LOCUS       NM_013674               4762 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus interferon regulatory factor 4 (Irf4), transcript
            variant 1, mRNA.
ACCESSION   NM_013674
VERSION     NM_013674.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4762)
  AUTHORS   Zhou,L., Lin,P., Deng,G., Mo,L., Hong,C., Jiang,Z., Zhu,Y.,
            Zhao,Y., Qi,Y., Hu,T., Wu,Q., Zhang,J., Li,Q. and Yang,Q.
  TITLE     IRF4 regulates myeloid-derived suppressor cells expansion and
            function in Schistosoma japonicum-infected mice
  JOURNAL   Parasit Vectors 17 (1), 492 (2024)
   PUBMED   39609883
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4762)
  AUTHORS   Gelineau,A., Marcelin,G., Ouhachi,M., Dussaud,S., Voland,L.,
            Manuel,R., Baba,I., Rouault,C., Yvan-Charvet,L., Clement,K.,
            Tussiwand,R., Huby,T. and Gautier,E.L.
  TITLE     Fructooligosaccharides benefits on glucose homeostasis upon
            high-fat diet feeding require type 2 conventional dendritic cells
  JOURNAL   Nat Commun 15 (1), 5413 (2024)
   PUBMED   38926424
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4762)
  AUTHORS   Mandula,J.K., Sierra-Mondragon,R.A., Jimenez,R.V., Chang,D.,
            Mohamed,E., Chang,S., Vazquez-Martinez,J.A., Cao,Y., Anadon,C.M.,
            Lee,S.B., Das,S., Rocha-Munguba,L., Pham,V.M., Li,R., Tarhini,A.A.,
            Furqan,M., Dalton,W., Churchman,M., Moran-Segura,C.M., Nguyen,J.,
            Perez,B., Kojetin,D.J., Obermayer,A., Yu,X., Chen,A., Shaw,T.I.,
            Conejo-Garcia,J.R. and Rodriguez,P.C.
  TITLE     Jagged2 targeting in lung cancer activates anti-tumor immunity via
            Notch-induced functional reprogramming of tumor-associated
            macrophages
  JOURNAL   Immunity 57 (5), 1124-1140 (2024)
   PUBMED   38636522
REFERENCE   4  (bases 1 to 4762)
  AUTHORS   Ochiai,K., Shima,H., Tamahara,T., Sugie,N., Funayama,R.,
            Nakayama,K., Kurosaki,T. and Igarashi,K.
  TITLE     Accelerated plasma-cell differentiation in Bach2-deficient mouse B
            cells is caused by altered IRF4 functions
  JOURNAL   EMBO J 43 (10), 1947-1964 (2024)
   PUBMED   38605225
  REMARK    GeneRIF: Accelerated plasma-cell differentiation in Bach2-deficient
            mouse B cells is caused by altered IRF4 functions.
REFERENCE   5  (bases 1 to 4762)
  AUTHORS   Wu,X., Yang,C., Chen,X., Shan,Z. and Wu,X.
  TITLE     Interferon Regulatory Factor 4 (IRF4) Plays a Key Role in
            Osteoblast Differentiation of Postmenopausal Osteoporosis
  JOURNAL   Front Biosci (Landmark Ed) 29 (3), 115 (2024)
   PUBMED   38538259
  REMARK    GeneRIF: Interferon Regulatory Factor 4 (IRF4) Plays a Key Role in
            Osteoblast Differentiation of Postmenopausal Osteoporosis.
REFERENCE   6  (bases 1 to 4762)
  AUTHORS   Mittrucker,H.W., Matsuyama,T., Grossman,A., Kundig,T.M., Potter,J.,
            Shahinian,A., Wakeham,A., Patterson,B., Ohashi,P.S. and Mak,T.W.
  TITLE     Requirement for the transcription factor LSIRF/IRF4 for mature B
            and T lymphocyte function
  JOURNAL   Science 275 (5299), 540-543 (1997)
   PUBMED   8999800
REFERENCE   7  (bases 1 to 4762)
  AUTHORS   Grossman,A., Mittrucker,H.W., Nicholl,J., Suzuki,A., Chung,S.,
            Antonio,L., Suggs,S., Sutherland,G.R., Siderovski,D.P. and Mak,T.W.
  TITLE     Cloning of human lymphocyte-specific interferon regulatory factor
            (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
  JOURNAL   Genomics 37 (2), 229-233 (1996)
   PUBMED   8921401
REFERENCE   8  (bases 1 to 4762)
  AUTHORS   Henkel,G.W., McKercher,S.R., Yamamoto,H., Anderson,K.L.,
            Oshima,R.G. and Maki,R.A.
  TITLE     PU.1 but not ets-2 is essential for macrophage development from
            embryonic stem cells
  JOURNAL   Blood 88 (8), 2917-2926 (1996)
   PUBMED   8874188
REFERENCE   9  (bases 1 to 4762)
  AUTHORS   Matsuyama,T., Grossman,A., Mittrucker,H.W., Siderovski,D.P.,
            Kiefer,F., Kawakami,T., Richardson,C.D., Taniguchi,T.,
            Yoshinaga,S.K. and Mak,T.W.
  TITLE     Molecular cloning of LSIRF, a lymphoid-specific member of the
            interferon regulatory factor family that binds the
            interferon-stimulated response element (ISRE)
  JOURNAL   Nucleic Acids Res 23 (12), 2127-2136 (1995)
   PUBMED   7541907
REFERENCE   10 (bases 1 to 4762)
  AUTHORS   Eisenbeis,C.F., Singh,H. and Storb,U.
  TITLE     Pip, a novel IRF family member, is a lymphoid-specific,
            PU.1-dependent transcriptional activator
  JOURNAL   Genes Dev 9 (11), 1377-1387 (1995)
   PUBMED   7797077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645745.7 and BC137714.1.
            
            On Nov 30, 2016 this sequence version replaced NM_013674.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U11692.1, AK154315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL645745.7         19100-19136
            38-2461             BC137714.1         1-2424
            2462-4762           AL645745.7         34548-36848
FEATURES             Location/Qualifiers
     source          1..4762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 13.28 cM"
     gene            1..4762
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /note="interferon regulatory factor 4"
                     /db_xref="GeneID:16364"
                     /db_xref="MGI:MGI:1096873"
     exon            1..63
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            64..311
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1448
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /note="isoform a is encoded by transcript variant 1; PU.1
                     interaction partner; transcriptional activator PIP;
                     lymphocyte-specific interferon regulatory factor;
                     Sfpi1/PU.1 interaction partner"
                     /codon_start=1
                     /product="interferon regulatory factor 4 isoform a"
                     /protein_id="NP_038702.1"
                     /db_xref="CCDS:CCDS26419.1"
                     /db_xref="GeneID:16364"
                     /db_xref="MGI:MGI:1096873"
                     /translation="MNLETGSRGSEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWEN
                     EEKSVFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALN
                     KSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLDDTQMAMGHPYPMTAPYGS
                     LPAQQVHNYMMPPHDRSWRDYAPDQSHPEIPYQCPVTFGPRGHHWQGPSCENGCQVTG
                     TFYACAPPESQAPGIPIEPSIRSAEALALSDCRLHICLYYRDILVKELTTTSPEGCRI
                     SHGHTYDVSNLDQVLFPYPDDNGQRKNIEKLLSHLERGLVLWMAPDGLYAKRLCQSRI
                     YWDGPLALCSDRPNKLERDQTCKLFDTQQFLSELQVFAHHGRPAPRFQVTLCFGEEFP
                     DPQRQRKLITAHVEPLLARQLYYFAQQNTGHFLRGYELPEHVTTPDYHRSLRHSSIQE
                     "
     exon            312..498
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            499..587
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            588..732
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            733..840
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            841..1194
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1307
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..4762
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4739..4744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /note="hexamer: AATAAA"
     polyA_site      4757
                     /gene="Irf4"
                     /gene_synonym="IRF-4; LSIRF; NF-EM5; Spip"
                     /note="major polyA site"
ORIGIN      
        1 tttcctagtt tcaccacttg aacttgggac cctttgctgc cctcagctaa gagtgcgggt
       61 gagcgcacaa gcccaggagg aggtccgcac gcgtcatgaa cttggagacg ggcagccggg
      121 gctcagagtt cggcatgagc gcagtgagct gcggcaatgg gaaactccga cagtggttga
      181 tcgaccagat cgacagcggc aagtaccccg ggctggtgtg ggagaacgag gagaagagcg
      241 tcttccgcat cccgtggaaa cacgcgggca agcaggacta caatcgtgag gaggacgctg
      301 ccctcttcaa ggcttgggca ttgtttaaag gcaagttccg agaagggatc gacaagccag
      361 atcctcctac ttggaagaca agattacgat gtgctctgaa caagagcaat gactttgagg
      421 aattggtcga gaggagccag ctggatatct ctgacccata caaggtgtac aggattgttc
      481 cagagggagc caaaaaagga gcaaagcagc tcactttgga tgacacacag atggccatgg
      541 gccaccccta ccccatgaca gcaccttatg gctctctgcc agcccagcag gttcataact
      601 acatgatgcc accccatgac aggagctgga gggattatgc ccctgaccag tcacacccag
      661 aaatcccata tcaatgtcct gtgacgtttg gcccacgagg ccaccactgg caaggcccat
      721 cttgtgaaaa tggttgccag gtgacaggaa ccttttatgc ttgtgcccca cctgagtccc
      781 aggctcctgg aatccccatt gagccaagca taaggtctgc tgaagccttg gcgctctcag
      841 actgccggct gcatatctgc ctgtattacc gggacatcct cgtgaaagag ctgaccacga
      901 cgagccctga aggctgccgg atctcccacg gacacaccta tgatgttagc aacctggacc
      961 aggtcctgtt tccctacccg gacgacaatg gacagaggaa gaacattgag aagttgctga
     1021 gccacctgga gaggggactg gtcctctgga tggctccaga tgggctttat gccaaaagac
     1081 tctgccagag taggatctac tgggatgggc ccctggcact gtgcagcgat cggcccaaca
     1141 agctagaaag agaccagact tgcaagctct ttgacacaca gcagtttcta tcagagctgc
     1201 aagtgtttgc tcaccatggc cggccagcac cgagattcca ggtgactctg tgctttggtg
     1261 aggagtttcc agaccctcag agacagagga agctcatcac agctcatgtg gaacctctgc
     1321 tagccagaca actgtattac tttgctcaac aaaacactgg acatttcctg aggggctacg
     1381 agttacctga acacgttacc actccagatt accaccgctc cctccgtcat tcttccatcc
     1441 aagagtgaga agaaatactc tgacagggca gccggctgct gccctttctc tttggaagag
     1501 ctaagaagtg agtgggtttc cacttgaaga caacaacagg gctttgtgag gaaaaacagc
     1561 tgtatctgct caacagagga gcttccccca gaagagtgcc tgtcatccag gtcttgacaa
     1621 gtgccaggac ttgggtgact gtgccctggc ttataactgt gaaacttgat cagtgttgtg
     1681 tttacatgta cttgaatgct ggctttagcc tggtatagat ggacttttgc ttgaagactg
     1741 aaaacctgtg ccagcatgaa tccctgacaa gagaagacat acgtattatt ggtccatttc
     1801 tcagggaagt aaagtctaga ctagagacta cgctgtccac tcacagagaa acgcattcct
     1861 ggatagagga gctgtaggtt gcccagatca tgtccactga gtgaagggac ttggttctta
     1921 ggtccagtct aggctatcat gtcctgatcc tgcactctct ctgagtagac cctacatcct
     1981 gtttgctccc tcttcttgcc cttccctaaa agccagctgg tggactcttg ttgccacata
     2041 cttgagccaa aaaaccatca gggacatata agatgagaca tgtttgcatc tcctctgatc
     2101 taacaacggc tacaaagttt tttgttgttg ttgtctcccc tttctgtttt gcctctcatt
     2161 ctttagaatt gttgcttttt tgtaaagaaa ggaagagaga gagaccgaat atactagaga
     2221 tagattttta aaattctgtg ccatttcccc ttctatttgt tttgttggcc atcagtggtc
     2281 cccatggcaa cactggaagg gcggagcctt tgagcaggtt gggaactgtc ccggacacca
     2341 gtggttcagt gtacagctgt agactcagtg agctgtttct gcttattttg tatattagat
     2401 gcttccttgt gccaataata gtttgacaga gtctcaaagc taccgggctt cttttccaac
     2461 aacacattct ttcacagaat cccaaagagt ctcacttgcc ttcacaaccg tctgatcctt
     2521 tattgttact gttttgttta ggtggctttg ccatgctctg ggatttttct cctaccacaa
     2581 catcattcct gactctttcg ggctcagaaa gagttaagcg ctcttgcaca cttggcactt
     2641 acttcttttt aatttttttt ttaacatgcc actcttaata tttcttctta agtctttcag
     2701 cagcatacat tcaataagca atggaccatt gggtgtctca tttcattgtt ttatttttaa
     2761 aaaggaacct ttgacaaata atacacatta cagaaaatgg aagcattttt catagagaag
     2821 gtaagaactg aaatgcattt tatgttcgaa tcctccttgc tagtattagc cccaagagtt
     2881 cagtctgtcc tttaagcatg ttttagtttt caatacatat atatgaagtt gccctttctt
     2941 agagagagag agagagatat gtgatgacac tcttatgtac ccaactatac agatttacct
     3001 catcttttga gtggcatgtg gacttccact gctatgtgcc taggtgcagt ttagacatct
     3061 tcttagctac ccatcccagc agcccactga gtctcgtgaa ctaaagtcac ttatacatct
     3121 tatagatgca aaacattctg gggtatatta tcccaaggga agatgaaggc aaaatcggga
     3181 agcactcttc ctgaggcccc aagccacagc tgtcctcctg gagtatctta accatatctg
     3241 gcacttcacc aaggtccctt gcctggtcct gtatgaccat gactcttcag tccataagca
     3301 gatgctttgt ctcaattgcc atgtgaagtc ttttggtttt tggttttttt ccttaatgtt
     3361 aagctgtttt aacagtgaag ctgaattttc tggaaaatgc tgtatggttc gagcccccag
     3421 ttcatgtttc actttacagc catgcatgct gatgccttcc atcttgacaa atggaatgat
     3481 gggtaaacac tcctgacaca aagaggaaca ccttcctcgt cccttgctga aacaaagtgc
     3541 aatgcacaca gtagaattta gtttgcttgc actggaagat gccgttgaag aggtaggctg
     3601 aggaacactg tatcctaggg agaaaatatg caagtctcac gggtgctttc tgttggcttg
     3661 tttctggtcc ttgagcaggc ttaagtatct agtttcaaac tagaagcccc aaagccctca
     3721 gtcgttgtcc tggacagagt tggtagaccc cacctgtaga aatccagatg cactctggga
     3781 ttggagcaca gagaggcttg ctctatcgtg agaatgccca gcctgcagag gcccaggtgc
     3841 ggtgcctgag tggctgtatg ccagacacag gaacgccagc aggctgagtg tggtgactga
     3901 tatgtgaggt gcccttgccc tgcagacagg ctgaatgtga gccccagcag cagaggattc
     3961 tgagagtcag ggtggtgtca tgtcctacac aggaagagcc ttcaatatta ctttttaaac
     4021 gaactttccc attgctgata ttttgataaa aacccacaca aggtttaatt acatgccccc
     4081 tcatccctct ccacacagtc ttgcccatcc cactggtgaa ttgttgttgt tcttgttgtt
     4141 gttttttgtt attggtgaaa attgtgaaat tgttaaggtc tctgtttttg ttatttatct
     4201 ccctaaatca catggctgct gcatacattg caatgttgcc ctaccacatg tatgtttttg
     4261 caagttgctt cttcactcat tgaagaagcc tgcaccgtaa gtgaaactca cttagtcctt
     4321 gctaattgct gctcactgtc acgtgaacgc agagaaggct gattttcctg gacccatttt
     4381 cagtgctttg aggaacatga gtccagagta tattgaagta gaagacagtg tttggcaagc
     4441 cagttcttat tagacactgc tacaggcttc acaatcttca aggtggaccc acctcatgtg
     4501 gaagggcatc attgcccctc tgctcccatg cgctgtgcac ccccttcaca gtgaaagacc
     4561 tgctggggac caggactcag agatctctgg cttcgagctc atatcttggc ttcctgtcat
     4621 gtctaagccc gacaggaaag tgtggcacca tcctgcctgc ggcgttggat ggataggcca
     4681 tggattttgc tgtaaacttg cttcacaagg aaagctgtgt gttttaaaat atttgataaa
     4741 taaaggattt ctagaaagat tg
//
