LOCUS       NM_008391               2484 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus interferon regulatory factor 2 (Irf2), transcript
            variant 1, mRNA.
ACCESSION   NM_008391
VERSION     NM_008391.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2484)
  AUTHORS   Chaudhary,J.K., Ahamad,N. and Rath,P.C.
  TITLE     Mesenchymal stem cells (MSCs) from the mouse bone marrow show
            differential expression of interferon regulatory factors IRF-1 and
            IRF-2
  JOURNAL   Mol Biol Rep 51 (1), 97 (2024)
   PUBMED   38194130
  REMARK    GeneRIF: Mesenchymal stem cells (MSCs) from the mouse bone marrow
            show differential expression of interferon regulatory factors IRF-1
            and IRF-2.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2484)
  AUTHORS   Lukhele,S., Rabbo,D.A., Guo,M., Shen,J., Elsaesser,H.J.,
            Quevedo,R., Carew,M., Gadalla,R., Snell,L.M., Mahesh,L.,
            Ciudad,M.T., Snow,B.E., You-Ten,A., Haight,J., Wakeham,A.,
            Ohashi,P.S., Mak,T.W., Cui,W., McGaha,T.L. and Brooks,D.G.
  TITLE     The transcription factor IRF2 drives interferon-mediated CD8+ T
            cell exhaustion to restrict anti-tumor immunity
  JOURNAL   Immunity 55 (12), 2369-2385 (2022)
   PUBMED   36370712
REFERENCE   3  (bases 1 to 2484)
  AUTHORS   He,T., Yang,L. and Wu,D.
  TITLE     Effect of interferon regulatory factor 2 on inflammatory response
            and oxidative stress in lipopolysaccharide-induced acute kidney
            injury
  JOURNAL   Drug Dev Res 83 (4), 940-951 (2022)
   PUBMED   35088417
  REMARK    GeneRIF: Effect of interferon regulatory factor 2 on inflammatory
            response and oxidative stress in lipopolysaccharide-induced acute
            kidney injury.
REFERENCE   4  (bases 1 to 2484)
  AUTHORS   Li,Y., Wang,Y., Guo,H., Wu,Q. and Hu,Y.
  TITLE     IRF2 contributes to myocardial infarction via regulation of GSDMD
            induced pyroptosis
  JOURNAL   Mol Med Rep 25 (2) (2022)
   PUBMED   34878155
  REMARK    GeneRIF: IRF2 contributes to myocardial infarction via regulation
            of GSDMD induced pyroptosis.
REFERENCE   5  (bases 1 to 2484)
  AUTHORS   Kim,I., Kim,J.H., Kim,K., Seong,S., Lee,K.B. and Kim,N.
  TITLE     IRF2 enhances RANKL-induced osteoclast differentiation via
            regulating NF-kappaB/NFATc1 signaling
  JOURNAL   BMB Rep 54 (9), 482-487 (2021)
   PUBMED   34488926
  REMARK    GeneRIF: IRF2 enhances RANKL-induced osteoclast differentiation via
            regulating NF-kappaB/NFATc1 signaling.
REFERENCE   6  (bases 1 to 2484)
  AUTHORS   Horiuchi,M., Koike,G., Yamada,T., Mukoyama,M., Nakajima,M. and
            Dzau,V.J.
  TITLE     The growth-dependent expression of angiotensin II type 2 receptor
            is regulated by transcription factors interferon regulatory
            factor-1 and -2
  JOURNAL   J Biol Chem 270 (34), 20225-20230 (1995)
   PUBMED   7650042
REFERENCE   7  (bases 1 to 2484)
  AUTHORS   Riego,E., Perez,A., Martinez,R., Castro,F.O., Lleonart,R. and de la
            Fuente,J.
  TITLE     Differential constitutive expression of interferon genes in early
            mouse embryos
  JOURNAL   Mol Reprod Dev 41 (2), 157-166 (1995)
   PUBMED   7654369
REFERENCE   8  (bases 1 to 2484)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   9  (bases 1 to 2484)
  AUTHORS   Driggers,P.H., Ennist,D.L., Gleason,S.L., Mak,W.H., Marks,M.S.,
            Levi,B.Z., Flanagan,J.R., Appella,E. and Ozato,K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (bases 1 to 2484)
  AUTHORS   Harada,H., Fujita,T., Miyamoto,M., Kimura,Y., Maruyama,M.,
            Furia,A., Miyata,T. and Taniguchi,T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132099.1 and AK036652.1.
            
            On Dec 11, 2007 this sequence version replaced NM_008391.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155025.1, AK036652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1155              AK132099.1         14-1168
            1156-1454           AK132099.1         1170-1468
            1455-1584           AK036652.1         1429-1558
            1585-2302           AK132099.1         1599-2316
            2303-2484           AK036652.1         2278-2459
FEATURES             Location/Qualifiers
     source          1..2484
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.42 cM"
     gene            1..2484
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="interferon regulatory factor 2"
                     /db_xref="GeneID:16363"
                     /db_xref="MGI:MGI:96591"
     exon            1..192
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            193..285
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..385
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            386..562
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..609
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            610..727
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..892
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            893..939
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..2484
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="hexamer: AATATA"
     polyA_site      2308
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="major polyA site"
     regulatory      2450..2455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="hexamer: AATAAA"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="hexamer: AATGAA"
     polyA_site      2470
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="major polyA site"
     polyA_site      2484
                     /gene="Irf2"
                     /gene_synonym="9830146E22Rik; Irf-2"
                     /note="major polyA site"
ORIGIN      
        1 gctcctcgca gtttcctctc cttgttttgc tttcgatctg gactgttctc aggcaagccg
       61 gggactaact tttagttttg ctcctgcgat tattcaactg acgggctttc atttccattt
      121 tacacaccct aacaacactc acaccttgcg ggattgtatt ggtagcgtgg aaaaaaaaaa
      181 gcacattgag agggtaccat gccggtggaa cggatgcgaa tgcgcccgtg gctggaggag
      241 cagataaatt ccaatacgat accagggcta aagtggctga acaaggagaa gaagattttc
      301 cagatcccct ggatgcatgc ggctcggcac ggatgggacg tggaaaagga tgctccgctc
      361 ttcagaaact gggcgatcca tacaggaaag catcaaccag gaatagataa accagatcca
      421 aaaacatgga aagcaaattt tcgatgtgcc atgaattccc tgcccgacat tgaggaagtg
      481 aaggacagaa gcataaagaa aggaaacaac gccttcagag tctaccggat gctgccctta
      541 tccgaacgac cttccaagaa aggaaagaaa ccaaagacag aaaaagaaga gagagttaag
      601 cacatcaagc aagaaccagt tgagtcatct ttggggctta gtaatggagt aagtggcttt
      661 tctcctgagt atgcggtcct gacttcagct ataaaaaatg aagtggatag tacggtgaac
      721 atcatagttg taggacagtc ccatctggac agcaacattg aagatcaaga gatcgtcact
      781 aacccgccag acatctgcca ggttgtagaa gtgaccactg agagtgatga ccagccagtc
      841 agcatgagtg agctctaccc tctacagatt tctcctgtgt cttcctacgc agaaagcgaa
      901 actaccgaca gtgtggccag tgatgaagag aacgcagagg ggagaccaca ctggaggaag
      961 aggagcatcg aaggcaagca gtacctcagc aacatgggga cacggaacac ctatctgctg
     1021 cccagcatgg cgacctttgt cacctccaac aagccagatc tgcaggtcac catcaaagag
     1081 gatagctgtc cgatgcctta caacagctcc tggcccccat ttacagacct tccccttcct
     1141 gccccagtga cccccacgcc cagcagcagt cggccagacc gggagacccg ggccagtgtc
     1201 atcaagaaga catctgatat cacccaggcc cgtgtcaaga gctgttaagc ctttgactct
     1261 ccctggtggt tgttgggatt tcttagcttt gtgttgttct ttgtttgtat tatattattt
     1321 tttttctcta tgatacctat cttagacaca tctaagggag aaagccttga cgatagatta
     1381 ttgattgctg tgtccaactc cagagctgga gcttcttctt aactcaggac tccagccccc
     1441 cccccccctc ggtagatgcg tatctctaga acctgctgga tctgccaggg ctactccctc
     1501 aagttcaagg accaacagcc acacgggcag tggaggtgct gcgttgccta cggtcaaggc
     1561 cagcatggtg gagtggatgc ctcagaacgg aggagaaaat gtgaactagc tggaattttt
     1621 ttattcttgt gaatatgtac atagggcagt acgagcaatg tcgcgggctg cttctgcacc
     1681 ttatcttgaa gcacttacaa taggccttct tgtaatcttg ctctccttca cagcacactc
     1741 ggcgacccct tctgtgtcca ctaccccact acccacccct ccctcctcaa cccctccatc
     1801 ccggtcctct atgcgcccct tccccccaac caatcccatc acaacctctt acctatcctt
     1861 tccctcccaa ccccttctat cccagcccac cacctacccc actcctcccc aactcctcca
     1921 ttctagccca ttacccacgc ctctctcctc agcccagcct accccatccc accctgttcc
     1981 tttcctccag tttcctctcc tcaaaggcaa ggctctacat cttggaggag gaggaggaga
     2041 agaaaatgag tttcttcacc gctgtcccat tttaagactg cttgaataat aaaaaaaaaa
     2101 tctttctaat ctgctatgct tgaatggcac gcggtacaaa ggaaaactgt catggaaata
     2161 ttatgcaaat tcccagatct gaagacggaa aatactctaa ttctaaccag agcaagcttt
     2221 tttatttttt tatacaaggg gaatatttta ttcaaggtaa aaaaattcta aataaaatat
     2281 aattgttttt tatcttttct acagcaaatt tataatttta agattccttt tcctgttcat
     2341 cagcagttgt tattacatcc cttgtggcac attttttttt taattttgta aaggtgaaaa
     2401 aaaaactttt atgagctcat gtagcaatca aattatcctg tggattgata ataaatgaat
     2461 atggtatata gttaaagatt ttaa
//
