LOCUS       NM_008394               2459 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus interferon regulatory factor 9 (Irf9), transcript
            variant 3, mRNA.
ACCESSION   NM_008394 XM_207652
VERSION     NM_008394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2459)
  AUTHORS   Lercher,A., Cheong,J.G., Bale,M.J., Jiang,C., Hoffmann,H.H.,
            Ashbrook,A.W., Lewy,T., Yin,Y.S., Quirk,C., DeGrace,E.J.,
            Chiriboga,L., Rosenberg,B.R., Josefowicz,S.Z. and Rice,C.M.
  TITLE     Antiviral innate immune memory in alveolar macrophages following
            SARS-CoV-2 infection ameliorates secondary influenza A virus
            disease
  JOURNAL   Immunity 57 (11), 2530-2546 (2024)
   PUBMED   39353439
REFERENCE   2  (bases 1 to 2459)
  AUTHORS   Fortelny,N., Farlik,M., Fife,V., Gorki,A.D., Lassnig,C., Maurer,B.,
            Meissl,K., Dolezal,M., Boccuni,L., Ravi Sundar Jose Geetha,A.,
            Akagha,M.J., Karjalainen,A., Shoebridge,S., Farhat,A., Mann,U.,
            Jain,R., Tikoo,S., Zila,N., Esser-Skala,W., Krausgruber,T.,
            Sitnik,K., Penz,T., Hladik,A., Suske,T., Zahalka,S.,
            Senekowitsch,M., Barreca,D., Halbritter,F., Macho-Maschler,S.,
            Weninger,W., Neubauer,H.A., Moriggl,R., Knapp,S., Sexl,V.,
            Strobl,B., Decker,T., Muller,M. and Bock,C.
  TITLE     JAK-STAT signaling maintains homeostasis in T cells and macrophages
  JOURNAL   Nat Immunol 25 (5), 847-859 (2024)
   PUBMED   38658806
REFERENCE   3  (bases 1 to 2459)
  AUTHORS   Lan,C., Zhou,X., Shen,X., Lin,Y., Chen,X., Lin,J., Zhang,Y.,
            Zheng,L. and Yan,S.
  TITLE     Suppression of IRF9 Promotes Osteoclast Differentiation by
            Decreased Ferroptosis via STAT3 Activation
  JOURNAL   Inflammation 47 (1), 99-113 (2024)
   PUBMED   37804406
  REMARK    GeneRIF: Suppression of IRF9 Promotes Osteoclast Differentiation by
            Decreased Ferroptosis via STAT3 Activation.
            Erratum:[Inflammation. 2024 Oct;47(5):1884-1886. doi:
            10.1007/s10753-024-02001-w.. PMID: 38488993]
REFERENCE   4  (bases 1 to 2459)
  AUTHORS   Zhao,Q., Shao,T., Zhu,Y., Zong,G., Zhang,J., Tang,S., Lin,Y.,
            Ma,H., Jiang,Z., Xu,Y., Wu,X. and Zhang,T.
  TITLE     An MRTF-A-ZEB1-IRF9 axis contributes to fibroblast-myofibroblast
            transition and renal fibrosis
  JOURNAL   Exp Mol Med 55 (5), 987-998 (2023)
   PUBMED   37121967
  REMARK    GeneRIF: An MRTF-A-ZEB1-IRF9 axis contributes to
            fibroblast-myofibroblast transition and renal fibrosis.
REFERENCE   5  (bases 1 to 2459)
  AUTHORS   Wang,H., Yang,H., Chang,M., Sun,F., Qi,H. and Li,X.
  TITLE     Long non-coding RNA TTTY15 sponges miR-520a-3p to exacerbate neural
            apoptosis induced by cerebral ischemia/reperfusion via targeting
            IRF9 both in vivo and in vitro
  JOURNAL   Biomed J 46 (2), 100530 (2023)
   PUBMED   35439640
  REMARK    GeneRIF: Long non-coding RNA TTTY15 sponges miR-520a-3p to
            exacerbate neural apoptosis induced by cerebral
            ischemia/reperfusion via targeting IRF9 both in vivo and in vitro.
REFERENCE   6  (bases 1 to 2459)
  AUTHORS   Weihua,X., Lindner,D.J. and Kalvakolanu,D.V.
  TITLE     The interferon-inducible murine p48 (ISGF3gamma) gene is regulated
            by protooncogene c-myc
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7227-7232 (1997)
   PUBMED   9207073
REFERENCE   7  (bases 1 to 2459)
  AUTHORS   Weihua,X., Kolla,V. and Kalvakolanu,D.V.
  TITLE     Interferon gamma-induced transcription of the murine ISGF3gamma
            (p48) gene is mediated by novel factors
  JOURNAL   Proc Natl Acad Sci U S A 94 (1), 103-108 (1997)
   PUBMED   8990168
REFERENCE   8  (bases 1 to 2459)
  AUTHORS   Suhara,W., Yoneyama,M., Yonekawa,H. and Fujita,T.
  TITLE     Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3
            gamma/p48) cDNA and chromosomal localization of the gene
  JOURNAL   J Biochem 119 (2), 231-234 (1996)
   PUBMED   8882710
REFERENCE   9  (bases 1 to 2459)
  AUTHORS   Kimura,T., Kadokawa,Y., Harada,H., Matsumoto,M., Sato,M.,
            Kashiwazaki,Y., Tarutani,M., Tan,R.S., Takasugi,T., Matsuyama,T.,
            Mak,T.W., Noguchi,S. and Taniguchi,T.
  TITLE     Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in
            both type I and type II interferon responses, as revealed by gene
            targeting studies
  JOURNAL   Genes Cells 1 (1), 115-124 (1996)
   PUBMED   9078371
REFERENCE   10 (bases 1 to 2459)
  AUTHORS   Kawakami,T., Matsumoto,M., Sato,M., Harada,H., Taniguchi,T. and
            Kitagawa,M.
  TITLE     Possible involvement of the transcription factor ISGF3 gamma in
            virus-induced expression of the IFN-beta gene
  JOURNAL   FEBS Lett 358 (3), 225-229 (1995)
   PUBMED   7843405
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN531811.1, U51992.2, BY761438.1 and AC174678.2.
            
            On Apr 16, 2009 this sequence version replaced NM_008394.2.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            5' coding region and uses a downstream translational start codon,
            compared to variant 1. The resulting isoform (3) is shorter at the
            N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U51992.2, SRR7345562.185027.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               CN531811.1         415-634
            221-2153            U51992.2           1-1933
            2154-2453           BY761438.1         466-765
            2454-2459           AC174678.2         51135-51140         c
FEATURES             Location/Qualifiers
     source          1..2459
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..2459
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /note="interferon regulatory factor 9"
                     /db_xref="GeneID:16391"
                     /db_xref="MGI:MGI:107587"
     exon            1..259
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            260..440
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            441..624
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            625..698
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            699..819
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            820..891
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1233
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1349
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..2459
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2435..2440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /note="hexamer: ATTAAA"
     polyA_site      2459
                     /gene="Irf9"
                     /gene_synonym="Irf-9; Isgf3g; p48"
                     /note="major polyA site"
ORIGIN      
        1 cttcctggga accagacacg gggcgtagtt ctgggaggaa ggaggagtct cacagagcca
       61 caggcccaag gtgctactgc tgactgaggc tgcttccctc tggtggtaac cgcttgccct
      121 gcaactcaga ccacgtggtt tctaggaaat gcacctcccc ggaggagaat tgaaacttag
      181 ggtggggact gtagaaaggg gaggagagat cagaaaaagc ctagaacctg ctaagcctgg
      241 gaccttttca gcggctcagg atggcctcag gcaaagtacg ctgcacccga aagctgcgga
      301 gctggatcgt ggagcaggtg gagagtggcc atttcccagg ggtgtgctgg gacgatgcag
      361 ccaagaccat gttccggatt ccctggaagc atgcaggcaa gcaagacttc cgagaggacc
      421 aggatgctgc catattcaag gcttgggcac tgtttaagga aaagcacaaa gatggggaca
      481 taggacaccc cgctgtctgg aagactcgcc tacgctgtgc cctcaacaag agttccgaat
      541 ttgaggaggt tcccgagaga ggtcgtatgg atgttgctga accctacaaa gtatatcgaa
      601 tactgccagc aggaaccctc cctaaccaac cacggaacca gaaatcacca tgcaagcgaa
      661 gtatcagttg tgtgtcacct gagagggaag aaaatatgga aaatgggagg accaatggcg
      721 ttgtaaacca ctcagacagt ggcagcaaca taggcggtgg tggcaatggc agcaacagga
      781 gcgacagcaa cagcaactgc aactctgagc tagaggaggg agctggcaca actgaggcca
      841 ccattagaga ggacccagtg ttcctggagc atcaacttcc tctgaactca gactactcgc
      901 tgctgctcac cttcatctat ggtggccgag tggtgggtaa gacccaggtg cacagcctag
      961 actgtcggct cgtggctgag cgctcagact cggagagcag catggagcag gtggagtttc
     1021 ccaaacccga cccactggag cctacccagc acctgctgaa tcagcttgac agaggcgtcc
     1081 tggtggccag caattccaga ggcctctttg ttcagcgcct ttgccccatc cccatctcct
     1141 ggaatgcacc agaggcccca cccgggcctg gtcctcatct gctgcccagc aataagtgtg
     1201 tggagctctt caagaccacc tacttctgta gagatttggc ccagtacttc cagggccagg
     1261 ggcccccacc caagttccaa gcaaccctac atttctggga ggagagtcct ggctctagcc
     1321 atagccaaga gaatctcatc acagtgcaga tggagcaggc ctttgcccga catttactgg
     1381 agaagattcc agaagaggag aaagctgcct tgttcctgtt acagcacaca gagcagtcac
     1441 cctctgctct gggacactga tcgtcgcgtc tccatggaaa tagacttgtt ctccacactc
     1501 ttggtcggcc tgcttctgtg atggttctta tcaccgtgtg ttatccagca tggccaagag
     1561 aaagtgcaag ggtgatgttt ctccttacaa attgagtttg cgaggcagac ttgttgagga
     1621 tacttgtaat ctcagcactt ggaagacaga ccaaatggtt atgagctcaa agacaacctg
     1681 gaagagactt ttatctcctt ttttttaaag ctatattctc tctcagctcc aaggaactgg
     1741 aaagttccaa agggtgtgat ctcagaggga attgtatgct cctcccagtc ccaaactcta
     1801 aatctaagca ctttatatat tttatctccc agtcctcact agactgaaat aaaatttagc
     1861 tgggtgaggt attacatagt tggcacatgt gagacaagag gcaagaagac tgtgagttca
     1921 aattcaaggc cagtcttggt gacactgtct ccaaaaaaaa taaataaaaa gcttcctaag
     1981 agcggctgga gagatggctc ggtgattaag agcactgact gcccttctga agatcctgag
     2041 ttcaaatccc agcaaccaca tggttgctca cacctgtctt cagacaccct cttctggtgt
     2101 gtctgaagac agctacagta tacttacata taataataaa taactctttg ggccagagat
     2161 cagcctccat ccgctcacat gttgactact tggtcctcag tggaaccact tgggatgact
     2221 agaggtgtgg ggttgttggt tgagttgtgt cactggccat gggctttaag gtttccaaag
     2281 acccttgcca ttcctagcta gcacactctc tctgtgtctc atgcttataa gtcagatgta
     2341 aactctcaac ctcagctcca tgcttgcctg cctcctgctt tgttctctgt tgtgatggtc
     2401 atggacccta aacctttaga aatgtgagct ccaaattaaa ttttgccttt tctaagtta
//
