LOCUS       NM_022986               1893 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 1 binding
            protein 1 (Irak1bp1), transcript variant 1, mRNA.
ACCESSION   NM_022986
VERSION     NM_022986.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1893)
  AUTHORS   Zhao,W., Breese,E., Bowers,A., Hoggatt,J., Pelus,L.M.,
            Broxmeyer,H.E., Goebl,M. and Harrington,M.A.
  TITLE     SIMPL enhancement of tumor necrosis factor-alpha dependent p65-MED1
            complex formation is required for mammalian hematopoietic stem and
            progenitor cell function
  JOURNAL   PLoS One 8 (4), e61123 (2013)
   PUBMED   23630580
  REMARK    GeneRIF: SIMPL functions as a TNFalpha-dependent p65 co-activator
            by facilitating the recruitment of MED1 to p65 containing
            transcriptional complexes to control the expression of a subset of
            TNFalpha-induced genes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1893)
  AUTHORS   Conner,J.R., Smirnova,I.I., Moseman,A.P. and Poltorak,A.
  TITLE     IRAK1BP1 inhibits inflammation by promoting nuclear translocation
            of NF-kappaB p50
  JOURNAL   Proc Natl Acad Sci U S A 107 (25), 11477-11482 (2010)
   PUBMED   20534545
  REMARK    GeneRIF: IRAK1BP1 functions through its effects on NF-kappaB as a
            molecular switch to bias innate immune pathways toward the
            resolution of inflammation
REFERENCE   3  (bases 1 to 1893)
  AUTHORS   Benson,E.A., Goebl,M.G., Yang,F.C., Kapur,R., McClintick,J.,
            Sanghani,S., Clapp,D.W. and Harrington,M.A.
  TITLE     Loss of SIMPL compromises TNF-alpha-dependent survival of
            hematopoietic progenitors
  JOURNAL   Exp Hematol 38 (2), 71-81 (2010)
   PUBMED   19941935
  REMARK    GeneRIF: Signals transduced through the tumor necrosis
            factor-alpha-tumor necrosis factor -receptor I-SIMPL(substrate that
            interacts with mouse pelle-like kinase) pathway support
            hematopoietic progenitor cell survival, growth and differentiation
REFERENCE   4  (bases 1 to 1893)
  AUTHORS   Conner,J.R., Smirnova,I.I. and Poltorak,A.
  TITLE     Forward genetic analysis of Toll-like receptor responses in
            wild-derived mice reveals a novel antiinflammatory role for
            IRAK1BP1
  JOURNAL   J Exp Med 205 (2), 305-314 (2008)
   PUBMED   18268037
  REMARK    GeneRIF: IRAK1BP1 regulates transcription of a specific subset of
            Toll-like receptor responsive genes, producing an overall
            antiinflammatory profile
REFERENCE   5  (bases 1 to 1893)
  AUTHORS   Haag Breese,E., Uversky,V.N., Georgiadis,M.M. and Harrington,M.A.
  TITLE     The disordered amino-terminus of SIMPL interacts with members of
            the 70-kDa heat-shock protein family
  JOURNAL   DNA Cell Biol 25 (12), 704-714 (2006)
   PUBMED   17233114
  REMARK    GeneRIF: Hsp70/Hsc70 bind the intrinsically disordered
            amino-terminal region of SIMPL to stabilize the protein and thereby
            regulate its activity.
REFERENCE   6  (bases 1 to 1893)
  AUTHORS   Kwon,H.J., Breese,E.H., Vig-Varga,E., Luo,Y., Lee,Y., Goebl,M.G.
            and Harrington,M.A.
  TITLE     Tumor necrosis factor alpha induction of NF-kappaB requires the
            novel coactivator SIMPL
  JOURNAL   Mol Cell Biol 24 (21), 9317-9326 (2004)
   PUBMED   15485901
  REMARK    GeneRIF: TNF-alpha activation of NF-kappaB dependent-gene
            expression requires nuclear relocalization of p65 as well as
            nuclear relocalization of SIMPL, generating a TNF-alpha-specific
            induction of gene expression.
REFERENCE   7  (bases 1 to 1893)
  AUTHORS   Vig,E., Green,M., Liu,Y., Yu,K.Y., Kwon,H.J., Tian,J., Goebl,M.G.
            and Harrington,M.A.
  TITLE     SIMPL is a tumor necrosis factor-specific regulator of nuclear
            factor-kappaB activity
  JOURNAL   J Biol Chem 276 (11), 7859-7866 (2001)
   PUBMED   11096118
REFERENCE   8  (bases 1 to 1893)
  AUTHORS   Pfeuffer,T., Goebel,W., Laubinger,J., Bachmann,M. and Kuhn,M.
  TITLE     LaXp180, a mammalian ActA-binding protein, identified with the
            yeast two-hybrid system, co-localizes with intracellular Listeria
            monocytogenes
  JOURNAL   Cell Microbiol 2 (2), 101-114 (2000)
   PUBMED   11207567
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY719456.1 and AK045436.1.
            
            On Nov 24, 2009 this sequence version replaced NM_022986.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045436.1, AK076594.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               BY719456.1         1-205
            206-1893            AK045436.1         2-1689
FEATURES             Location/Qualifiers
     source          1..1893
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 45.16 cM"
     gene            1..1893
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /note="interleukin-1 receptor-associated kinase 1 binding
                     protein 1"
                     /db_xref="GeneID:65099"
                     /db_xref="MGI:MGI:1929475"
     exon            1..534
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1002
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Plk-interacting protein; Acta-binding protein 70; Acta
                     binding protein 3; signaling molecule that associates with
                     the mouse pelle-like kinase; IRAK1-binding protein 1"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase
                     1-binding protein 1 isoform 1"
                     /protein_id="NP_075362.3"
                     /db_xref="CCDS:CCDS23372.1"
                     /db_xref="GeneID:65099"
                     /db_xref="MGI:MGI:1929475"
                     /translation="MSLQPAPASRVFMELVPWADRGRENHPISAAEAQPIGRRPHVAE
                     AHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVSAEAKKSVCRRLDYITQSLQQQG
                     FQAENVTVTKNIRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPEFY
                     HTPGSVENLRRQACLVAVENAWRKAQEVCDLVGQTLGKPLLIKEEETKDWEGQTDDHQ
                     LSRLPGTLTVQQKIKSATIHAASKVFITFEVKGKEKKKKHL"
     exon            535..600
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /inference="alignment:Splign:2.1.0"
     exon            601..731
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1893
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1257..1262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /note="hexamer: AATAAA"
     polyA_site      1278
                     /gene="Irak1bp1"
                     /gene_synonym="4921528N06Rik; Aabp3; Aip70; Simpl"
                     /note="major polyA site"
ORIGIN      
        1 tgaccgcgag ggcaggacag acagctccgg ttcttgcagg ccatgaggag gtaactattt
       61 aaaatgtgtg caggcctcct tccctggggg aaaacccggt ctccacgctg cagcggcgcc
      121 tccatcccgg catcctccgc gcggactagc aagcgcgcgg cagctaaacg tcactccccg
      181 ccatcaacct ggcgttgcta tggcaacaca gctgccccag ctatgtcgct gcaacccgcc
      241 cctgcatcgc gggtgttcat ggaactggtt ccctgggctg accggggccg ggaaaaccat
      301 ccgatctcgg ccgcggaggc gcagccgatc ggccgccgac cccacgtcgc ggaggcccac
      361 cccggagccc gtgaggtcca cgtgagcggc gcggccgagg tgtccgccag ccccgaccga
      421 gcgctggtga ccgtgcgagt gagcagcacc aaggaggtgt cggccgaggc caagaagagt
      481 gtgtgtcgcc gcctggacta catcacgcag agcctccagc agcaggggtt tcaggcagaa
      541 aatgtaactg tgacaaagaa cattagaaga gtagaaaatg cgtatcacat ggaagccgag
      601 gtctgcatta catttactga atttggaaaa atgcaaaata tttgtaactt tctggttgaa
      661 aaactagata gctctgttgt catcagccca cctgagttct atcacacacc aggttctgtt
      721 gagaatcttc ggcggcaggc ctgtctggtt gctgttgaga atgcatggcg caaagctcag
      781 gaagtctgtg acctcgttgg ccaaactctg ggaaaacctt tactaatcaa agaagaagaa
      841 acaaaagact gggaaggcca aacggatgat catcagttat ccagactgcc aggcacatta
      901 actgtacaac agaaaatcaa aagtgcaacc atccatgcag cttcgaaggt gttcattact
      961 tttgaggtaa aaggaaaaga gaagaaaaaa aagcatcttt aaaattctaa ctaaaacatg
     1021 atgtgtctgt acttttaaat ctgtttttat acatttttac agtgcttctt tctgtctcgg
     1081 acattcaaca tattgtatgg catattaagt aagcctcagt aaaatctgcc actttttgaa
     1141 cataatgcca cagaatatat acgattactt tctagtttcc agaacactca gagaaacgct
     1201 gtaagaaata aatgtattaa aacatacttt tgtatactga gaatttatat attgaaaata
     1261 aaattaacaa aaaaccccgc tcatactgaa tttttacttc gcaaaacagg ttgtcatgtc
     1321 ttgcttgtat ttgttgtata aaactgtaga acctgagctg catctgagaa aagcacagtt
     1381 catgttccat gaaacatgtt aacgttttcc atttcatcac aatctatatg cttttctttt
     1441 aaaatgtttc atacaatgta ttttgattat attatttccc ccccccagct ccccacagat
     1501 tctaccccct ccatctgtag aatccaaaat aaatccaaga ccacccagcc ccttccccct
     1561 ctgaagggac tttccaaact atattagtgg gccaagtaca gagccagata aagaagctgg
     1621 ccgactaaac aatgctgaga aaaaaaccac aagggcaggc agagtgaggg actaggccaa
     1681 agatagtcac cctatgcaaa ccaaccagtg cctgaaaggg ttacttgcta caccaatgag
     1741 aataaaccag ctagccctgt tgcctaaatc tgccccttac aaggtataaa aagtgtgttc
     1801 tttgtttgtt cggggtctct gctcttgcct gtgtgctggt gggggggagg gtccccaagg
     1861 cattggatca ataaaaaaat cctcttgcag ttt
//
