LOCUS       NM_016849               2053 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus interferon regulatory factor 3 (Irf3), transcript
            variant 1, mRNA.
ACCESSION   NM_016849
VERSION     NM_016849.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2053)
  AUTHORS   Ninh,V.K., Calcagno,D.M., Yu,J.D., Zhang,B., Taghdiri,N.,
            Sehgal,R., Mesfin,J.M., Chen,C.J., Kalhor,K., Toomu,A., Duran,J.M.,
            Adler,E., Hu,J., Zhang,K., Christman,K.L., Fu,Z., Bintu,B. and
            King,K.R.
  TITLE     Spatially clustered type I interferon responses at injury
            borderzones
  JOURNAL   Nature 633 (8028), 174-181 (2024)
   PUBMED   39198639
REFERENCE   2  (bases 1 to 2053)
  AUTHORS   Tong,Z., Zou,J.P., Wang,S.Y., Luo,W.W. and Wang,Y.Y.
  TITLE     Activation of the cGAS-STING-IRF3 Axis by Type I and II Interferons
            Contributes to Host Defense
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308890 (2024)
   PUBMED   39004913
  REMARK    GeneRIF: Activation of the cGAS-STING-IRF3 Axis by Type I and II
            Interferons Contributes to Host Defense.
REFERENCE   3  (bases 1 to 2053)
  AUTHORS   Joshi,R., Brezani,V., Mey,G.M., Guixe-Muntet,S., Ortega-Ribera,M.,
            Zhuang,Y., Zivny,A., Werneburg,S., Gracia-Sancho,J. and Szabo,G.
  TITLE     IRF3 regulates neuroinflammatory responses and the expression of
            genes associated with Alzheimer's disease
  JOURNAL   J Neuroinflammation 21 (1), 212 (2024)
   PUBMED   39215356
  REMARK    GeneRIF: IRF3 regulates neuroinflammatory responses and the
            expression of genes associated with Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2053)
  AUTHORS   Liu,X., Cui,L., Tao,Y., Xia,S., Hou,J., Cao,X. and Xu,S.
  TITLE     The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target
            IRF3 to activate and resolve the antiviral innate immune response
  JOURNAL   Cell Rep 43 (8), 114608 (2024)
   PUBMED   39120972
REFERENCE   5  (bases 1 to 2053)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
REFERENCE   6  (bases 1 to 2053)
  AUTHORS   Stockinger,S., Materna,T., Stoiber,D., Bayr,L., Steinborn,R.,
            Kolbe,T., Unger,H., Chakraborty,T., Levy,D.E., Muller,M. and
            Decker,T.
  TITLE     Production of type I IFN sensitizes macrophages to cell death
            induced by Listeria monocytogenes
  JOURNAL   J Immunol 169 (11), 6522-6529 (2002)
   PUBMED   12444163
  REMARK    GeneRIF: activation of transcription factor IFN regulatory factor
            3, the synthesis of large amounts of IFN-beta mRNA, and
            IFN-alpha/beta signal transduction in macrophages infected with
            Listeria monocytogenes
REFERENCE   7  (bases 1 to 2053)
  AUTHORS   Suhara,W., Yoneyama,M., Kitabayashi,I. and Fujita,T.
  TITLE     Direct involvement of CREB-binding protein/p300 in
            sequence-specific DNA binding of virus-activated interferon
            regulatory factor-3 holocomplex
  JOURNAL   J Biol Chem 277 (25), 22304-22313 (2002)
   PUBMED   11940575
  REMARK    GeneRIF: Direct involvement of CREB-binding protein/p300 in
            sequence-specific DNA binding of virus-activated interferon
            regulatory factor-3 holocomplex.
REFERENCE   8  (bases 1 to 2053)
  AUTHORS   Malakhova,O., Malakhov,M., Hetherington,C. and Zhang,D.E.
  TITLE     Lipopolysaccharide activates the expression of ISG15-specific
            protease UBP43 via interferon regulatory factor 3
  JOURNAL   J Biol Chem 277 (17), 14703-14711 (2002)
   PUBMED   11854279
  REMARK    GeneRIF: role in regulating expression of ISG15-specific protease
            UBP43 in conjunction with lipopolysaccharide
REFERENCE   9  (bases 1 to 2053)
  AUTHORS   Sato,M., Suemori,H., Hata,N., Asagiri,M., Ogasawara,K., Nakao,K.,
            Nakaya,T., Katsuki,M., Noguchi,S., Tanaka,N. and Taniguchi,T.
  TITLE     Distinct and essential roles of transcription factors IRF-3 and
            IRF-7 in response to viruses for IFN-alpha/beta gene induction
  JOURNAL   Immunity 13 (4), 539-548 (2000)
   PUBMED   11070172
REFERENCE   10 (bases 1 to 2053)
  AUTHORS   Bellingham,J., Gregory-Evans,K. and Gregory-Evans,C.Y.
  TITLE     Mapping of human interferon regulatory factor 3 (IRF3) to
            chromosome 19q13.3-13.4 by an intragenic polymorphic marker
  JOURNAL   Ann Hum Genet 62 (Pt 3), 231-234 (1998)
   PUBMED   9803267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY089035.1, AK013944.1, AK151750.1 and BC050882.1.
            
            On Dec 9, 2011 this sequence version replaced NM_016849.3.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050882.1, AK013944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY089035.1         2-13
            13-677              AK013944.1         5-669
            678-1569            AK151750.1         658-1549
            1570-2053           BC050882.1         1432-1915
FEATURES             Location/Qualifiers
     source          1..2053
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.07 cM"
     gene            1..2053
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /note="interferon regulatory factor 3"
                     /db_xref="GeneID:54131"
                     /db_xref="MGI:MGI:1859179"
     exon            1..261
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..434
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1529
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /codon_start=1
                     /product="interferon regulatory factor 3"
                     /protein_id="NP_058545.1"
                     /db_xref="CCDS:CCDS21224.1"
                     /db_xref="GeneID:54131"
                     /db_xref="MGI:MGI:1859179"
                     /translation="METPKPRILPWLVSQLDLGQLEGVAWLDESRTRFRIPWKHGLRQ
                     DAQMADFGIFQAWAEASGAYTPGKDKPDVSTWKRNFRSALNRKEVLRLAADNSKDPYD
                     PHKVYEFVTPGARDFVHLGASPDTNGKSSLPHSQENLPKLFDGLILGPLKDEGSSDLA
                     IVSDPSQQLPSPNVNNFLNPAPQENPLKQLLAEEQWEFEVTAFYRGRQVFQQTLFCPG
                     GLRLVGSTADMTLPWQPVTLPDPEGFLTDKLVKEYVGQVLKGLGNGLALWQAGQCLWA
                     QRLGHSHAFWALGEELLPDSGRGPDGEVHKDKDGAVFDLRPFVADLIAFMEGSGHSPR
                     YTLWFCMGEMWPQDQPWVKRLVMVKVVPTCLKELLEMAREGGASSLKTVDLHISNSQP
                     ISLTSDQYKAYLQDLVEDMDFQATGNI"
     exon            435..606
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            607..677
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..852
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1230
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1346
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..2031
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /note="hexamer: AATAAA"
     polyA_site      1573
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
                     /note="major polyA site"
     polyA_site      2031
                     /gene="Irf3"
                     /gene_synonym="C920001K05Rik; IRF-3"
ORIGIN      
        1 aggcggaagg ccaaaaaagg gcatttgagg gagttaggcc tgctaagccg aagtgcgctc
       61 cgggatttct tgactttatt tcgtcaatgt tgagaaaaac tttttatatc tcaaaatatc
      121 gttagaaaag gaagtcccag cgctcggagg cttagctgac aaagaagggg gttgcgtggc
      181 tgcgagtctc agaactactg tttgggagcc ccaaaaccac tgctggcacc cgcgccgcac
      241 gggcgcccaa ttcctcccct ggctagagca tggaaacccc gaaaccgcgg attttgccct
      301 ggctggtgtc acagctggac ctggggcagc tggaaggcgt ggcctggctg gacgagagcc
      361 gaacgaggtt caggatcccg tggaagcatg gcctacggca ggacgcacag atggctgact
      421 ttggcatctt ccaggcctgg gcagaagcca gtggtgccta caccccgggg aaggataagc
      481 cggacgtgtc aacctggaag aggaatttcc ggtcagccct gaaccggaaa gaagtgttgc
      541 ggttagctgc tgacaatagc aaggaccctt atgaccctca taaagtgtat gagtttgtga
      601 ctccaggggc gcgggacttc gtacatctgg gtgcctctcc tgacaccaat ggcaaaagca
      661 gcctgcctca ctcccaggaa aacctaccga agttatttga tggcctgatc ttggggcccc
      721 tcaaagatga ggggtcctca gatctggcta ttgtttctga tccttctcaa caactgccaa
      781 gccccaatgt gaacaacttc ctaaaccctg caccccaaga aaatccactg aagcagctgc
      841 tagctgagga acaatgggag ttcgaggtga ccgccttcta ccgaggccgc caggtcttcc
      901 agcagacact cttttgcccg gggggcctgc ggctggtggg cagcacagct gacatgacac
      961 tgccctggca gccagtcacc ctgcccgatc ctgaggggtt tctgacggac aagcttgtga
     1021 aggagtacgt ggggcaggtg ctcaaagggc tgggcaatgg gctggcactg tggcaggctg
     1081 ggcagtgcct ctgggcccag cgcctaggcc actcccacgc cttctgggct ctgggggagg
     1141 agctgcttcc agacagtggg cgagggcctg atggagaggt ccacaaggac aaggacggag
     1201 ccgtgttcga cctcaggccc ttcgtggcag atctgattgc cttcatggaa ggaagtggac
     1261 actccccacg ctacactctg tggttctgca tgggggaaat gtggccccag gaccagccat
     1321 gggtcaagag gcttgtgatg gtcaaggttg ttcctacatg tcttaaggag ctgttagaga
     1381 tggcccggga agggggagcc tcttcactga aaaccgtgga cttgcacatc tccaacagcc
     1441 agcctatctc ccttacctct gaccagtaca aggcctacct ccaggacttg gtggaggaca
     1501 tggacttcca ggccactgga aatatctgag ccccactcag ctgctaccaa taaagcagtt
     1561 tatgccgcca tcacatctgc tgtcgactgc gtctaggctg gtggttattc tacaaggctc
     1621 agtcttccca tctgcagctg aggtctaggt gctccaggag ggaggcacag ggacaaaaca
     1681 cagcatggct gccaaggtcg tggagaaagt atcacaaaga aagcaaggac aagacaggtc
     1741 cagagctgca cacacattgt ccctacgtgg agcaagggac actgtcacag gtggtgatgg
     1801 ttggcaaccg gcaagcttgc tgtggggcgg gcgggctgac tcaccaccac ggactgagtc
     1861 actgcagccc cacagtgcta ctgataccag aggccactcg ggtgatgctc aaggctggac
     1921 cctgcctcct gttaccccca tatccccaca ttcctaagtc tggtgtgaca ccatcatggt
     1981 tccccactca cacaccccaa ctctttcctc ctgaaaaaaa gcatttcatg aaaaaaaaaa
     2041 aaaaaaaaaa aaa
//
