LOCUS       NM_172161               3209 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 2 (Irak2),
            transcript variant 1, mRNA.
ACCESSION   NM_172161 XM_974569
VERSION     NM_172161.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3209)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3209)
  AUTHORS   Pereira,M., Ramalho,T., Andrade,W.A., Durso,D.F., Souza,M.C.,
            Fitzgerald,K.A., Golenbock,D.T., Silverman,N. and Gazzinelli,R.T.
  TITLE     The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and
            control of Toxoplasma gondii infection
  JOURNAL   Cell Rep 43 (2), 113795 (2024)
   PUBMED   38367238
REFERENCE   3  (bases 1 to 3209)
  AUTHORS   Jiang,M.Y., Man,W.R., Zhang,X.B., Zhang,X.H., Duan,Y., Lin,J.,
            Zhang,Y., Cao,Y., Wu,D.X., Shu,X.F., Xin,L., Wang,H., Zhang,X.,
            Li,C.Y., Gu,X.M., Zhang,X. and Sun,D.D.
  TITLE     Adipsin inhibits Irak2 mitochondrial translocation and improves
            fatty acid beta-oxidation to alleviate diabetic cardiomyopathy
  JOURNAL   Mil Med Res 10 (1), 63 (2023)
   PUBMED   38072993
  REMARK    GeneRIF: Adipsin inhibits Irak2 mitochondrial translocation and
            improves fatty acid beta-oxidation to alleviate diabetic
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3209)
  AUTHORS   Ferraro,F., Steinle,A., Narasimhan,H., Bleilevens,A.,
            Stolzenberg,P.M., Braunschweig,T., Stickeler,E. and Maurer,J.
  TITLE     IRAK2 Downregulation in Triple-Negative Breast Cancer Cells
            Decreases Cellular Growth In Vitro and Delays Tumour Progression in
            Murine Models
  JOURNAL   Int J Mol Sci 24 (3), 2520 (2023)
   PUBMED   36768848
  REMARK    GeneRIF: IRAK2 Downregulation in Triple-Negative Breast Cancer
            Cells Decreases Cellular Growth In Vitro and Delays Tumour
            Progression in Murine Models.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3209)
  AUTHORS   Joshi,H., Lunz,B., Peters,A., Zolch,M., Berberich,I. and
            Berberich-Siebelt,F.
  TITLE     The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination
            and optimal TLR signaling
  JOURNAL   Mol Immunol 134, 172-182 (2021)
   PUBMED   33799071
  REMARK    GeneRIF: The extreme C-terminus of IRAK2 assures full TRAF6
            ubiquitination and optimal TLR signaling.
REFERENCE   6  (bases 1 to 3209)
  AUTHORS   Conner,J.R., Smirnova,I.I. and Poltorak,A.
  TITLE     Forward genetic analysis of Toll-like receptor responses in
            wild-derived mice reveals a novel antiinflammatory role for
            IRAK1BP1
  JOURNAL   J Exp Med 205 (2), 305-314 (2008)
   PUBMED   18268037
REFERENCE   7  (bases 1 to 3209)
  AUTHORS   Hardy,M.P. and O'Neill,L.A.
  TITLE     The murine IRAK2 gene encodes four alternatively spliced isoforms,
            two of which are inhibitory
  JOURNAL   J Biol Chem 279 (26), 27699-27708 (2004)
   PUBMED   15082713
  REMARK    GeneRIF: Alternative splicing of the Irak2 gene in mice will
            generate agonistic or antagonistic Irak2 isoforms, which is likely
            to have consequences for the regulation of Toll-like receptors
            signaling.
REFERENCE   8  (bases 1 to 3209)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   9  (bases 1 to 3209)
  AUTHORS   Rosati,O. and Martin,M.U.
  TITLE     Identification and characterization of murine IRAK-2
  JOURNAL   Biochem Biophys Res Commun 297 (1), 52-58 (2002)
   PUBMED   12220507
REFERENCE   10 (bases 1 to 3209)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY110939.1, AY162378.1, AK078062.1 and CJ212338.1.
            
            On Jan 17, 2008 this sequence version replaced NM_172161.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and enodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148248.1, AK150056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY110939.1         2-22
            22-1423             AY162378.1         1-1402
            1424-3179           AK078062.1         1220-2975
            3180-3209           CJ212338.1         412-441
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.82 cM"
     gene            1..3209
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /note="interleukin-1 receptor-associated kinase 2"
                     /db_xref="GeneID:108960"
                     /db_xref="MGI:MGI:2429603"
     exon            1..175
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1950
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /note="isoform a is encoded by transcript variant 1;
                     interleukin-1 receptor-associated kinase-like 2;
                     interleukin-1 receptor-associated kinase 2c; mu-IRAK-2"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase-like 2
                     isoform a"
                     /protein_id="NP_751893.3"
                     /db_xref="CCDS:CCDS20430.1"
                     /db_xref="GeneID:108960"
                     /db_xref="MGI:MGI:2429603"
                     /translation="MACYIYQLPSWVLDDLCRNIDTLSEWDWMQFASYVITDLTQLRK
                     IKSMERVQGVSITRELLWWWSMRQATVQQLVDLLCHLELYRAAQIVLSWKPVPESTSP
                     LPAFPEAVKPGAVATSRRNLKDEQEKVRPVKPRSLLDTGPIMAGAQRQRPCEMDAPCS
                     LKTDAPDSPQSKYCSTSTSAPKQERLLGLPGDRLFWSEADVVQATEDFDQSHRISEGT
                     FADIYQGQRNGVAFAFKKLREVAGSSPGSMDRFLQAEMQLCLRCCHANVLPLLGFCTG
                     RQFHSLIYPYMANGSLHDRLWAQGNSDMLPWPQRASICSGLLLAVEHLHSLDIIHSNV
                     KSANVLLDQHLNPKLAHPVAHPHPDNKKTKYTVMRTHLFQASAAYLPEHFIRVGQLTK
                     QVDIFSCGIVLAEVLTGIPAMDKDRSPVYLKDLLLSEIPNSTSSVCSRKTSMGKAVVK
                     EICQRHVEKRAGLLPEACEEAWATAVSVCLRRRNASVEEARVSLAGVEEQLRGQLSLP
                     WSRVSEATGSSSNTPEETDDVDNSSLSVPSLVMMASCPGAASSPLFTGHGAAQPSTSG
                     RQEADSSSEACTGPQTPQNATETSWKIEINEAKRRLMENIVLYKEERLDSSELFGP"
     exon            176..358
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            359..502
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..597
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            598..798
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..863
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            864..978
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1088
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1284
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1347
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1548
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1837
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..3196
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2929
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /note="hexamer: AATAAA"
     polyA_site      3181
                     /gene="Irak2"
                     /gene_synonym="6330415L08Rik; IRAK-2"
                     /note="major polyA site"
ORIGIN      
        1 agtggggccg cgggcagcgc cgccctttac tagggaagtc gcggccctcc gccacaggct
       61 cagtcgccag gcagtctcgc catggcttgc tacatctacc agctgccgtc ctgggtgctg
      121 gacgacctgt gccgcaatat cgacacgctc agtgagtggg actggatgca gttcgcttcc
      181 tacgtgatca cagacctgac acagctgagg aagatcaagt ccatggagag ggtccagggg
      241 gtgagcatca cccgggagct actgtggtgg tggtccatgc ggcaggccac ggtccagcag
      301 ctggtggacc tcctgtgtca cctggaactc taccgagctg cccagattgt cttgagctgg
      361 aagccggttc ctgagagcac atctcccctc ccagccttcc cagaggctgt gaagccaggg
      421 gctgtggcta cttctagaag aaacctcaag gatgaacagg agaaagtccg gcctgtgaag
      481 ccacgttccc ttctagacac agggcccatc atggctgggg cccagcggca gcgtccgtgc
      541 gagatggatg ccccttgttc cctgaaaact gatgcacccg actctcccca gtctaagtat
      601 tgcagtactt ccacatctgc ccccaagcaa gaaaggcttt tgggtttgcc cggagacagg
      661 cttttctgga gtgaagcaga tgtcgtccaa gcaactgagg actttgacca aagccaccga
      721 atcagcgagg gcacctttgc cgatatctac cagggtcaaa ggaacggtgt ggccttcgcc
      781 ttcaagaagc tcagggaggt ggccggctcc agtccagggt ccatggacag attcctacag
      841 gcagagatgc agctctgcct cagatgctgc cacgcgaacg tcctacctct gctgggtttc
      901 tgcactggaa gacagttcca cagcctcatc tacccctaca tggcaaatgg ctctctgcac
      961 gacagactct gggctcaggg caactcagac atgctgccct ggccacagcg ggccagcatc
     1021 tgctcagggc tgcttctagc cgtggagcac ctgcatagcc tggacatcat ccacagcaat
     1081 gttaagagtg ccaacgtctt gctggaccag catcttaacc ccaagctggc tcatcctgtg
     1141 gctcaccctc atcccgacaa taaaaagacc aaatataccg tcatgaggac tcacctgttc
     1201 caggcctcag ctgcatatct gccggaacac ttcatcagag tggggcagct gaccaagcag
     1261 gtggacatct tcagctgtgg aattgtattg gccgaggtcc ttaccggcat ccctgcgatg
     1321 gacaaggacc gcagtccagt ttacctgaag gatttgcttc tcagtgagat tcccaacagt
     1381 acttcttcag tctgctccag gaagaccagc atggggaagg cagtggtgaa agagatctgc
     1441 cagagacatg tggagaagag ggcagggctg ctgcctgagg cctgtgagga agcctgggcc
     1501 accgctgtga gtgtctgcct gcggaggcgc aatgccagcg tggaggaggc acgagtctcc
     1561 ctggccgggg tggaggagca actccgaggg cagctgtccc ttccctggag cagggtttct
     1621 gaggccacag gctcatcttc caataccccg gaggaaacag atgacgttga caattccagc
     1681 ctcagcgtcc cttctttggt tatgatggca tcgtgcccag gggctgcctc ctctccactc
     1741 ttcacgggac atggagcagc acagccatcc accagtggga gacaggaggc tgactcctcg
     1801 tcagaggctt gcacaggccc acagacaccc cagaacgcta cagagacttc atggaaaatt
     1861 gagatcaatg aagccaaaag gagactgatg gagaacatcg tactctacaa agaagagaga
     1921 ctggacagca gcgagctctt tggaccctga tgaccagcgc acagctgaag acccttattc
     1981 tcaactggac agacaaacgt ccaggcaggg aagaggtctt tggctgccca aggtctgttg
     2041 agacccacac aacccaaaca tcagcctgaa cagaaggaaa catggcttca tcagagtcga
     2101 gttgcagggg ggtgggggta ggggacctca gcttatacag acaccatatc caggaagcac
     2161 tcctcctctc tgagtcgtct tagttagagg gctgtgaagt ggaacacctt gtatgtgatc
     2221 caaggatttg ggtggttttt gtggttccgg ggaacccacg ttgttgacca ccccaagaga
     2281 tgctgttgcc cccaaacctc ttagttctcc acaacggaca gagcaatcct gcagcatccg
     2341 tggcgttttc cagagttatc atctgtcagt catatttgta gacagctttc tgcaaattcc
     2401 cacttcttaa aagacctaca gccggtgtct ccgcaagttc tcaagttcag gactgcaaaa
     2461 gcaggacggt tggcaaagga ctccgtaggc tttctccttc ttcagttggt gatcctgtaa
     2521 gccaccggta tttaggaact gcctgctttt caccttcgac ctcccattgt gcccatattt
     2581 attttaatgg agactcagag gttgtgtgtt atttatagct aggtgaagaa gcatgagaaa
     2641 cagtctcatg tttgattctg ctgctagtta agtcaatcac ttggtgggtg gtagctcagt
     2701 atccttgtaa gataaccctg ctctgttctc cctggggaag aacagagctg ctctattcag
     2761 ctcttgggag gatgggtgca gcggctgcag aagcactttg aaaatgtatc tgttctgtgt
     2821 tctcaatgga gtaaaaggta tgtagttcat ggctctgcca tgtagaaaat gtttatgaag
     2881 tgaatatatt tttgaaaagt catgttgcaa acatgttttg taaaacaaag ctatttcttt
     2941 cttttttttt ttgttttttt tttgtttttt cgagacaggg tttctctgta tagccctggc
     3001 tgtccgggac ctcactttgt agaccaggct ggcctcgaac tcagaaatcc gcctgcctct
     3061 gcctcccgag tgctgggatt aaaggcgtgc gccaccatgc ccggctaaca aagctatttc
     3121 taattcacta tttaaaaaaa gaattccatt atagtgacaa aataaaaatg tttgtaatct
     3181 agcagctgtc ttataaaaaa aaaaaaaaa
//
