LOCUS       NM_016851               4140 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus interferon regulatory factor 6 (Irf6), mRNA.
ACCESSION   NM_016851
VERSION     NM_016851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4140)
  AUTHORS   Wright,A.P., Harris,S., Madden,S., Reyes,B.R., Mulamula,E.,
            Gibson,A., Rauch,I., Constant,D.A. and Nice,T.J.
  TITLE     Interferon regulatory factor 6 (IRF6) determines intestinal
            epithelial cell development and immunity
  JOURNAL   Mucosal Immunol 17 (4), 633-650 (2024)
   PUBMED   38604478
  REMARK    GeneRIF: Interferon regulatory factor 6 (IRF6) determines
            intestinal epithelial cell development and immunity.
REFERENCE   2  (bases 1 to 4140)
  AUTHORS   Antiguas,A. and Dunnwald,M.
  TITLE     A novel noncanonical function for IRF6 in the recycling of
            E-cadherin
  JOURNAL   Mol Biol Cell 35 (7), ar102 (2024)
   PUBMED   38809584
REFERENCE   3  (bases 1 to 4140)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4140)
  AUTHORS   Li,J., He,Y., Qu,Y., Ren,C., Wang,X., Cheng,Y., Sun,L., Zhang,X.
            and Zhang,G.
  TITLE     Promotion of BST2 expression by the transcription factor IRF6
            affects the progression of endometriosis
  JOURNAL   Front Immunol 14, 1115504 (2023)
   PUBMED   37143676
  REMARK    GeneRIF: Promotion of BST2 expression by the transcription factor
            IRF6 affects the progression of endometriosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4140)
  AUTHORS   Bertol,J.W., Johnston,S., Ahmed,R., Xie,V.K., Hubka,K.M., Cruz,L.,
            Nitschke,L., Stetsiv,M., Goering,J.P., Nistor,P., Lowell,S.,
            Hoskens,H., Claes,P., Weinberg,S.M., Saadi,I., Farach-Carson,M.C.
            and Fakhouri,W.D.
  TITLE     TWIST1 interacts with beta/delta-catenins during neural tube
            development and regulates fate transition in cranial neural crest
            cells
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35781329
REFERENCE   6  (bases 1 to 4140)
  AUTHORS   Chen,Y., Perry,D., Boackle,S.A., Sobel,E.S., Molina,H., Croker,B.P.
            and Morel,L.
  TITLE     Several genes contribute to the production of autoreactive B and T
            cells in the murine lupus susceptibility locus Sle1c
  JOURNAL   J Immunol 175 (2), 1080-1089 (2005)
   PUBMED   16002709
REFERENCE   7  (bases 1 to 4140)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 4140)
  AUTHORS   Ding,H., Wu,X., Bostrom,H., Kim,I., Wong,N., Tsoi,B., O'Rourke,M.,
            Koh,G.Y., Soriano,P., Betsholtz,C., Hart,T.C., Marazita,M.L.,
            Field,L.L., Tam,P.P. and Nagy,A.
  TITLE     A specific requirement for PDGF-C in palate formation and
            PDGFR-alpha signaling
  JOURNAL   Nat Genet 36 (10), 1111-1116 (2004)
   PUBMED   15361870
REFERENCE   9  (bases 1 to 4140)
  AUTHORS   Kondo,S., Schutte,B.C., Richardson,R.J., Bjork,B.C., Knight,A.S.,
            Watanabe,Y., Howard,E., de Lima,R.L., Daack-Hirsch,S., Sander,A.,
            McDonald-McGinn,D.M., Zackai,E.H., Lammer,E.J., Aylsworth,A.S.,
            Ardinger,H.H., Lidral,A.C., Pober,B.R., Moreno,L., Arcos-Burgos,M.,
            Valencia,C., Houdayer,C., Bahuau,M., Moretti-Ferreira,D.,
            Richieri-Costa,A., Dixon,M.J. and Murray,J.C.
  TITLE     Mutations in IRF6 cause Van der Woude and popliteal pterygium
            syndromes
  JOURNAL   Nat Genet 32 (2), 285-289 (2002)
   PUBMED   12219090
REFERENCE   10 (bases 1 to 4140)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY100044.1, AK143954.1 and BP774622.1.
            
            On Sep 7, 2006 this sequence version replaced NM_016851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008515.1, U73029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BY100044.1         2-17
            17-3673             AK143954.1         2-3658
            3674-4140           BP774622.1         25-491              c
FEATURES             Location/Qualifiers
     source          1..4140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.6 cM"
     gene            1..4140
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="interferon regulatory factor 6"
                     /db_xref="GeneID:54139"
                     /db_xref="MGI:MGI:1859211"
     exon            1..188
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            189..365
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     CDS             192..1595
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="IRF-6"
                     /codon_start=1
                     /product="interferon regulatory factor 6"
                     /protein_id="NP_058547.2"
                     /db_xref="CCDS:CCDS15632.1"
                     /db_xref="GeneID:54139"
                     /db_xref="MGI:MGI:1859211"
                     /translation="MALHPRRVRLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHAT
                     RHSPQQEEENTIFKAWAVETGKYQEGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKE
                     VPMNPVKIYQVCDIPQTQGSVINPGSTGSAPWDEKDNDVDEDEEEDELEQSQHHVPIQ
                     DTFPFLNINGSPMAPASVGNCSVGNCSPESVWPKTEPLEMEVPQAPIQPFYSSPELWI
                     SSLPMTDLDIKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKF
                     PGPEHITNEKQKLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLAAP
                     NLIERQKKVKLFCLETFLSELIAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILV
                     QVIPVVARMIYEMFSGDFTRSFDSGSVRLQISTPDIKDNIVAQLKQLYRILQTQESWQ
                     PMQPAPSMQLPQALPAQ"
     exon            366..570
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            571..699
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            700..858
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1251
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1370
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..4125
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4039..4044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="hexamer: AATAAA"
     polyA_site      4061
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="major polyA site"
     regulatory      4098..4103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="hexamer: AATAAA"
     polyA_site      4121
                     /gene="Irf6"
                     /gene_synonym="E230028I05Rik; mirf6"
                     /note="major polyA site"
ORIGIN      
        1 agaccgtgca ggggctgtgg catccagggc taggctctga gcactgggca ccgaggtggg
       61 caggtgcggg cctgtgccgg ccgcagagga gcccgcggtt cccagccgca cctagccgtc
      121 gggggagctc ctgtgctgcg gcggtgtgaa ctcttgtgca cctgctcctg agcacggact
      181 gaggccagat catggccctc caccctcgaa gagtccggct gaagccctgg ctggtggccc
      241 aggtggacag tggcctctac cctggtctca tctggctaca cagagattcc aaacgcttcc
      301 agatcccctg gaaacatgcc acgcggcaca gcccccaaca agaggaagaa aacaccattt
      361 ttaaggcttg ggctgtggag accggaaagt accaggaagg ggtagacgat cctgacccag
      421 ctaaatggaa ggctcagctc cgctgtgctc tcaacaaaag cagggagttc aacttgatgt
      481 acgatggcac caaggaagtg cccatgaatc ctgtgaagat ctatcaagtg tgtgacatcc
      541 cccagaccca gggctctgtc attaatccag gatccacagg gtctgctcct tgggatgaga
      601 aagataatga tgtggatgaa gatgaggagg aggatgaact tgagcagtca cagcaccatg
      661 tccccatcca ggacaccttc cccttcctga acatcaacgg ttctcccatg gcgccagcca
      721 gcgtgggcaa ctgcagtgtg ggaaactgca gccccgaatc agtgtggccc aaaacagaac
      781 ctctggagat ggaagtaccc caggcaccca ttcaaccctt ctacagttct ccagagctat
      841 ggatcagctc tctccccatg actgacttgg acatcaaatt tcagtatcgt gggaaggagt
      901 atgggcaaac tatgacggtg agcaaccccc agggctgccg gctcttctat ggggacctgg
      961 gccccatgcc cgaccaggag gagctctttg gtcctgtcag cctggagcag gtcaagttcc
     1021 caggtccaga gcatatcacc aacgagaagc agaagctgtt caccagcaag ctgttggatg
     1081 tcatggacag gggactgatc ctggaggtca gcggacatgc catttatgcc atcaggctgt
     1141 gccagtgcaa agtgtactgg tcagggccat gtgctccctc gcttgctgct cctaacctga
     1201 ttgagaggca gaagaaggtc aagttgtttt gtctggaaac cttcctgagt gagctcattg
     1261 cccaccagaa aggacagata gagaagcagc cgccttttga gatctactta tgctttgggg
     1321 aagagtggcc agatggaaag cccctggaga ggaagctcat cttggtccag gtcatcccag
     1381 tggtggctcg catgatctat gagatgtttt ctggtgattt tacccggtcc tttgacagtg
     1441 gcagcgttcg cctgcagatc tccactccag acatcaaaga taacatcgtt gctcagctca
     1501 agcagctgta ccgcatcctt caaacccagg agagctggca gcccatgcag cctgccccca
     1561 gcatgcagct gccacaggct ctgcctgccc agtgacccag actgctgtgc gtgtcctctt
     1621 ctctcctctc tcatttttat attgtacata aggatttttt ttaagttcag gtttagtcaa
     1681 tttttaaatc tcctttctat aacctcatta gaagtctgag actttccaaa tatgcctagt
     1741 tttaaaagtt cctctaactt atcaaggtat catcccctga ggggttcctt ttagatcttc
     1801 catggttggt gtaggagatt tgatgtcgaa gtttagacac cagaactcta actgcagctg
     1861 tgtttccgtc tgacgttaga cagatcgttt aactggaggg catcagatgc atcacttgta
     1921 aataaaaaag gtttggaatg atgcccaaaa ttgcatttgg ccttaaaact ctgactcgat
     1981 tattttcctc tacttgttta agacaaaact gcctgaacag gacccttctg cattgtgttt
     2041 agaccacatg gtttcccctt cttgctttca tccaagttcc ttgaacactg atctgatctg
     2101 aattgagctc tgtttgacct gttctgctag tacagtcagc tggctccctg ctggaggaag
     2161 taagagagga gctgattggt tgcctagcaa ccagtcttga tatctaaata gagatggtgc
     2221 caaggtctga aagtcaccca acctgtgtgt ggagtaaaag ctcataaagt aagtattaaa
     2281 ggagaagatg gtgacatgga aagccaaagg attccacgag agtaagaatg gttgtcagtg
     2341 gagggactcc atgggagaat tgtcaccagc cacatacctt gtcaccactc acaccatctt
     2401 atatgtgaag ttgatgagca actatgattc catgtgcctc atggcagaca ctctcctctt
     2461 ccttattttc ttctcaaaga ccatctggag ggagtcgggc atctgtgata tgctctgaca
     2521 acaaaattga ccgttcttgt tcagagactt tcaagagtct gacattcaga tttttccatt
     2581 tatgaaaatg aggtgtttca tatattaaac gtctggatag tgctcttctg gggaaggctc
     2641 aaacctgctt atatcacttg ttgtgagcca tggagacagt gaagaacagt gcagttatgt
     2701 ctcatagagt gtctgctcca gtcccttctc ataatttgaa ttccaagact tagatgaaaa
     2761 gtaagatggg tctctctggt tatagcctca atcctcttga atactggtgt ctatctgttt
     2821 catgtcacag ggatatgcct ctctgtacag tctgctgccc ttacactaaa ggtagcacct
     2881 tttgcttttc tagccactga aagttgggat gcatttaaag tctaacagct caacctaatt
     2941 ttggtggcag tgagacttac ttaggatgct taagatttgg tttaaagttc tcttagagat
     3001 tattaaaagg aggaccaaga gaaatctggg tgagttagga aaggcaggtg tctctgtgaa
     3061 taagagcaaa gtataatttt atacacatgg ccatagtatg aacatgtcag agtaaaactc
     3121 tttgtatgct aactaaaaat gtttaaagag aagtttaggt agaagtttaa aagttaggct
     3181 tttatagacc aggaatcatg caaggctagg gactttattc ttttttggag gaatgagtag
     3241 catcatttgg tgagatgaag tgagggagtc ttgatgtgtg gatgctccat ctggaagctc
     3301 agagttaaaa gtaacccatt acagagaaag tgggagggta gctgtggaat aggggacatt
     3361 tcctttccct tctgtgacaa gtcagcaggc tatgaggaat gtccagacaa caggatctgg
     3421 taaagaatgt tgaaaaatat gttctgaggg ctatggattg agttattagt gtgtgaccat
     3481 aatgaaaaat tgacaaatat gttgggacaa tgcatgattt tgtgtggtcc tatctaggca
     3541 gtccagtttc ttgtcttgca tctttttcgg aatgctggga gcacacacta catgcaggat
     3601 cttctcttgt catattcagt aagctttctc tggttttagt agataccaag tccccaggag
     3661 ctctaagttt cccaatgctc ccattcactc tccagctgtc ttcttcctgc cttcatttga
     3721 agactcagaa gggaggagga tttcccccag ttcctccttt tccttactgt gcactccaga
     3781 ttaactccaa tgttaaaaga accactacag ataaaccctg aaggcagatg ctgaatctca
     3841 tctcctctcc acagttctca gttgtatgtt catgtagcat cttaaacttt aagagtaact
     3901 gtgtcgtttg taaattgctc cgcatctatg ttctgcttga ctgactgcca acttggaaag
     3961 tcaaaactgt ttgtcttaga tttattgcca ggtctttagc agtgtctgat acagtgtgtt
     4021 ctaagatatt tgtgctgtaa taaatgacct acgtctttca atttggagat ttattgctaa
     4081 ctatcatgag aacgtaaaat aaacttggga agaaaaaaat ataaaaaaaa aaaaaaaaaa
//
