LOCUS       NM_028679               3035 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3),
            transcript variant 1, mRNA.
ACCESSION   NM_028679
VERSION     NM_028679.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3035)
  AUTHORS   Liu,J., Copland,D.A., Clare,A.J., Gorski,M., Richards,B.T.,
            Scott,L., Theodoropoulou,S., Greferath,U., Cox,K., Shi,G.,
            Bell,O.H., Ou,K., Powell,J.L.B., Wu,J., Robles,L.M., Li,Y.,
            Nicholson,L.B., Coffey,P.J., Fletcher,E.L., Guymer,R., Radeke,M.J.,
            Heid,I.M., Hageman,G.S., Chan,Y.K. and Dick,A.D.
  TITLE     Replenishing IRAK-M expression in retinal pigment epithelium
            attenuates outer retinal degeneration
  JOURNAL   Sci Transl Med 16 (750), eadi4125 (2024)
   PUBMED   38838135
  REMARK    GeneRIF: Replenishing IRAK-M expression in retinal pigment
            epithelium attenuates outer retinal degeneration.
REFERENCE   2  (bases 1 to 3035)
  AUTHORS   Wen,X., Fang,G., Li,H., Jiang,Z., Du,X., Liao,Z., Liu,R., Huang,G.,
            Meng,F., Liao,W. and Zhang,Z.
  TITLE     CircIRAK3 exerts negative feedback regulation on inflammation by
            binding to HNRNP U and destabilizing proinflammatory cytokine mRNA
            in osteoarthritis and chondrogenesis
  JOURNAL   Int J Biol Macromol 256 (Pt 2), 128453 (2024)
   PUBMED   38016613
  REMARK    GeneRIF: CircIRAK3 exerts negative feedback regulation on
            inflammation by binding to HNRNP U and destabilizing
            proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.
REFERENCE   3  (bases 1 to 3035)
  AUTHORS   Liu,H., Li,N., Kuang,G., Gong,X., Wang,T., Hu,J., Du,H., Zhong,M.,
            Guo,J., Xie,Y., Xiang,Y., Wu,S., Yuan,Y., Yin,X., Wan,J. and Li,K.
  TITLE     Protectin D1 inhibits TLR4 signaling pathway to alleviate
            non-alcoholic steatohepatitis via upregulating IRAK-M
  JOURNAL   Free Radic Biol Med 210, 42-53 (2024)
   PUBMED   37984750
REFERENCE   4  (bases 1 to 3035)
  AUTHORS   Lin,C., Wang,S., Xie,J., Zhu,J., Xu,J., Liu,K., Chen,J., Yu,M.,
            Zhong,H., Huang,K. and Pan,S.
  TITLE     Ketogenic diet and beta-Hydroxybutyrate alleviate ischemic brain
            injury in mice via an IRAKM-dependent pathway
  JOURNAL   Eur J Pharmacol 955, 175933 (2023)
   PUBMED   37481199
REFERENCE   5  (bases 1 to 3035)
  AUTHORS   Thiel,F.G., Asgarbeik,S., Glaubitz,J., Wilden,A., Lerch,M.M.,
            Weiss,F.U. and Sendler,M.
  TITLE     IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK signaling
            affects disease severity in acute pancreatitis
  JOURNAL   Sci Rep 13 (1), 10833 (2023)
   PUBMED   37402858
  REMARK    GeneRIF: IRAK3-mediated suppression of pro-inflammatory MyD88/IRAK
            signaling affects disease severity in acute pancreatitis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3035)
  AUTHORS   Nakayama,K., Okugawa,S., Yanagimoto,S., Kitazawa,T., Tsukada,K.,
            Kawada,M., Kimura,S., Hirai,K., Takagaki,Y. and Ota,Y.
  TITLE     Involvement of IRAK-M in peptidoglycan-induced tolerance in
            macrophages
  JOURNAL   J Biol Chem 279 (8), 6629-6634 (2004)
   PUBMED   14660668
  REMARK    GeneRIF: induction of IRAK-M and inhibition of kinase activity of
            IRAK-1 are crucial to PGN-induced tolerance in macrophages
REFERENCE   7  (bases 1 to 3035)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 3035)
  AUTHORS   Kobayashi,K., Hernandez,L.D., Galan,J.E., Janeway,C.A. Jr.,
            Medzhitov,R. and Flavell,R.A.
  TITLE     IRAK-M is a negative regulator of Toll-like receptor signaling
  JOURNAL   Cell 110 (2), 191-202 (2002)
   PUBMED   12150927
  REMARK    GeneRIF: Endotoxin tolerance was significantly reduced in
            macrophages from IRAK-M knockout mice. IRAK-M regulates TLR
            signaling and innate immune homeostasis.
REFERENCE   9  (bases 1 to 3035)
  AUTHORS   Rosati,O. and Martin,M.U.
  TITLE     Identification and characterization of murine IRAK-M
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1472-1477 (2002)
   PUBMED   12054681
  REMARK    Erratum:[Biochem Biophys Res Commun. 2003 Apr 25;304(1):213]
REFERENCE   10 (bases 1 to 3035)
  AUTHORS   Li,S., Strelow,A., Fontana,E.J. and Wesche,H.
  TITLE     IRAK-4: a novel member of the IRAK family with the properties of an
            IRAK-kinase
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5567-5572 (2002)
   PUBMED   11960013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC144942.4 and AK029057.1.
            
            On Dec 23, 2017 this sequence version replaced NM_028679.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029057.1, BC120831.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC144942.4         62726-62785
            61-3029             AK029057.1         2-2970
            3030-3035           AC144942.4         122670-122675
FEATURES             Location/Qualifiers
     source          1..3035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.94 cM"
     gene            1..3035
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="interleukin-1 receptor-associated kinase 3"
                     /db_xref="GeneID:73914"
                     /db_xref="MGI:MGI:1921164"
     exon            1..271
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            272..454
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            455..558
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            559..613
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            614..765
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            766..830
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            831..945
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1064
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1263
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1326
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1491
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..3035
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="hexamer: ATTATA"
     polyA_site      2589
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="major polyA site"
     regulatory      2654..2659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="hexamer: AATAAA"
     polyA_site      2674
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="major polyA site"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
                     /note="hexamer: ATTAAA"
     polyA_site      3035
                     /gene="Irak3"
                     /gene_synonym="4833428C18Rik; IRAK-M"
ORIGIN      
        1 tacgtcacgt ggggcccgcc ctgcgacggc gtgttgcaag ctccgggcag ccgtcgtgga
       61 gctgaatttc cgcggttgtg aaaggcggtg acagcggcga cctccctgct tctctgcgtg
      121 gggtcccggg actccgcgat ggccggccgg tgcggggccc gtggcgcgct gtcgccacag
      181 ttgctgctct tcgacctgcc gcccgcactg ctgggagagc tttgcgggat cctggacagc
      241 tgcgatggcc cgctcggctg gcggggcctg gcggagcgac tttcaaacag ctggctggat
      301 gttcgtcata ttgaaaagta cgtaaaccaa ggtaaaagtg gaacaagaga attgctctgg
      361 tcctgggcac agaaaaacaa gacgatcggc gaccttttag aggttctcca ggacatgggg
      421 catcaacgag ctatccactt aatcatcaac tatggagtaa gctggactcc ttcagtgcag
      481 acgcatcacg agcttccatt ccccagcttc ccacctgagg tgaagcatgc gtgcagagaa
      541 aacgaccctg gacctctgga accagccaat gtcacagtgg ataatgttct tgttcctgaa
      601 cataatgaaa aaggaacact gcagaaaacc cctatcagct tccagagtat cctagaagga
      661 accaaacatt tccacaaaga cttcctgatt ggagaagggg agatattcga agtatacaga
      721 gtggacattc gaaaccaagc atatgctgtt aaattgttta aacaggagaa aaaaatgcaa
      781 ctaaagaagc actggaagag atttttatca gaactggaag ttctactcct gttccgtcac
      841 ccccacatac tagagctggc tgcatatttc acggagactg agaaactttg tctggtttat
      901 ccctatatga gcaacgggac gcttttcgac agattacagt gcacaaatgg cacaaccccg
      961 ctttcctggc acgttcgaat cagcgtattg ataggaatag ccaaagccat ccaatacttg
     1021 cacaacactc agccgtgcgc cgtcatctgt ggcaacgttt ccagtgcaaa catactcttg
     1081 gatgaccagc tccaacccaa actaacggat tttgctgcag cgcacttccg acccaatcta
     1141 gagcagcaga gttctaccat aaatatgacc ggcggtggca ggaaacatct gtggtacatg
     1201 ccagaagaat acatcagaca gggaagactt tccgttaaaa ctgatgtcta cagcttcgga
     1261 atcgtgatca tggaggttct aacgggctgc aaagtggtgc tggatgaccc gaaacacgtt
     1321 cagctgcggg acctcctcat ggaactgatg gagaaaagag gcctagactc ctgcctgtcc
     1381 ttcttagaca ggaagatacc accctgtcct cggaacttct ctgcaaagct cttctctctg
     1441 gcgggccggt gtgtggcaac gaaggccaag ttaagaccca cgatggacga agtcctgtcc
     1501 tctctggaga gcacccagcc tagcttgtat tttgcagaag accctcccac gtccttgaag
     1561 tccttcaggt gtccttctcc actgttcttg gataatgtcc caagtattcc agtagaagat
     1621 gatgaaaacc agaataacca ttcagtacct cccaaggaag ttttggggac agatagagtg
     1681 actcagaaaa ccccctttga atgcagccag tctgaggtca cctttctagg cttggaccga
     1741 aacagaggga acaggggaag tgaagcggat tgcaacgtgc ccagttcttc tcatgaggaa
     1801 tgctggtccc cagagcttgt ggcgccatcc caggacttaa gtcctactgt gatcagtttg
     1861 ggctcgtctt gggaagtacc aggccattct tatgggagca agccaatgga gaagaggtgt
     1921 tcctctgggc tcttttgcag tgagcatgaa cagtccaaaa agcagtgaat ccaccagaag
     1981 atcaagcaaa aaataaaagc aaacgtcact gaaggcactg agcaaatagc atccccgtga
     2041 aaagacacga gctctgagct ccgtgagtac agccaaggga ccaactgatg gagaatttga
     2101 atggtgcaga ttagcagcaa ggaagtctat tccttcctcc aaacagaata atttcaagag
     2161 atgctttatt caagtgaccg cctctcagtc aaacctgaga agctaaactg gagccaatca
     2221 gaattatcca agattccggg ttctgacaac caaaacctag caaagagtag caggacaagt
     2281 ctctctctta agtctctcac tctctctcat catccgagtg agatcttggt ataggtgaac
     2341 agagaaccac ccaccttcca gaaccagaac caccttttcc ccaagccagc agtcagtcac
     2401 tcaccatcag cagccagtag tcaccagcag ccaatcatga tacagtgtca ctctccctct
     2461 gcgcatgccc tacgtccttt ataaaaccca ggtcttcagg gcccacccct ttctttttcc
     2521 atccttgctc agaggcagcc ttttgtatac attccctgac cccaccccaa ttatatctct
     2581 catatgatat ctgttgcgta gtgtgacttt gtggcatgac ttggttgtca gatcatttgc
     2641 acaagaacaa acgaataaac aacaacaaag cccaccatca ttaccaccgg cacttaatgc
     2701 tagtctttct gctagggata ctgacagtct atttgcttcc catggtcata gggaagttgc
     2761 tcaaatgcaa aggttgtagg gaatgtctaa tttgtaaatg gcgtcgggtg cctttggaag
     2821 gaattgtgtt tttacagcca gttgctactc ttgtttatcg ctggttaacc ggtctgtccg
     2881 gaagtgagcc aagtcatcct tgctagggct ttttctgtgt agagagggaa ttccagtcca
     2941 aagtctgctt ctctgtattt aaattcttag aagagttgcc tgtggcattc caattgttat
     3001 ataaaaaaat tatattaaag aattacagca ctgtt
//
