LOCUS       NM_001177975            3835 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Mus musculus interleukin-1 receptor-associated kinase 1 (Irak1),
            transcript variant 3, mRNA.
ACCESSION   NM_001177975
VERSION     NM_001177975.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3835)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3835)
  AUTHORS   Pereira,M., Ramalho,T., Andrade,W.A., Durso,D.F., Souza,M.C.,
            Fitzgerald,K.A., Golenbock,D.T., Silverman,N. and Gazzinelli,R.T.
  TITLE     The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and
            control of Toxoplasma gondii infection
  JOURNAL   Cell Rep 43 (2), 113795 (2024)
   PUBMED   38367238
  REMARK    GeneRIF: The IRAK1/IRF5 axis initiates IL-12 response by dendritic
            cells and control of Toxoplasma gondii infection.
REFERENCE   3  (bases 1 to 3835)
  AUTHORS   Zhang,L., Wu,J.H., Jean-Charles,P.Y., Murali,P., Zhang,W.,
            Jazic,A., Kaur,S., Nepliouev,I., Stiber,J.A., Snow,K.,
            Freedman,N.J. and Shenoy,S.K.
  TITLE     Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation
  JOURNAL   J Biol Chem 299 (7), 104911 (2023)
   PUBMED   37311534
  REMARK    GeneRIF: Phosphorylation of USP20 on Ser334 by IRAK1 promotes
            IL-1beta-evoked signaling in vascular smooth muscle cells and
            vascular inflammation.
REFERENCE   4  (bases 1 to 3835)
  AUTHORS   Wang,Y., Pei,S., Liu,Z., Ding,Y., Qian,T., Wen,H., Hsu,S.W.,
            Zhou,Z., Zhang,J. and Wang,H.
  TITLE     IRAK-M suppresses the activation of microglial NLRP3 inflammasome
            and GSDMD-mediated pyroptosis through inhibiting IRAK1
            phosphorylation during experimental autoimmune encephalomyelitis
  JOURNAL   Cell Death Dis 14 (2), 103 (2023)
   PUBMED   36765034
  REMARK    GeneRIF: IRAK-M suppresses the activation of microglial NLRP3
            inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1
            phosphorylation during experimental autoimmune encephalomyelitis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3835)
  AUTHORS   Zhou,X., Zhang,Z., Xu,H., Zhu,B., Zhang,L., Lie,L., Huang,Y.,
            Du,X., Liu,H., Li,Y., Huang,Y., Hu,S., Zhou,C., Wen,Q.,
            Pepplenbosch,M.P. and Ma,L.
  TITLE     Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection
  JOURNAL   Sci Signal 15 (754), eabe1621 (2022)
   PUBMED   36194648
  REMARK    GeneRIF: Viperin impairs the innate immune response through the
            IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
REFERENCE   6  (bases 1 to 3835)
  AUTHORS   Kanakaraj,P., Ngo,K., Wu,Y., Angulo,A., Ghazal,P., Harris,C.A.,
            Siekierka,J.J., Peterson,P.A. and Fung-Leung,W.P.
  TITLE     Defective interleukin (IL)-18-mediated natural killer and T helper
            cell type 1 responses in IL-1 receptor-associated kinase
            (IRAK)-deficient mice
  JOURNAL   J Exp Med 189 (7), 1129-1138 (1999)
   PUBMED   10190904
REFERENCE   7  (bases 1 to 3835)
  AUTHORS   Kanakaraj,P., Schafer,P.H., Cavender,D.E., Wu,Y., Ngo,K.,
            Grealish,P.F., Wadsworth,S.A., Peterson,P.A., Siekierka,J.J.,
            Harris,C.A. and Fung-Leung,W.P.
  TITLE     Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement
            for optimal induction of multiple IL-1 signaling pathways and IL-6
            production
  JOURNAL   J Exp Med 187 (12), 2073-2079 (1998)
   PUBMED   9625767
REFERENCE   8  (bases 1 to 3835)
  AUTHORS   Centanni,J.M., de Miguel,M., Gopalan,G., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     Interleukin-1 receptor-associated kinase gene Il1rak maps to the
            mouse X chromosome
  JOURNAL   Mamm Genome 9 (4), 340-341 (1998)
   PUBMED   9530638
REFERENCE   9  (bases 1 to 3835)
  AUTHORS   Manning,K.L., Novinger,S., Sullivan,P.S. and McDonald,T.P.
  TITLE     Successful determination of platelet lifespan in C3H mice by in
            vivo biotinylation
  JOURNAL   Lab Anim Sci 46 (5), 545-548 (1996)
   PUBMED   8905588
REFERENCE   10 (bases 1 to 3835)
  AUTHORS   Trofimova,M., Sprenkle,A.B., Green,M., Sturgill,T.W., Goebl,M.G.
            and Harrington,M.A.
  TITLE     Developmental and tissue-specific expression of mouse pelle-like
            protein kinase
  JOURNAL   J Biol Chem 271 (30), 17609-17612 (1996)
   PUBMED   8663605
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY729815.1, AK143694.1 and AL672002.14.
            
            Transcript Variant: This variant (3) lacks an alternate exon in the
            coding region compared to variant 1. The resulting protein (isoform
            3) is shorter but has the same N- and C-termini compared to isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143694.1, AK045958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY729815.1         3-91
            90-2943             AK143694.1         1-2854
            2944-3835           AL672002.14        132255-133146       c
FEATURES             Location/Qualifiers
     source          1..3835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 37.61 cM"
     gene            1..3835
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="interleukin-1 receptor-associated kinase 1"
                     /db_xref="GeneID:16179"
                     /db_xref="MGI:MGI:107420"
     exon            1..309
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2309
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     pelle-like protein kinase; interleukin-1
                     receptor-associated kinase-1b"
                     /codon_start=1
                     /product="interleukin-1 receptor-associated kinase 1
                     isoform 3"
                     /protein_id="NP_001171446.1"
                     /db_xref="CCDS:CCDS53104.1"
                     /db_xref="GeneID:16179"
                     /db_xref="MGI:MGI:107420"
                     /translation="MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQ
                     FAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAW
                     HPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESELLQ
                     VPLPVSLGPPLPSSAPSSTKQSSPESPVSGLQRAHPSPFCWPFCEISQGTCNFSEELR
                     IGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFA
                     GYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDS
                     PSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYL
                     PEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTL
                     KSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKK
                     RPPMTQVYKRLEGLQAGPPWELEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTT
                     RAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPGSHPSPASFREASCTQGGTT
                     RESSVRSSPGFQPTTMEGSPTGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSL
                     QLLSSGFFPGLDLEPEKSQGPEESDEFQS"
     exon            310..477
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            478..609
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            610..713
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            714..905
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            906..970
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1085
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1204
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1412
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1478
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1715
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..2097
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2247
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     exon            2248..3835
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3436..3441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="hexamer: AATAAA"
     polyA_site      3467
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="major polyA site"
     regulatory      3804..3809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="hexamer: AATAAA"
     polyA_site      3835
                     /gene="Irak1"
                     /gene_synonym="Il1rak; IRAK; IRAK-1; IRAK1-S; IRAK1b;
                     mPLK; Plpk"
                     /note="major polyA site"
ORIGIN      
        1 aggccgcgga gggcaagatg gcggcgggtc gagcgccgcc tcttccgccc ggccgggtgt
       61 cgcacgaggc cggcctgaag gggaagtgag tcagtgtccg cggacccggc ccgctaaggc
      121 ccgcgcccgc cgaggccccg agaggcctcg gcccgggggc ggcggcggcg gccatggccg
      181 gggggccggg ccccggggag cctgtggttc caggcgccca gcacttcttg tacgaggtgc
      241 caccctgggt tatgtgccgc ttctacaaag tgatggacgc cctggagccc gccgactggt
      301 gccagttcgc ggccttgatc gtgcgcgacc agacagagct gcggctgtgc gagcgctccg
      361 agcagcgcac agccagtgtt ctgtggccct ggatcaaccg caacgcgcgc gtagctgacc
      421 tcgttcacat cctcacgcac ctgcagctgc tgcgtgcgag ggacatcatc acagcctggc
      481 accctcctgc ccccgttgtg cccccaagca ccgctgcccc aaggcccagc agcatctctg
      541 caggctctga ggccggggac tggagccccc ggaaattgca gtcctctgcc tccaccttcc
      601 tctccccagc ttttccaggc tcccagaccc attctgagtc agagctcctc caggttccac
      661 tccctgtttc cctcgggcca ccactaccat cttcagcccc ttcctccacc aagcagtcaa
      721 gcccagagag cccagtgtct ggcctccaaa gagcccatcc ctccccgttt tgctggccct
      781 tctgtgagat ttcccaaggc acctgcaact tctctgaaga actcaggatt ggagagggtg
      841 gttttggatg tgtgtaccga gcagtcatga gaaatactac atatgctgtg aagagactga
      901 aggaggaagc tgacctagag tggactatgg tgaaacagag cttcttaaca gaggtggaac
      961 agctatcaag gtttcgtcac ccaaatatcg tagactttgc tggctactgt gcagagagtg
     1021 gcttatactg ccttgtttat ggcttcttgc ccaatggctc cttggaggat cagctccacc
     1081 ttcagaccca ggcctgctcc ccactttcct ggcctcaacg actggacatt cttctgggca
     1141 cagcccgggc tattcagttt ttacatcagg atagccccag ccttatccat ggagacatca
     1201 agagttctaa cgtgcttctg gatgagagac tgatgcccaa gctgggagac tttggcctgg
     1261 ctcgtttcag ccgctttgcg ggggccaaag caagccagag cagtactgtg gcccggactt
     1321 ccacagttcg aggtaccctc gcctacttgc ctgaggagta catcaagaca ggccgactgg
     1381 ctgtggacac cgataccttc agctttgggg tggtaatact ggagaccctt gctggtcaga
     1441 gggctgtgag gacacaaggt gcaaagacca agtatttgaa agacctgatt gaagatgagg
     1501 ctgaagaggc tggagtgacc ctgaaaagca cccagcctac tctgtgggtg ggtgtagcca
     1561 cggatgcttg ggctgctcca attgctgccc agatctataa gaagcacctg gactccagac
     1621 ctgggccctg cccaccccag ttgggcctgg ccctggctca actagcttgc tgctgcatgc
     1681 accgtcgggc caagaagagg ccccccatga cccaggtata caagagacta gaagggcttc
     1741 aggcagggcc tccctgggag ctagaggttg ccggccatgg ctccccttcc ccacaggaga
     1801 actcctacat gtctaccact ggcagtgccc agagtgggga tgaaccatgg cagcctctag
     1861 tagtgaccac aagagcccca gcccaggctg cccagcaact ccagagaagt cccaaccagc
     1921 cagtggaaag tgatgagagt gttcccggcc tctctgctac cctgcattcc tggcacttga
     1981 ctccaggttc ccacccaagc ccagcgtcct tcagagaggc tagctgtacc cagggaggca
     2041 ctaccagaga atcaagtgtg aggagtagcc caggcttcca gcctacaacc atggaaggct
     2101 cacccacggg cagctcatcc ctgctgtcat cagaaccacc acagatcatc atcaacccag
     2161 cccgacagaa gatggtacaa aagctggctc tttatgaaga aggggtcttg gatagcctgc
     2221 aactgctgtc atcaggcttt ttcccaggct tggatttaga acctgaaaag agccagggac
     2281 ctgaagaaag tgatgaattc cagagctgat ttgttcactc tgacaaatcc ctcagactca
     2341 gaggtcaaag ttctcatgct tggaagttct catagtgtgc aaactcctca gtagcccaaa
     2401 ggcatcaggt gtgggggctc actctggcaa aggagagagg gcagtggacc ctgctgttct
     2461 cagaatgtga acacagacag ggccagccaa agaacttgat agaagctgat aaggcaggca
     2521 atgtgaggcc agcatttgtg agcaaggcaa gcagagtacc taaggaattg ggtagtacaa
     2581 aacagaagac tggggctggt gagatggctc agtgggtatg agcacccgat tgctcttcca
     2641 aaggtccgga gttcaaatcc cagcaaccac atggtggctc acaaccatct gtaacaagat
     2701 ctgacgccct cttctggagt gtctgaagac agctacagtg tacttatata taataaataa
     2761 atctttaaaa aaaaaaaaca gaagactgct agctacacag gcccagagga cacaagtagg
     2821 tctgtttgta tggtgggagc tagctcccct gagagctaga taatatatct gcagtctgtg
     2881 agtctattcc tcagaacttc cctaaaacac caagcgaaag tagctgttgt gcttgtaaat
     2941 tgcaaaaaaa aaaaaaaaaa aaaaaaaaag agtgtcttac agttcagtcc actagctaga
     3001 agtgagcact ctgagattct cccaagagtc taataaaacc cccctcccca tcttgggtgg
     3061 atatatgcaa gccttgccag atagcagtga gctagtttca tatgactacc tgcctgccta
     3121 ggcaggctct ctctataccc tgcaaattga ctgtggatgc ccaaggttct gcttatggca
     3181 gaaaggtcca gcaaagccca gctttgtggt acccagacag tgagaagccc caagaaagaa
     3241 gaaactgaga gcaaagctaa gtatttgagg gggaagaatg ttacatttaa aaaaaaaaca
     3301 acaagttttt gtataattaa gtgtcttcac aagtagccca gggctatagc ccaggcttac
     3361 agtgattctg tgtttgagtc atgagtcaca ctacatgccc ctgtgtaatt ggtgacatcc
     3421 aatttgtcct tgagtaataa aagcatacat ttcactgtct ggttaaactt gtggaatttg
     3481 ttgtgctaaa agtgttatgc tttcctaatg ctttatatct ctgggctctt aagtgtccac
     3541 ccaaaactca ggcccctagc atttgttctt ttctcttgtc aggccagact ggggatagat
     3601 ccccttgctt tcttgtcttg cagatttcgt ggatattgat gctattggaa ttgaagcctt
     3661 catgtctgaa ttattcatca atcatatata gaaatttcat taagttttga tcctgatctt
     3721 tattctgtgg ccttacttct tagccccact tgttttgggg gtgattactc tgagatagtt
     3781 tgtatacaat caacctatct gaaaataaag ataattttac tccattgcca accta
//
