LOCUS       NM_001358033            1738 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus immunity related GTPase cinema (Irgc), transcript
            variant 1, mRNA.
ACCESSION   NM_001358033 XM_006539708
VERSION     NM_001358033.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Li,J., Xu,X., Liu,J., Zhang,S., Wang,T., Liu,Y. and Wang,Z.
  TITLE     The immunity-related GTPase IRGC mediates interaction between lipid
            droplets and mitochondria to facilitate sperm motility
  JOURNAL   FEBS Lett 597 (12), 1595-1605 (2023)
   PUBMED   37195149
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Kaneda,Y., Miyata,H., Shimada,K., Oyama,Y., Iida-Norita,R. and
            Ikawa,M.
  TITLE     IRGC1, a testis-enriched immunity related GTPase, is important for
            fibrous sheath integrity and sperm motility in mice
  JOURNAL   Dev Biol 488, 104-113 (2022)
   PUBMED   35618043
  REMARK    GeneRIF: IRGC1, a testis-enriched immunity related GTPase, is
            important for fibrous sheath integrity and sperm motility in mice.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159140.10.
            
            On Nov 16, 2017 this sequence version replaced XM_006539708.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133005.1, BB615720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC159140.10        4710-4919
            211-1738            AC159140.10        6796-8323
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 10.74 cM"
     gene            1..1738
                     /gene="Irgc"
                     /gene_synonym="F630044M05Rik; Gm1102; Gm474; Ifgge; Iigp5;
                     Irgc1"
                     /note="immunity related GTPase cinema"
                     /db_xref="GeneID:210145"
                     /db_xref="MGI:MGI:2685948"
     exon            1..210
                     /gene="Irgc"
                     /gene_synonym="F630044M05Rik; Gm1102; Gm474; Ifgge; Iigp5;
                     Irgc1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..1738
                     /gene="Irgc"
                     /gene_synonym="F630044M05Rik; Gm1102; Gm474; Ifgge; Iigp5;
                     Irgc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1658
                     /gene="Irgc"
                     /gene_synonym="F630044M05Rik; Gm1102; Gm474; Ifgge; Iigp5;
                     Irgc1"
                     /note="interferon inducible GTPase family member 5;
                     immunity-related GTPase family, cinema 1;
                     interferon-gamma-inducible GTPase Ifgge protein; immunity
                     related GTPase cinema 1"
                     /codon_start=1
                     /product="interferon-inducible GTPase 5"
                     /protein_id="NP_001344962.1"
                     /db_xref="CCDS:CCDS39831.1"
                     /db_xref="GeneID:210145"
                     /db_xref="MGI:MGI:2685948"
                     /translation="MATSRLPAVPEETTILMAKEELEALRTAFESGDIPQAASRLREL
                     LANSETTRLEVGVTGESGAGKSSLINALRGLGAEDPGAALTGVVETTMQPSPYPHPQF
                     PDVTLWDLPGAGSPGCSADKYLKQVDFGRYDFFLLVSPRRCGAVESRLASEILRQGKK
                     FYFVRTKVDEDLAATRSQRPSGFSEAAVLQEIRDHCTERLRVAGVNDPRIFLVSNLSP
                     TRYDFPMLVTTWEHDLPAHRRHAGLLSLPDISLEALQKKKDMLQEQVLKTALVSGVIQ
                     ALPVPGLAAAYDDALLIRSLRGYHRSFGLDDDSLAKLAEQVGKQAGDLRSVIRSPLAN
                     EVSPETVLRLYSQSSDGAMRVARAFERGIPVFGTLVAGGISFGTVYTMLQGCLNEMAE
                     DAQRVRIKALEEDEPQGGEVSLEAAGDNLVEKRSTGEGTSEEAPLSTRRKLGLLLKYI
                     LDSWKRRDLSEDK"
     polyA_site      1738
                     /gene="Irgc"
                     /gene_synonym="F630044M05Rik; Gm1102; Gm474; Ifgge; Iigp5;
                     Irgc1"
                     /note="major polyA site"
ORIGIN      
        1 gggctaaccg gggaggagac cccaccagct gggagagtgt gaggggaagg gagagcctgc
       61 aggcaggtga gtccctgagg gccaggctct ccagctgggc cctgcgggtc tgtgcacaga
      121 gacccaggct tctgaaagtc ccgatcccca cctgccacct cttactgttc agcctctagc
      181 tgctgggacc tgtctcaggt cacatctgag ccactgagga gtcacattct gtgactgtcc
      241 cccatcttcc tgcccagctc tgaaccatgg caacttccag gttgcccgcc gtgcctgagg
      301 agaccaccat cctcatggcc aaggaagagc tggaggccct gcgcactgct tttgagtctg
      361 gcgacatccc tcaagccgcc tctcgccttc gggagctgct ggccaactca gagaccaccc
      421 ggctggaagt gggcgtcacg ggtgagtcgg gagccggcaa gtcctccctc atcaatgccc
      481 tacgcggcct gggggccgag gatcctggcg cagctctcac tggggtcgtg gagaccacca
      541 tgcagccttc gccctacccg cacccgcagt ttcccgacgt gaccctgtgg gacctgccgg
      601 gggccggttc tccaggctgc tcagcagaca agtatctgaa gcaggtggat ttcggccgct
      661 atgacttctt cttgctcgtc tccccccgtc gctgtggcgc cgtggagtcc cgcctcgctt
      721 ctgagatcct gcgccagggg aagaagtttt actttgtgcg caccaaggtg gacgaggatc
      781 tggcggccac ccgcagccag aggccctcgg gtttcagcga ggctgcagtc ctccaggaga
      841 tccgagatca ctgcacggag cggctgcggg tagcgggtgt gaatgatccc cgcatcttcc
      901 tggtgtccaa cctgtcgcca acccgctatg acttcccgat gctcgtgacc acctgggagc
      961 acgacctgcc cgcccaccgt cgccacgccg gtctgctgtc cctgcctgac atctcgctgg
     1021 aggctctgca gaagaagaag gacatgctac aagagcaggt gcttaagact gccttggtat
     1081 ctggtgtcat ccaggccctg ccggtccccg gactggcagc cgcctacgac gacgccttgc
     1141 ttatccgctc actgcggggc taccaccgca gcttcggcct agacgacgac tcgctggcca
     1201 agctggccga gcaggtgggc aaacaggcag gggacctgcg ctccgtcatc cgctcccccc
     1261 tggccaacga ggtctcacca gagactgtcc tgagactcta ctcgcagtcc tcagatggtg
     1321 ccatgcgggt ggcccgtgcc tttgagaggg gcatccctgt tttcggcacg ctggtggccg
     1381 ggggtatcag cttcggcacg gtctacacca tgctccaggg ctgtctcaat gagatggctg
     1441 aggacgccca acgcgtccgc atcaaagccc tggaggaaga tgagccccag gggggtgagg
     1501 tgagcttgga ggcggctggt gacaatttag tggaaaagcg gagcactggg gaaggaacca
     1561 gcgaggaagc cccgctgtcc acccgcagga agctcggcct cctcctcaag tatattcttg
     1621 acagctggaa gaggcgcgac ttgtcagaag acaaataaaa cgcagccctg cccctcctcc
     1681 ccacctccgc ctcacccacc agccaagccc tttaaaaaaa aaaccaacat caaccaaa
//
