LOCUS       NM_001164598            5080 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus interferon regulatory factor 2 binding protein 2
            (Irf2bp2), mRNA.
ACCESSION   NM_001164598 XM_001002526 XM_284454
VERSION     NM_001164598.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Vilmundarson,R.O., Heydarikhorneh,N., Duong,A., Ho,T.,
            Keyhanian,K., Soheili,F., Chen,H.H. and Stewart,A.F.R.
  TITLE     Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma
            in Irf2bp2-Null Mice
  JOURNAL   Front Immunol 13, 868053 (2022)
   PUBMED   35865523
  REMARK    GeneRIF: Savior Siblings Might Rescue Fetal Lethality But Not Adult
            Lymphoma in Irf2bp2-Null Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5080)
  AUTHORS   Li,T., Luo,Q., He,L., Li,D., Li,Q., Wang,C., Xie,J. and Yi,C.
  TITLE     Interferon Regulatory Factor-2 Binding Protein 2 Ameliorates
            Sepsis-Induced Cardiomyopathy via AMPK-Mediated Anti-Inflammation
            and Anti-Apoptosis
  JOURNAL   Inflammation 43 (4), 1464-1475 (2020)
   PUBMED   32239393
  REMARK    GeneRIF: Interferon Regulatory Factor-2 Binding Protein 2
            Ameliorates Sepsis-Induced Cardiomyopathy via AMPK-Mediated
            Anti-Inflammation and Anti-Apoptosis.
REFERENCE   3  (bases 1 to 5080)
  AUTHORS   Fang,J., Ji,Y.X., Zhang,P., Cheng,L., Chen,Y., Chen,J., Su,Y.,
            Cheng,X., Zhang,Y., Li,T., Zhu,X., Zhang,X.J. and Wei,X.
  TITLE     Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease by
            Directly Repressing the Transcription of ATF3
  JOURNAL   Hepatology 71 (5), 1592-1608 (2020)
   PUBMED   31529495
  REMARK    GeneRIF: Hepatic IRF2BP2 Mitigates Nonalcoholic Fatty Liver Disease
            by Directly Repressing the Transcription of ATF3.
REFERENCE   4  (bases 1 to 5080)
  AUTHORS   Fang,J., Li,T., Zhu,X., Deng,K.Q., Ji,Y.X., Fang,C., Zhang,X.J.,
            Guo,J.H., Zhang,P., Li,H. and Wei,X.
  TITLE     Control of Pathological Cardiac Hypertrophy by Transcriptional
            Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein
            2)
  JOURNAL   Hypertension 70 (3), 515-523 (2017)
   PUBMED   28716987
  REMARK    GeneRIF: IRF2BP2 as a novel negative regulator in controlling
            pathological Cardiac Hypertrophy at the transcriptional level was
            defined.
REFERENCE   5  (bases 1 to 5080)
  AUTHORS   Hari,A., Cruz,S.A., Qin,Z., Couture,P., Vilmundarson,R.O.,
            Huang,H., Stewart,A.F.R. and Chen,H.H.
  TITLE     IRF2BP2-deficient microglia block the anxiolytic effect of enhanced
            postnatal care
  JOURNAL   Sci Rep 7 (1), 9836 (2017)
   PUBMED   28852125
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5080)
  AUTHORS   Cruz,S.A., Hari,A., Qin,Z., Couture,P., Huang,H., Lagace,D.C.,
            Stewart,A.F.R. and Chen,H.H.
  TITLE     Loss of IRF2BP2 in Microglia Increases Inflammation and Functional
            Deficits after Focal Ischemic Brain Injury
  JOURNAL   Front Cell Neurosci 11, 201 (2017)
   PUBMED   28769762
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5080)
  AUTHORS   Secca,C., Faget,D.V., Hanschke,S.C., Carneiro,M.S., Bonamino,M.H.,
            de-Araujo-Souza,P.S. and Viola,J.P.
  TITLE     IRF2BP2 transcriptional repressor restrains naive CD4 T cell
            activation and clonal expansion induced by TCR triggering
  JOURNAL   J Leukoc Biol 100 (5), 1081-1091 (2016)
   PUBMED   27286791
  REMARK    GeneRIF: Irf2bp2 gene expression was decreased in CD4 T cells upon
            activation.  Ectopic expression of IRF2BP2 led to a reduction in
            CD25 expression and STAT5 phosphorylation, along with an impaired
            proliferative capacity.  IRF2BP2 overexpression in differentiated
            Th cells resulted in reduced IL-4 and pro-TGF-beta production in
            Th2 and iTregs but had no effect on IFN-gamma or IL-17 expression
            in Th1 and Th17 cells, respectively.
REFERENCE   8  (bases 1 to 5080)
  AUTHORS   Stadhouders,R., Cico,A., Stephen,T., Thongjuea,S., Kolovos,P.,
            Baymaz,H.I., Yu,X., Demmers,J., Bezstarosti,K., Maas,A.,
            Barroca,V., Kockx,C., Ozgur,Z., van Ijcken,W., Arcangeli,M.L.,
            Andrieu-Soler,C., Lenhard,B., Grosveld,F. and Soler,E.
  TITLE     Control of developmentally primed erythroid genes by combinatorial
            co-repressor actions
  JOURNAL   Nat Commun 6, 8893 (2015)
   PUBMED   26593974
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5080)
  AUTHORS   Chen,H.H., Keyhanian,K., Zhou,X., Vilmundarson,R.O.,
            Almontashiri,N.A., Cruz,S.A., Pandey,N.R., Lerma Yap,N., Ho,T.,
            Stewart,C.A., Huang,H., Hari,A., Geoffrion,M., McPherson,R.,
            Rayner,K.J. and Stewart,A.F.
  TITLE     IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to
            Atherosclerosis
  JOURNAL   Circ Res 117 (8), 671-683 (2015)
   PUBMED   26195219
  REMARK    GeneRIF: Ablation of IRF2BP2 in macrophages worsens atherosclerosis
            in mice.
REFERENCE   10 (bases 1 to 5080)
  AUTHORS   Teng,A.C., Kuraitis,D., Deeke,S.A., Ahmadi,A., Dugan,S.G.,
            Cheng,B.L., Crowson,M.G., Burgon,P.G., Suuronen,E.J., Chen,H.H. and
            Stewart,A.F.
  TITLE     IRF2BP2 is a skeletal and cardiac muscle-enriched
            ischemia-inducible activator of VEGFA expression
  JOURNAL   FASEB J 24 (12), 4825-4834 (2010)
   PUBMED   20702774
  REMARK    GeneRIF: IRF2BP2 is a novel ischemia-induced coactivator of VEGFA
            expression that may contribute to revascularization of ischemic
            cardiac and skeletal muscles.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC137157.3.
            
            On Jul 30, 2020 this sequence version replaced NM_001164598.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927936.1297670.1,
                                           SRR11927934.4232061.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1547              AC137157.3         144813-146359
            1548-5080           AC137157.3         146971-150503
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 74.57 cM"
     gene            1..5080
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="interferon regulatory factor 2 binding protein 2"
                     /db_xref="GeneID:270110"
                     /db_xref="MGI:MGI:2443921"
     exon            1..1547
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             551..2263
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="IRF-2-binding protein 2"
                     /codon_start=1
                     /product="interferon regulatory factor 2-binding protein
                     2"
                     /protein_id="NP_001158070.1"
                     /db_xref="CCDS:CCDS52711.1"
                     /db_xref="GeneID:270110"
                     /db_xref="MGI:MGI:2443921"
                     /translation="MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYE
                     GADRVEFVIETARQLKRAHGCFPEGRSPTGAQPAAAKPPPLSAKDLLLQPPPQLGHAG
                     AEAARAQAMERYPLAPDRAPRLASDFSTRAGAGLPQSAAQQSAPANGILVPNGFSKLE
                     EPPELNRQSPNPRRAHAVPPTLVPLVNGSAALGLSGRAAATLAAVSGTPGLGAQPAEL
                     GTHKRPASVSSAAAEHEAREPSKEKAQPAHRSPADSLSSAAGASELSAEGAGKGRAPG
                     EQDWASRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVA
                     RTARKRKPSPEPEGEVGPPKINGETQPWLSTSTEGLKIPITPTSSFVSPPPPTASPHS
                     NRTTPPEAAQNGQSPMAALILVADNAGGSHASKDATQVHSTTRRNSSSPPSPSSMNQR
                     RLGPREVGGQATGSTGGLEPVHPASLPDSSLAASAPLCCTLCHERLEDTHFVQCPSVP
                     SHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKK
                     ERDS"
     exon            1548..5080
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="hexamer: AATACA"
     polyA_site      2720
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="major polyA site"
     regulatory      5054..5059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="hexamer: AATAAA"
     regulatory      5060..5065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
                     /note="hexamer: AATAAA"
     polyA_site      5075
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
     polyA_site      5080
                     /gene="Irf2bp2"
                     /gene_synonym="E130305N23Rik; IRF-2BP2"
ORIGIN      
        1 gtagaagtgg agcggccgcg gcggtagcag cagcaacagc ggcggcgcag gagctgaggc
       61 gcagtgggtg ctgtgcagcg gccgcgccgg ggcccgggac cgagctgcac gccgccgcgc
      121 gcggcatgcc ccgccgctcg ggctgagctg ccccggcggc tgccccgcgt cccccgtacc
      181 tcgcgcggct ctgcgccccg ggcgccagcg cgacctgctg cgctcgcggc ccgtctttgc
      241 cccggtctgg aggcccgagc ccgcggcccc ggccgagccg ccgcccccgc gcgcgccgcg
      301 ccgccccgcc gcccgtgggg acctgcagcc gcgccccgcc gcgcgcccgc cgcccctcgt
      361 gccccggggg cgccgcgcgg gcgccgcgcc ggcccgggct ctgccgccgc cgcctcctcg
      421 cctgcggccg ccgccgccgc tagtcgcgca gacgcgggct tgggccggcc ggcgcgcgcg
      481 cgcgggatcc acggggggcg gcggcgtccc ctcacccggc tcctcctgcg gcgcggcggg
      541 ctgtgcggac atggccgcgg cggtggcggt ggcggccgcc tctcggcgcc agtcgtgcta
      601 tctgtgtgac ctgccccgca tgccctgggc catgatctgg gacttcacgg agcccgtgtg
      661 ccgcggctgc gtcaactacg agggagccga ccgcgtggag ttcgtcatcg agacggcccg
      721 ccagctgaag cgtgctcacg gctgcttccc ggagggccgc tccccgaccg gtgcacagcc
      781 cgcagccgcc aagccaccgc cactgtcggc caaggaccta ctgctgcagc cgccgccgca
      841 gctgggccac gcgggcgccg aggccgcgcg cgctcaggct atggagcgct acccgctggc
      901 gccggatcgt gccccgcgcc tggcctccga cttcagcacg cgtgcgggtg caggcctccc
      961 acagtcggcc gcgcagcagt ccgcgccggc gaacggcatc ctggtgccca acgggttctc
     1021 caaactggag gagccgccgg agctgaatcg ccagagcccg aaccctcggc gtgcacacgc
     1081 cgttccgccc actctggtgc ctctggtcaa cggttctgcc gcgctggggt tgagcggccg
     1141 tgctgcggcc acactggccg cggtgagcgg aacaccgggc ctgggagctc agcccgccga
     1201 gttgggcacc cacaaacgcc cggcgtctgt gtcgagcgcg gcggcggagc acgaggcgcg
     1261 cgagccgagc aaggagaagg cgcagcccgc gcaccggagt ccggccgaca gcttatccag
     1321 cgcggccggg gccagcgagc tgagcgccga gggtgcaggc aaaggccgcg cgcccgggga
     1381 gcaggactgg gccagcaggc ctaagacggt gcgggacacg ctcctggcgc tgcaccagca
     1441 cggccactcg gggcccttcg agagcaagtt caagaaggag ccggctctga ctgcagcagg
     1501 caggttgttg ggtttcgagg ccaacggggc caacgggtct aaagcagttg caaggacagc
     1561 aaggaaaagg aagccttccc cagaaccgga aggggaagtc gggcccccta agatcaatgg
     1621 tgagacacag ccttggctgt ccacttccac agaagggctc aagatcccca tcacccctac
     1681 atcctctttt gtgtctccac caccccctac tgcctctcct cattccaacc ggaccacacc
     1741 gcctgaagcg gcccagaatg gccagtcccc aatggcagcc ctgattttag tagcagacaa
     1801 tgccgggggc agtcacgcct caaaagatgc cacccaggtt cactccacca ccaggaggaa
     1861 cagcagcagc ccgccctctc cctcctctat gaaccaaaga aggcttggcc ccagagaggt
     1921 ggggggccag gccaccggca gcaccggagg actggagccg gtgcaccctg ccagcctccc
     1981 agactcctct ctggcagcca gcgcccccct gtgctgcacc ctctgccacg agcggctgga
     2041 ggatactcac tttgtgcagt gcccgtctgt cccttcgcac aagttctgtt tcccttgctc
     2101 cagacaaagc attaaacagc agggcgctag cggagaggtc tattgcccaa gtggagagaa
     2161 gtgtcctctg gtgggctcca atgtcccctg ggccttcatg caaggagaga ttgctaccat
     2221 cctcgccgga gatgtgaaag tgaagaagga gagagactcg tgactttctg cgttcagaaa
     2281 agcccatggt tacccttaac tcaaacttgt tgaactgtat atagatctcc atacatatat
     2341 atatatatat aaatataaat atatatatcc aagacaaggg aaatgtagac ttcataacat
     2401 ggctgtataa ttttgatttt ttttgaatac attgtgtttc tatatttttt ttgacgacaa
     2461 aaggtatgta ctttaaggca ttttcttctt ttgttaacgt tgttaggctg tctgtgtttg
     2521 actctttggg tgacagttgc tgttctttgt aggctgcgac ttggctgctt ttgttttttt
     2581 ttgttttatt ttgttttttg tttttttttt gtttgtttgt ttttaaagag cacttggcaa
     2641 acaaatgctt ctagctgtat ttgtatgcac ttattttaaa aaagaaaaaa agccaaatac
     2701 atttttttct gacattgtaa gattgcctta ctgtctgtca tttctcctcg ctggcctctc
     2761 tcaggctgga ggccagttgg tggaggagaa aggaagtgag tggaaggggg acacctgtca
     2821 caagggcatt ccccgtcccc caggaaatgt cacccacctt tccgagggag ggaaaatggg
     2881 gtttgaatct tgtcaacggt tcagctcttg caatactggt cgtcagaggt gctgctgaaa
     2941 ggttatttgc aacattgtgt gttcagggtt tgttttgttt tgttttttaa tggaaggcaa
     3001 gctagctgat gtttgctctg cccacgtgac cggttgtaag ctttcagtgc tgcgtgctcc
     3061 tcctcctcgg tggccccacc ggtggttcca gctgtagaag tagttgtcag ggtggtgtgg
     3121 aaatcaggtg gctttcctgc tgaccagcct ggctctgagg tgctccttaa gtgttgcagg
     3181 ccccgggtga acttgtggga ttcgtgtttt cttctgttct ggtgtgtttg gtctacgtgt
     3241 tcagttcttg cctgcgtgct gtcccccttg tgacgagtgc ttactgcagt gtgcacgttg
     3301 atagtcacag ccttggatgc tgccaggagg acctgtgggc actgtcagtg gtgggcccag
     3361 tgtgggtaga ggaagcctgc agtttttcct taggtgtgtc tgaaatacta agagaataat
     3421 actgttctga aaaaaaaatg agagagaacc tagtgagaat acttacatga agggttttta
     3481 cataagcaag ccccacctct aactattttt agaagcctct tgtaaactaa tttcttttgg
     3541 tcactatttt gccttagtga agtgattgtt tttaatgtaa acaacatcag gtcattagct
     3601 accagtagtg gtgcccttag tgatgctggt tttgtgggtt tttttttttt cttcttcttt
     3661 gtgctttttt ttggtttaat gtcaacagga acactaccct ctcaaccctg acttgaggtg
     3721 tttgtaactt ggccttgtcg gctcaatcat ggcttctaag tctactatgg tttgtgtgtt
     3781 gttcacagcc tggcttctat tttaatttga aaatagagat tatcaccagc ttgacatcat
     3841 ttctagttac ttagttcttg gttttgtttt ttgttttgtt tttagttttt gtttttaacc
     3901 tttttttttt ttctttagta gtcaagttac taacacttga cactgaagca aatacagtat
     3961 ttcttgtctg gtttttcttg agtgcacctc ggcctctgtt atcttgttac cagttgtggt
     4021 gttacagccg ggcttgcatg attagaccag ttgatcctaa ctgtgactca ggtccgacag
     4081 gtctctctct gaggcagatg tacacacaca cacacacaca cacacacaca caaagcagag
     4141 tcagtttcac ctgcccataa agacatttgt gaagggctca actattatgg tctgtactat
     4201 aaatgtgttt ctaagcactt tattataaac tggaatttgg cctcatagat gttacaacta
     4261 gattagtcat ttgacctaat ttgctgtggc tgtctgtaat ctcagcacag ataaggtctc
     4321 caaaaaaacc aagaataaag aaccatcctg ctgaacagaa gtctgtccag cagcagaaac
     4381 ggccacctgt ggtttttctc tctctactag tagcaaggcc agatctgacc tgtttaaaag
     4441 gggccgtagt ttgagattaa gggtggactt cagaaggctt gaagctaaag tgttgtcctg
     4501 gagtggggcg gggcagggtc gggggagtct ttctctggcc tactctgaaa ccggtcacac
     4561 ggggccctcg gttgatcttt tcttgtcctt gatgacactg tggatgtagt ccacagctgg
     4621 gtagagatgt caggttccca acactgcttc tgctgtgact ttgatatgct cagaatagtg
     4681 gggggggatg gggtggtcgg tcaggttttt gttttttttt cttttaacag tttatagaat
     4741 ttaacagata gagttagtgt ctttcatgtg gcctcactct ggagttaatg agaacataca
     4801 cgtggtttac agcttttcta tatacctttc cctggccacc aggtgttttg aaagtgtgcc
     4861 acctttcaaa ctttgcttta tttttttttt aagtcgaagg tgataatttt tctatatctg
     4921 atgaaactca atgtctactg aaataagtgt aatctgagct atcaacggta tattttaaac
     4981 ccacgctatg gagatatcac ctgcattctg tcatttgtca gatttacagt actttttttt
     5041 tcttttagca ttaaataaaa ataaaattgg gagcactgaa
//
