LOCUS       NM_029926               2825 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 4 (Irak4),
            mRNA.
ACCESSION   NM_029926 NM_153180 XM_001003187
VERSION     NM_029926.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2825)
  AUTHORS   Menoret,A., Agliano,F., Karginov,T.A., Hu,X. and Vella,A.T.
  TITLE     IRAK4 is an immunological checkpoint in neuropsychiatric systemic
            lupus erythematosus
  JOURNAL   Sci Rep 14 (1), 16393 (2024)
   PUBMED   39014006
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2825)
  AUTHORS   Pereira,M., Ramalho,T., Andrade,W.A., Durso,D.F., Souza,M.C.,
            Fitzgerald,K.A., Golenbock,D.T., Silverman,N. and Gazzinelli,R.T.
  TITLE     The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and
            control of Toxoplasma gondii infection
  JOURNAL   Cell Rep 43 (2), 113795 (2024)
   PUBMED   38367238
REFERENCE   3  (bases 1 to 2825)
  AUTHORS   Picard,A., Berney,X., Castillo-Armengol,J., Tarussio,D., Jan,M.,
            Sanchez-Archidona,A.R., Croizier,S. and Thorens,B.
  TITLE     Hypothalamic Irak4 is a genetically controlled regulator of
            hypoglycemia-induced glucagon secretion
  JOURNAL   Mol Metab 61, 101479 (2022)
   PUBMED   35339728
  REMARK    GeneRIF: Hypothalamic Irak4 is a genetically controlled regulator
            of hypoglycemia-induced glucagon secretion.
REFERENCE   4  (bases 1 to 2825)
  AUTHORS   Somani,V.K., Zhang,D., Dodhiawala,P.B., Lander,V.E., Liu,X.,
            Kang,L.I., Chen,H.P., Knolhoff,B.L., Li,L., Grierson,P.M.,
            Ruzinova,M.B., DeNardo,D.G. and Lim,K.H.
  TITLE     IRAK4 Signaling Drives Resistance to Checkpoint Immunotherapy in
            Pancreatic Ductal Adenocarcinoma
  JOURNAL   Gastroenterology 162 (7), 2047-2062 (2022)
   PUBMED   35271824
REFERENCE   5  (bases 1 to 2825)
  AUTHORS   Tanaka,Y., Takeda,R., Fukushima,T., Mikami,K., Tsuchiya,S.,
            Tamura,M., Adachi,K., Umemoto,T., Asada,S., Watanabe,N.,
            Morishita,S., Imai,M., Nagata,M., Araki,M., Takizawa,H.,
            Fukuyama,T., Lamagna,C., Masuda,E.S., Ito,R., Goyama,S.,
            Komatsu,N., Takaku,T. and Kitamura,T.
  TITLE     Eliminating chronic myeloid leukemia stem cells by IRAK1/4
            inhibitors
  JOURNAL   Nat Commun 13 (1), 271 (2022)
   PUBMED   35022428
  REMARK    GeneRIF: Eliminating chronic myeloid leukemia stem cells by IRAK1/4
            inhibitors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2825)
  AUTHORS   Suzuki,N., Chen,N.J., Millar,D.G., Suzuki,S., Horacek,T., Hara,H.,
            Bouchard,D., Nakanishi,K., Penninger,J.M., Ohashi,P.S. and Yeh,W.C.
  TITLE     IL-1 receptor-associated kinase 4 is essential for IL-18-mediated
            NK and Th1 cell responses
  JOURNAL   J Immunol 170 (8), 4031-4035 (2003)
   PUBMED   12682231
  REMARK    GeneRIF: Irak4 is required for the majority of IL-18-mediated
            functions both in vitro and in vivo; Th1 cells lacking Irak4 fail
            to produce IFN-gamma and undergo proliferation in response to
            IL-18.
REFERENCE   7  (bases 1 to 2825)
  AUTHORS   Burns,K., Janssens,S., Brissoni,B., Olivos,N., Beyaert,R. and
            Tschopp,J.
  TITLE     Inhibition of interleukin 1 receptor/Toll-like receptor signaling
            through the alternatively spliced, short form of MyD88 is due to
            its failure to recruit IRAK-4
  JOURNAL   J Exp Med 197 (2), 263-268 (2003)
   PUBMED   12538665
  REMARK    GeneRIF: MyD88s acts as a negative regulator of
            IL-1R/TLR/MyD88-triggered signals, leading to a transcriptionally
            controlled negative regulation of innate immune responses.
REFERENCE   8  (bases 1 to 2825)
  AUTHORS   Suzuki,N., Suzuki,S., Duncan,G.S., Millar,D.G., Wada,T.,
            Mirtsos,C., Takada,H., Wakeham,A., Itie,A., Li,S., Penninger,J.M.,
            Wesche,H., Ohashi,P.S., Mak,T.W. and Yeh,W.C.
  TITLE     Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4
  JOURNAL   Nature 416 (6882), 750-756 (2002)
   PUBMED   11923871
  REMARK    GeneRIF: Severe impairment of interleukin-1 and Toll-like receptor
            signalling in mice lacking IRAK-4. (IRAK4)
REFERENCE   9  (bases 1 to 2825)
  AUTHORS   Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
  TITLE     IRAK-4: a novel member of the IRAK family with the properties of an
            IRAK-kinase
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5567-5572 (2002)
   PUBMED   11960013
REFERENCE   10 (bases 1 to 2825)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK029028.1, AK028837.1, BC051676.1 and BE635313.1.
            
            On Oct 27, 2009 this sequence version replaced NM_029926.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029028.1, AK028837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AK029028.1         2-61
            61-1582             AK028837.1         2-1523
            1583-2407           BC051676.1         1577-2401
            2408-2540           AK028837.1         2348-2480
            2541-2825           BE635313.1         152-436
FEATURES             Location/Qualifiers
     source          1..2825
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 48.55 cM"
     gene            1..2825
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /note="interleukin-1 receptor-associated kinase 4"
                     /db_xref="GeneID:266632"
                     /db_xref="MGI:MGI:2182474"
     exon            1..167
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            168..335
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1554
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 4"
                     /protein_id="NP_084202.2"
                     /db_xref="CCDS:CCDS27772.1"
                     /db_xref="GeneID:266632"
                     /db_xref="MGI:MGI:2182474"
                     /translation="MNKPLTPSTYIRNLNVGILRKLSDFIDPQEGWKKLAVAIKKPSG
                     DDRYNQFHIRRFEALLQTGKSPTCELLFDWGTTNCTVGDLVDLLVQIELFAPATLLLP
                     DAVPQTVKSLPPREAATVAQTHGPCQEKDRTSVMPMPKLEHSCEPPDSSSPDNRSVES
                     SDTRFHSFSFHELKSITNNFDEQPASAGGNRMGEGGFGVVYKGCVNNTIVAVKKLGAM
                     VEISTEELKQQFDQEIKVMATCQHENLVELLGFSSDSDNLCLVYAYMPNGSLLDRLSC
                     LDGTPPLSWHTRCKVAQGTANGIRFLHENHHIHRDIKSANILLDKDFTAKISDFGLAR
                     ASARLAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLELITGLAAVDENRE
                     PQLLLDIKEEIEDEEKTIEDYTDEKMSDADPASVEAMYSAASQCLHEKKNRRPDIAKV
                     QQLLQEMSA"
     exon            336..481
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            482..664
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            665..825
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            826..890
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1005
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1115
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1299
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1362
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1521
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..2825
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /note="hexamer: ACTAAA"
     polyA_site      2201
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /note="major polyA site"
     regulatory      2387..2392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
     regulatory      2519..2524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
                     /note="hexamer: AGTAAA"
     polyA_site      2541
                     /gene="Irak4"
                     /gene_synonym="8430405M07Rik; 9330209D03Rik; IRAK-4;
                     NY-REN-64"
ORIGIN      
        1 cctccctgtc ccacaggggg atatgatgcc ccggtgaccc gcagcatccc gatcgcaggc
       61 agtctgaagt cgcctggtgg tcctgcgtcc tccacccccg agtcctcgcc ggaccgtggc
      121 gggacgccga tcgccttgtc caggaagcga gggacgtccg agaggaagta gaagatgaac
      181 aagccgttga caccatcgac atacatacgc aaccttaatg tggggatcct taggaagctg
      241 tcggatttta ttgatcctca agaagggtgg aagaaattag cagtagctat caaaaagccg
      301 tccggcgacg acagatacaa tcagttccat ataaggagat tcgaagcctt acttcagacc
      361 gggaagagcc ccacctgtga actgctgttt gactggggca ccacgaactg cacagttggc
      421 gaccttgtgg atctactggt ccagattgag ctgtttgccc ccgccactct cctgctgccg
      481 gatgccgttc cccaaaccgt caaaagcctg cctcctagag aagcggcaac agtggcacaa
      541 acacacgggc cttgtcagga aaaggacagg acatccgtaa tgcctatgcc gaagctagaa
      601 cacagctgcg agccaccgga ctcctcaagc ccagacaaca gaagtgtaga gtccagcgac
      661 actcggttcc acagcttctc gttccatgaa ctgaagagca tcacaaacaa cttcgacgag
      721 caacccgcgt ctgccggtgg caaccggatg ggagaggggg gatttggagt ggtgtacaag
      781 ggctgtgtga acaacaccat cgtggcggtg aagaagctcg gagcgatggt tgaaatcagt
      841 actgaagaac taaagcaaca gtttgatcaa gaaattaaag taatggcaac gtgtcagcac
      901 gagaacctgg tggagctgct cggcttctcc agcgacagcg acaacctgtg cttagtgtat
      961 gcttacatgc ccaacgggtc cttgctggac agactgtcct gcctggatgg tacaccaccg
     1021 ctttcctggc acacaaggtg caaggttgct caggggacag caaatggcat caggtttctg
     1081 catgaaaatc atcacattca tagagatatt aaaagtgcaa atatcttact agacaaagac
     1141 tttactgcca aaatatctga ctttgggctt gcacgggctt cggcaaggct agcgcagacg
     1201 gtcatgacca gccgaatcgt gggcacaacg gcttacatgg cacccgaagc tttgcgggga
     1261 gaaataacac ccaaatctga catctacagc ttcggcgtgg ttctgttgga gctgataacc
     1321 gggctggcgg ctgtggatga aaaccgtgaa cctcaactac tgctggatat taaagaagag
     1381 attgaagatg aagagaagac gattgaagat tacacggatg agaagatgag cgatgcggac
     1441 cctgcttcgg tggaagcaat gtactctgct gctagccagt gtctgcatga gaagaaaaac
     1501 agacggccag acattgcaaa ggttcaacag ctgctacaag agatgtctgc ttaaaactaa
     1561 taaacttttt tttttttttt tttacttctc gagaacctgg agaccggaaa agcactttga
     1621 cactgagctg cgtcacctac ctgttgtttg catttgtttt tgttttccta aatgcgcttt
     1681 atgtttaaca tggtagcata gtgcaatgta ccaatgtact ggttagttag ttaatagacg
     1741 agttggcacc gcagccaaag tgatagttgc atggtagcac ttggccccgc ccacctagta
     1801 tggggctcat gttccacagc aacatcacca aactatagtg aacttaagat tcaggaaaac
     1861 agcactgtgc tatacagaga caataggatt atttggggcg gggggagtga gacacggtgt
     1921 ctctgtgtag ccctggatgt cctggaactt gctctgtaga ccaggctggc cttgaactca
     1981 gcaatctgcc tgtctctgcc tactgcgtgt tgggattaaa ggtgtgtgcc actcctgtaa
     2041 agctttggac cagctcttag ctgccttaag ccttagtgct ggcttttggt ttttgatagg
     2101 aacttcatgc tcctgtaaat agctcctcac ctaggttcct gtaaggaacc tctctccact
     2161 gctcctgtaa ccctaactaa actcattggt tcaacaatgt agacatgagt ggaatctatt
     2221 cttctgtctg ttattgtggt cctattttga atgaatagat gtttgcttgt catccctccc
     2281 cccccacccc aattcacata catggtacta tacgtggggt ataacagaac caatagtgag
     2341 tttggagggt gtgtgtgtgt gtgcttgtat tgtctctgca atgggcaata aaacatgtaa
     2401 ctgaggccaa gctgtctgag gggggagcat ttaagggggc aattccgaca ccaccctttc
     2461 ccttatggta gacatggtag gcccccttgc tgtatattga ttgtactgct cccgctgaag
     2521 taaaaagaca tataacttcc acaggcctgc tccatctgca tgagtctctg taaagaaagt
     2581 tctggagagg ccattttcct ctatcaatgg acaaaggaat gcctctataa tgaatggaat
     2641 cagccattcc gtactacagt tcttgaaggt agcacatatg agatggggtc ataagcaccc
     2701 tgtggcatca ctaagacttg ccactagagc tgagctgtct cttcagcctg cctgtttaag
     2761 cagagaatta caagatgcag atgctatgta tcctctgaac tggcaggtaa aatgaaagaa
     2821 agaaa
//
