LOCUS       NM_012057               2206 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus interferon regulatory factor 5 (Irf5), transcript
            variant 2, mRNA.
ACCESSION   NM_012057
VERSION     NM_012057.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Li,Y., Ji,L., Liu,C., Li,J., Wen,D., Li,Z., Yu,L., Guo,M.,
            Zhang,S., Duan,W., Yi,L., Bi,Y., Bu,H., Li,C. and Liu,Y.
  TITLE     TBK1 is involved in M-CSF-induced macrophage polarization through
            mediating the IRF5/IRF4 axis
  JOURNAL   FEBS J 291 (23), 5214-5235 (2024)
   PUBMED   39434428
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Fan,Z., Zhang,X., Zhao,S., Zhong,S., Li,Z., Yan,Y., Zhang,B. and
            Chen,Y.
  TITLE     Interferon Regulatory Factor 5 Regulates the Phagocytosis of
            Microglia and Alleviate Alzheimer's Pathology
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (4) (2024)
   PUBMED   38271298
  REMARK    GeneRIF: Interferon Regulatory Factor 5 Regulates the Phagocytosis
            of Microglia and Alleviate Alzheimer's Pathology.
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2206)
  AUTHORS   Pereira,M., Ramalho,T., Andrade,W.A., Durso,D.F., Souza,M.C.,
            Fitzgerald,K.A., Golenbock,D.T., Silverman,N. and Gazzinelli,R.T.
  TITLE     The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and
            control of Toxoplasma gondii infection
  JOURNAL   Cell Rep 43 (2), 113795 (2024)
   PUBMED   38367238
  REMARK    GeneRIF: The IRAK1/IRF5 axis initiates IL-12 response by dendritic
            cells and control of Toxoplasma gondii infection.
REFERENCE   5  (bases 1 to 2206)
  AUTHORS   Wang,Y., Liu,Z., Song,S., Wang,J., Jin,C., Jia,L., Ma,Y., Yuan,T.,
            Cai,Z. and Xiang,M.
  TITLE     IRF5 governs macrophage adventitial infiltration to fuel abdominal
            aortic aneurysm formation
  JOURNAL   JCI Insight 9 (3), e171488 (2024)
   PUBMED   38175709
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2206)
  AUTHORS   Ouyang,X., Negishi,H., Takeda,R., Fujita,Y., Taniguchi,T. and
            Honda,K.
  TITLE     Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5
            activation
  JOURNAL   Biochem Biophys Res Commun 354 (4), 1045-1051 (2007)
   PUBMED   17275788
  REMARK    GeneRIF: we also provide evidence that this TLR synergy is
            mediated, at least in part, by activation of the transcription
            factor interferon regulatory factor 5 (IRF5).
REFERENCE   7  (bases 1 to 2206)
  AUTHORS   Yanai,H., Chen,H.M., Inuzuka,T., Kondo,S., Mak,T.W., Takaoka,A.,
            Honda,K. and Taniguchi,T.
  TITLE     Role of IFN regulatory factor 5 transcription factor in antiviral
            immunity and tumor suppression
  JOURNAL   Proc Natl Acad Sci U S A 104 (9), 3402-3407 (2007)
   PUBMED   17360658
  REMARK    GeneRIF: IRF5 is critical for antiviral immunity and for the
            induction of apoptosis, but not cell cycle arrest in response to
            DNA damage, and acts as a tumor suppressor on a pathway that may be
            distinct from that for p53.
REFERENCE   8  (bases 1 to 2206)
  AUTHORS   Negishi,H., Ohba,Y., Yanai,H., Takaoka,A., Honma,K., Yui,K.,
            Matsuyama,T., Taniguchi,T. and Honda,K.
  TITLE     Negative regulation of Toll-like-receptor signaling by IRF-4
  JOURNAL   Proc Natl Acad Sci U S A 102 (44), 15989-15994 (2005)
   PUBMED   16236719
REFERENCE   9  (bases 1 to 2206)
  AUTHORS   Takaoka,A., Yanai,H., Kondo,S., Duncan,G., Negishi,H., Mizutani,T.,
            Kano,S., Honda,K., Ohba,Y., Mak,T.W. and Taniguchi,T.
  TITLE     Integral role of IRF-5 in the gene induction programme activated by
            Toll-like receptors
  JOURNAL   Nature 434 (7030), 243-249 (2005)
   PUBMED   15665823
  REMARK    GeneRIF: study identifies IRF-5 as a new, principal downstream
            regulator of the TLR-MyD88 signalling pathway and a potential
            target of therapeutic intervention to control harmful immune
            responses
REFERENCE   10 (bases 1 to 2206)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749561.1, AF028725.1 and AW491843.1.
            
            On Nov 14, 2011 this sequence version replaced NM_012057.3.
            
            Transcript Variant: This variant (2) contains a different 5' end,
            which results in the use of an upstream start codon, compared to
            variant 1. The resulting protein (isoform 2) has a shorter and
            different N-terminus when it is compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150598.1, AK151019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               BY749561.1         1-485
            486-2181            AF028725.1         378-2073
            2182-2206           AW491843.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..2206
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /note="interferon regulatory factor 5"
                     /db_xref="GeneID:27056"
                     /db_xref="MGI:MGI:1350924"
     exon            1..150
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            151..356
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1655
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     interferon regulatory factor 5 bone marrow"
                     /codon_start=1
                     /product="interferon regulatory factor 5 isoform 2"
                     /protein_id="NP_036187.1"
                     /db_xref="CCDS:CCDS19962.1"
                     /db_xref="GeneID:27056"
                     /db_xref="MGI:MGI:1350924"
                     /translation="MNHSAPGIPPPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFY
                     IPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQL
                     FYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEEEELQRMLPGLSITE
                     PALPGPPNAPYSLPKEDTKWPPALQPPVGLGPPVPDPNLLAPPSGNPAGFRQLLPEVL
                     EPGPLASSQPPTEPLLPDLLISPHMLPLTDLEIKFQYRGRAPRTLTISNPQGCRLFYS
                     QLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLY
                     AIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPF
                     EIFFCFGEEWPDVKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLK
                     DHMVEQFKELHHLWQSQQQLQPMVQAPPVAGLDASQGPWPMHPVGMQ"
     exon            357..546
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            547..605
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            606..639
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            640..897
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1290
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1409
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2190
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /note="hexamer: AATAAA"
     polyA_site      2190
                     /gene="Irf5"
                     /gene_synonym="mirf5"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggggc gctgccccgg gcgggggcgg cgcgatgcgg aagtgcgggg cgggctgggc
       61 gacccgcggg cggtgcagct cggcgagagc tcagctcggc cgcagcgcca ggccggggct
      121 ccaggctccc cgcgggcgca cagcaaacag agccctttgc catgaaccac tcagccccag
      181 ggattccccc accaccccgc cgtgtgaggc tgaagccctg gttggtggcc caggtgaaca
      241 gctgccagta cccagggctt cagtgggtca acggggaaaa gaaactcttc tatataccct
      301 ggcgccatgc cacgaggcat ggtcccagcc aggatgggga caacaccatc ttcaaggcct
      361 gggctaaaga gacagggaag tacactgaag gggtggatga ggctgaccca gccaagtgga
      421 aggccaacct gcgctgtgcc cttaacaaaa gccgtgactt ccagctgttc tatgatggcc
      481 ctcgggacat gccacctcag ccgtacaaga tctacgaggt ctgctccaac ggccctgctc
      541 ccacagagag ccaacccact gatgattacg ttctgggaga agaggaggag gaggaagagg
      601 aagagctcca gagaatgcta ccaggcctga gcatcacaga gcctgcgcta cctgggcctc
      661 ccaacgcacc ctattcctta cccaaagaag acaccaagtg gccacctgct ctccagccac
      721 ctgtagggct gggtccccct gtcccagacc caaatctcct ggcccctccc tctggaaatc
      781 ctgctggctt caggcagctt ctccctgagg tcctggagcc tggacctctg gcttccagcc
      841 agccccctac agaaccactc ttgcctgacc tgctgatcag cccccacatg ttgcctttga
      901 cggacctaga gatcaagttc cagtaccggg gacgcgcacc ccggaccctc accatcagca
      961 acccacaagg ctgcaggctc ttctacagcc agctagaggc tacccaggag caagtggaac
     1021 tctttggccc tgtgaccctg gagcaagtgc gcttccctag cccagaggac atccccagtg
     1081 acaagcagcg tttctatacg aaccagctgc tagatgtcct ggaccgtggg ctcatcctgc
     1141 agctgcaggg ccaggacctg tacgccatcc gtctgtgcca gtgtaaggtg ttctggagtg
     1201 ggccctgcgc cttggcccat ggctcctgcc ccaaccccat tcagcgggaa gtcaagacga
     1261 agctctttag cctagagcag tttctcaatg agctcatcct gttccagaag ggccagacta
     1321 ataccccacc accttttgag atcttctttt gctttggaga agaatggcct gatgtcaaac
     1381 cccgagagaa gaagctcatt actgtacagg tggtacctgt tgcagcccgg ttgctgctgg
     1441 agatgttctc aggggagctt tcttggtcgg cagacagcat ccgactgcag atctcaaacc
     1501 cggatctcaa agaccacatg gtagagcagt ttaaagagct tcatcacctc tggcagtccc
     1561 agcagcaatt gcagcccatg gtccaggccc ctcctgtggc aggcctcgat gcaagccagg
     1621 ggccctggcc catgcaccca gttggcatgc aataatgagg ctacagatag tggctgcctt
     1681 ggacctcctg ggacagccac gtagactgat atagcaatgt ggtggcccca gcaggcctgg
     1741 ctggctacag ggttctgagt ctcttggaag cagagtcggg gtaacaagaa catagaagag
     1801 aggcctgagg tttcatttcc cctaaacatt ttctatttga gcaccacctt ctggtgattt
     1861 ctctaatatg cctggctggg aagaaatgaa gccagcagcc ccagtgggag ggagggaaca
     1921 tcactagcct gaggccttta gtaccacgga gtccaattac cccagggtag ccaactttta
     1981 aggttgcccc aattcttcta gcaaaacctg ccaaggagtg ttgtgggggc tttctgcaga
     2041 gaataaccct gatttagggg tcccctagtt tgaacctttc ccctcatcct tatgacaagg
     2101 atttctccag gcaccctcct tcagagtctg agatgctggg acagaaagta gaatttaata
     2161 tatttttgga ttaataaatg ttaaaaacca aaaaaaaaaa aaaaaa
//
