LOCUS       NM_008390               2151 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus interferon regulatory factor 1 (Irf1), transcript
            variant 1, mRNA.
ACCESSION   NM_008390
VERSION     NM_008390.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Sun,K., Lu,F., Hou,L., Zhang,X., Pan,C., Liu,H., Zheng,Z., Guo,Z.,
            Ruan,Z., Hou,Y., Zhang,J., Guo,F. and Zhu,W.
  TITLE     IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte
            damage in osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 366 (2024)
   PUBMED   39026271
  REMARK    GeneRIF: IRF1 regulation of ZBP1 links mitochondrial DNA and
            chondrocyte damage in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
  REMARK    GeneRIF: Opposing tumor-cell-intrinsic and -extrinsic roles of the
            IRF1 transcription factor in antitumor immunity.
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Wang,Y., Shen,Y., Liang,J., Wang,S., Huang,Y., Zhu,Q., Zhang,X.,
            Yu,K., Tong,G., Yang,C., Li,Y., Wang,J. and Zhao,Y.
  TITLE     Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by
            CD8+ T cells in cerebral malaria
  JOURNAL   J Neuroinflammation 21 (1), 119 (2024)
   PUBMED   38715061
  REMARK    GeneRIF: Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate
            damage by CD8[+] T cells in cerebral malaria.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Loftus,S.N., Gharaee-Kermani,M., Xu,B., Moore,T.M., Hannoudi,A.,
            Mallbris,M.J., Klein,B., Gudjonsson,J.E. and Kahlenberg,J.M.
  TITLE     Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1
  JOURNAL   Front Immunol 15, 1384606 (2024)
   PUBMED   38660315
  REMARK    GeneRIF: Interferon alpha promotes caspase-8 dependent ultraviolet
            light-mediated keratinocyte apoptosis via interferon regulatory
            factor 1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Gribaudo,G., Caliendo,A., Lembo,D., Cavallo,R. and Landolfo,S.
  TITLE     Molecular cloning of interferon-gamma inducible genes from a murine
            pre-B cell leukemia
  JOURNAL   J Biol Regul Homeost Agents 6 (4), 137-141 (1992)
   PUBMED   1296455
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Tanaka,N. and Taniguchi,T.
  TITLE     Cytokine gene regulation: regulatory cis-elements and DNA binding
            factors involved in the interferon system
  JOURNAL   Adv Immunol 52, 263-281 (1992)
   PUBMED   1442307
  REMARK    Review article
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Buckwalter,M.S., Lossie,A.C., Scarlett,L.M. and Camper,S.A.
  TITLE     Localization of the human chromosome 5q genes Gabra-1, Gabrg-2,
            Il-4, Il-5, and Irf-1 on mouse chromosome 11
  JOURNAL   Mamm Genome 3 (10), 604-607 (1992)
   PUBMED   1358285
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Driggers,P.H., Ennist,D.L., Gleason,S.L., Mak,W.H., Marks,M.S.,
            Levi,B.Z., Flanagan,J.R., Appella,E. and Ozato,K.
  TITLE     An interferon gamma-regulated protein that binds the
            interferon-inducible enhancer element of major histocompatibility
            complex class I genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (10), 3743-3747 (1990)
   PUBMED   2111015
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Harada,H., Fujita,T., Miyamoto,M., Kimura,Y., Maruyama,M.,
            Furia,A., Miyata,T. and Taniguchi,T.
  TITLE     Structurally similar but functionally distinct factors, IRF-1 and
            IRF-2, bind to the same regulatory elements of IFN and
            IFN-inducible genes
  JOURNAL   Cell 58 (4), 729-739 (1989)
   PUBMED   2475256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY266109.1, AK152005.1 and BE950981.1.
            
            On Apr 16, 2009 this sequence version replaced NM_008390.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Both variants 1 and
            2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152005.1, AK152104.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                BY266109.1         2-38
            38-2133             AK152005.1         2-2097
            2134-2151           BE950981.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.0 cM"
     gene            1..2151
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /note="interferon regulatory factor 1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
     exon            1..264
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            265..356
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1259
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="interferon regulatory factor 1 isoform a"
                     /protein_id="NP_032416.1"
                     /db_xref="CCDS:CCDS24686.1"
                     /db_xref="GeneID:16362"
                     /db_xref="MGI:MGI:96590"
                     /translation="MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKH
                     GWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKG
                     SSAVRVYRMLPPLTRNQRKERKSKSSRDTKSKTKRKLCGDVSPDTFSDGLSSSTLPDD
                     HSSYTTQGYLGQDLDMERDITPALSPCVVSSSLSEWHMQMDIIPDSTTDLYNLQVSPM
                     PSTSEAATDEDEEGKIAEDLMKLFEQSEWQPTHIDGKGYLLNEPGTQLSSVYGDFSCK
                     EEPEIDSPRGDIGIGIQHVFTEMKNMDSIMWMDSLLGNSVRLPPSIQAIPCAP"
     exon            357..456
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..633
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..683
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..816
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..939
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..989
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1125
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..2137
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /note="hexamer: TATAAA"
     polyA_site      2137
                     /gene="Irf1"
                     /gene_synonym="Irf-1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtttag atttcttcgc ggcgccgcgg actcgccagt gcgcaccact ccttcgtcga
       61 ggtaggacgt gctttcacag tctaagccga accgaaccga accgaaccga accgaaccgg
      121 gccgagttgc gccgaggtca gccgaggtgg ccagaggacc ccagcatctc gggcatcttt
      181 cgcttcgtgc gcgcatcgcg tacctacacc gcaactccgt gcctcgctct ccggcaccct
      241 ctgcgaatcg ctcctgcagc aaagccacca tgccaatcac tcgaatgcgg atgagaccct
      301 ggctagagat gcagattaat tccaaccaaa tcccagggct gatctggatc aataaagaag
      361 agatgatctt ccagattcca tggaagcacg ctgctaagca cggctgggac atcaacaagg
      421 atgcctgtct gttccggagc tgggccattc acacaggccg atacaaagca ggagaaaaag
      481 agccagatcc caagacatgg aaggcaaact tccgttgtgc catgaactcc ctgccagaca
      541 tcgaggaagt gaaggatcag agtaggaaca agggcagctc tgctgtgcgg gtgtaccgga
      601 tgctgccacc cctcaccagg aaccagagga aagagagaaa gtccaagtcc agccgagaca
      661 ctaagagcaa aaccaagagg aagctgtgtg gagatgttag cccggacact ttctctgatg
      721 gactcagcag ctctacccta cctgatgacc acagcagtta caccactcag ggctacctgg
      781 gtcaggactt ggatatggaa agggacataa ctccagcact gtcaccgtgt gtcgtcagca
      841 gcagtctctc tgagtggcat atgcagatgg acattatacc agatagcacc actgatctgt
      901 ataacctaca ggtgtcaccc atgccttcca cctccgaagc cgcaacagac gaggatgagg
      961 aagggaagat agccgaagac cttatgaagc tctttgaaca gtctgagtgg cagccgacac
     1021 acatcgatgg caagggatac ttgctcaatg agccagggac ccagctctct tctgtctatg
     1081 gagacttcag ctgcaaagag gaaccagaga ttgacagccc tcgaggggac attgggatag
     1141 gcatacaaca tgtcttcacg gagatgaaga atatggactc catcatgtgg atggacagcc
     1201 tgctgggcaa ctctgtgagg ctgccgccct ctattcaggc cattccttgt gcaccatagt
     1261 ttgggtctct gacccgttct tgccctcctg agtgagttag gccttggcat catggtggct
     1321 gtgatacaaa aaaagctaga ctcctgtggg ccccttgaca catggcaaag catagtccca
     1381 ctgcaaacag gggaccatcc tccttgggtc agtgggctct cagggcttag gaggcagagt
     1441 ctgagttttc ttgtgaggtg aagctggccc tgactcctag gaagatggat tggggggtct
     1501 gaggtgtaag gcagaggcca tggacaggag tcatcttcta gctttttaaa agccttgttg
     1561 catagagagg gtcttatcgc tgggctggcc ctgaggggaa tagaccagcg cccacagaag
     1621 agcatagcac tggccctaga gctggctctg tactaggaga caattgcact aaatgagtcc
     1681 tattcccaaa gaactgctgc ccttcccaac cgagccctgg gatggttccc aagccagtga
     1741 aatgtgaagg gaaaaaaaat ggggtcctgt gaaggttggc tcccttagcc tcagagggaa
     1801 tctgcctcac tacctgctcc agctgtgggg ctcaggaaaa aaaaatggca ctttctctgt
     1861 ggactttgcc acatttctga tcagaggtgt acactaacat ttctccccag tctaggcctt
     1921 tgcatttatt tatatagtgc cttgcctggt gcctgctgtc tcctcaggcc ttggcagtcc
     1981 tcagcaggcc cagggaaaag gggggttgtg agcgccttgg cgtgactctt gactatctat
     2041 tagaaacgcc acctaactgc taaatggtgt ttggtcatgt ggtggacctg tgtaaatatg
     2101 tatatttgtc tttttataaa aatttaagtt gtttacaaaa aaaaaaaaaa a
//
