LOCUS       NM_001177976            2478 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 1 (Irak1),
            transcript variant 2, mRNA.
ACCESSION   NM_001177976
VERSION     NM_001177976.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2478)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2478)
  AUTHORS   Pereira,M., Ramalho,T., Andrade,W.A., Durso,D.F., Souza,M.C.,
            Fitzgerald,K.A., Golenbock,D.T., Silverman,N. and Gazzinelli,R.T.
  TITLE     The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and
            control of Toxoplasma gondii infection
  JOURNAL   Cell Rep 43 (2), 113795 (2024)
   PUBMED   38367238
  REMARK    GeneRIF: The IRAK1/IRF5 axis initiates IL-12 response by dendritic
            cells and control of Toxoplasma gondii infection.
REFERENCE   3  (bases 1 to 2478)
  AUTHORS   Zhang,L., Wu,J.H., Jean-Charles,P.Y., Murali,P., Zhang,W.,
            Jazic,A., Kaur,S., Nepliouev,I., Stiber,J.A., Snow,K.,
            Freedman,N.J. and Shenoy,S.K.
  TITLE     Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation
  JOURNAL   J Biol Chem 299 (7), 104911 (2023)
   PUBMED   37311534
  REMARK    GeneRIF: Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation.
REFERENCE   4  (bases 1 to 2478)
  AUTHORS   Wang,Y., Pei,S., Liu,Z., Ding,Y., Qian,T., Wen,H., Hsu,S.W.,
            Zhou,Z., Zhang,J. and Wang,H.
  TITLE     IRAK-M suppresses the activation of microglial NLRP3 inflammasome
            and GSDMD-mediated pyroptosis through inhibiting IRAK1
            phosphorylation during experimental autoimmune encephalomyelitis
  JOURNAL   Cell Death Dis 14 (2), 103 (2023)
   PUBMED   36765034
  REMARK    GeneRIF: IRAK-M suppresses the activation of microglial NLRP3
            inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1
            phosphorylation during experimental autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2478)
  AUTHORS   Zhou,X., Zhang,Z., Xu,H., Zhu,B., Zhang,L., Lie,L., Huang,Y.,
            Du,X., Liu,H., Li,Y., Huang,Y., Hu,S., Zhou,C., Wen,Q.,
            Pepplenbosch,M.P. and Ma,L.
  TITLE     Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection
  JOURNAL   Sci Signal 15 (754), eabe1621 (2022)
   PUBMED   36194648
  REMARK    GeneRIF: Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
REFERENCE   6  (bases 1 to 2478)
  AUTHORS   Kanakaraj,P., Ngo,K., Wu,Y., Angulo,A., Ghazal,P., Harris,C.A.,
            Siekierka,J.J., Peterson,P.A. and Fung-Leung,W.P.
  TITLE     Defective interleukin (IL)-18-mediated natural killer and T helper
            cell type 1 responses in IL-1 receptor-associated kinase
            (IRAK)-deficient mice
  JOURNAL   J Exp Med 189 (7), 1129-1138 (1999)
   PUBMED   10190904
REFERENCE   7  (bases 1 to 2478)
  AUTHORS   Kanakaraj,P., Schafer,P.H., Cavender,D.E., Wu,Y., Ngo,K.,
            Grealish,P.F., Wadsworth,S.A., Peterson,P.A., Siekierka,J.J.,
            Harris,C.A. and Fung-Leung,W.P.
  TITLE     Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement
            for optimal induction of multiple IL-1 signaling pathways and IL-6
            production
  JOURNAL   J Exp Med 187 (12), 2073-2079 (1998)
   PUBMED   9625767
REFERENCE   8  (bases 1 to 2478)
  AUTHORS   Centanni,J.M., de Miguel,M., Gopalan,G., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     Interleukin-1 receptor-associated kinase gene Il1rak maps to the
            mouse X chromosome
  JOURNAL   Mamm Genome 9 (4), 340-341 (1998)
   PUBMED   9530638
REFERENCE   9  (bases 1 to 2478)
  AUTHORS   Manning,K.L., Novinger,S., Sullivan,P.S. and McDonald,T.P.
  TITLE     Successful determination of platelet lifespan in C3H mice by in
            vivo biotinylation
  JOURNAL   Lab Anim Sci 46 (5), 545-548 (1996)
   PUBMED   8905588
REFERENCE   10 (bases 1 to 2478)
  AUTHORS   Trofimova,M., Sprenkle,A.B., Green,M., Sturgill,T.W., Goebl,M.G.
            and Harrington,M.A.
  TITLE     Developmental and tissue-specific expression of mouse pelle-like
            protein kinase
  JOURNAL   J Biol Chem 271 (30), 17609-17612 (1996)
   PUBMED   8663605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672002.14, U56773.2 and BP760087.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region compared to variant 1, one of which results in a
            translational frameshift. The resulting protein (isoform 2) has a
            distinct C-terminus and is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY184364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL672002.14        142087-142262       c
            177-2247            U56773.2           1-2071
            2248-2478           BP760087.1         26-256              c
FEATURES             Location/Qualifiers
     source          1..2478
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.61 cM"
     gene            1..2478
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="interleukin-1 receptor-associated kinase 1"
                     /db_xref="GeneID:16179"
                     /db_xref="MGI:MGI:107420"
     exon            1..312
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2315
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     pelle-like protein kinase; interleukin-1
                     receptor-associated kinase-1b"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 1
                     isoform 2"
                     /protein_id="NP_001171447.1"
                     /db_xref="CCDS:CCDS53103.1"
                     /db_xref="GeneID:16179"
                     /db_xref="MGI:MGI:107420"
                     /translation="MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQ
                     FAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAW
                     HPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESELLQ
                     VPLPVSLGPPLPSSAPSSTKSSPESPVSGLQRAHPSPFCWPFCEISQGTCNFSEELRI
                     GEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAG
                     YCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSP
                     SLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLP
                     EEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLK
                     STQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKR
                     PPMTQVYKRLEGLQAGPPWELEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTR
                     APAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPGSHPSPASFREASCTQGGTTR
                     ESSVRSSPGFQPTTMEGSPTGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQ
                     LLSSGFFPDFVDIDAIGIEAFMSELFINHI"
     exon            313..480
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            481..612
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            613..716
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            717..905
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            906..970
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1085
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1204
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1412
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1478
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1715
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2097
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2247
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..2459
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="hexamer: AATAAA"
     polyA_site      2459
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggccgc ggagggcaag atggcggcgg gtcgagcgcc gcctcttccg cccggccggg
       61 tgtcgcacga ggccggcctg aaggggaagt gagtcagtgt ccgcggaccc ggcccgctaa
      121 ggcccgcgcc cgccgaggcc ccgagaggcc tcggcccggg ggcggcggcg gcggccatgg
      181 ccggggggcc gggccccggg gagcctgtgg ttccaggcgc ccagcacttc ttgtacgagg
      241 tgccaccctg ggttatgtgc cgcttctaca aagtgatgga cgccctggag cccgccgact
      301 ggtgccagtt cgcggccttg atcgtgcgcg accagacaga gctgcggctg tgcgagcgct
      361 ccgagcagcg cacagccagt gttctgtggc cctggatcaa ccgcaacgcg cgcgtagctg
      421 acctcgttca catcctcacg cacctgcagc tgctgcgtgc gagggacatc atcacagcct
      481 ggcaccctcc tgcccccgtt gtgcccccaa gcaccgctgc cccaaggccc agcagcatct
      541 ctgcaggctc tgaggccggg gactggagcc cccggaaatt gcagtcctct gcctccacct
      601 tcctctcccc agcttttcca ggctcccaga cccattctga gtcagagctc ctccaggttc
      661 cactccctgt ttccctcggg ccaccactac catcttcagc cccttcctcc accaagtcaa
      721 gcccagagag cccagtgtct ggcctccaaa gagcccatcc ctccccgttt tgctggccct
      781 tctgtgagat ttcccaaggc acctgcaact tctctgaaga actcaggatt ggagagggtg
      841 gttttggatg tgtgtaccga gcagtcatga gaaatactac atatgctgtg aagagactga
      901 aggaggaagc tgacctagag tggactatgg tgaaacagag cttcttaaca gaggtggaac
      961 agctatcaag gtttcgtcac ccaaatatcg tagactttgc tggctactgt gcagagagtg
     1021 gcttatactg ccttgtttat ggcttcttgc ccaatggctc cttggaggat cagctccacc
     1081 ttcagaccca ggcctgctcc ccactttcct ggcctcaacg actggacatt cttctgggca
     1141 cagcccgggc tattcagttt ttacatcagg atagccccag ccttatccat ggagacatca
     1201 agagttctaa cgtgcttctg gatgagagac tgatgcccaa gctgggagac tttggcctgg
     1261 ctcgtttcag ccgctttgcg ggggccaaag caagccagag cagtactgtg gcccggactt
     1321 ccacagttcg aggtaccctc gcctacttgc ctgaggagta catcaagaca ggccgactgg
     1381 ctgtggacac cgataccttc agctttgggg tggtaatact ggagaccctt gctggtcaga
     1441 gggctgtgag gacacaaggt gcaaagacca agtatttgaa agacctgatt gaagatgagg
     1501 ctgaagaggc tggagtgacc ctgaaaagca cccagcctac tctgtgggtg ggtgtagcca
     1561 cggatgcttg ggctgctcca attgctgccc agatctataa gaagcacctg gactccagac
     1621 ctgggccctg cccaccccag ttgggcctgg ccctggctca actagcttgc tgctgcatgc
     1681 accgtcgggc caagaagagg ccccccatga cccaggtata caagagacta gaagggcttc
     1741 aggcagggcc tccctgggag ctagaggttg ccggccatgg ctccccttcc ccacaggaga
     1801 actcctacat gtctaccact ggcagtgccc agagtgggga tgaaccatgg cagcctctag
     1861 tagtgaccac aagagcccca gcccaggctg cccagcaact ccagagaagt cccaaccagc
     1921 cagtggaaag tgatgagagt gttcccggcc tctctgctac cctgcattcc tggcacttga
     1981 ctccaggttc ccacccaagc ccagcgtcct tcagagaggc tagctgtacc cagggaggca
     2041 ctaccagaga atcaagtgtg aggagtagcc caggcttcca gcctacaacc atggaaggct
     2101 cacccacggg cagctcatcc ctgctgtcat cagaaccacc acagatcatc atcaacccag
     2161 cccgacagaa gatggtacaa aagctggctc tttatgaaga aggggtcttg gatagcctgc
     2221 aactgctgtc atcaggcttt ttcccagatt tcgtggatat tgatgctatt ggaattgaag
     2281 ccttcatgtc tgaattattc atcaatcata tatagaaatt tcattaagtt ttgatcctga
     2341 tctttattct gtggccttac ttcttagccc cacttgtttt gggggtgatt actctgagat
     2401 agtttgtata caatcaacct atctgaaaat aaagataatt ttactccatt gccaacctaa
     2461 aaaaaaaaaa aaaaaaaa
//
