LOCUS       NM_008511               2283 bp    mRNA    linear   ROD 10-FEB-2024
DEFINITION  Mus musculus inositol 1,4,5-triphosphate receptor associated 2
            (Irag2), transcript variant 1, mRNA.
ACCESSION   NM_008511
VERSION     NM_008511.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Pruschenk,S. and Schlossmann,J.
  TITLE     Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets
  JOURNAL   Int J Mol Sci 23 (12), 6695 (2022)
   PUBMED   35743138
  REMARK    GeneRIF: Function of IRAG2 Is Modulated by NO/cGMP in Murine
            Platelets.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Pruschenk,S., Majer,M., Schreiber,R. and Schlossmann,J.
  TITLE     IRAG2 Interacts with IP3-Receptor Types 1, 2, and 3 and Regulates
            Intracellular Ca2+ in Murine Pancreatic Acinar Cells
  JOURNAL   Int J Mol Sci 22 (24), 13409 (2021)
   PUBMED   34948204
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Chang,C.Y., Wang,J., Zhao,Y., Liu,J., Yang,X., Yue,X., Wang,H.,
            Zhou,F., Inclan-Rico,J.M., Ponessa,J.J., Xie,P., Zhang,L.,
            Siracusa,M.C., Feng,Z. and Hu,W.
  TITLE     Tumor suppressor p53 regulates intestinal type 2 immunity
  JOURNAL   Nat Commun 12 (1), 3371 (2021)
   PUBMED   34099671
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Kozono,T., Tadahira,K., Okumura,W., Itai,N., Tamura-Nakano,M.,
            Dohi,T., Tonozuka,T. and Nishikawa,A.
  TITLE     Jaw1/LRMP has a role in maintaining nuclear shape via interaction
            with SUN proteins
  JOURNAL   J Biochem 164 (4), 303-311 (2018)
   PUBMED   29878215
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Wang,M., Lemon,W.J., Liu,G., Wang,Y., Iraqi,F.A., Malkinson,A.M.
            and You,M.
  TITLE     Fine mapping and identification of candidate pulmonary adenoma
            susceptibility 1 genes using advanced intercross lines
  JOURNAL   Cancer Res 63 (12), 3317-3324 (2003)
   PUBMED   12810665
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Grimm,C.H., Rogner,U.C. and Avner,P.
  TITLE     Lrmp and Bcat1 are candidates for the type I diabetes
            susceptibility locus Idd6
  JOURNAL   Autoimmunity 36 (4), 241-246 (2003)
   PUBMED   14563018
  REMARK    GeneRIF: Lrmp is a condidate for the type I diabetes susceptility
            locus Idd6.
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Maria,D.A., Manenti,G., Galbiati,F., Ribeiro,O.G., Cabrera,W.H.,
            Barrera,R.G., Pettinicchio,A., De Franco,M., Starobinas,N.,
            Siqueira,M., Dragani,T.A. and Ibanez,O.M.
  TITLE     Pulmonary adenoma susceptibility 1 (Pas1) locus affects
            inflammatory response
  JOURNAL   Oncogene 22 (3), 426-432 (2003)
   PUBMED   12545163
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Behrens,T.W., Kearns,G.M., Rivard,J.J., Bernstein,H.D.,
            Yewdell,J.W. and Staudt,L.M.
  TITLE     Carboxyl-terminal targeting and novel post-translational processing
            of JAW1, a lymphoid protein of the endoplasmic reticulum
  JOURNAL   J Biol Chem 271 (38), 23528-23534 (1996)
   PUBMED   8798562
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Behrens,T.W., Jagadeesh,J., Scherle,P., Kearns,G., Yewdell,J. and
            Staudt,L.M.
  TITLE     Jaw1, A lymphoid-restricted membrane protein localized to the
            endoplasmic reticulum
  JOURNAL   J Immunol 153 (2), 682-690 (1994)
   PUBMED   8021504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121950.2.
            
            [WARNING] On Mar 6, 2024 this sequence was replaced by NM_008511.5.
            
            On Mar 5, 2019 this sequence version replaced NM_008511.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160009.1, BC052909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC121950.2         87829-88166
            339-486             AC121950.2         103520-103667
            487-568             AC121950.2         104242-104323
            569-615             AC121950.2         113696-113742
            616-680             AC121950.2         113840-113904
            681-779             AC121950.2         114039-114137
            780-850             AC121950.2         115347-115417
            851-908             AC121950.2         124704-124761
            909-972             AC121950.2         126434-126497
            973-1000            AC121950.2         126593-126620
            1001-1141           AC121950.2         126937-127077
            1142-1276           AC121950.2         131257-131391
            1277-1424           AC121950.2         134029-134176
            1425-1468           AC121950.2         135807-135850
            1469-1531           AC121950.2         137564-137626
            1532-1581           AC121950.2         137715-137764
            1582-1683           AC121950.2         138044-138145
            1684-1791           AC121950.2         139764-139871
            1792-2283           AC121950.2         140497-140988
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.34 cM"
     gene            1..2283
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /note="inositol 1,4,5-triphosphate receptor associated 2"
                     /db_xref="GeneID:16970"
                     /db_xref="MGI:MGI:108424"
     exon            1..338
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            339..486
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..2035
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphoid-restricted membrane protein"
                     /codon_start=1
                     /product="inositol 1,4,5-triphosphate receptor associated
                     2 isoform 1"
                     /protein_id="NP_032537.3"
                     /db_xref="CCDS:CCDS39704.1"
                     /db_xref="GeneID:16970"
                     /db_xref="MGI:MGI:108424"
                     /translation="MLCVKGPPEQEPEDGALDVTRGCQCPLPTEGSILGQELLDCTRM
                     NEDQSTDENGADHLYSESPSQLREYLTQPSSEQTSSSESTVTSSESGSDILHMASGDL
                     DCKPLCEKEEEARAASAMQGTSLAPAAYGDYTSVGVAKAASQLEAGEELRTTENGGKG
                     SAPGETEISMPPKASVKLVNFQQSENTSANEKEVEAEFLRLSLGLKCDWFTLEKRVKL
                     EERSRDLAEENLKKEITNCLKLLESLTPLCEEDNQAQEIVKKLEKSIVLLSQCTARVA
                     SRAEMLGAINQESRVSRAVEVMIQHVENLKRMYAKEHAELEDLKQALLQNDRSFNSLP
                     DEDDCQIKKRSSSLNSKPSSLRRVTIASLPRNLGNVGLVSGMENNDRFSRRSSSWRIL
                     GTKQGEHRPSLHRFISTYSWADAEDERSDVKARDAPEPQGEEAVEGTRKPSLSERRSS
                     TLAWDRGTICSSVASWVTHLQASFRRANRALWLTGLIIILIAALMSFLTGQLFQTAVE
                     AAPTQEGDSWLSLEHILWPFTRLGHDGPLPV"
     exon            487..568
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            569..615
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            616..680
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            681..779
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            780..850
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            851..908
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            909..972
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1000
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1141
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1276
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1424
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1468
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1531
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1581
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1683
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1791
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2283
                     /gene="Irag2"
                     /gene_synonym="D6Int3; D6Int4; D6Int5; D6Int7; D6Int8;
                     Jaw1; Lrmp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaaagct taagttgctt ctagggactc tctgggtgga aggatctggg cctgctgcgc
       61 ccgcccgtgc aaacagaatt gcagaagttg agcctacgct tatcatttcc ctgagaagaa
      121 aagcatattt ccagtttcct gtgcctaaga acaagcatcc agcgcccttc ccgcggctca
      181 aacccaggct gacctgtgca tatgggtcag ggggatcagg atggggcctg cgcatgaggc
      241 aagcctctgc tacaagaact agaggaagcg attccagaag gagatcacag tccccagcac
      301 tactcagact caggagctga agaccagggg cgttcagtat gcctgtgtct tgacggcctc
      361 acagcaattc caaggctaga actgacaccc atctcatgtg ccagaaactc agcccatgct
      421 ctgtgtaaaa ggtcccccag agcaggaacc agaagatggg gctttggacg tgacaagagg
      481 gtgccagtgc ccactcccca cggaaggctc catcttggga caggagcttc tagactgtac
      541 cagaatgaac gaggaccaga gtacagacga gaatggtgct gaccacttgt attccgagag
      601 cccgtcacag ctcagggagt atctcacaca gccatcgtct gaacagactt catcctcgga
      661 gagcactgtg acgtcaagtg agtctggatc agacattttg cacatggctt ctggtgacct
      721 tgactgcaaa cctctctgtg agaaggagga ggaagcaaga gccgcctctg ccatgcaagg
      781 caccagccta gctcctgctg cttatggaga ctacacgagt gtgggcgtgg ccaaggctgc
      841 atcccagctg gaagcaggag aggaactcag aaccacagaa aacggaggga agggcagtgc
      901 cccgggagag acggagattt ccatgccccc caaagcatct gtgaagctcg ttaactttca
      961 gcagagtgaa aacacttcag ctaatgagaa ggaagtggag gcagagttcc tcaggttatc
     1021 tttgggactt aagtgtgact ggtttacatt ggagaagagg gtgaagcttg aagagaggtc
     1081 ccgggacctg gcagaggaaa atttgaagaa agaaatcaca aactgtttaa agcttttaga
     1141 gtcgctgact cccctgtgtg aagaggacaa ccaggctcag gaaatcgtta agaagctgga
     1201 gaagagtata gtactgctca gccagtgcac agcccgagtg gccagcaggg ctgagatgct
     1261 gggcgccatc aaccaggaaa gccgggtgag tagagcggtg gaggtgatga tccagcacgt
     1321 ggagaacctg aagcggatgt acgccaaaga gcacgcagag ctggaggatc tgaagcaagc
     1381 actgctgcag aacgacaggt cttttaactc tctgccagat gaagatgact gtcagattaa
     1441 aaagcgttca tcttctctaa attccaagcc atcttctctt cgaagagtga ccattgcctc
     1501 tttgcccagg aatcttggaa atgtggggct ggtgtcaggc atggaaaata atgacagatt
     1561 cagccggcgg tcgagcagct ggagaatcct ggggacaaag cagggtgagc accgcccctc
     1621 gctgcatcgc ttcatcagca cctattcctg ggccgacgct gaggacgaga gaagtgacgt
     1681 gaaagccaga gacgccccag aaccacaagg cgaagaggca gtggagggga ccaggaagcc
     1741 cagcctttct gagaggagaa gcagcacatt ggcctgggac aggggcacaa tctgcagctc
     1801 agtggcttcc tgggtcactc acctgcaggc gtccttcaga agagccaaca gagcactctg
     1861 gctcacgggg ctcatcatca tactgatcgc agcgctgatg agcttcctca caggtcagct
     1921 cttccagaca gccgtggagg ctgcgcccac acaggagggg gactcctggc tgtctctaga
     1981 acacatctta tggccattta ccagactcgg gcatgatgga ccactgccag tgtgactgac
     2041 gtgcagctca atgtaccctt ggattttaac gtttccttct gagatttgta aattggtaac
     2101 ttttttttag taactatagt gcaaagctag ggtcctcagc agctgggatc tttttattcc
     2161 ccaacaaaag cacaggggac tacaaaaggg aggggacccc acctagggta ttttaatgag
     2221 ctttctgagt gagaggcatc agactttatt gagatgtatc caaataaaga ccattcaaat
     2281 ctt
//
