LOCUS       NM_016850               1876 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus interferon regulatory factor 7 (Irf7), transcript
            variant 1, mRNA.
ACCESSION   NM_016850
VERSION     NM_016850.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Sepahpour,T., Alshaweesh,J., Azodi,N., Singh,K., Ireland,D.D.C.,
            Valanezhad,F., Nakamura,R., Satoskar,A.R., Dey,R., Hamano,S.,
            Nakhasi,H.L. and Gannavaram,S.
  TITLE     Downregulation of IRF7-mediated type-I interferon response by
            LmCen-/- parasites is necessary for protective immunity
  JOURNAL   NPJ Vaccines 9 (1), 250 (2024)
   PUBMED   39702382
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Wang,C., Khatun,M.S., Ellsworth,C.R., Chen,Z., Islamuddin,M.,
            Nisperuza Vidal,A.K., Afaque Alam,M., Liu,S., Mccombs,J.E.,
            Maness,N.J., Blair,R.V., Kolls,J.K. and Qin,X.
  TITLE     Deficiency of Tlr7 and Irf7 in mice increases the severity of
            COVID-19 through the reduced interferon production
  JOURNAL   Commun Biol 7 (1), 1162 (2024)
   PUBMED   39289468
  REMARK    GeneRIF: Deficiency of Tlr7 and Irf7 in mice increases the severity
            of COVID-19 through the reduced interferon production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Kim,H., Choi,I.A., Umemoto,A., Bae,S., Kaneko,K., Mizuno,M.,
            Giannopoulou,E., Pannellini,T., Deng,L. and Park-Min,K.H.
  TITLE     SREBP2 restricts osteoclast differentiation and activity by
            regulating IRF7 and limits inflammatory bone erosion
  JOURNAL   Bone Res 12 (1), 48 (2024)
   PUBMED   39191742
  REMARK    GeneRIF: SREBP2 restricts osteoclast differentiation and activity
            by regulating IRF7 and limits inflammatory bone erosion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Carus-Cadavieco,M., Gonzalez de la Fuente,S., Berenguer Lopez,I.,
            Serrano-Lope,M.A., Aguado,B., Guix,F., Palomer,E. and Dotti,C.G.
  TITLE     Loss of Cldn5 -and increase in Irf7-in the hippocampus and cerebral
            cortex of diabetic mice at the early symptomatic stage
  JOURNAL   Nutr Diabetes 14 (1), 64 (2024)
   PUBMED   39147772
  REMARK    GeneRIF: Loss of Cldn5 -and increase in Irf7-in the hippocampus and
            cerebral cortex of diabetic mice at the early symptomatic stage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Zhan,T., Zou,Y., Han,Z., Tian,X., Chen,M., Liu,J., Yang,X., Zhu,Q.,
            Liu,M., Chen,W., Chen,M., Huang,X., Tan,J., Liu,W. and Tian,X.
  TITLE     Single-cell sequencing combined with spatial transcriptomics
            reveals that the IRF7 gene in M1 macrophages inhibits the
            occurrence of pancreatic cancer by regulating lipid
            metabolism-related mechanisms
  JOURNAL   Clin Transl Med 14 (8), e1799 (2024)
   PUBMED   39118300
  REMARK    GeneRIF: Single-cell sequencing combined with spatial
            transcriptomics reveals that the IRF7 gene in M1 macrophages
            inhibits the occurrence of pancreatic cancer by regulating lipid
            metabolism-related mechanisms.
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Yoshida,H., Okabe,Y., Kawane,K., Fukuyama,H. and Nagata,S.
  TITLE     Lethal anemia caused by interferon-beta produced in mouse embryos
            carrying undigested DNA
  JOURNAL   Nat Immunol 6 (1), 49-56 (2005)
   PUBMED   15568025
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Honda,K., Yanai,H., Mizutani,T., Negishi,H., Shimada,N., Suzuki,N.,
            Ohba,Y., Takaoka,A., Yeh,W.C. and Taniguchi,T.
  TITLE     Role of a transductional-transcriptional processor complex
            involving MyD88 and IRF-7 in Toll-like receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 101 (43), 15416-15421 (2004)
   PUBMED   15492225
  REMARK    GeneRIF: transcription factor IRF-7 interacts with MyD88 to form a
            complex in the cytoplasm
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Kawai,T., Sato,S., Ishii,K.J., Coban,C., Hemmi,H., Yamamoto,M.,
            Terai,K., Matsuda,M., Inoue,J., Uematsu,S., Takeuchi,O. and
            Akira,S.
  TITLE     Interferon-alpha induction through Toll-like receptors involves a
            direct interaction of IRF7 with MyD88 and TRAF6
  JOURNAL   Nat Immunol 5 (10), 1061-1068 (2004)
   PUBMED   15361868
  REMARK    GeneRIF: TLR-mediated IFN-alpha induction requires the formation of
            a complex consisting of MyD88, TRAF6 and IRF7 as well as
            TRAF6-dependent ubiquitination.
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Wang,Y.X., Zhang,C.L., Yu,R.T., Cho,H.K., Nelson,M.C.,
            Bayuga-Ocampo,C.R., Ham,J., Kang,H. and Evans,R.M.
  TITLE     Regulation of muscle fiber type and running endurance by PPARdelta
  JOURNAL   PLoS Biol 2 (10), e294 (2004)
   PUBMED   15328533
  REMARK    Erratum:[PLoS Biol. 2005 Jan;3(1):e61]
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Hoebe,K., Du,X., Goode,J., Mann,N. and Beutler,B.
  TITLE     Lps2: a new locus required for responses to lipopolysaccharide,
            revealed by germline mutagenesis and phenotypic screening
  JOURNAL   J Endotoxin Res 9 (4), 250-255 (2003)
   PUBMED   12935356
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY155234.1, AK079685.1 and BQ033099.1.
            
            On Nov 19, 2011 this sequence version replaced NM_016850.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150403.1, AK152401.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY155234.1         3-3
            2-1853              AK079685.1         2-1853
            1854-1876           BQ033099.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.57 cM"
     gene            1..1876
                     /gene="Irf7"
                     /note="interferon regulatory factor 7"
                     /db_xref="GeneID:54123"
                     /db_xref="MGI:MGI:1859212"
     exon            1..35
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            36..457
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     CDS             444..1817
                     /gene="Irf7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IRF-7"
                     /codon_start=1
                     /product="interferon regulatory factor 7 isoform 1"
                     /protein_id="NP_058546.1"
                     /db_xref="CCDS:CCDS22005.1"
                     /db_xref="GeneID:54123"
                     /db_xref="MGI:MGI:1859212"
                     /translation="MAEVRGVQRVLFGDWLLGEVSSGQYEGLQWLNEARTVFRVPWKH
                     FGRRDLDEEDAQIFKAWAVARGRWPPSGVNLPPPEAEAAERRERRGWKTNFRCALHST
                     GRFILRQDNSGDPVDPHKVYELSRELGSTVGPATENREEVSLSNALPTQGVSPGSFLA
                     RENAGLQTPSPLLSSDAGDLLLQVLQYSHILESESGADPVPPQAPGQEQDRVYEEPYA
                     AWQVEAVPSPRPQQPALTERSLGFLDVTIMYKGRTVLQAVVGHPRCVFLYSPMAPAVR
                     TSEPQPVIFPSPAELPDQKQLHYTETLLQHVSPGLQLELRGPSLWALRMGKCKVYWEV
                     GSPMGTTGPSTPPQLLERNRHTPIFDFSTFFRELEEFRARRRQGSPHYTIYLGFGQDL
                     SAGRPKEKTLILVKLEPWVCKAYLEGVQREGVSSLDSSSLGLCLSSTNSLYEDIEHFL
                     MDLGQWP"
     exon            458..620
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            621..837
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            838..896
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1059
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1152
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1542
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1661
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1859
                     /gene="Irf7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf7"
                     /note="hexamer: AATAAA"
     polyA_site      1859
                     /gene="Irf7"
                     /note="major polyA site"
ORIGIN      
        1 tgagataaaa cccgtcccgg cggctccggt accagggtcc agcctgtgac agcccatcca
       61 ggctcggacg ctggattaac acctgtgaca tcacgtgtgc gctcccgcta catctgtagt
      121 cacatctaca gccaccttgg cagaggaatc tacactgagt tctgaaccta ggtgaccaca
      181 agttctcaaa cctcatctgt gaccctcaac accctaatac ctgggtcaca cttgtgaaac
      241 tgaaattcct acctgttacc aacacttgta acgtttaaaa cacatttgtg aaacttggtc
      301 acactatctg tggctacaac ctaaaaccat agaggcaccc aaggggcctt atttgcaata
      361 gctgactgct ccagtgacta caaggcatca cagagtagta gcatctactt tgattctccc
      421 agactgcctg tgtagacgga gcaatggctg aagtgagggg ggtccagcga gtgctgtttg
      481 gagactggct attgggggag gtcagcagcg gccagtacga ggggctgcag tggctgaacg
      541 aggctcgcac agtcttccgc gtaccctgga agcatttcgg tcgtagggat ctggatgaag
      601 aagatgcaca gatcttcaag gcctgggctg tggcccgagg gaggtggcca cctagtggag
      661 ttaacctgcc acccccagag gctgaggctg ctgagcgaag agagcgaaga ggctggaaga
      721 ccaacttccg ctgtgcactc cacagcacag ggcgttttat cttgcgccaa gacaattcag
      781 gggatccagt tgatccgcat aaggtgtacg aacttagccg ggagcttgga tctactgtgg
      841 gcccagccac ggaaaatagg gaagaagtga gcctcagcaa tgctctgccc acacagggtg
      901 tgtccccagg atcatttctg gcaagagaaa atgctgggct ccaaacccca agccctctgc
      961 tttctagtga tgccggggac ctcttgcttc aggttctgca gtacagccac atactggaat
     1021 ccgagtctgg ggcagacccc gtcccaccac aggctcctgg ccaggagcaa gaccgtgttt
     1081 acgaggaacc ctatgcagca tggcaggtgg aagctgtccc cagtcccagg cctcaacagc
     1141 cagctctcac cgagcgcagc cttgggttcc tggatgtgac catcatgtac aagggccgca
     1201 cagtgctaca ggcagtggtg gggcacccca gatgcgtgtt cctgtacagc cccatggccc
     1261 cagcagtaag aacttcagag ccccagccgg tgatctttcc cagtcctgct gagctcccag
     1321 atcagaagca gctgcactac acagagacgc ttctccagca tgtgtctccc ggccttcagc
     1381 tggagcttcg aggaccgtca ctgtgggccc tgcgtatggg caagtgcaag gtgtactggg
     1441 aggtaggcag ccctatgggc actaccggcc cctccacccc accccagctg ctggagcgca
     1501 accgccacac ccccatcttc gacttcagca ctttcttccg agaactggag gagtttcggg
     1561 ctcggaggcg gcaagggtca ccacactaca ccatctacct gggttttggg caagacttgt
     1621 cagcagggag gcccaaggag aagaccctga tcctggtgaa gctggagcca tgggtatgca
     1681 aggcatacct ggagggcgtg cagcgtgagg gtgtgtcctc cctggacagc agcagtctcg
     1741 gcttgtgctt gtctagcacc aacagtctct acgaagacat cgaacacttc ctcatggacc
     1801 tgggtcagtg gccttgactc agaatcccaa ctcccaataa atagttcaaa atcagtggaa
     1861 aaaaaaaaaa aaaaaa
//
