppression of type I interferon in mice
  JOURNAL   J Clin Invest 133 (21), e171982 (2023)
   PUBMED   37698925
  REMARK    GeneRIF: IRGM1 supports host defense against intracellular bacteria
            through suppression of type I interferon in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2321)
  AUTHORS   Martens,S., Sabel,K., Lange,R., Uthaiah,R., Wolf,E. and Howard,J.C.
  TITLE     Mechanisms regulating the positioning of mouse p47 resistance
            GTPases LRG-47 and IIGP1 on cellular membranes: retargeting to
            plasma membrane induced by phagocytosis
  JOURNAL   J Immunol 173 (4), 2594-2606 (2004)
   PUBMED   15294976
  REMARK    GeneRIF: LRG-47 is a Golgi-associated protein in the IFN-stimulated
            cell, which is rapidly recruited to active plasma membrane upon
            phagocytosis and remains associated with phagosomes as they mature
REFERENCE   7  (bases 1 to 2321)
  AUTHORS   Feng,C.G., Collazo-Custodio,C.M., Eckhaus,M., Hieny,S., Belkaid,Y.,
            Elkins,K., Jankovic,D., Taylor,G.A. and Sher,A.
  TITLE     Mice deficient in LRG-47 display increased susceptibility to
            mycobacterial infection associated with the induction of
            lymphopenia
  JOURNAL   J Immunol 172 (2), 1163-1168 (2004)
   PUBMED   14707092
  REMARK    GeneRIF: A role is established for LRG-47 in host control of
            mycobacteria; in the context of the IFN-gamma response to
            persistent infection, LRG-47 can have downstream regulatory effects
            on lymphocyte survival.
REFERENCE   8  (bases 1 to 2321)
  AUTHORS   MacMicking,J.D., Taylor,G.A. and McKinney,J.D.
  TITLE     Immune control of tuberculosis by IFN-gamma-inducible LRG-47
  JOURNAL   Science 302 (5645), 654-659 (2003)
   PUBMED   14576437
  REMARK    GeneRIF: LRG-47 may serve as a critical vacuolar trafficking
            component used to dispose of intracellular pathogens like
            Mycobacterium tuberculosis
REFERENCE   9  (bases 1 to 2321)
  AUTHORS   Collazo,C.M., Yap,G.S., Sempowski,G.D., Lusby,K.C., Tessarollo,L.,
            Vande Woude,G.F., Sher,A. and Taylor,G.A.
  TITLE     Inactivation of LRG-47 and IRG-47 reveals a family of interferon
            gamma-inducible genes with essential, pathogen-specific roles in
            resistance to infection
  JOURNAL   J Exp Med 194 (2), 181-188 (2001)
   PUBMED   11457893
REFERENCE   10 (bases 1 to 2321)
  AUTHORS   Sorace,J.M., Johnson,R.J., Howard,D.L. and Drysdale,B.E.
  TITLE     Identification of an endotoxin and IFN-inducible cDNA: possible
            identification of a novel protein family
  JOURNAL   J Leukoc Biol 58 (4), 477-484 (1995)
   PUBMED   7561525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY159883.1, AK002545.1 and CJ217401.1.
            
            On Sep 28, 2017 this sequence version replaced NM_008326.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002545.1, U19119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BY159883.1         2-54
            54-2292             AK002545.1         2-2240
            2293-2321           CJ217401.1         368-396
FEATURES             Location/Qualifiers
     source          1..2321
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 28.84 cM"
     gene            1..2321
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /note="immunity-related GTPase family M member 1"
                     /db_xref="GeneID:15944"
                     /db_xref="MGI:MGI:107567"
     exon            1..327
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /inference="alignment:Splign:2.1.0"
     exon            328..546
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1749
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /note="isoform 1 is encoded by transcript variant 1;
                     interferon-inducible protein 1; immunity-related GTPase
                     family M protein 1; LPS-stimulated RAW 264.7 macrophage
                     protein 47; interferon-gamma-inducible GTPase Ifggd3
                     protein; immunity related GTPase m1"
                     /codon_start=1
                     /product="immunity-related GTPase family M protein 1
                     isoform 1"
                     /protein_id="NP_032352.1"
                     /db_xref="CCDS:CCDS24588.1"
                     /db_xref="GeneID:15944"
                     /db_xref="MGI:MGI:107567"
                     /translation="MKPSHSSCEAAPLLPNMAETHYAPLSSAFPFVTSYQTGSSRLPE
                     VSRSTERALREGKLLELVYGIKETVATLSQIPVSIFVTGDSGNGMSSFINALRVIGHD
                     EDASAPTGVVRTTKTRTEYSSSHFPNVVLWDLPGLGATAQTVEDYVEEMKFSTCDLFI
                     IIASEQFSSNHVKLSKIIQSMGKRFYIVWTKLDRDLSTSVLSEVRLLQNIQENIRENL
                     QKEKVKYPPVFLVSSLDPLLYDFPKLRDTLHKDLSNIRCCEPLKTLYGTYEKIVGDKV
                     AVWKQRIANESLKNSLGVRDDDNMGECLKVYRLIFGVDDESVQQVAQSMGTVVMEYKD
                     NMKSQNFYTLRREDWKLRLMTCAIVNAFFRLLRFLPCVCCCLRRLRHKRMLFLVAQDT
                     KNILEKILRDSIFPPQI"
     exon            547..2305
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /note="hexamer: AATAAA"
     polyA_site      2305
                     /gene="Irgm1"
                     /gene_synonym="Ifggd3; Ifi1; Iigp3; Iipg3; Irgm"
                     /note="major polyA site"
ORIGIN      
        1 gagtccgtcc cccccccgct cccccgctgg gcccaggcag gcatatctcc ggtctagaaa
       61 gtgcaggaca aaaagcaagg tctgctcgaa gaccagaagc tgaaagaaaa tccacgcgat
      121 cagacctcct cttggttcgt ctcctctcag aaggactcca gacctctgca tctcatctct
      181 caacatccgg gtctatattc cagttttgga tctctacata gggaacttct gccggaggac
      241 agcaacgttt ttgtcctagg aagaaagggg tgacgttcca ggaaggccac taacatcgaa
      301 tcacacataa taactcctct ggatcagggt ttgaggagta ttaagtgaga taaggcattc
      361 gaaggaacca actcagattc acagacagag gacctgtgtg cttaaagtct aagagtggag
      421 gaagaacctg aggagcggct tcctcagaga ccctaataaa accagagagc ctcaccaggg
      481 agctgaaagg tccacagaca gcgtcactcg gatcttatca tgaaaccatc acacagttcc
      541 tgcgaggctg ctccactact ccccaacatg gcagagaccc attatgctcc cctgagctca
      601 gccttcccct ttgtcacgtc ataccaaaca ggctccagca ggttacctga ggtcagtagg
      661 agcaccgaaa gagctttaag agaaggaaaa ctactggaac tggtctacgg aatcaaggag
      721 actgtggcaa cattgtccca gattccagtg agcatctttg tgactgggga ctctggcaat
      781 ggcatgtcat ctttcatcaa tgcacttcga gtcatcggcc atgatgaaga tgcctcggct
      841 cccactgggg tggtgaggac cacgaagacg cggactgagt actcttcatc ccactttccc
      901 aatgtggtgc tgtgggactt acctggattg ggggccacag cccaaaccgt agaggactat
      961 gtggaagaga tgaaatttag cacatgtgac ttattcatca tcattgcctc tgagcagttc
     1021 agctcgaatc atgtgaagct gtccaaaatt atccagagca tgggaaagag gttctatatt
     1081 gtctggacca agctggacag ggacctcagc accagtgtcc tatcagaggt ccggctccta
     1141 cagaatatcc aggagaatat ccgagagaat ctgcagaagg agaaagtgaa gtaccccccc
     1201 gtgttcctgg tatccagtct agacccttta ctatatgact tcccgaagct tagggacaca
     1261 cttcataaag atctctccaa catcaggtgc tgtgaaccct taaagaccct ttatggcact
     1321 tatgagaaga tcgttggtga taaagtagca gtctggaagc agagaatagc caacgagtcc
     1381 ttgaagaatt ctctcggtgt cagagatgat gacaacatgg gcgagtgtct gaaagtgtac
     1441 cgactgatat ttggtgtaga tgacgaatca gttcagcagg tagcccagag tatggggaca
     1501 gtagtcatgg agtacaagga caacatgaag tcccaaaact tttatactct ccgcagagag
     1561 gactggaaac tgaggctgat gacatgtgca attgtgaatg cattcttccg tttgttgaga
     1621 tttctcccat gcgtatgctg ctgtttaaga cgcttgagac ataaacgcat gcttttctta
     1681 gttgcccagg acaccaagaa catcctagag aaaatcctga gggactccat cttccctccg
     1741 cagatctagt ataagggcag cctggtaccc ttcttcttcc acagaagcca ggttacctta
     1801 gatctctttc ctagatccct atttctccac cagaaatcaa gagatacaaa aatgcttcct
     1861 gtaagggttt tagattctct gagaggagtt aaaatcactc atctcccctg tctcgattct
     1921 aatgcattgt tccactgagg gacagggaca agtagtgatt aaaattcatt gaccatgatt
     1981 cttagatttg gaatatagaa attttgtttt tgggctggag agatggctta gcagttaaga
     2041 acaccaactg cttttccgaa ggtcatgagt tcaaatccca gcaaccacgt gatggctcac
     2101 aaccatccgt agtgagatct gatgccctct tctgagatgt ctgaagacag ctacagtgta
     2161 cttacatata ataaataaat aaataaataa ataaataaat aaatctttgg gaaaaaaatt
     2221 agaaattttg ttttcagcta ttaaatgtga tatatgtcca aatcaatttt cctctgaaac
     2281 aataaagtcg gttcctcttc attaaaaaaa aaaaaaaaaa a
//
